{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:42:25Z","timestamp":1785404545646,"version":"3.56.0"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"FWF","doi-asserted-by":"publisher","award":["W1241"],"award-info":[{"award-number":["W1241"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"award":["W1241"],"award-info":[{"award-number":["W1241"]}],"id":[{"id":"https:\/\/ror.org\/013tf3c58","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/02n0bts35","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Kulturamt der Stadt Graz"},{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["17950"],"award-info":[{"award-number":["17950"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]},{"award":["17950"],"award-info":[{"award-number":["17950"]}],"id":[{"id":"https:\/\/ror.org\/00nkcmy90","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The first trimester (FT) of pregnancy is characterized by rapid placental growth and differentiation, rendering this period sensitive to maternal metabolic influences. Maternal obesity is associated with chronic low-grade inflammation and altered redox homeostasis with implications in later cardiometabolic risk in offspring, yet its impact on early placental oxidative stress remains unclear. Here, we investigated whether maternal overweight and obesity are associated with oxidative lipid and protein damage and altered expression of antioxidant enzymes and stress signaling pathways. Placental tissue from lean (BMI &lt; 25 kg\/m2), overweight (BMI \u2265 25 kg\/m2) and obese (BMI \u2265 30 kg\/m2) non-smoking women (5\u201312 weeks\u2019 gestation) was analyzed. Oxidative damage was assessed by immunoblotting for 4-hydroxynonenal and 3-nitrotyrosine, and antioxidant and stress-related transcripts were quantified using targeted mRNA arrays. Explants were exposed to increased oxygen tension or TNF-\u03b1 to evaluate transcriptional responsiveness. No differences in oxidative lipid or protein modifications were detected between groups. In contrast, overweight and obesity were associated with reduced expression of selected antioxidant enzymes and transcriptional remodeling of MAPK-related genes. These changes correlated with IL6 expression but not with oxidative damage markers. Collectively, maternal overweight and obesity are linked to inflammation-associated transcriptional adaptation in FT placenta without detectable oxidative injury.<\/jats:p>","DOI":"10.3390\/biom16071033","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:39:38Z","timestamp":1784093978000},"page":"1033","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation-Associated Transcriptional Remodeling of Antioxidant and Stress Signaling Pathways in First-Trimester Placenta in Maternal Overweight and Obesity"],"prefix":"10.3390","volume":"16","author":[{"given":"Denise","family":"Hoch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-5810","authenticated-orcid":false,"given":"Alejandro","family":"Majali-Martinez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria"},{"name":"Departamento de Medicina, Salud y Deportes, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"Endometriosis and Female Reproductive Health Research Group, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-1502","authenticated-orcid":false,"given":"Francisco","family":"Algaba Chueca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria"},{"name":"Endometriosis and Female Reproductive Health Research Group, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"},{"name":"Department of Basic Medical Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvija","family":"Tokic","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Medical University of Graz, 8036 Graz, Austria"},{"name":"Research Unit of Analytical Mass Spectrometry, Cell Biology and Biochemistry of Inborn Errors of Metabolism, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-3230","authenticated-orcid":false,"given":"Gernot","family":"Desoye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref_1","first-page":"2401","article-title":"Global Trends in Prevalence of Maternal Overweight and Obesity: A Systematic Review and Meta-Analysis of Routinely Collected Data Retrospective Cohorts","volume":"9","author":"Kent","year":"2024","journal-title":"Int. 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