{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:05:22Z","timestamp":1784189122977,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Natural Science Foundation of Hunan Province","award":["2026JJ50619"],"award-info":[{"award-number":["2026JJ50619"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Hypertension-induced vascular remodeling is a major contributor to cardiovascular morbidity and is characterized by endothelial dysfunction, vascular smooth muscle cell phenotypic switching, fibrosis, and inflammation. Sirtuin 3 (SIRT3), a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, plays an important role in maintaining mitochondrial homeostasis, regulating redox balance, and modulating cellular energy metabolism. Emerging evidence suggests that SIRT3 deficiency accelerates hypertensive vascular remodeling through multiple mechanisms. In vascular smooth muscle cells (VSMCs), reduced SIRT3 activity enhances mitochondrial reactive oxygen species generation, promotes glycolytic reprogramming, and contributes to phenotypic switching and proliferation. In endothelial cells, SIRT3 mitigates oxidative stress (OS) by regulating the activity of superoxide dismutase 2, thereby preserving nitric oxide (NO) bioavailability and improving vascular function. SIRT3 also suppresses fibroblast-to-myofibroblast transformation by inhibiting the transforming growth factor-\u03b2\/Smad3 pathway, thereby reducing vascular fibrosis. Furthermore, SIRT3 regulates macrophage metabolic reprogramming and autophagy, inhibits NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome activation, and attenuates vascular inflammation. In perivascular adipose tissue, SIRT3 deficiency exacerbates angiotensin II-induced fibrosis and cytokine secretion, thereby aggravating vascular dysfunction. Collectively, SIRT3 acts as a mitochondrial regulator against hypertension-induced oxidative and inflammatory injury. Targeting SIRT3-dependent pathways may represent a promising therapeutic approach to restore vascular homeostasis and prevent hypertensive vascular remodeling.<\/jats:p>","DOI":"10.3390\/biom16071037","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:49:36Z","timestamp":1784184576000},"page":"1037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in the Role of SIRT3 in Vascular Remodeling in Hypertension"],"prefix":"10.3390","volume":"16","author":[{"given":"Abdul","family":"Wahid","sequence":"first","affiliation":[{"name":"International School of Medicine, Changsha Medical University, 1501 Leifeng Road, Changsha 410219, China"},{"name":"Department of Cardiology of the Third Xiang-Ya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-8760","authenticated-orcid":false,"given":"Md. Tariqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Biomedical Sciences, Khwaja Yunus Ali University, Sirajganj 6751, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sohel","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Biomedical Sciences, Khwaja Yunus Ali University, Sirajganj 6751, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Morium","family":"Parvin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Biomedical Sciences, Khwaja Yunus Ali University, Sirajganj 6751, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Cardiology of the Third Xiang-Ya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology of the Third Xiang-Ya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref_1","first-page":"3331","article-title":"An Essential Introduction to the Annual Report on Cardiovascular Health and Diseases in China (2021)","volume":"25","author":"Ma","year":"2022","journal-title":"Chin. 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