{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:08:26Z","timestamp":1785409706761,"version":"3.56.0"},"reference-count":159,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Health Research (DHR), Ministry of Health and Family Welfare, Government of India"},{"name":"Anusandhan National Research Foundation (ANRF) under the Early Career Research Grant","award":["ANRF\/ECRG\/2024\/001727\/LS"],"award-info":[{"award-number":["ANRF\/ECRG\/2024\/001727\/LS"]}]},{"name":"SGT University","award":["SGTU\/ORG\/IMRG-II\/2024\/1"],"award-info":[{"award-number":["SGTU\/ORG\/IMRG-II\/2024\/1"]}]},{"award":["SGTU\/ORG\/IMRG-II\/2024\/1"],"award-info":[{"award-number":["SGTU\/ORG\/IMRG-II\/2024\/1"]}],"id":[{"id":"https:\/\/ror.org\/04yk1tp18","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019286","name":"Ajman University","doi-asserted-by":"crossref","award":["2025-IRG-CoPHS-9"],"award-info":[{"award-number":["2025-IRG-CoPHS-9"]}],"id":[{"id":"10.13039\/501100019286","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2025-IRG-CoPHS-9"],"award-info":[{"award-number":["2025-IRG-CoPHS-9"]}],"id":[{"id":"https:\/\/ror.org\/01j1rma10","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The most persistent biomedical challenges of the 21st century are neurodegenerative disorders (NDs), where molecular alterations lead to devastating clinical consequences and progressive neuronal loss. The prevalence of neurodegeneration is continuously rising and becoming the main contributor to chronic disability and mortality. Despite their clinical differences, many conditions share pathogenic processes, including oxidative stress, protein misfolding and aggregation, mitochondrial dysfunction, and neuroinflammation. Instead of functioning independently, these processes cooperate to form a self-reinforcing network that gradually weakens synapses and ultimately leads to neuronal death. This study redefines neurodegeneration as a disorder of system-level failure by emphasizing poor cellular stress integration. In addition to demonstrating how gut microbiome gene networks impact inflammation and amyloid production, new research highlights the relationships between mitochondrial\u2013lysosomal interactions, endoplasmic reticulum stress responses, and transcriptionally driven synaptic vulnerability. A key molecular topic is the interaction and pathogenic convergence of the JAK\/STAT, HIF-1\u03b1, and Notch signaling pathways. Under ongoing metabolic stress, prolonged stimulation of this triad increases inflammation, hinders the regenerative processes, and maintains pseudo-hypoxic conditions, explaining why single-target treatments have mostly been unsuccessful. This review also explores progress in fluid, digital, and imaging biomarkers that facilitate early diagnosis and patient stratification, and assesses new disease-modifying approaches such as antisense oligonucleotides, immunomodulators, gene therapies, and small-molecular agents. Artificial intelligence is emphasized as an essential tool for integrating multimodal data, drug discovery and predictive modeling.<\/jats:p>","DOI":"10.3390\/biom16070944","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:06:34Z","timestamp":1782875194000},"page":"944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network Biology of Alzheimer\u2019s Disease and Related Neurodegenerative Disorders: Molecular Mechanisms and Therapeutic Strategies"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1516-4772","authenticated-orcid":false,"given":"Zitin","family":"Wali","sequence":"first","affiliation":[{"name":"Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-5990","authenticated-orcid":false,"family":"Neha","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, School of Basic & Applied Sciences, SGT University, Gurugram 122505, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyad","family":"Shahwan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates"},{"name":"Center of Excellence in Precision Medicine and Digital Health, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuzin","family":"Dinislam","sequence":"additional","affiliation":[{"name":"Department of General Chemistry, Bashkir State Medical University, Ulitsa Lenina, 3, 450008 Ufa, Republic of Bashkortostan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-7056","authenticated-orcid":false,"given":"Anas","family":"Shamsi","sequence":"additional","affiliation":[{"name":"Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleha","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, Delhi, India"},{"name":"Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","unstructured":"Alzheimer\u2019s Association (2024). Alzheimer\u2019s Association 2024 Alzheimer\u2019s Disease Facts and Figures, Alzheimer\u2019s Association."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00415-024-12743-0","article-title":"Incidence and mortality of ALS: A 42-year population-based nationwide study","volume":"272","author":"Levison","year":"2025","journal-title":"J. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1212\/WNL.0000000000207474","article-title":"Global Prevalence and Incidence of Amyotrophic Lateral Sclerosis: A Systematic Review","volume":"101","author":"Wolfson","year":"2023","journal-title":"Neurology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/mds.29228","article-title":"Prevalence and Incidence of Huntington\u2019s Disease: An Updated Systematic Review and Meta-Analysis","volume":"37","author":"Medina","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler. J."},{"key":"ref_6","first-page":"14","article-title":"Multiple sclerosis: 2024 update","volume":"6","author":"Klotz","year":"2025","journal-title":"Free Neuropathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/21678421.2024.2447919","article-title":"Amyotrophic lateral sclerosis estimated prevalence cases from 2022 to 2030, data from the national ALS Registry","volume":"26","author":"Mehta","year":"2025","journal-title":"Amyotroph. Lateral Scler. Front. Degener."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102357","DOI":"10.1016\/j.arr.2024.102357","article-title":"Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance","volume":"99","author":"Gadhave","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_9","first-page":"2937","article-title":"The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need","volume":"16","author":"Wang","year":"2024","journal-title":"Aging Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hou, M., and Yang, L. (2025). Trends and forecasts of the prevalence and mortality of Alzheimer\u2019s disease and other dementias in China. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1616232"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Shafi, O., Waqas, M., Virk, L.N., Hameed Siddiqui, S.A., Khan, O.J., Rahman, I.A., Karim, A., Khalid, M.D., Anum, M., and Makwana, S. (2025). Clinical Implications of Inflammation-Mediated Dysregulation of Glial Cell Fate: A Systematic Review for Early Brain Tumor Risk Detection and Improved Patient Outcomes. medRxiv.","DOI":"10.1101\/2025.08.05.25333055"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chen, B., and Jin, W. (2023). A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1200061"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1111\/febs.16815","article-title":"Notch signalling: Multifaceted role in development and disease","volume":"291","author":"Sachan","year":"2024","journal-title":"FEBS J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Huang, T., Fakurazi, S., Cheah, P.S., and Ling, K.H. (2023). REST Targets JAK\u2013STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24129980"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/med.21867","article-title":"Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases","volume":"42","author":"Wang","year":"2022","journal-title":"Med. Res. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Shukla, A.K., Nilgirwar, P.S., and Bali, S.D. (2024). Current pharmacological treatments for neurodegenerative diseases. The Neurodegeneration Revolution: Emerging Therapies and Sustainable Solutions, Elsevier.","DOI":"10.1016\/B978-0-443-28822-7.00005-2"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer\u2019s disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gouda, N.A., Elkamhawy, A., and Cho, J. (2022). Emerging Therapeutic Strategies for Parkinson\u2019s Disease and Future Prospects: A 2021 Update. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020371"},{"key":"ref_19","unstructured":"(2025). Emerging Therapeutic Targets in Molecular Neuropharmacology for Alzheimer\u2019s Disease. J. Biol. Regul. Homeost. Agents, 37."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cardona, F. (2024). Special Issue \u201cMechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases\u201d. Biomedicines, 12.","DOI":"10.3390\/biomedicines12112554"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e168553","DOI":"10.1172\/JCI168553","article-title":"Tau pathology in neurodegenerative disease: Disease mechanisms and therapeutic avenues","volume":"133","author":"Samudra","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1007\/s10571-023-01408-7","article-title":"Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer\u2019s Disease: Recent Trends and Future Development","volume":"43","author":"Dave","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Toader, C., Dobrin, N., Brehar, F.M., Popa, C., Covache-Busuioc, R.A., Glavan, L.A., Costin, H.P., Bratu, B.G., Corlatescu, A.D., and Popa, A.A. (2023). From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216119"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11033-025-10463-w","article-title":"Molecular mechanisms and biomarkers in neurodegenerative disorders: A comprehensive review","volume":"52","author":"Ali","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.3390\/cimb46060325","article-title":"Molecular Mechanisms in the Design of Novel Targeted Therapies for Neurodegenerative Diseases","volume":"46","author":"Nowak","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e202400277","DOI":"10.1002\/chem.202400277","article-title":"Aggregation Mechanisms and Molecular Structures of Amyloid-\u03b2 in Alzheimer\u2019s Disease","volume":"30","author":"Niu","year":"2024","journal-title":"Chem. A Eur. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1038\/s41467-024-50692-4","article-title":"\u03b1-Synuclein oligomers form by secondary nucleation","volume":"15","author":"Xu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kim, J.R. (2023). Oligomerization by co-assembly of \u03b2-amyloid and \u03b1-synuclein. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1153839"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s12964-024-01791-8","article-title":"Misfolding and aggregation in neurodegenerative diseases: Protein quality control machinery as potential therapeutic clearance pathways","volume":"22","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sidoryk-W\u0119grzynowicz, M., Adamiak, K., and Stru\u017cy\u0144ska, L. (2024). Targeting Protein Misfolding and Aggregation as a Therapeutic Perspective in Neurodegenerative Disorders. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212448"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Malik, R., and Wiedau, M. (2020). Therapeutic Approaches Targeting Protein Aggregation in Amyotrophic Lateral Sclerosis. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.00098"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s43044-024-00517-y","article-title":"Tafamidis therapy in transthyretin amyloid cardiomyopathy: A narrative review from clinical trials and real-world evidence","volume":"76","author":"Ogieuhi","year":"2024","journal-title":"Egypt. Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41422-021-00526-5","article-title":"Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation","volume":"31","author":"Gu","year":"2021","journal-title":"Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104356","DOI":"10.1016\/j.isci.2022.104356","article-title":"Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation","volume":"25","author":"Li","year":"2022","journal-title":"iScience"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Garcia-Toscano, L., Currey, H.N., Hincks, J.C., Stair, J.G., Lehrbach, N.J., and Liachko, N.F. (2024). Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis. PLoS Genet., 20.","DOI":"10.1371\/journal.pgen.1011518"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1038\/s41598-022-12191-8","article-title":"Heat shock protein Grp78\/BiP\/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology","volume":"12","author":"Scott","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"101905","DOI":"10.1016\/j.jbc.2022.101905","article-title":"Folding or holding?\u2014Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease","volume":"298","author":"Rutledge","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Albinhassan, T.H., Alharbi, B.M., AlSuhaibani, E.S., Mohammad, S., and Malik, S.S. (2025). Small Heat Shock Proteins: Protein Aggregation Amelioration and Neuro- and Age-Protective Roles. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041525"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"eadw1061","DOI":"10.1126\/sciadv.adw1061","article-title":"Chaperone nanomotors with chemotactic ability for the treatment of Parkinson\u2019s disease","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_40","first-page":"235","article-title":"Extracellular protein homeostasis in neurodegenerative diseases","volume":"19","author":"Wilson","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1007\/s12035-023-03846-2","article-title":"Molecular Chaperones as Therapeutic Target: Hallmark of Neurodegenerative Disorders","volume":"61","author":"Sharma","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ciechanover, A., and Livneh, I. (2025). Protein quality control systems in neurodegeneration\u2014Culprits, mitigators, and solutions?. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1604076"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of autophagy\u2013lysosome dysfunction in neurodegenerative diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molmed.2019.10.009","article-title":"Mitochondria\u2013Lysosome Crosstalk: From Physiology to Neurodegeneration","volume":"26","author":"Deus","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jurcau, A. (2021). Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111847"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2400023","DOI":"10.1002\/bies.202400023","article-title":"Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?","volume":"47","author":"Leroy","year":"2025","journal-title":"BioEssays"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zheng, W., and Fan, D. (2022). Glucocerebrosidase Mutations Cause Mitochondrial and Lysosomal Dysfunction in Parkinson\u2019s Disease: Pathogenesis and Therapeutic Implications. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.851135"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"114757","DOI":"10.1016\/j.expneurol.2024.114757","article-title":"Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases","volume":"376","author":"Kou","year":"2024","journal-title":"Exp. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"100408","DOI":"10.1016\/j.coisb.2021.100408","article-title":"Lessons from metabolic perturbations in lysosomal storage disorders for neurodegeneration","volume":"29","author":"Medoh","year":"2022","journal-title":"Curr. Opin. Syst. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Stepien, K.M., Cufflin, N., Donald, A., Jones, S., Church, H., and Hargreaves, I.P. (2022). Secondary Mitochondrial Dysfunction as a Cause of Neurodegenerative Dysfunction in Lysosomal Storage Diseases and an Overview of Potential Therapies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810573"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.1007\/s12035-024-04469-x","article-title":"Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology","volume":"62","author":"Kathiresan","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"169151","DOI":"10.1016\/j.jmb.2025.169151","article-title":"Autophagy, ER-phagy and ER Dynamics During Cell Differentiation","volume":"437","author":"Cillo","year":"2025","journal-title":"J. Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ghemrawi, R., and Khair, M. (2020). Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176127"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kim, S., Kim, D.K., Jeong, S., and Lee, J. (2022). The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115894"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chipurupalli, S., Samavedam, U., and Robinson, N. (2021). Crosstalk Between ER Stress, Autophagy and Inflammation. Front. Med., 8.","DOI":"10.3389\/fmed.2021.758311"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ren, H., Zhai, W., Lu, X., and Wang, G. (2021). The Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.691881"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1007\/s12035-020-01929-y","article-title":"Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer\u2019s Disease","volume":"57","author":"Uddin","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Diab, R., Pilotto, F., and Saxena, S. (2023). Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology. Front. Cell Neurosci., 17.","DOI":"10.3389\/fncel.2023.1086895"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/NRR.NRR-D-23-00995","article-title":"Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases","volume":"20","author":"Zhao","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4","DOI":"10.20517\/rdodj.2024.55","article-title":"Organellar crosstalk as a potential therapeutic target for rare neurodegenerative diseases","volume":"4","author":"Lam","year":"2025","journal-title":"Rare Dis. Orphan Drugs J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s10020-024-00808-9","article-title":"Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer","volume":"30","author":"Yuan","year":"2024","journal-title":"Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Goel, P., Chakrabarti, S., Goel, K., Bhutani, K., Chopra, T., and Bali, S. (2022). Neuronal cell death mechanisms in Alzheimer\u2019s disease: An insight. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.937133"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Subramanian, J., and Tremblay, M.\u00c8. (2021). Editorial: Synaptic Loss and Neurodegeneration. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.681029"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Iskusnykh, I.Y., Zakharova, A.A., Kryl\u2019skii, E.D., and Popova, T.N. (2024). Aging, Neurodegenerative Disorders, and Cerebellum. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021018"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Griffioen, G. (2023). Calcium Dyshomeostasis Drives Pathophysiology and Neuronal Demise in Age-Related Neurodegenerative Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713243"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Behl, T., Makkar, R., Sehgal, A., Singh, S., Sharma, N., Zengin, G., Bungau, S., Andronie-Cioara, F.L., Munteanu, M.A., and Brisc, M.C. (2021). Current trends in neurodegeneration: Cross talks between oxidative stress, cell death, and inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147432"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.12703\/r\/10-81","article-title":"Recent advances in preventing neurodegenerative diseases","volume":"10","author":"Chou","year":"2021","journal-title":"Fac. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.immuni.2024.03.010","article-title":"Innate immune activation in neurodegenerative diseases","volume":"57","author":"Heneka","year":"2024","journal-title":"Immunity"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41582-024-01046-7","article-title":"Immune mechanisms and shared immune targets in neurodegenerative diseases","volume":"21","author":"Weiner","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/18796397251338207","article-title":"Neuroinflammation in Huntington\u2019s disease: Causes, consequences, and treatment strategies","volume":"14","author":"Blusch","year":"2025","journal-title":"J. Huntingt. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Adamu, A., Li, S., Gao, F., and Xue, G. (2024). The role of neuroinflammation in neurodegenerative diseases: Current understanding and future therapeutic targets. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1347987"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.it.2020.02.002","article-title":"Neuroimmune Connections in Aging and Neurodegenerative Diseases","volume":"41","author":"Scheiblich","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12974-022-02605-9","article-title":"The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases","volume":"19","author":"DeMaio","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4103\/1673-5374.268971","article-title":"Neurodegenerative diseases as proteinopathies-driven immune disorders","volume":"15","author":"Ciccocioppo","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Padhi, P., Worth, C., Zenitsky, G., Jin, H., Sambamurti, K., Anantharam, V., Kanthasamy, A., and Kanthasamy, A.G. (2022). Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.836605"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"113958","DOI":"10.1016\/j.biopha.2022.113958","article-title":"Deciphering the gut microbiome in neurodegenerative diseases and metagenomic approaches for characterization of gut microbes","volume":"156","author":"Singh","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"833","DOI":"10.4103\/1673-5374.382223","article-title":"Correlation between the gut microbiome and neurodegenerative diseases: A review of metagenomics evidence","volume":"19","author":"Liu","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/microbiolres15020033","article-title":"The Role of the Gut Microbiota in Neurodegenerative Diseases","volume":"15","author":"Balasubramanian","year":"2024","journal-title":"Microbiol. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/acschemneuro.2c00803","article-title":"Short-Chain Fatty Acids in the Microbiota-Gut-Brain Axis: Role in Neurodegenerative Disorders and Viral Infections","volume":"14","author":"Majumdar","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Koutsokostas, C., Merkouris, E., Goulas, A., Aidinopoulou, K., Sini, N., Dimaras, T., Tsiptsios, D., Mueller, C., Nystazaki, M., and Tsamakis, K. (2024). Gut Microbes Associated with Neurodegenerative Disorders: A Comprehensive Review of the Literature. Microorganisms, 12.","DOI":"10.3390\/microorganisms12081735"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000518147","article-title":"Parkinson\u2019s Disease and Gut Microbiota","volume":"77","author":"Hirayama","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Stolzer, I., Scherer, E., S\u00fc\u00df, P., Rothhammer, V., Winner, B., Neurath, M.F., and G\u00fcnther, C. (2023). Impact of Microbiome\u2013Brain Communication on Neuroinflammation and Neurodegeneration. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914925"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2422468","DOI":"10.1080\/19490976.2024.2422468","article-title":"Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic\/pathogenic balance in neurodegenerative diseases","volume":"16","author":"Munir","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota\u2013gut\u2013brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mitroshina, E.V., Savyuk, M.O., Ponimaskin, E., and Vedunova, M.V. (2021). Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.703084"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Mitroshina, E.V., and Vedunova, M.V. (2024). The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094581"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"151419","DOI":"10.1016\/j.bbrc.2025.151419","article-title":"Involvement of the STAT3\/HIF-1\u03b1 signaling pathway in \u03b1-synuclein-induced ferroptosis","volume":"752","author":"Zhang","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"60","DOI":"10.71012\/pro-ageing-2025-2-05","article-title":"The role of HIF-1\u03b1 in the pathogenesis of neuroinflammation","volume":"30","author":"Farkhidinov","year":"2025","journal-title":"\u041f\u0440o\u0431\u043b\u0435\u043c\u0438 \u0421\u0442\u0430\u0440\u0456\u043d\u043d\u044f \u0406 \u0414o\u0432\u0433o\u043b\u0456\u0442\u0442\u044f (\u0423\u043a\u0440\u0430\u0457\u043d\u0430) Probl. Ageing Longev."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Thangaleela, S., Ali, A., Tandoro, Y., and Wang, C.K. (2026). Shared Neuroinflammatory Mechanisms Across Dementia Types: An Integrative Review. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27010179"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Arias, C., Sep\u00falveda, P., Castillo, R.L., and Salazar, L.A. (2023). Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1\u03b1 and Th17 Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043073"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jnr.24551","article-title":"The emerging role of Hippo signaling in neurodegeneration","volume":"98","author":"Sahu","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2174\/1570159X19666210729123137","article-title":"The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System Diseases","volume":"20","author":"Chen","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3233\/JAD-201448","article-title":"Role of hypoxia inducible factor-1\u03b1; in Alzheimer\u2019s disease","volume":"80","author":"Wang","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Lin, T.K., Huang, C.R., Lin, K.J., Hsieh, Y.H., Chen, S.D., Lin, Y.C., Chao, A.C., and Yang, D.I. (2024). Potential Roles of Hypoxia-Inducible Factor-1 in Alzheimer\u2019s Disease: Beneficial or Detrimental?. Antioxidants, 13.","DOI":"10.3390\/antiox13111378"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"105923","DOI":"10.1016\/j.neuint.2024.105923","article-title":"HIF-1\u03b1 downregulates the APP protein after oxygen and glucose deprivation in the APPswe\/PSEN1 mouse model of Alzheimer\u2019s disease","volume":"183","author":"Jurado","year":"2025","journal-title":"Neurochem. Int."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1139\/bcb-2019-0117","article-title":"Protective effect of hydralazine on a cellular model of parkinson\u2019s disease: A possible role of hypoxia-inducible factor (HIF)-1\u03b1","volume":"98","author":"Mehrabani","year":"2020","journal-title":"Biochem. Cell Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"102543","DOI":"10.1016\/j.ceb.2025.102543","article-title":"The Notch pathway: A guardian of cell fate during neurogenesis","volume":"95","author":"Gonzalez","year":"2025","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Lampada, A., and Taylor, V. (2023). Notch signaling as a master regulator of adult neurogenesis. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1179011"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"20221051","DOI":"10.1515\/biol-2022-1051","article-title":"Neurodegenerative diseases and neuroinflammation-induced apoptosis","volume":"20","author":"Huang","year":"2025","journal-title":"Open Life Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/1570159X18666200807130637","article-title":"Neurodegenerative Pathways in Alzheimer\u2019s Disease: A Review","volume":"19","author":"Ramachandran","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"103657","DOI":"10.1016\/j.mcn.2021.103657","article-title":"Revealing NOTCH-dependencies in synaptic targets associated with Alzheimer\u2019s disease","volume":"115","author":"Perna","year":"2021","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.semcdb.2020.12.011","article-title":"Role of Notch signaling in neurovascular aging and Alzheimer\u2019s disease","volume":"116","author":"Kapoor","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e13101","DOI":"10.1111\/acel.13101","article-title":"Parkinson\u2019s disease, aging and adult neurogenesis: Wnt\/\u03b2-catenin signalling as the key to unlock the mystery of endogenous brain repair","volume":"19","author":"Marchetti","year":"2020","journal-title":"Aging Cell"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Surguchov, A. (2021). Invertebrate models untangle the mechanism of neurodegeneration in parkinson\u2019s disease. Cells, 10.","DOI":"10.3390\/cells10020407"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10571-021-01089-0","article-title":"The Notch Signaling Pathway Regulates Differentiation of NG2 Cells into Oligodendrocytes in Demyelinating Diseases","volume":"42","author":"Li","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"577758","DOI":"10.1016\/j.jneuroim.2021.577758","article-title":"The involvement of JAK\/STAT signaling pathway in the treatment of Parkinson\u2019s disease","volume":"361","author":"Lashgari","year":"2021","journal-title":"J. Neuroimmunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/09727531211070532","article-title":"Role of JAK\/STAT in the Neuroinflammation and its Association with Neurological Disorders","volume":"28","author":"Jain","year":"2021","journal-title":"Ann. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Rusek, M., Smith, J., El-Khatib, K., Aikins, K., Czuczwar, S.J., and Pluta, R. (2023). The Role of the JAK\/STAT Signaling Pathway in the Pathogenesis of Alzheimer\u2019s Disease: New Potential Treatment Target. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010864"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s10787-025-01796-w","article-title":"Targeting the JAK\/STAT3\/SOCS signaling pathway in Alzheimer\u2019s disease","volume":"33","author":"Sulaiman","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12974-024-03210-8","article-title":"Suppression of the JAK\/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson\u2019s disease","volume":"21","author":"Hong","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_111","first-page":"485","article-title":"Impact of 6-OHDA injection and microtrauma in the rat substantia nigra on local brain amyloid beta protein concentrations in the affected area","volume":"40","author":"Tsytsarev","year":"2025","journal-title":"Histol. Histopathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10517-022-05560-w","article-title":"The Role of JAKs and STAT3 in Regulation of Regenerative-Competent Cells of the Nervous Tissue in \u03b2-Amyloid-Induced Neurodegeneration","volume":"173","author":"Miroshnichenko","year":"2022","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s10571-021-01111-5","article-title":"HIF-1\u03b1 in the Crosstalk Between Reactive Oxygen Species and Autophagy Process: A Review in Multiple Sclerosis","volume":"42","author":"Asgari","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.1007\/s12035-025-04914-5","article-title":"The Bidirectional Role of Hypoxia-Inducible Factor 1 Alpha in Vascular Dementia Caused by Chronic Cerebral Hypoperfusion","volume":"62","author":"Thangwong","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/08919887221141651","article-title":"Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review","volume":"36","author":"Santos","year":"2023","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.2174\/1389203721666200511094222","article-title":"Proteomics and Neurodegenerative Disorders: Advancements in the Diagnostic Analysis","volume":"21","author":"Puranik","year":"2020","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.5530\/ijper.20250179","article-title":"Biomarkers Unveiling Neurodegeneration: Keys to Progression and Therapeutic Insights","volume":"59","author":"Das","year":"2025","journal-title":"Indian. J. Pharm. Educ. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1038\/s41591-023-02443-z","article-title":"CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer\u2019s disease","volume":"29","author":"Horie","year":"2023","journal-title":"Nat. Med."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Azam, H.M.H., R\u00f6\u00dfling, R.I., Geithe, C., Khan, M.M., Dinter, F., Hanack, K., Pr\u00fc\u00df, H., Husse, B., Roggenbuck, D., and Schierack, P. (2024). MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: A comprehensive review. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1386735"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Song, J., Cho, E., Lee, H., Lee, S., Kim, S., and Kim, J. (2025). Development of Neurodegenerative Disease Diagnosis and Monitoring from Traditional to Digital Biomarkers. Biosensors, 15.","DOI":"10.3390\/bios15020102"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"fcab237","DOI":"10.1093\/braincomms\/fcab237","article-title":"Linking immune-mediated damage to neurodegeneration in multiple sclerosis: Could network-based MRI help?","volume":"3","author":"Groppa","year":"2021","journal-title":"Brain Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13195-020-00601-w","article-title":"Relevance of biomarkers across different neurodegenerative diseases","volume":"12","author":"Ehrenberg","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/14737159.2020.1731306","article-title":"The path to biomarker-based diagnostic criteria for the spectrum of neurodegenerative diseases","volume":"20","author":"Baldacci","year":"2020","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"566","DOI":"10.25259\/JNRP_356_2023","article-title":"Guidelines for pharmacotherapy in Alzheimer\u2019s disease\u2014A primer on FDA-approved drugs","volume":"14","author":"Varadharajan","year":"2023","journal-title":"J. Neurosci. Rural. Pr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/01616412.2024.2302271","article-title":"Agents at the Peak of US FDA Approval for the Treatment of Alzheimer\u2019s Disease","volume":"46","author":"Alam","year":"2024","journal-title":"Neurol. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e10367","DOI":"10.1002\/btm2.10367","article-title":"Alzheimer\u2019s and Parkinson\u2019s disease therapies in the clinic","volume":"8","author":"Chopade","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/13543784.2020.1764534","article-title":"Glucagon-like peptide-1 (GLP-1)-based receptor agonists as a treatment for Parkinson\u2019s disease","volume":"29","author":"Glotfelty","year":"2020","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Bross, M., Hackett, M., and Bernitsas, E. (2020). Approved and emerging disease modifying therapies on neurodegeneration in multiple sclerosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124312"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Niazi, S.K. (2024). Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs\u2014Protocols and Advice for the FDA to Meet the ALS Act Vision. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810211"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1021\/acs.jmedchem.0c01516","article-title":"A Decade of FDA-Approved Drugs (2010\u20132019): Trends and Future Directions","volume":"64","author":"Brown","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0000000000012329","article-title":"Implications of FDA Approval of a First Disease-Modifying Therapy for a Neurodegenerative Disease on the Design of Subsequent Clinical Trials","volume":"97","author":"Grill","year":"2021","journal-title":"Neurology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1007\/s12035-024-04285-3","article-title":"From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer\u2019s Disease","volume":"62","author":"Ortega","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_134","first-page":"e67037","article-title":"Emerging Gene Therapies for Alzheimer\u2019s and Parkinson\u2019s Diseases: An Overview of Clinical Trials and Promising Candidates","volume":"16","author":"Roberts","year":"2024","journal-title":"Cureus"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/13543784.2023.2178416","article-title":"Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis","volume":"32","author":"Martinez","year":"2023","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4103\/1673-5374.385285","article-title":"Antisense therapy: A potential breakthrough in the treatment of neurodegenerative diseases","volume":"19","author":"Romano","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Mortada, I., Farah, R., Nabha, S., Ojcius, D.M., Fares, Y., Almawi, W.Y., and Sadier, N.S. (2021). Immunotherapies for Neurodegenerative Diseases. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.654739"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.4103\/1673-5374.373670","article-title":"Therapies for Tau-associated neurodegenerative disorders: Targeting molecules, synapses, and cells","volume":"18","author":"Robbins","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Andrade, S., Nunes, D., Dabur, M., Ramalho, M.J., Pereira, M.C., and Loureiro, J.A. (2023). Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010212"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Angelopoulou, E., Pyrgelis, E.S., and Piperi, C. (2022). Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence. Molecules, 27.","DOI":"10.3390\/molecules27238448"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1007\/s00210-024-03757-6","article-title":"Trace amine-associated receptor 1 (TAAR1): An emerging therapeutic target for neurodegenerative, neurodevelopmental, and neurotraumatic disorders","volume":"398","author":"Dalvi","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41573-025-01165-w","article-title":"Biomarker-guided decision making in clinical drug development for neurodegenerative disorders","volume":"24","author":"Cummings","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Pandey, S., Jir\u00e1sko, M., Lochman, J., Chv\u00e1tal, A., Chottova Dvorakova, M., and Ku\u010dera, R. (2022). iPSCs in Neurodegenerative Disorders: A Unique Platform for Clinical Research and Personalized Medicine. J. Pers. Med., 12.","DOI":"10.3390\/jpm12091485"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Stefano, G.B. (2023). Artificial Intelligence as a Tool for the Diagnosis and Treatment of Neurodegenerative Diseases. Brain Sci., 13.","DOI":"10.3390\/brainsci13060938"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.30574\/wjarr.2023.19.2.1432","article-title":"Artificial intelligence-powered analysis of medical images for early detection of neurodegenerative diseases","volume":"19","author":"Fanijo","year":"2023","journal-title":"World J. Adv. Res. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1002\/alz.13479","article-title":"Artificial intelligence for neurodegenerative experimental models","volume":"19","author":"Marzi","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Feng, T. (2023). Applications of artificial intelligence to diagnosis of neurodegenerative diseases. Studies in Health Technology and Informatics, IOS Press.","DOI":"10.3233\/SHTI230896"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e3061","DOI":"10.31661\/gmj.v12i.3061","article-title":"The Use of Artificial Intelligence in the Management of Neurodegenerative Disorders; Focus on Alzheimer\u2019s Disease","volume":"12","author":"Khastehband","year":"2023","journal-title":"Galen. Med. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/cpt.2987","article-title":"Repurposing Artificial Intelligence Tools for Disease Modeling: Case Study of Face Recognition Deficits in Neurodegenerative Diseases","volume":"114","author":"Singh","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_150","first-page":"54","article-title":"AI-Enabled Predictive Modeling of Disease Progression in Neurodegenerative Disorders: Developing Machine Learning Algorithms for Early Detection, Patient Monitoring, and Therapeutic Interventions","volume":"7","author":"Mitta","year":"2023","journal-title":"Am. J. Cogn. Comput. AI Syst."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Mathur, S., and Jaiswal, A. (2024). Demystifying the Role of Artificial Intelligence in Neurodegenerative Diseases. AI and Neuro-Degenerative Diseases, Springer. Studies in Computational Intelligence.","DOI":"10.1007\/978-3-031-53148-4_1"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yu, L., Lv, Y., Yang, T., and Guo, Q. (2025). Artificial intelligence in neurodegenerative diseases research: A bibliometric analysis since 2000. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1607924"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"124","DOI":"10.69980\/ajpr.v28i1.71","article-title":"AI-Driven Drug Discovery: Transforming Neurological and Neurodegenerative Disease Treatment Through Bioinformatics and Genomic Research","volume":"28","author":"Nuka","year":"2025","journal-title":"Am. J. Psychiatr. Rehabil."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Calderone, A., Latella, D., La Fauci, E., Puleo, R., Sergi, A., De Francesco, M., Mauro, M., Foti, A., Salemi, L., and Calabr\u00f2, R.S. (2025). Artificial Intelligence-Driven Neuromodulation in Neurodegenerative Disease: Precision in Chaos, Learning in Loss. Biomedicines, 13.","DOI":"10.3390\/biomedicines13092118"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zou, H., and Zhang, C. (2024). Editorial: Artificial intelligence, biosensing, and brain stimulation in neurodegenerative diseases: Progress and challenges. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1362574"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Rajaraman, S. (2024). Artificial Intelligence in Neuro Degenerative Diseases: Opportunities and Challenges. AI and Neuro-Degenerative Diseases, Springer. Studies in Computational Intelligence.","DOI":"10.1007\/978-3-031-53148-4_8"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Mangalampalli, S., Karri, G.R., and Shaw, A. (2024). Exploring AI\u2019s Role in Managing Neurodegenerative Disorders: Possibilities and Hurdles. AI and Neuro-Degenerative Diseases, Springer. Studies in Computational Intelligence.","DOI":"10.1007\/978-3-031-53148-4_7"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Singh, D.P., Kaushik, B., Khan, Y.F., Chadha, A., Mahajan, A., Jandwani, A., and Narula, G.S. (2024). Emerging Trends of Artificial Intelligence in Detecting Neurodegeneration. Proceedings of the Fifth International Conference on Computing, Communications, and Cyber-Security, Springer. Lecture Notes in Networks and Systems.","DOI":"10.1007\/978-981-97-2550-2_42"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"81","DOI":"10.61424\/ijmhr.v3i3.382","article-title":"Artificial Intelligence in Early Diagnosis of Neurodegenerative Disorders: A Systematic Review of Clinical Applications and Challenges","volume":"3","author":"Rana","year":"2025","journal-title":"Int. J. Med. 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