{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:22:54Z","timestamp":1785410574436,"version":"3.56.0"},"reference-count":238,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270599"],"award-info":[{"award-number":["82270599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82270599"],"award-info":[{"award-number":["82270599"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Hepatic ischemia\u2013reperfusion injury (HIRI) is a major cause of postoperative liver dysfunction and adverse outcomes in hepatectomy, liver transplantation, and hemorrhagic shock. Among the multiple mechanisms implicated in HIRI, mitochondria are recognized as central organelles that integrate metabolic failure, oxidative stress, inflammation, and cell death. During ischemia, interruption of oxygen and nutrient supply impairs oxidative phosphorylation, depletes ATP, disrupts ionic homeostasis, and renders mitochondria highly vulnerable to subsequent injury. Upon reperfusion, reoxygenation triggers excessive reactive oxygen species production, calcium overload, mitochondrial permeability transition pore opening, and release of damage-associated molecular patterns, thereby amplifying hepatocellular injury and sterile inflammatory responses. As a key component of mitochondrial quality control, mitophagy plays a context-dependent role in HIRI. Appropriate activation of mitophagy facilitates the clearance of damaged mitochondria, limits oxidative stress, restrains inflammasome activation, and preserves hepatocellular homeostasis, whereas insufficient or dysregulated mitophagy contributes to mitochondrial accumulation and aggravates liver injury. This review summarizes mitochondrial alterations during the ischemic and reperfusion phases, outlines the major mitophagy pathways involved in HIRI and discusses recent advances in upstream regulation, disease-specific dysregulation, and mitophagy-targeted interventions. A better understanding of the dynamic and biphasic nature of mitophagy in HIRI may provide a stronger theoretical basis for precision liver-protective strategies and future translational therapies.<\/jats:p>","DOI":"10.3390\/biom16070941","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:06:34Z","timestamp":1782875194000},"page":"941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitophagy in Hepatic Ischemia\u2013Reperfusion Injury: From Mitochondrial Dysfunction to Therapeutic Targeting"],"prefix":"10.3390","volume":"16","author":[{"given":"Xinlei","family":"Zou","sequence":"first","affiliation":[{"name":"General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyue","family":"Li","sequence":"additional","affiliation":[{"name":"General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Jiang","sequence":"additional","affiliation":[{"name":"General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41575-021-00549-8","article-title":"Liver ischaemia-reperfusion injury: A new understanding of the role of innate immunity","volume":"19","author":"Hirao","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e2007727","DOI":"10.1002\/smll.202007727","article-title":"Nanotheranostics for the Management of Hepatic Ischemia-Reperfusion Injury","volume":"17","author":"Guan","year":"2021","journal-title":"Small"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103258","DOI":"10.1016\/j.redox.2024.103258","article-title":"Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches","volume":"75","author":"George","year":"2024","journal-title":"Redox Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1053\/j.gastro.2011.04.051","article-title":"Wnt-\u03b2-catenin signaling protects against hepatic ischemia and reperfusion injury in mice","volume":"141","author":"Lehwald","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Pretzsch, E., Nie\u00df, H., Khaled, N.B., B\u00f6sch, F., Guba, M., Werner, J., Angele, M., and Chaudry, I.H. (2022). Molecular Mechanisms of Ischaemia-Reperfusion Injury and Regeneration in the Liver-Shock and Surgery-Associated Changes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112942"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3350\/cmh.2024.0222","article-title":"Current status and perspective on molecular targets and therapeutic intervention strategy in hepatic ischemia-reperfusion injury","volume":"30","author":"Liu","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-cellbio-120420-015303","article-title":"Mitochondria as Cellular and Organismal Signaling Hubs","volume":"38","author":"Shen","year":"2022","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s43556-025-00284-5","article-title":"Role of mitochondria in physiological activities, diseases, and therapy","volume":"6","author":"Wang","year":"2025","journal-title":"Mol. Biomed."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Andrianova, N.V., Buyan, M.I., Brezgunova, A.A., Cherkesova, K.S., Zorov, D.B., and Plotnikov, E.Y. (2025). Hemorrhagic Shock and Mitochondria: Pathophysiology and Therapeutic Approaches. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26051843"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: From mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102926","DOI":"10.1016\/j.redox.2023.102926","article-title":"Mitochondrial complex I ROS production and redox signaling in hypoxia","volume":"67","author":"Okoye","year":"2023","journal-title":"Redox Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107466","DOI":"10.1016\/j.phrs.2024.107466","article-title":"The PINK1\/Parkin signaling pathway-mediated mitophagy: A forgotten protagonist in myocardial ischemia\/reperfusion injury","volume":"209","author":"Zhao","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Teodoro, J.S., Da Silva, R.T., Machado, I.F., Panisello-Rosell\u00f3, A., Rosell\u00f3-Catafau, J., Rolo, A.P., and Palmeira, C.M. (2022). Shaping of Hepatic Ischemia\/Reperfusion Events: The Crucial Role of Mitochondria. Cells, 11.","DOI":"10.3390\/cells11040688"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41419-024-06804-5","article-title":"Mitophagy-related regulated cell death: Molecular mechanisms and disease implications","volume":"15","author":"Yang","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_15","first-page":"59","article-title":"Targeting mitochondrial quality control: New therapeutic strategies for major diseases","volume":"11","author":"Hong","year":"2024","journal-title":"Mil. Med. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101974","DOI":"10.1016\/j.mito.2024.101974","article-title":"Fighting ischemia-reperfusion injury: Focusing on mitochondria-derived ferroptosis","volume":"79","author":"Tian","year":"2024","journal-title":"Mitochondrion"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11064-016-2149-9","article-title":"Glucose and Intermediary Metabolism and Astrocyte-Neuron Interactions Following Neonatal Hypoxia-Ischemia in Rat","volume":"42","author":"Brekke","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ma, X., McKeen, T., Zhang, J., and Ding, W.-X. (2020). Role and Mechanisms of Mitophagy in Liver Diseases. Cells, 9.","DOI":"10.3390\/cells9040837"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhang, S., Rao, S., Yang, M., Ma, C., Hong, F., and Yang, S. (2022). Role of Mitochondrial Pathways in Cell Apoptosis during He-Patic Ischemia\/Reperfusion Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042357"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"115267","DOI":"10.1016\/j.intimp.2025.115267","article-title":"Hepatic ischemia-reperfusion and mitochondrial quality control: Potential therapeutic targets","volume":"163","author":"Wang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cmet.2011.03.024","article-title":"Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: Coupled mechanisms of energy metabolism regulation","volume":"13","author":"Gatti","year":"2011","journal-title":"Cell Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e42556","DOI":"10.1097\/MD.0000000000042556","article-title":"Exploration of the effects of 66 mitochondria-associated proteins on different cardiomyopathies: A bidirectional 2-sample mendelian randomization study","volume":"104","author":"Peng","year":"2025","journal-title":"Medicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2741\/4511","article-title":"The little big genome: The organization of mitochondrial DNA","volume":"22","author":"Garcia","year":"2017","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.celrep.2018.08.036","article-title":"Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle","volume":"24","author":"Maurya","year":"2018","journal-title":"Cell Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"C1172","DOI":"10.1152\/ajpcell.00195.2006","article-title":"Physiological diversity of mitochondrial oxidative phosphorylation","volume":"291","author":"Benard","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e13125","DOI":"10.14814\/phy2.13125","article-title":"Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain","volume":"5","author":"Khalifa","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00018-023-04827-3","article-title":"Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function","volume":"80","author":"Chi","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/japplphysiol.00759.2013","article-title":"Regulation of oxidative phosphorylation during work transitions results from its kinetic properties","volume":"116","author":"Korzeniewski","year":"2013","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100077","DOI":"10.1016\/j.crimmu.2024.100077","article-title":"Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response","volume":"5","author":"Kumar","year":"2024","journal-title":"Curr. Res. Immunol."},{"key":"ref_32","first-page":"207","article-title":"Tissue-specific differences in mitochondrial activity and biogenesis","volume":"11","author":"Montoya","year":"2010","journal-title":"Mitochondrion"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1113\/jphysiol.2012.230185","article-title":"Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects","volume":"590","author":"Larsen","year":"2012","journal-title":"J. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"aad0189","DOI":"10.1126\/science.aad0189","article-title":"Systems proteomics of liver mitochondria function","volume":"352","author":"Williams","year":"2016","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Haskins, N., Bhuvanendran, S., Anselmi, C., Gams, A., Kanholm, T., Kocher, K.M., LoTempio, J., Krohmaly, K.I., Sohai, D., and Stearrett, N. (2021). Mitochondrial Enzymes of the Urea Cycle Cluster at the Inner Mitochondrial Membrane. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.542950"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/pr400539j","article-title":"Characterization, design, and function of the mitochondrial proteome: From organs to organisms","volume":"13","author":"Lotz","year":"2013","journal-title":"J. Proteome Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17599","DOI":"10.1038\/s41598-020-74718-1","article-title":"Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs","volume":"10","author":"McLaughlin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"G287","DOI":"10.1152\/ajpgi.00105.2023","article-title":"Medium-chain fatty acid oxidation is independent of l-carnitine in liver and kidney but not in heart and skeletal muscle","volume":"325","author":"Pereyra","year":"2023","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.biocel.2009.03.013","article-title":"Capacity of oxidative phosphorylation in human skeletal muscle: New perspectives of mitochondrial physiology","volume":"41","author":"Gnaiger","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/hep.32408","article-title":"Liver zonation, revisited","volume":"76","author":"Paris","year":"2022","journal-title":"Hepatology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/s41467-024-45751-9","article-title":"A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling","volume":"15","author":"Kang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.redox.2017.01.012","article-title":"Metabolic zonation of the liver: The oxygen gradient revisited","volume":"11","author":"Kietzmann","year":"2017","journal-title":"Redox Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/lt.24369","article-title":"First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion","volume":"22","author":"Perera","year":"2016","journal-title":"Liver Transpl."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trre.2011.10.006","article-title":"Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species","volume":"26","author":"Jaeschke","year":"2012","journal-title":"Transpl. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-082509-141720","article-title":"The mitochondrial proteome and human disease","volume":"11","author":"Calvo","year":"2010","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1073\/pnas.1722086115","article-title":"Assembly of the membrane domain of ATP synthase in human mitochondria","volume":"115","author":"He","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.2174\/092986709787846578","article-title":"Mitochondrial respiratory complex I: Structure, function and implication in human diseases","volume":"16","author":"Sharma","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature19794","article-title":"Atomic structure of the entire mammalian mitochondrial complex I","volume":"538","author":"Fiedorczuk","year":"2016","journal-title":"Nature"},{"key":"ref_51","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.mito.2010.03.001","article-title":"Succinate dehydrogenase-Assembly, regulation and role in human disease","volume":"10","author":"Rutter","year":"2010","journal-title":"Mitochondrion"},{"key":"ref_53","first-page":"168","article-title":"Protein-mediated assembly of succinate dehydrogenase and its cofactors","volume":"50","author":"Na","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2015.12.009","article-title":"A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury","volume":"23","author":"Chouchani","year":"2016","journal-title":"Cell Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101733","DOI":"10.1016\/j.redox.2020.101733","article-title":"Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury","volume":"37","author":"Milliken","year":"2020","journal-title":"Redox Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10545-011-9382-9","article-title":"Mitochondrial ATP synthase: Architecture, function and pathology","volume":"35","author":"Jonckheere","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.1801697115","article-title":"Assembling the mitochondrial ATP synthase","volume":"115","author":"Song","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1053\/j.gastro.2008.06.048","article-title":"Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion","volume":"135","author":"Moon","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102164","DOI":"10.1016\/j.redox.2021.102164","article-title":"Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology","volume":"47","author":"Read","year":"2021","journal-title":"Redox Biol."},{"key":"ref_61","first-page":"1066","article-title":"Iron-Sulfur Clusters in Mitochondrial Metabolism: Multifaceted Roles of a Simple Cofactor","volume":"81","author":"Stiban","year":"2016","journal-title":"Biochemistry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1021\/acs.accounts.9b00150","article-title":"Aconitases: Non-redox Iron-Sulfur Proteins Sensitive to Reactive Species","volume":"52","author":"Castro","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_63","first-page":"217","article-title":"Prolonged warm ischemia aggravates hepatic mitochondria damage and apoptosis in DCD liver by regulating Ca2+\/CaM\/CaMKII signaling pathway","volume":"12","author":"Zhang","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_64","first-page":"2036","article-title":"The mechanisms and strategies to protect from hepatic ischemia-reperfusion injury","volume":"19","author":"Li","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.redox.2017.04.036","article-title":"ROS homeostasis, a key determinant in liver ischemic-preconditioning","volume":"12","author":"Prieto","year":"2017","journal-title":"Redox Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.12701\/jyms.2022.00017","article-title":"Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: A narrative review","volume":"40","author":"Choi","year":"2022","journal-title":"J. Yeungnam Med. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.tibs.2016.09.001","article-title":"Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes","volume":"41","author":"Raffaello","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_68","first-page":"593","article-title":"Mitochondrial Ca2+ Transport: Mechanisms, Molecular Structures, and Role in Cells","volume":"84","author":"Belosludtsev","year":"2019","journal-title":"Biochemistry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17077","DOI":"10.1038\/cddiscovery.2017.77","article-title":"Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia\/reperfusion liver injury","volume":"3","author":"Rossetti","year":"2017","journal-title":"Cell Death Discov."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2022.11.003","article-title":"Mitochondrial permeability transition pore-dependent necrosis","volume":"174","author":"Robichaux","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e17702","DOI":"10.1016\/j.heliyon.2023.e17702","article-title":"Mitochondrial quality control in hepatic ischemia-reperfusion injury","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.bbamcr.2012.08.007","article-title":"Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner","volume":"1823","author":"Frank","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","article-title":"PINK1-PRKN mediated mitophagy: Differences between in vitro and in vivo models","volume":"19","author":"Han","year":"2022","journal-title":"Autophagy"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9905","DOI":"10.1111\/jcmm.16943","article-title":"Regulation of autophagy protects against liver injury in liver surgery-induced ischaemia\/reperfusion","volume":"25","author":"Hu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"248","DOI":"10.7150\/ijms.22891","article-title":"Recent insights into mitochondrial targeting strategies in liver transplantation","volume":"15","author":"Martins","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"ref_76","first-page":"298657","article-title":"The current state of knowledge of hepatic ischemia-reperfusion injury based on its study in experimental models","volume":"2012","author":"Ramalho","year":"2012","journal-title":"J. BioMed Biotechnol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2017.06.016","article-title":"The role of succinate and ROS in reperfusion injury-A critical appraisal","volume":"110","author":"Andrienko","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Scial\u00f2, F., Fern\u00e1ndez-Ayala, D.J., and Sanz, A. (2017). Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00428"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00595-013-0736-9","article-title":"Ischemia\u2013reperfusion injury in patients with fatty liver and the clinical impact of steatotic liver on hepatic surgery","volume":"44","author":"Tashiro","year":"2014","journal-title":"Surg. Today"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1038\/s41598-019-47216-2","article-title":"Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma","volume":"9","author":"Enooku","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1038\/s41598-024-54122-9","article-title":"Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury","volume":"14","author":"Liss","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"10152","DOI":"10.1111\/jcmm.16952","article-title":"Exosomes from adipose-derived mesenchymal stem cells alleviate liver ischaemia reperfusion injury subsequent to hepatectomy in rats by regulating mitochondrial dynamics and biogenesis","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/lt.25313","article-title":"The Reactive Oxygen Species-Mitophagy Signaling Pathway Regulates Liver Endothelial Cell Survival During Ischemia\/Reperfusion Injury","volume":"24","author":"Bhogal","year":"2018","journal-title":"Liver Transpl."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cotox.2017.10.003","article-title":"Role of cytochrome P450s in the generation and metabolism of reactive oxygen species","volume":"7","author":"Veith","year":"2017","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2021.07.008","article-title":"Reperfusion mediates heme impairment with increased protein cysteine sulfonation of mitochondrial complex III in the post-ischemic heart","volume":"161","author":"Chen","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1096\/fj.03-0012com","article-title":"Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria","volume":"17","author":"Petrosillo","year":"2003","journal-title":"FASEB J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nchembio727","article-title":"Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors","volume":"1","author":"Kagan","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.abb.2003.12.002","article-title":"The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis","volume":"423","author":"Iverson","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/sj.cdd.4402135","article-title":"Role of cardiolipin in cytochrome c release from mitochondria","volume":"14","author":"Ott","year":"2007","journal-title":"Cell Death Differ."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"183469","DOI":"10.1155\/2015\/183469","article-title":"Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia\/Reperfusion Injury","volume":"2015","author":"Go","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1499-3872(17)60014-6","article-title":"Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance","volume":"16","author":"Khan","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/08941939.2010.496036","article-title":"Intracellular calcium signaling pathways during liver ischemia and reperfusion","volume":"23","author":"Chang","year":"2010","journal-title":"J. Investig. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1016\/j.jss.2010.04.009","article-title":"Diazoxide suppresses hepatic ischemia\/reperfusion injury after mouse liver transplantation by a BCL-2-dependent mechanism","volume":"169","author":"Wu","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11033-012-1939-7","article-title":"Mutations in the D-loop region and increased copy number of mitochondrial DNA in human laryngeal squamous cell carcinoma","volume":"40","author":"Guo","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2016.08.010","article-title":"Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion","volume":"308","author":"Hong","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jhep.2013.06.017","article-title":"Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu","volume":"59","author":"Peralta","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1590\/s0102-865020180080000008","article-title":"Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy","volume":"33","author":"Nakazato","year":"2018","journal-title":"Acta Cir. Bras."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/hep.27841","article-title":"Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury","volume":"62","author":"Huang","year":"2015","journal-title":"Hepatology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.3748\/wjg.v21.i27.8314","article-title":"TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia\/reperfusion injury","volume":"21","author":"Wang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Mihm, S. (2018). Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103104"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1600-6143.2011.03579.x","article-title":"Liver ischemia and reperfusion injury: New insights into mechanisms of innate-adaptive immune-mediated tissue inflammation","volume":"11","author":"Zhai","year":"2011","journal-title":"Am. J. Transpl."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Yang, H., Zhang, P., Wang, Q., Cheng, K., and Zhao, Y. (2023). The research development of STAT3 in hepatic ischemia-reperfusion injury. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1066222"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40169-016-0095-4","article-title":"Mitochondrial transplantation for therapeutic use","volume":"5","author":"McCully","year":"2016","journal-title":"Clin. Transl. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/MCB.00774-13","article-title":"Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis","volume":"34","author":"Li","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"H1215","DOI":"10.1152\/ajpheart.00124.2018","article-title":"Mitochondria \u201cTHE\u201d target of myocardial conditioning","volume":"315","author":"Boengler","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"G536","DOI":"10.1152\/ajpgi.00400.2002","article-title":"Regulation of postischemic liver injury following different durations of ischemia","volume":"284","author":"Hines","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/01.TP.0000128188.45553.8C","article-title":"Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation","volume":"78","author":"Varadarajan","year":"2004","journal-title":"Transplantation"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.3748\/wjg.v23.i14.2505","article-title":"New progress in roles of nitric oxide during hepatic ischemia reperfusion injury","volume":"23","author":"Zhang","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.ph.28.030166.002251","article-title":"Functions of lysosomes","volume":"28","author":"Wattiaux","year":"1966","journal-title":"Annu. Rev. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/embor.2012.14","article-title":"Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment","volume":"13","author":"Greene","year":"2012","journal-title":"EMBO Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1073\/pnas.0705363105","article-title":"Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP","volume":"105","author":"Haque","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1083\/jcb.201008084","article-title":"Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL","volume":"191","author":"Jin","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/hmg\/ddq526","article-title":"PINK1 cleavage at position A103 by the mitochondrial protease PARL","volume":"20","author":"Deas","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D.-F., Gautier, C.A., Shen, J., Cookson, M.R., and Youle, R.J. (2010). PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000298"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","article-title":"Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin","volume":"22","author":"Lazarou","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/33271","article-title":"Putting the parkin into Parkinson\u2019s","volume":"392","author":"Nussbaum","year":"1998","journal-title":"Nature"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12043","article-title":"Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization","volume":"496","author":"Sarraf","year":"2013","journal-title":"Nature"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.cmet.2019.08.023","article-title":"Miro1 Marks Parkinson\u2019s Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson\u2019s Models","volume":"30","author":"Hsieh","year":"2019","journal-title":"Cell Metab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"jcs239822","DOI":"10.1242\/jcs.239822","article-title":"OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion","volume":"133","author":"Kruppa","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201607039","article-title":"Atg8 family LC3\/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1\/Parkin mitophagy and starvation","volume":"215","author":"Nguyen","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41467-019-08335-6","article-title":"LC3\/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy","volume":"10","author":"Padman","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.molcel.2009.01.020","article-title":"A role for NBR1 in autophagosomal degradation of ubiquitinated substrates","volume":"33","author":"Kirkin","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN\/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb3097","article-title":"USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria","volume":"17","author":"Cunningham","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1080\/15548627.2017.1281492","article-title":"Autophagosome formation and cargo sequestration in the absence of LC3\/GABARAPs","volume":"13","author":"Padman","year":"2017","journal-title":"Autophagy"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1074\/jbc.M112.399345","article-title":"Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis","volume":"288","author":"Zhu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/sj.cdd.4401936","article-title":"Response to myocardial ischemia\/reperfusion injury involves Bnip3 and autophagy","volume":"14","author":"Brady","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/cdd.2009.16","article-title":"Role of BNIP3 and NIX in cell death, autophagy, and mitophagy","volume":"16","author":"Zhang","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_133","first-page":"1232","article-title":"Dimerization of mitophagy receptor BNIP3L\/NIX is essential for recruitment of autophagic machinery","volume":"17","author":"Novak","year":"2020","journal-title":"Autophagy"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"8036","DOI":"10.1074\/jbc.M611473200","article-title":"The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation","volume":"282","author":"Yamada","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jmb.2019.07.016","article-title":"Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors","volume":"432","author":"Johansen","year":"2019","journal-title":"J. Mol. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"20526","DOI":"10.1038\/s41598-021-00170-4","article-title":"ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3","volume":"11","author":"Poole","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41419-022-05418-z","article-title":"BNIP3 phosphorylation by JNK1\/2 promotes mitophagy via enhancing its stability under hypoxia","volume":"13","author":"He","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e112799","DOI":"10.15252\/embj.2022112799","article-title":"FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels","volume":"42","author":"Elcocks","year":"2023","journal-title":"EMBO J."},{"key":"ref_139","first-page":"e112767","article-title":"FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors","volume":"42","author":"Kozul","year":"2023","journal-title":"EMBO J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e202010006","DOI":"10.1083\/jcb.202010006","article-title":"USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites","volume":"220","author":"Chai","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s13238-016-0328-8","article-title":"Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy","volume":"8","author":"Lv","year":"2016","journal-title":"Protein Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/15548627.2016.1151580","article-title":"Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy","volume":"12","author":"Chen","year":"2016","journal-title":"Autophagy"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1080\/15548627.2016.1238552","article-title":"Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy","volume":"12","author":"Kuang","year":"2016","journal-title":"Autophagy"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1038\/ncomms8527","article-title":"Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation","volume":"6","author":"Murakawa","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1080\/15548627.2015.1084459","article-title":"BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32","volume":"11","author":"Otsu","year":"2015","journal-title":"Autophagy"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41419-023-06112-4","article-title":"BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1074\/jbc.RA119.008630","article-title":"The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice","volume":"294","author":"Fujiwara","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"947","DOI":"10.15252\/embr.201643147","article-title":"FKBP8 recruits LC3A to mediate Parkin-independent mitophagy","volume":"18","author":"Bhujabal","year":"2017","journal-title":"EMBO Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biocel.2014.03.007","article-title":"Mitochondria: FKBP38 and mitochondrial degradation","volume":"51","author":"Nakayama","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"10249","DOI":"10.1523\/JNEUROSCI.1917-11.2011","article-title":"Parkin interacts with Ambra1 to induce mitophagy","volume":"31","author":"Cornelissen","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/s41467-018-05722-3","article-title":"HUWE1 E3 ligase promotes PINK1\/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKK\u03b1","volume":"9","author":"Peschiaroli","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tem.2009.04.004","article-title":"Prohibitin and mitochondrial biology","volume":"20","author":"Tavernarakis","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2016.11.042","article-title":"Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor","volume":"168","author":"Wei","year":"2016","journal-title":"Cell"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1093\/emboj\/19.11.2444","article-title":"Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins","volume":"19","author":"Nijtmans","year":"2000","journal-title":"EMBO J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/15548627.2019.1628520","article-title":"PHB2 (prohibitin 2) promotes PINK1-PRKN\/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis","volume":"16","author":"Yan","year":"2019","journal-title":"Autophagy"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Bustillo-Zabalbeitia, I., Montessuit, S., Raemy, E., Basa\u00f1ez, G., Terrones, O., and Martinou, J.-C. (2014). Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102738"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ncb2837","article-title":"Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells","volume":"15","author":"Chu","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4161\/auto.27191","article-title":"LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: Implications for Parkinson disease","volume":"10","author":"Chu","year":"2013","journal-title":"Autophagy"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1080\/15548627.2022.2062111","article-title":"LC3 subfamily in cardiolipin-mediated mitophagy: A comparison of the LC3A, LC3B and LC3C homologs","volume":"18","author":"Iriondo","year":"2022","journal-title":"Autophagy"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1002\/jcp.28125","article-title":"mTOR and Beclin1: Two key autophagy-related molecules and their roles in myocardial ischemia\/reperfusion injury","volume":"234","author":"Shi","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e00392-17","DOI":"10.1128\/MCB.00392-17","article-title":"Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1\/MON1 Regulator C18orf8\/RMC1 in Macroautophagic and Selective Autophagic Flux","volume":"38","author":"Vaites","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e2025347118","DOI":"10.1073\/pnas.2025347118","article-title":"Ceramide accumulation induces mitophagy and impairs \u03b2-oxidation in PINK1 deficiency","volume":"118","author":"Vos","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41574-020-0320-5","article-title":"The role of ceramides in metabolic disorders: When size and localization matters","volume":"16","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e202009092","DOI":"10.1083\/jcb.202009092","article-title":"SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components","volume":"220","author":"Abudu","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/1873-3468.12170","article-title":"SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells","volume":"590","author":"Liu","year":"2016","journal-title":"FEBS Lett."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.molcel.2017.10.029","article-title":"Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway","volume":"68","author":"Eck","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e202404009","DOI":"10.1083\/jcb.202404009","article-title":"SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics","volume":"224","author":"Veroni","year":"2025","journal-title":"J. Cell Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1002\/jcp.30173","article-title":"The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions","volume":"236","author":"Xu","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e106283","DOI":"10.15252\/embj.2020106283","article-title":"ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA","volume":"40","author":"Shu","year":"2021","journal-title":"EMBO J."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s41467-019-09291-x","article-title":"ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcmgh.2023.09.004","article-title":"Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy","volume":"17","author":"Zhang","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jcmgh.2021.03.007","article-title":"DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy","volume":"12","author":"Xu","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41420-023-01357-6","article-title":"MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury","volume":"9","author":"Xu","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"102305","DOI":"10.1016\/j.redox.2022.102305","article-title":"XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.trsl.2024.03.006","article-title":"Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy","volume":"272","author":"Kuang","year":"2024","journal-title":"Transl. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"529","DOI":"10.5483\/BMBRep.2016.49.10.115","article-title":"Mitophagy: A balance regulator of NLRP3 inflammasome activation","volume":"49","author":"Kim","year":"2016","journal-title":"BMB Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2020.09.015","article-title":"PINK1-mediated mitophagy protects against hepatic ischemia\/reperfusion injury by restraining NLRP3 inflammasome activation","volume":"160","author":"Xu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_179","first-page":"893","article-title":"Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells","volume":"42","author":"Long","year":"2019","journal-title":"Mol. Cells"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/ajt.16757","article-title":"Augmenter of liver regeneration-mediated mitophagy protects against hepatic ischemia\/reperfusion injury","volume":"22","author":"Kong","year":"2021","journal-title":"Am. J. Transpl."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e12986","DOI":"10.1111\/cpr.12986","article-title":"NLRX1\/FUNDC1\/NIPSNAP1-2 axis regulates mitophagy and alleviates intestinal ischaemia\/reperfusion injury","volume":"54","author":"Li","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"105157","DOI":"10.3748\/wjg.v31.i22.105157","article-title":"N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury","volume":"31","author":"Guo","year":"2025","journal-title":"World J. Gastroenterol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/lt.25053","article-title":"CAAT\/enhancer binding protein-homologous protein deficiency attenuates liver ischemia\/reperfusion injury in mice","volume":"24","author":"Wada","year":"2018","journal-title":"Liver Transpl."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/TP.0000000000004244","article-title":"CCAAT\/Enhancer-binding Protein Homologous Protein Promotes ROS-mediated Liver Ischemia and Reperfusion Injury by Inhibiting Mitophagy in Hepatocytes","volume":"107","author":"Zhou","year":"2022","journal-title":"Transplantation"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cstres.2024.05.004","article-title":"Mechanisms involved in the regulation of mitochondrial quality control by PGAM5 in heart failure","volume":"29","author":"Wang","year":"2024","journal-title":"Cell Stress Chaperones"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1002\/jcb.27711","article-title":"MiR-330-3p suppresses phosphoglycerate mutase family member 5 -inducted mitophagy to alleviate hepatic ischemia-reperfusion injury","volume":"120","author":"Sun","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.lfs.2018.03.017","article-title":"Heme oxygenase-1 protects liver against ischemia\/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control","volume":"200","author":"Hong","year":"2018","journal-title":"Life Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1053\/j.gastro.2011.08.005","article-title":"Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice","volume":"141","author":"Wang","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Kim, J.-S., Chapman, W.C., and Lin, Y. (2022). Mitochondrial Autophagy in Ischemic Aged Livers. Cells, 11.","DOI":"10.3390\/cells11244083"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e12761","DOI":"10.1111\/acel.12761","article-title":"Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia\/reperfusion injury in aged livers","volume":"17","author":"Chun","year":"2018","journal-title":"Aging Cell"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e651","DOI":"10.1097\/CCM.0000000000001637","article-title":"Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy","volume":"44","author":"Khader","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.18632\/aging.101511","article-title":"Aging aggravates hepatic ischemia-reperfusion injury in mice by impairing mitophagy with the involvement of the EIF2\u03b1-parkin pathway","volume":"10","author":"Li","year":"2018","journal-title":"Aging"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/lt.25470","article-title":"Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver Ischemia\/Reperfusion Injury by Regulating M1\/M2 Polarization","volume":"25","author":"Hu","year":"2019","journal-title":"Liver Transpl."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"e70243","DOI":"10.1002\/iid3.70243","article-title":"Liver X Receptor Activation Alleviates Hepatic Ischemia-Reperfusion Injury in Diabetes by Inhibiting NF-\u03baB-NLRP3 Activation","volume":"13","author":"Jiang","year":"2025","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jdi.13928","article-title":"Increased oxidative stress caused by impaired mitophagy aggravated liver ischemia and reperfusion injury in diabetic mice","volume":"14","author":"Zhijun","year":"2022","journal-title":"J. Diabetes Investig."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bcp.2017.02.008","article-title":"2-Methoxyestradiol protects against ischemia\/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy","volume":"131","author":"Cho","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"157034","DOI":"10.1016\/j.phymed.2025.157034","article-title":"Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin\u2019s protection against hepatic ischemia-reperfusion injury","volume":"145","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jphs.2021.09.005","article-title":"Pterostilbene alleviates liver ischemia\/reperfusion injury via PINK1-mediated mitophagy","volume":"148","author":"Shi","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"177100","DOI":"10.1016\/j.ejphar.2024.177100","article-title":"Taxifolin attenuates hepatic ischemia-reperfusion injury by enhancing PINK1\/Parkin-mediated mitophagy","volume":"985","author":"Zhang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"6481192","DOI":"10.1155\/2022\/6481192","article-title":"Formononetin Inhibits Hepatic I\/R-Induced Injury through Regulating PHB2\/PINK1\/Parkin Pathway","volume":"2022","author":"Ma","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2017.05.002","article-title":"Genipin protects the liver from ischemia\/reperfusion injury by modulating mitochondrial quality control","volume":"328","author":"Shin","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_202","first-page":"16","article-title":"Ginsenoside Rg1 Alleviates Rat Liver Ischemia-Reperfusion Ischemia Through Mitochondrial Autophagy Pathway","volume":"29","author":"Lin","year":"2023","journal-title":"Altern. Ther. Health Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.intimp.2015.06.017","article-title":"Resolvin D1 protects against hepatic ischemia\/reperfusion injury in rats","volume":"28","author":"Zhang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1111\/bph.14212","article-title":"Resolvin D1 attenuates liver ischaemia\/reperfusion injury through modulating thioredoxin 2-mediated mitochondrial quality control","volume":"175","author":"Kang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"107643","DOI":"10.1016\/j.intimp.2021.107643","article-title":"25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy","volume":"96","author":"Cao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.livres.2025.11.001","article-title":"Nicotinic acid protects against hepatic ischemia-reperfusion injury via suppressing mitochondrial damage-induced ferroptosis","volume":"9","author":"Zeng","year":"2025","journal-title":"Liver Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1684\/ecn.2019.0431","article-title":"Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2\/HO-1 signaling pathway","volume":"30","author":"Zhao","year":"2019","journal-title":"Eur. Cytokine Netw."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"115915","DOI":"10.1016\/j.biopha.2023.115915","article-title":"Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2\/GPx4-dependent antioxidant responses","volume":"169","author":"Zhang","year":"2023","journal-title":"BioMed Pharmacother."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"114437","DOI":"10.1016\/j.intimp.2025.114437","article-title":"Met-Exo attenuates pyroptosis in miniature pig liver IRI by improving mitochondrial quality control","volume":"152","author":"Cao","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"121618","DOI":"10.1016\/j.lfs.2023.121618","article-title":"Exosomes from adipose-derived mesenchymal stem cells can attenuate liver injury caused by minimally invasive hemihepatectomy combined with ischemia-reperfusion in minipigs by modulating the endoplasmic reticulum stress response","volume":"321","author":"Wang","year":"2023","journal-title":"Life Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jss.2007.12.747","article-title":"Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury\u2014A review","volume":"150","author":"Tapuria","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s12964-025-02497-1","article-title":"Hypoxia-preconditioning human bone marrow-derived mesenchymal stem cells induce high-quality mitochondrial transfer through gap junctions to alleviate ischemia-reperfusion injury in liver graft","volume":"23","author":"Luo","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2005.04.044","article-title":"Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: Role of the autonomic nervous system","volume":"46","author":"Loukogeorgakis","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mito.2023.03.002","article-title":"Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock","volume":"70","author":"Petrut","year":"2023","journal-title":"Mitochondrion"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"goae066","DOI":"10.1093\/gastro\/goae066","article-title":"Research progress on the role of mitochondria in the process of hepatic ischemia-reperfusion injury","volume":"12","author":"Zhou","year":"2024","journal-title":"Gastroenterol. Rep."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"9131","DOI":"10.7150\/thno.119357","article-title":"Nanotuner targeting mitochondrial redox and iron homeostasis imbalance for the treatment of acute liver injury","volume":"15","author":"Li","year":"2025","journal-title":"Theranostics"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.actbio.2025.07.004","article-title":"Mitochondria-targeted ROS-scavenging polymer protects the hepatocytes and macrophages against hepatic ischemia-reperfusion injury","volume":"202","author":"Hu","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-8278(02)00327-6","article-title":"Ischemic preconditioning protects from hepatic ischemia\/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state","volume":"38","author":"Glanemann","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1021\/acs.analchem.0c05220","article-title":"In Situ Observation of mtDNA Damage during Hepatic Ischemia-Reperfusion","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3748\/wjg.v10.i13.1934","article-title":"Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning","volume":"10","author":"Sun","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.freeradbiomed.2023.04.012","article-title":"Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury","volume":"204","author":"Press","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1021\/acs.analchem.3c05479","article-title":"Mitochondria-Targetable Near-Infrared Fluorescent Probe for Visualization of Hydrogen Peroxide in Lung Injury, Liver Injury, and Tumor Models","volume":"96","author":"Zan","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.freeradbiomed.2023.11.040","article-title":"Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia\/reperfusion","volume":"210","author":"Xia","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1039\/D2CC06238K","article-title":"Mitochondria-targeted fluorescent probe for imaging viscosity in hepatic ischemia-reperfusion injury cell model","volume":"59","author":"Xie","year":"2023","journal-title":"Chem. Commun."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.7150\/ijbs.103789","article-title":"Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis","volume":"21","author":"Fang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12951-019-0451-9","article-title":"Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"21627","DOI":"10.1021\/acs.inorgchem.4c03170","article-title":"Mitochondria-Targetable Cyclometalated Iridium(III) Complex-Based Luminescence Probe for Monitoring and Assessing Treatment Response of Ferroptosis-Mediated Hepatic Ischemia-Reperfusion Injury","volume":"63","author":"Liu","year":"2024","journal-title":"Inorg. Chem."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"116","DOI":"10.7150\/thno.88061","article-title":"Reprogramming Exosomes to Escape from Immune Surveillance for Mitochondrial Protection in Hepatic Ischemia-Reperfusion Injury","volume":"14","author":"Liu","year":"2024","journal-title":"Theranostics"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Picard, M., Taivassalo, T., Ritchie, D., Wright, K.J., Thomas, M.M., Romestaing, C., and Hepple, R.T. (2011). Mitochondrial structure and function are disrupted by standard isolation methods. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018317"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1113\/jphysiol.2011.212712","article-title":"Mitochondria: Isolation, structure and function","volume":"589","author":"Picard","year":"2011","journal-title":"J. Physiol."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Aoki, T., Okuma, Y., Becker, L.B., Hayashida, K., and Shinozaki, K. (2021). Methodological Issue of Mitochondrial Isolation in Acute-Injury Rat Model: Asphyxia Cardiac Arrest and Resuscitation. Front. Med., 8.","DOI":"10.3389\/fmed.2021.666735"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000541733","article-title":"Comparative Assessment of Mitochondria Isolation Buffers for Optimizing Tissue-Specific Yields in Buffalo","volume":"214","author":"Kumari","year":"2024","journal-title":"Cells Tissues Organs"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3390\/biom5031319","article-title":"High-Resolution Respirometry for Simultaneous Measurement of Oxygen and Hydrogen Peroxide Fluxes in Permeabilized Cells, Tissue Homogenate and Isolated Mitochondria","volume":"5","author":"Krumschnabel","year":"2015","journal-title":"Biomolecules"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/abio.2002.5658","article-title":"Evaluation of mitochondrial respiratory function in small biopsies of liver","volume":"305","author":"Kuznetsov","year":"2002","journal-title":"Anal. Biochem."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s42003-023-04564-0","article-title":"Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model","volume":"6","author":"Xin","year":"2023","journal-title":"Commun. Biol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jss.2014.06.024","article-title":"Rodent models of hepatic ischemia-reperfusion injury: Time and percentage-related pathophysiological mechanisms","volume":"191","author":"Karatzas","year":"2014","journal-title":"J. Surg. Res."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/TP.0000000000002156","article-title":"Porcine Isolated Liver Perfusion for the Study of Ischemia Reperfusion Injury: A Systematic Review","volume":"102","author":"Maione","year":"2018","journal-title":"Transplantation"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Whalen, C., Verma, A., Kurashima, K., Carter, J., Nazzal, H., and Jain, A. (2024). Novel Models for Assessing and Pathophysiology of Hepatic Ischemia-Reperfusion Injury Mechanisms. Medicina, 60.","DOI":"10.3390\/medicina60091507"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/7\/941\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:26:52Z","timestamp":1782880012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/7\/941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":238,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["biom16070941"],"URL":"https:\/\/doi.org\/10.3390\/biom16070941","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]}}}