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This review summarizes current evidence on the role of excessive reactive oxygen species (ROS) production, impaired oxidized nicotinamide adenine dinucleotide (NAD+) metabolism, altered mitochondrial bioenergetics, disrupted mitochondrial dynamics, and defective mitochondrial quality control pathways, including mitophagy and the mitochondrial unfolded protein response (UPRmt), in kidney disease progression. Experimental and clinical studies indicate that these mechanisms contribute to inflammation, fibrosis, apoptosis, and maladaptive repair, promoting progression from AKI to CKD and worsening DKD. The review also discusses emerging biomarkers and therapeutic strategies targeting oxidative stress and mitochondrial dysfunction. Overall, redox-mediated mitochondrial injury represents a shared pathogenic axis and a potential therapeutic target across kidney diseases.<\/jats:p>","DOI":"10.3390\/biom16081148","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T09:14:28Z","timestamp":1786094068000},"page":"1148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Redox-Mediated Mitochondrial Dysfunction as a Common Pathogenic Axis in Acute Kidney Injury and Chronic Kidney Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-4746","authenticated-orcid":false,"given":"Ewelina","family":"M\u0142ynarska","sequence":"first","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1234-3409","authenticated-orcid":false,"given":"Kinga","family":"Bojdo","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0674-6227","authenticated-orcid":false,"given":"Katarzyna","family":"Hossa","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-2518","authenticated-orcid":false,"given":"Wiktoria","family":"Lisi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Krawiranda","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Krupi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6075-9627","authenticated-orcid":false,"given":"Natalia","family":"Kustosik","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wieczorek","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Rysz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Internal Medicine, Medical University of Lodz, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Franczyk","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"ref_1","first-page":"1074","article-title":"Acute kidney injury, its definition, and treatment in adults: Guidelines and reality","volume":"130","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2215\/CJN.02730313","article-title":"Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals","volume":"9","author":"Zeng","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2024). KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int., 105, S117\u2013S314.","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.2337\/dci22-0027","article-title":"Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"45","author":"Khunti","year":"2022","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Aranda-Rivera, A.K., Cruz-Gregorio, A., Aparicio-Trejo, O.E., and Pedraza-Chaverri, J. (2021). Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases. Biomolecules, 11.","DOI":"10.3390\/biom11081144"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2393262","DOI":"10.1080\/0886022X.2024.2393262","article-title":"Mitochondrial dysfunction in acute kidney injury","volume":"46","author":"Yao","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"F1105","DOI":"10.1152\/ajprenal.00285.2020","article-title":"Mitochondrial dysfunction and the AKI-to-CKD transition","volume":"319","author":"Jiang","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD+ metabolism: Pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.tcb.2023.02.004","article-title":"The autophagy-NAD axis in longevity and disease","volume":"33","author":"Wilson","year":"2023","journal-title":"Trends Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41581-019-0216-6","article-title":"NAD+ homeostasis in renal health and disease","volume":"16","author":"Ralto","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molmed.2024.12.004","article-title":"NAD+ metabolism in acute kidney injury and chronic kidney disease transition","volume":"31","author":"Alhumaidi","year":"2025","journal-title":"Trends Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yan, L.J. (2021). NADH\/NAD+ Redox Imbalance and Diabetic Kidney Disease. Biomolecules, 11.","DOI":"10.3390\/biom11050730"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.freeradbiomed.2025.03.029","article-title":"Reductive stress and mitochondrial dysfunction: The hidden link in chronic disease","volume":"233","author":"Mercola","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kandel, R., Roy, P., and Singh, K.P. (2025). Molecular Basis of Oxidative Stress-Induced Acute Kidney Injury, Kidney Fibrosis, Chronic Kidney Disease, and Clinical Significance of Targeting Reactive Oxygen Species-Regulated Pathways to Treat Kidney Disease. Front. Biosci. Sch. Ed., 17.","DOI":"10.31083\/FBS38963"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sim\u00f5es E Silva, A.C. (2025). Oxidative Stress in Renal Health. Antioxidants, 14.","DOI":"10.3390\/antiox14020144"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Schiffer, T.A., Carvalho, L.R.R.A., Guimaraes, D., Boeder, A., Wikstr\u00f6m, P., and Carlstr\u00f6m, M. (2024). Specific NOX4 Inhibition Preserves Mitochondrial Function and Dampens Kidney Dysfunction Following Ischemia-Reperfusion-Induced Kidney Injury. Antioxidants, 13.","DOI":"10.2139\/ssrn.4663648"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Guerrero-Hue, M., Rayego-Mateos, S., V\u00e1zquez-Carballo, C., Palomino-Antol\u00edn, A., Garc\u00eda-Caballero, C., Opazo-Rios, L., Morgado-Pascual, J.L., Herencia, C., Mas, S., and Ortiz, A. (2020). Protective Role of Nrf2 in Renal Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10010039"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pavlovi\u0107, N., Kri\u017eanac, M., Kumri\u0107, M., Vukojevi\u0107, K., and Bo\u017ei\u0107, J. (2025). Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression. Cells, 14.","DOI":"10.3390\/cells14110794"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"119573","DOI":"10.1016\/j.bbamcr.2023.119573","article-title":"Reactive oxygen species and cell signaling. Review","volume":"1871","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution. Antioxidants, 13.","DOI":"10.3390\/antiox13030312"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00424-022-02701-y","article-title":"Metabolic mechanisms of acute proximal tubular injury","volume":"474","author":"Hall","year":"2022","journal-title":"Pfl\u00fcg. Arch."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jang, H.-S., Noh, M.R., Kim, J., and Padanilam, B.J. (2020). Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases. Front. Med., 7.","DOI":"10.3389\/fmed.2020.00065"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"F768","DOI":"10.1152\/ajprenal.00189.2023","article-title":"Mitochondrial dysfunction in the pathophysiology of renal diseases","volume":"326","author":"Guo","year":"2024","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41419-024-06833-0","article-title":"Mitochondrial metabolic reprogramming in diabetic kidney disease","volume":"15","author":"Fan","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","article-title":"A mitochondrial specific stress response in mammalian cells","volume":"21","author":"Zhao","year":"2002","journal-title":"EMBO J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1038\/cddis.2012.46","article-title":"Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: Dual roles for ERK1\/2","volume":"3","author":"Zhu","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fontecha-Barriuso, M., Martin-Sanchez, D., Martinez-Moreno, J.M., Monsalve, M., Ramos, A.M., Sanchez-Ni\u00f1o, M.D., Ruiz-Ortega, M., Ortiz, A., and Sanz, A.B. (2020). The Role of PGC-1\u03b1 and Mitochondrial Biogenesis in Kidney Diseases. Biomolecules, 10.","DOI":"10.3390\/biom10020347"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","article-title":"PGC1\u03b1 drives NAD biosynthesis linking oxidative metabolism to renal protection","volume":"531","author":"Tran","year":"2016","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.semnephrol.2018.01.003","article-title":"The Role of Peroxisome Proliferator-Activated Receptor \u03b3 Coactivator 1\u03b1 (PGC-1\u03b1) in Kidney Disease","volume":"38","author":"Li","year":"2018","journal-title":"Semin. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41581-020-00369-0","article-title":"Mitochondrial quality control in kidney injury and repair","volume":"17","author":"Tang","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: Overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Qin, L., and Xi, S. (2022). The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314725"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.kint.2017.05.034","article-title":"The hallmarks of mitochondrial dysfunction in chronic kidney disease","volume":"92","author":"Galvan","year":"2017","journal-title":"Kidney Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","article-title":"Mitochondria ROS and mitophagy in acute kidney injury","volume":"19","author":"Su","year":"2023","journal-title":"Autophagy"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Stanigut, A.M., Tuta, L., Pana, C., Alexandrescu, L., Suceveanu, A., Blebea, N.-M., and Vacaroiu, I.A. (2025). Autophagy and Mitophagy in Diabetic Kidney Disease\u2014A Literature Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020806"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.cub.2016.06.002","article-title":"The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR","volume":"26","author":"Fiorese","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41419-021-04085-w","article-title":"CPT1\u03b1 maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair","volume":"12","author":"Yuan","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/cr.2018.16","article-title":"UPRmt regulation and output: A stress response mediated by mitochondrial-nuclear communication","volume":"28","author":"Melber","year":"2018","journal-title":"Cell Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Torres, A.K., Fleischhart, V., and Inestrosa, N.C. (2024). Mitochondrial unfolded protein response (UPRmt): What we know thus far. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1405393"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-020-2076-4","article-title":"A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol","volume":"579","author":"Fessler","year":"2020","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/2211-5463.12863","article-title":"HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response","volume":"10","author":"Katiyar","year":"2020","journal-title":"FEBS Open Bio"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/MCB.01337-13","article-title":"SirT3 regulates the mitochondrial unfolded protein response","volume":"34","author":"Papa","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s10020-023-00651-4","article-title":"ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response","volume":"29","author":"Liu","year":"2023","journal-title":"Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e14121","DOI":"10.1111\/apha.14121","article-title":"Mitochondrial fumarate promotes ischemia\/reperfusion-induced tubular injury","volume":"240","author":"Li","year":"2024","journal-title":"Acta Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2020.04.025","article-title":"Protection against renal ischemia and reperfusion injury by short-term time-restricted feeding involves the mitochondrial unfolded protein response","volume":"154","author":"Gonzaga","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kim, D.K., Kim, Y.S., Kim, M.J., Kim, R.S., Lee, D.W., Lee, S.B., and Kim, I.Y. (2024). Time-Restricted Feeding Protects against Renal Ischemia-Reperfusion Injury in Mice. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147652"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41419-024-07231-2","article-title":"Slc25a21 in cisplatin-induced acute kidney injury: A new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis","volume":"15","author":"Su","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e16581","DOI":"10.15252\/emmm.202216581","article-title":"LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease","volume":"15","author":"Bai","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e70090","DOI":"10.1111\/jcmm.70090","article-title":"LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis","volume":"28","author":"Zhang","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"103929","DOI":"10.1016\/j.redox.2025.103929","article-title":"Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination","volume":"88","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115641","DOI":"10.1016\/j.intimp.2025.115641","article-title":"Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease","volume":"166","author":"Wang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101254","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41419-023-05587-5","article-title":"HIF1\u03b1-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/s41419-019-1899-0","article-title":"Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury","volume":"10","author":"Tang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.7150\/ijbs.83906","article-title":"PTEN-induced kinase 1 exerts protective effects in diabetic kidney disease by attenuating mitochondrial dysfunction and necroptosis","volume":"19","author":"Sung","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F788","DOI":"10.1152\/ajprenal.00184.2024","article-title":"Transition from acute kidney injury to chronic kidney disease: Mechanisms, models, and biomarkers","volume":"327","author":"Jones","year":"2024","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Niculae, A., Gherghina, M.E., Peride, I., Tiglis, M., Nechita, A.M., and Checherita, I.A. (2023). Pathway from Acute Kidney Injury to Chronic Kidney Disease: Molecules Involved in Renal Fibrosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814019"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/ndt\/gfaf093","article-title":"Long-term risks of adverse kidney outcomes after acute kidney injury: A systematic review and meta-analysis","volume":"40","author":"Veltkamp","year":"2025","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1053\/j.ajkd.2015.02.337","article-title":"A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex with Acute Kidney Injury","volume":"66","author":"Grams","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Thongprayoon, C., Hansrivijit, P., Kovvuru, K., Kanduri, R.S., Torres-Ortiz, A., Acharya, P., Gonzalez-Suarez, M.L., Kaewput, W., Bathini, T., and Cheungpasitporn, W. (2020). Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041104"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Turgut, F., Awad, A.S., and Abdel-Rahman, E.M. (2023). Acute Kidney Injury: Medical Causes and Pathogenesis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12010375"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0140-6736(25)01942-7","article-title":"Chronic kidney disease","volume":"407","author":"Herrington","year":"2026","journal-title":"Lancet"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhang, X., Agborbesong, E., and Li, X. (2021). The Role of Mitochondria in Acute Kidney Injury and Chronic Kidney Disease and Its Therapeutic Potential. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011253"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1111\/febs.17130","article-title":"Role of mitochondria in renal ischemia-reperfusion injury","volume":"291","author":"Huang","year":"2024","journal-title":"FEBS J."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"N\u00f8rg\u00e5rd, M.\u00d8., and Svenningsen, P. (2023). Acute Kidney Injury by Ischemia\/Reperfusion and Extracellular Vesicles. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015312"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Pefanis, A., Bongoni, A.K., McRae, J.L., Salvaris, E.J., Fisicaro, N., Murphy, J.M., Ierino, F.L., and Cowan, P.J. (2023). Dynamics of necroptosis in kidney ischemia-reperfusion injury. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1251452"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"F887","DOI":"10.1152\/ajprenal.00050.2001","article-title":"Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function","volume":"281","author":"Basile","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.2215\/CJN.00150118","article-title":"Pharmacology behind Common Drug Nephrotoxicities","volume":"13","author":"Perazella","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Kwiatkowska, E., Doma\u0144ski, L., Dziedziejko, V., Kajdy, A., Stefa\u0144ska, K., and Kwiatkowski, S. (2021). The Mechanism of Drug Nephrotoxicity and the Methods for Preventing Kidney Damage. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116109"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hosohata, K. (2016). Role of Oxidative Stress in Drug-Induced Kidney Injury. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111826"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"105394","DOI":"10.1016\/j.archger.2024.105394","article-title":"Non-steroidal anti-inflammatory drugs, renin-angiotensin system blockade or diuretics and risk of acute kidney injury: A case-crossover study","volume":"123","author":"Weng","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"114147","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"14439","DOI":"10.1007\/s11356-025-36538-6","article-title":"Metal mechanisms of mitochondrial toxicity: Recent review of arsenic, cadmium, and lead-induced nephrotoxicity","volume":"32","author":"Turkington","year":"2025","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/10408444.2021.1891196","article-title":"Associations between exposure to heavy metals and the risk of chronic kidney disease: A systematic review and meta-analysis","volume":"51","author":"Jalili","year":"2021","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.3892\/mmr.2017.6389","article-title":"Kidney and heavy metals\u2014The role of environmental exposure (Review)","volume":"15","author":"Lentini","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00467-018-4005-4","article-title":"Oxidative stress in chronic kidney disease","volume":"34","author":"Daenen","year":"2019","journal-title":"Pediatr. Nephrol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Arendshorst, W.J., Vendrov, A.E., Kumar, N., Ganesh, S.K., and Madamanchi, N.R. (2024). Oxidative Stress in Kidney Injury and Hypertension. Antioxidants, 13.","DOI":"10.3390\/antiox13121454"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1002\/j.2040-4603.2024.tb00287.x","article-title":"Renal Epithelial Mitochondria: Implications for Hypertensive Kidney Disease","volume":"14","author":"Stadler","year":"2023","journal-title":"Compr. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2337\/diaspect.28.3.167","article-title":"Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths","volume":"28","author":"Dieter","year":"2015","journal-title":"Diabetes Spectr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.kint.2017.05.015","article-title":"Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy","volume":"92","author":"Galvan","year":"2017","journal-title":"Kidney Int."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Mitrofanova, A., Fontanella, A.M., Burke, G.W., Merscher, S., and Fornoni, A. (2022). Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease. Cells, 11.","DOI":"10.3390\/cells11223635"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"F534","DOI":"10.1152\/ajprenal.00320.2023","article-title":"Mitochondria-Derived Reactive Oxygen Species Contribute to Synergistic Interaction of Diabetes and Hypertension in Causing Chronic Kidney Injury","volume":"326","author":"Wang","year":"2024","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/j.ackd.2010.10.003","article-title":"Hypertension in diabetic nephropathy: Epidemiology, mechanisms, and management","volume":"18","author":"Toto","year":"2011","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Fontecha-Barriuso, M., Lopez-Diaz, A.M., Guerrero-Mauvecin, J., Miguel, V., Ramos, A.M., Sanchez-Ni\u00f1o, M.D., Ruiz-Ortega, M., Ortiz, A., and Sanz, A.B. (2022). Tubular Mitochondrial Dysfunction, Oxidative Stress, and Progression of Chronic Kidney Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11071356"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Vodo\u0161ek Hojs, N., Bevc, S., Ekart, R., and Hojs, R. (2020). Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy. Antioxidants, 9.","DOI":"10.3390\/antiox9100925"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Kamal, F.Z., Lefter, R., Jaber, H., Balmus, I.-M., Ciobica, A., and Iordache, A.-C. (2023). The Role of Potential Oxidative Biomarkers in the Prognosis of Acute Ischemic Stroke and the Exploration of Antioxidants as Possible Preventive and Treatment Options. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076389"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ki.2015.240","article-title":"Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury","volume":"88","author":"Whitaker","year":"2015","journal-title":"Kidney Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"101195","DOI":"10.1016\/j.molmet.2021.101195","article-title":"Role of NAD+ in regulating cellular and metabolic signaling pathways","volume":"49","author":"Amjad","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Wang, P., Wu, Z., Song, Z., Deng, X., Zhang, Y., and Gong, X. (2026). Arsenic trioxide-induced acute kidney injury: OPA1- and Drp1-mediated mitochondrial dynamics imbalance, PINK1\/Parkin-dependent mitophagy, and Chuanhuang Fang III. Front. Mol. Biosci., 13.","DOI":"10.3389\/fmolb.2026.1778855"},{"key":"ref_95","first-page":"110502","article-title":"Urinary biomarkers of diabetic kidney disease","volume":"17","author":"Gembillo","year":"2026","journal-title":"World J. Diabetes"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00109-026-02646-0","article-title":"Bridging gaps in mitochondrial disease diagnosis: The role of advanced biomarker discovery","volume":"104","author":"Makwikwi","year":"2026","journal-title":"J. Mol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Ho, H.J., and Shirakawa, H. (2022). Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease. Cells, 12.","DOI":"10.3390\/cells12010088"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1016\/j.ekir.2024.07.020","article-title":"N-acetylcysteine in Kidney Disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness","volume":"9","author":"Hammami","year":"2024","journal-title":"Kidney Int. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e084088","DOI":"10.1136\/bmjopen-2024-084088","article-title":"Renoprotective effects of coenzyme Q10 supplementation in patients with chronic kidney disease: A protocol for a systematic review","volume":"14","author":"Abe","year":"2024","journal-title":"BMJ Open"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Liu, C.J., Wang, L.K., and Tsai, F.M. (2025). The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47030176"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Manful, C.F., Fordjour, E., Ikumoinein, E., Abbey, L., and Thomas, R. (2025). Therapeutic Strategies Targeting Oxidative Stress and Inflammation: A Narrative Review. BioChem, 5.","DOI":"10.3390\/biochem5040035"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cardfail.2020.02.001","article-title":"Effects of elamipretide on left ventricular function in patients with heart failure with reduced ejection fraction: The PROGRESS-HF phase 2 trial","volume":"26","author":"Butler","year":"2020","journal-title":"J. Card. Fail."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"C521","DOI":"10.1152\/ajpcell.00451.2021","article-title":"The CD38 glycohydrolase and the NAD sink: Implications for pathological conditions","volume":"322","author":"Zeidler","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1124\/jpet.119.261792","article-title":"Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure","volume":"371","author":"Tian","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Bellanti, F., Coda, A.R.D., Trecca, M.I., Lo Buglio, A., Serviddio, G., and Vendemiale, G. (2025). Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress. Antioxidants, 14.","DOI":"10.3390\/antiox14060656"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ekir.2024.10.035","article-title":"The Role of Mitochondria in Diabetic Kidney Disease and Potential Therapeutic Targets","volume":"10","author":"Takasu","year":"2024","journal-title":"Kidney Int. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13578-025-01519-2","article-title":"PGC-1\u03b1: Key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues","volume":"16","author":"Cao","year":"2025","journal-title":"Cell Biosci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Cilleros-Holgado, P., G\u00f3mez-Fern\u00e1ndez, D., Pi\u00f1ero-P\u00e9rez, R., Reche-L\u00f3pez, D., \u00c1lvarez-C\u00f3rdoba, M., Munuera-Cabeza, M., Talaver\u00f3n-Rey, M., Povea-Cabello, S., Su\u00e1rez-Carrillo, A., and Romero-Gonz\u00e1lez, A. (2023). mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021482"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1124\/pharmrev.122.000560","article-title":"Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease","volume":"75","author":"Cleveland","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e08878","DOI":"10.1016\/j.heliyon.2022.e08878","article-title":"Mitochondria-targeted drugs for diabetic kidney disease","volume":"8","author":"Mima","year":"2022","journal-title":"Heliyon"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s11658-024-00553-1","article-title":"Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury","volume":"29","author":"Song","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders\u2014A step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Wang, Z., and Zhang, C. (2022). From AKI to CKD: Maladaptive Repair and the Underlying Mechanisms. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810880"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Salvatore, T., Galiero, R., Caturano, A., Rinaldi, L., Di Martino, A., Albanese, G., Di Salvo, J., Epifani, R., Marfella, R., and Docimo, G. (2022). An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073651"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e70065","DOI":"10.1002\/jimd.70065","article-title":"Therapies for Mitochondrial Disease: Past, Present, and Future","volume":"48","author":"Ball","year":"2025","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/8\/1148\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T09:31:19Z","timestamp":1786095079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/8\/1148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":116,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["biom16081148"],"URL":"https:\/\/doi.org\/10.3390\/biom16081148","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]}}}