{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:19:09Z","timestamp":1785417549221,"version":"3.56.0"},"reference-count":48,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of T\u00fcrkiye","doi-asserted-by":"publisher","award":["1919B012223051"],"award-info":[{"award-number":["1919B012223051"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"award":["1919B012223051"],"award-info":[{"award-number":["1919B012223051"]}],"id":[{"id":"https:\/\/ror.org\/04w9kkr77","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011576","name":"Inonu University","doi-asserted-by":"publisher","award":["TSA-2026-4452"],"award-info":[{"award-number":["TSA-2026-4452"]}],"id":[{"id":"10.13039\/501100011576","id-type":"DOI","asserted-by":"publisher"}]},{"award":["TSA-2026-4452"],"award-info":[{"award-number":["TSA-2026-4452"]}],"id":[{"id":"https:\/\/ror.org\/04asck240","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Anthracycline cardiotoxicity involves early oxidative\u2013inflammatory injury to the myocardium and vasculature. Repurposing anti-inflammatory agents may offer pragmatic cardioprotection. The purpose of this study is to evaluate whether sulfasalazine (SSZ) mitigates doxorubicin (DOX)-induced myocardial and aortic injury in rats. Twenty-eight male Wistar albino rats were randomized to: Control (vehicle, n = 8), DOX (20 mg\/kg i.p., single dose; n = 10), and SSZ + DOX (SSZ 300 mg\/kg i.p. once daily for 3 days, then DOX 20 mg\/kg i.p.; n = 10). At 24 h post-DOX, ECG and invasive blood pressure (BP) were recorded. The heart and thoracic aorta were harvested for histopathology and oxidative stress assays (MDA, SOD, GSH, CAT; composite indices where applicable). Compared with SSZ + DOX, the DOX group exhibited higher BP and greater arrhythmic burden. In the aorta, DOX elevated MDA and reduced SOD, GSH, and CAT versus the control, whereas SSZ + DOX shifted these toward control values. In the myocardium, DOX decreased SOD and increased oxidative index; SSZ + DOX attenuated histological injury (edema, hemorrhage, cardiomyocyte degeneration) and restored aortic intima\u2013media thickness toward control. Heart rate was lower in SSZ + DOX than other groups. Short-course SSZ pretreatment alleviated early DOX-induced oxidative stress and structural damage in myocardial and aortic tissues, with concurrent improvement in hemodynamic and ECG profiles. These data support further dose\u2013timing optimization and longer-term functional studies to define SSZ\u2019s translational potential as an adjunct cardioprotective strategy during anthracycline exposure.<\/jats:p>","DOI":"10.3390\/biom16081085","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:38:41Z","timestamp":1784889521000},"page":"1085","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Protection with Sulfasalazine During Doxorubicin Challenge: Evidence from Oxidative and Histologic Endpoints"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-7849","authenticated-orcid":false,"given":"Onural","family":"Ozhan","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes","family":"Kaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Hakan","family":"Tasolar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0878-5129","authenticated-orcid":false,"given":"Mehmet Ertugrul","family":"Balkar","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-7867","authenticated-orcid":false,"given":"Azibe","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-9582","authenticated-orcid":false,"given":"Feyzi","family":"Dogru","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Malatya Turgut Ozal University, 44210 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6078-7480","authenticated-orcid":false,"given":"Zeynep","family":"Ulutas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-9272","authenticated-orcid":false,"given":"Zeynep","family":"Kucukakcali","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9497-3468","authenticated-orcid":false,"given":"Hakan","family":"Parlakpinar","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Contaldi, C., D\u2019Aniello, C., Panico, D., Zito, A., Calabro, P., Di Lorenzo, E., Golino, P., and Montesarchio, V. 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