{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:51:40Z","timestamp":1782885100308,"version":"3.54.5"},"reference-count":59,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Long-term clinical translation of left ventricular assist devices (LVADs) is severely hampered by thromboembolism and device-related infection, both originating from inadequate biocompatibility of the device-blood interface. Current titanium surface modifications fail to simultaneously deliver durable antithrombotic and antibacterial performance, while conventional polydopamine-copper (PDA-Cu) coatings suffer from inherent limitations. Herein, we report a one-step rapid co-polymerization strategy based on mussel-inspired polyphenol chemistry to fabricate a copper-integrated polydopamine\/tannic acid nanocoating on titanium (Ti\/PDT(Cu)). By incorporating tannic acid rich in catechol\/pyrogallol moieties, we achieve synergistic acceleration of dopamine oxidative polymerization with copper ions, dramatically shortening the fabrication time to 8 h (vs. 24 h for traditional PDA coatings). This process simultaneously constructs a robust dual-crosslinked network through covalent\/hydrogen bonds and metal-phenolic coordination, exhibiting a uniform nanoscale-roughened structure. Comprehensive physicochemical characterizations confirm homogeneous coating deposition, excellent hydrophilicity, uniform Cu distribution, and superior long-term structural stability (95.68% thickness retention after 7 days of physiological immersion). The optimized coating displays broad-spectrum and durable antibacterial activity, with 92.79% and 89.73% reduction of E. coli and S. aureus at 24 h, respectively, and retains &gt;89% antibacterial efficacy after 7 days of continuous elution (n = 3, * p&lt; 0.05). Moreover, the coating enables stable and sustained catalytic nitric oxide generation (43.85 \u00b1 2.36 \u03bcM cumulative release over 14 days) that mimics endothelial function, resulting in 69.4% inhibition of platelet adhesion and an ultralow hemolysis ratio of 0.97% (n = 3). Critically, it maintains excellent cytocompatibility with L929 fibroblasts (&gt;90% cell viability after 72 h co-culture). This work addresses key limitations of conventional PDA-based functional coatings, realizes synergistic antithrombotic and antibacterial dual functions showing great potential for blood-contacting cardiovascular device applications, and provides a facile and robust surface engineering platform for long-term implantable cardiovascular devices.<\/jats:p>","DOI":"10.3390\/biom16070953","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:06:34Z","timestamp":1782875194000},"page":"953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copper Integrated PDA-TA Nanocoating via One-Step Rapid Polymerization on Titanium for Anti-Thrombotic and Antibacterial Properties"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2967-0597","authenticated-orcid":false,"given":"Chuangxin","family":"Huang","sequence":"first","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"},{"name":"School of Rare Earths, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"},{"name":"School of Rare Earths, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5320-0807","authenticated-orcid":false,"given":"Jianli","family":"Meng","sequence":"additional","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China"},{"name":"School of Rare Earths, University of Science and Technology of China, Hefei 230026, China"},{"name":"Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41569-024-01046-6","article-title":"Global epidemiology of heart failure","volume":"21","author":"Khan","year":"2024","journal-title":"Nat. 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