{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:39:50Z","timestamp":1786523990841,"version":"build-2736575974"},"reference-count":150,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901430"],"award-info":[{"award-number":["81901430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["81901430"],"award-info":[{"award-number":["81901430"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Shandong Province Research and Development Plan","award":["2017G006043"],"award-info":[{"award-number":["2017G006043"]}]},{"name":"Shandong Provincial Sports and Fitness Technology Innovation Center","award":["SJSCXZX2025010"],"award-info":[{"award-number":["SJSCXZX2025010"]}]},{"name":"National Science and Technology Major Project of China-Major Project on Four Major Chronic Diseases","award":["2024ZD0531803"],"award-info":[{"award-number":["2024ZD0531803"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Bone remodeling imbalance represents the fundamental pathological basis of osteoporosis. Exercise is broadly regarded as a valuable non-pharmacological strategy for preventing and managing osteoporosis; however, the precise molecular mechanisms through which exercise modulates bone metabolism remain incompletely understood. Mitophagy has recently been recognized as an important mediator linking exercise to the regulation of bone remodeling. This review centers on the \u201cexercise\u2013mitophagy\u2013bone remodeling\u201d axis, systematically outlining the biological processes and regulatory determinants of mitophagy within the bone microenvironment. Evidence suggests that mitophagy facilitates bone formation by preserving mitochondrial quality, attenuating oxidative stress, and optimizing cellular energy metabolism. Moreover, it exerts stage-specific inhibitory effects on bone resorption during osteoclast differentiation. Particular emphasis is placed on the mechanisms by which exercise activates mitophagy-related signaling pathways via metabolic, mechanical, and hypoxic stimuli. In addition, exercise may enhance the efficiency of this regulatory axis by maintaining vitamin D and calcium homeostasis and modulating estrogen signaling pathways. The differential effects of exercise modalities and durations on these processes are also critically evaluated. Finally, this review addresses current limitations in existing research and highlights future directions, including the optimization of exercise interventions targeting mitophagy and the integration of multi-omics approaches. These findings offer a theoretical basis for designing precise exercise regimens and combined therapeutic approaches in the management of osteoporosis.<\/jats:p>","DOI":"10.3390\/biom16081171","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:30:32Z","timestamp":1786465832000},"page":"1171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise-Induced Regulation of Bone Remodeling via Mitophagy: A Review of Current Evidence"],"prefix":"10.3390","volume":"16","author":[{"given":"Sicheng","family":"Yan","sequence":"first","affiliation":[{"name":"College of Sports and Health, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Sports and Health, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-6330","authenticated-orcid":false,"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Sports and Health, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Sports and Health, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-8054","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Sports and Health, Shandong Sport University, Jinan 250102, China"},{"name":"Department of Sport and Recreation, Technological and Higher Education Institute of Hong Kong, Chai Wan, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2461-0105","authenticated-orcid":false,"given":"Shihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Sports and Health, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2001). NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA, 285, 785\u2013795.","DOI":"10.1001\/jama.285.6.785"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"114834","DOI":"10.1016\/j.biopha.2023.114834","article-title":"Oxidative stress: A common pathological state in a high-risk population for osteoporosis","volume":"163","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Aibar-Almazan, A., Voltes-Martinez, A., Castellote-Caballero, Y., Afanador-Restrepo, D.F., Carcelen-Fraile, M.D.C., and Lopez-Ruiz, E. (2022). Current Status of the Diagnosis and Management of Osteoporosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169465"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155292","DOI":"10.1016\/j.cyto.2020.155292","article-title":"Irisin promotes osteogenic differentiation of bone marrow mesenchymal stem cells by activating autophagy via the Wnt\/\/beta-catenin signal pathway","volume":"136","author":"Chen","year":"2020","journal-title":"Cytokine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pbiomolbio.2015.11.005","article-title":"The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis","volume":"122","author":"Yuan","year":"2016","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e23554","DOI":"10.1096\/fj.202301508RRR","article-title":"Exercise and osteoimmunology in bone remodeling","volume":"38","author":"Zhao","year":"2024","journal-title":"FASEB J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chang, X.Y., Xu, S., and Zhang, H. (2022). Regulation of bone health through physical exercise: Mechanisms and types. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1029475"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zeng, Z., Zhou, X., Wang, Y., Cao, H., Guo, J., Wang, P., Yang, Y., and Wang, Y. (2022). Mitophagy-A New Target of Bone Disease. Biomolecules, 12.","DOI":"10.3390\/biom12101420"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yan, C., Shi, Y., Yuan, L., Lv, D., Sun, B., Wang, J., Liu, X., and An, F. (2023). Mitochondrial quality control and its role in osteoporosis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1077058"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Taylor, D.F., and Bishop, D.J. (2022). Transcription Factor Movement and Exercise-Induced Mitochondrial Biogenesis in Human Skeletal Muscle: Current Knowledge and Future Perspectives. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031517"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1113\/JP278853","article-title":"Exercise and mitochondrial health","volume":"599","author":"Memme","year":"2021","journal-title":"J. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: Cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: Renovation of Cells and Tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.yjmcc.2009.02.023","article-title":"Morphological dynamics of mitochondria-A special emphasis on cardiac muscle cells","volume":"46","author":"Hom","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bbabio.2014.03.010","article-title":"The H-ATP synthase: A gate to ROS-mediated cell death or cell survival","volume":"1837","author":"Cuezva","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) -Bioenerg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2005.8.3","article-title":"Perspective-Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging","volume":"8","author":"Lemasters","year":"2005","journal-title":"Rejuvenat. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1113\/JP276841","article-title":"Guardian of mitochondrial function: An expanded role of Parkin in skeletal muscle","volume":"596","author":"Botella","year":"2018","journal-title":"J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2403907","DOI":"10.1002\/smll.202403907","article-title":"Honeycomb Bionic Graphene Oxide Quantum Dot\/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy","volume":"20","author":"Li","year":"2024","journal-title":"Small"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"116751","DOI":"10.1016\/j.bcp.2025.116751","article-title":"Pym-18a, a novel pyrimidine derivative ameliorates glucocorticoid induced osteoblast apoptosis and promotes osteogenesis via autophagy and PINK 1\/Parkin mediated mitophagy induction","volume":"233","author":"Khanka","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106682","DOI":"10.1016\/j.isci.2023.106682","article-title":"Effect of mitophagy in the formation of osteomorphs derived from osteoclasts","volume":"26","author":"Huang","year":"2023","journal-title":"iScience"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"156774","DOI":"10.1016\/j.phymed.2025.156774","article-title":"Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism","volume":"143","author":"Zhou","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114867","DOI":"10.1016\/j.intimp.2025.114867","article-title":"CREG1 alleviates bone loss in osteoporosis by enhancing the osteogenic differentiation of BMSCs through mitophagy","volume":"158","author":"Sha","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"111873","DOI":"10.1016\/j.cellsig.2025.111873","article-title":"METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs","volume":"133","author":"Shen","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2409936","DOI":"10.1002\/smll.202409936","article-title":"Regulating Mitochondrial Aging via Targeting the Gut-Bone Axis in BMSCs with Oral Hydrogel Microspheres to Inhibit Bone Loss","volume":"21","author":"Qu","year":"2025","journal-title":"Small"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157456","DOI":"10.1016\/j.phymed.2025.157456","article-title":"Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy","volume":"148","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102493","DOI":"10.1016\/j.ceb.2025.102493","article-title":"Advances in mitophagy initiation mechanisms","volume":"94","author":"Kung","year":"2025","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e104705","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/jb\/mvaf079","article-title":"Ubiquitin signaling in PINK1\/Parkin-dependent mitophagy","volume":"179","author":"Okatsu","year":"2025","journal-title":"J. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/15548627.2021.1888244","article-title":"Regulation of PRKN-independent mitophagy","volume":"18","author":"Teresak","year":"2022","journal-title":"Autophagy"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Carlberg, C. (2022). Vitamin D and Its Target Genes. Nutrients, 14.","DOI":"10.3390\/nu14071354"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11926-008-0020-y","article-title":"Calcium and vitamin D: Skeletal and extraskeletal health","volume":"10","author":"Khazai","year":"2008","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1210\/endrev\/bnae009","article-title":"Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows","volume":"45","author":"Giustina","year":"2024","journal-title":"Endocr. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"103062","DOI":"10.1016\/j.redox.2024.103062","article-title":"VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats","volume":"70","author":"Chen","year":"2024","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/10715762.2022.2094791","article-title":"VDR promotes nucleus pulposus cell mitophagy as a protective mechanism against oxidative stress injury","volume":"56","author":"Lan","year":"2022","journal-title":"Free Radic. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lee, T.L., Lee, M.H., Chen, Y.C., Lee, Y.C., Lai, T.C., Lin, H.Y.H., Hsu, L.F., Sung, H.C., Lee, C.W., and Chen, Y.L. (2020). Vitamin D Attenuates Ischemia\/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.604700"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10147","DOI":"10.1007\/s11033-023-08875-7","article-title":"Effect of vitamin D on cardiac hypertrophy in D-galactose-induced aging model through cardiac mitophagy","volume":"50","author":"Shahidi","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"108694","DOI":"10.1016\/j.abb.2020.108694","article-title":"Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK\/mTOR-mediated autophagy","volume":"697","author":"Yuan","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110839","DOI":"10.1016\/j.vetimm.2024.110839","article-title":"Vitamin D3 mediates autophagy to alleviate inflammatory responses in bovine endometrial epithelial cells and organoids via the PI3K\/AKT\/mTOR pathway","volume":"277","author":"Zhang","year":"2024","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1080\/15548627.2024.2367184","article-title":"Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca and SLC25A5\/ANT2-PINK1-PRKN-mediated mitophagy","volume":"20","author":"Jiang","year":"2024","journal-title":"Autophagy"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wang, S., Yao, Q., Zhao, F., Cui, W., Price, C.A., Wang, Y., Lv, J., Tang, H., and Jiang, Z. (2023). 1\u03b1,25(OH)2D3 Promotes the Autophagy of Porcine Ovarian Granulosa Cells as a Protective Mechanism against ROS through the BNIP3\/PINK1 Pathway. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054364"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1039\/D2FO01028C","article-title":"Vitamin D(3) attenuates cisplatin-induced intestinal injury by inhibiting ferroptosis, oxidative stress, and ROS-mediated excessive mitochondrial fission","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/15548627.2017.1384887","article-title":"Ion channels in the regulation of autophagy","volume":"14","author":"Kondratskyi","year":"2018","journal-title":"Autophagy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00109-021-02125-8","article-title":"AMPK: A key regulator of energy stress and calcium-induced autophagy","volume":"99","author":"Saikia","year":"2021","journal-title":"J. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2501164","DOI":"10.1002\/adhm.202501164","article-title":"Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis","volume":"14","author":"Yu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s44324-025-00049-2","article-title":"Calcium-mediated regulation of mitophagy: Implications in neurodegenerative diseases","volume":"3","author":"Borbolis","year":"2025","journal-title":"npj Metab. Health Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/bs.ircmb.2019.11.002","article-title":"The role of mitochondria-associated membranes in cellular homeostasis and diseases","volume":"350","author":"Perrone","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1161\/CIRCULATIONAHA.118.033552","article-title":"Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase alpha2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo","volume":"139","author":"Wu","year":"2019","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"117220","DOI":"10.1016\/j.bone.2024.117220","article-title":"Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair","volume":"188","author":"Shi","year":"2024","journal-title":"Bone"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"102649","DOI":"10.1016\/j.redox.2023.102649","article-title":"Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRalpha-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats","volume":"61","author":"Li","year":"2023","journal-title":"Redox Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13018-024-05400-9","article-title":"17beta-estradiol promotes osteogenic differentiation of BMSCs by regulating mitophagy through ARC","volume":"20","author":"Shi","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"903","DOI":"10.12659\/MSM.908705","article-title":"Effects of 17\u03b2-Estradiol on Mitophagy in the Murine MC3T3-E1 Osteoblast Cell Line is Mediated via G Protein-Coupled Estrogen Receptor and the ERK1\/2 Signaling Pathway","volume":"24","author":"Sun","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"105380","DOI":"10.1016\/j.jsbmb.2019.105380","article-title":"Role of estrogen and its receptors mediated-autophagy in cell fate and human diseases","volume":"191","author":"Wei","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109036","DOI":"10.1016\/j.reprotox.2025.109036","article-title":"Estrogen receptor 1 (ESR1) promotes Di-butyl phthalate (DBP)-induced hypospadias by regulating mitophagy through PINK1-Parkin axis to inhibit ferroptosis","volume":"137","author":"Liu","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"105636","DOI":"10.1016\/j.neuint.2023.105636","article-title":"Estrogen receptor beta exerts neuroprotective effects by fine-tuning mitochondrial homeostasis through NRF1\/PGC-1alpha","volume":"171","author":"Zhao","year":"2023","journal-title":"Neurochem. Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11064-025-04535-3","article-title":"Salidroside Attenuates Cerebral Ischemia-Reperfusion Injury via ERbeta\/BNIP3-Mediated Mitochondrial Autophagy Activation in a Rat Model","volume":"50","author":"Rong","year":"2025","journal-title":"Neurochem. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Mei, R., Lou, P., You, G., Jiang, T., Yu, X., and Guo, L. (2020). 17beta-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK\/mTOR Signaling Pathway. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.615250"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/en.2004-1064","article-title":"Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells","volume":"146","author":"Thomas","year":"2005","journal-title":"Endocrinology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105661","DOI":"10.1016\/j.jbc.2024.105661","article-title":"G protein-coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting AMPK-dependent signaling","volume":"300","author":"Li","year":"2024","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"120926","DOI":"10.1016\/j.lfs.2022.120926","article-title":"Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets","volume":"308","author":"Yao","year":"2022","journal-title":"Life Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.12659\/MSM.909365","article-title":"17beta-Estradiol on the Expression of G-Protein Coupled Estrogen Receptor (GPER\/GPR30) Mitophagy, and the PI3K\/Akt Signaling Pathway in ATDC5 Chondrocytes In Vitro","volume":"24","author":"Fan","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1111\/bph.14033","article-title":"Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia\/reperfusion injury by reducing mitochondrial dysfunction and mitophagy","volume":"174","author":"Feng","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_64","first-page":"2839","article-title":"17beta-estradiol protects INS-1 insulinoma cells from mitophagy via G protein-coupled estrogen receptors and the PI3K\/Akt signaling pathway","volume":"41","author":"Zhang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.130200197","article-title":"Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression","volume":"97","author":"Shevde","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1124\/molpharm.124.000889","article-title":"The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB","volume":"106","author":"Losby","year":"2024","journal-title":"Mol. Pharmacol."},{"key":"ref_67","first-page":"4421","article-title":"Mechanism of Buzhong Yiqi Decoction in Preventing and Treating Osteoporosis by Regulating ULK1\/FUNDC1-Mediated Mitophagy","volume":"36","author":"Fu","year":"2025","journal-title":"Lishizhen J. Tradit. Chin. Med. Mater. Medica"},{"key":"ref_68","first-page":"169","article-title":"Guilu Erxian Jia activates PINK1\/Parkin-mediated mitophagy to induce osteoblast differentiation","volume":"31","author":"Yu","year":"2025","journal-title":"Chin. J. Osteoporos."},{"key":"ref_69","unstructured":"(2024). MoTrPAC Study Group; Lead Analysts & MoTrPAC Study Group. Temporal dynamics of the multi-omic response to endurance exercise training. Nature, 629, 174\u2013183."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3319056","DOI":"10.1155\/2022\/3319056","article-title":"Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"111042","DOI":"10.1016\/j.isci.2024.111042","article-title":"Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation","volume":"27","author":"Li","year":"2024","journal-title":"iScience"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Pei, T., Su, G., Yang, J., Gao, W., Yang, X., Zhang, Y., Ren, J., Shen, Y., and Liu, X. (2022). Fluid Shear Stress Regulates Osteogenic Differentiation via AnnexinA6-Mediated Autophagy in MC3T3-E1 Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415702"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/ten.teb.2016.0454","article-title":"Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro","volume":"23","author":"Blair","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Ponzetti, M., and Rucci, N. (2021). Osteoblast Differentiation and Signaling: Established Concepts and Emerging Topics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136651"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e31484","DOI":"10.1002\/jcp.31484","article-title":"Osteoclast Secretes Stage-Specific Key Molecules for Modulating Osteoclast-Osteoblast Communication","volume":"240","author":"Fu","year":"2025","journal-title":"J. Cell Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4248\/BR201301003","article-title":"Osteoclasts: New Insights","volume":"1","author":"Feng","year":"2013","journal-title":"Bone Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Geissler, S., Textor, M., Kuhnisch, J., Konnig, D., Klein, O., Ode, A., Pfitzner, T., Adjaye, J., Kasper, G., and Duda, G.N. (2012). Functional comparison of chronological and in vitro aging: Differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052700"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3727\/096368912X639035","article-title":"Production of reactive oxygen species by multipotent stromal cells\/mesenchymal stem cells upon exposure to fas ligand","volume":"21","author":"Rodrigues","year":"2012","journal-title":"Cell Transplant."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/s13287-021-02656-4","article-title":"PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis","volume":"12","author":"Lee","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"30370","DOI":"10.1038\/s41598-025-16046-w","article-title":"HIF1A overexpression promotes osteoblast differentiation through activation of autophagy to alleviate osteoporosis","volume":"15","author":"Qiao","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101254","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41419-023-05587-5","article-title":"HIF1alpha-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jcpe.70031","article-title":"Parkin Acetylation-Mediated Mitophagy Orchestrates Periodontal Ligament Stem Cell Osteogenesis and Bone Regeneration During Ageing","volume":"53","author":"Zhang","year":"2026","journal-title":"J. Clin. Periodontol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e23865","DOI":"10.1096\/fj.202401280R","article-title":"Age-related mitophagy regulates orthodontic tooth movement by affecting PDLSCs mitochondrial function and RANKL\/OPG","volume":"38","author":"Yan","year":"2024","journal-title":"FASEB J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e2404107","DOI":"10.1002\/advs.202404107","article-title":"WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation","volume":"12","author":"Fan","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e13191","DOI":"10.1111\/cpr.13191","article-title":"Dysfunction of metabolic activity of bone marrow mesenchymal stem cells in aged mice","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1089\/scd.2014.0484","article-title":"The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: A review","volume":"24","author":"Atashi","year":"2015","journal-title":"Stem Cells Dev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2174\/1574888X10666150519093429","article-title":"PPARgamma and Wnt Signaling in Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells","volume":"11","author":"Yuan","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"27298","DOI":"10.1074\/jbc.M702811200","article-title":"Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription","volume":"282","author":"Almeida","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jcb.22846","article-title":"Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress","volume":"111","author":"Kim","year":"2010","journal-title":"J. Cell Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, Y.S., Yu, J.N., Han, M.Z., Si, B., Li, Z.H., and Han, J.C. (2025). Advances in research on the relationship between mitochondrial dysfunction and osteoporosis: A bibliometric study from 2014 to 2024. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1597116"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1083\/jcb.201402104","article-title":"PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity","volume":"205","author":"Kane","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"101963","DOI":"10.1016\/j.redox.2021.101963","article-title":"LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss","volume":"43","author":"Liu","year":"2021","journal-title":"Redox Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e78069","DOI":"10.7554\/eLife.78069","article-title":"Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway","volume":"11","author":"Kim","year":"2022","journal-title":"eLife"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: A pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.biopha.2019.01.034","article-title":"High-glucose induces retinal pigment epithelium mitochondrial pathways of apoptosis and inhibits mitophagy by regulating ROS\/PINK1\/Parkin signal pathway","volume":"111","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jcp.22768","article-title":"Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1alpha\/BNIP3 signaling pathway","volume":"227","author":"Zhao","year":"2012","journal-title":"J. Cell Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.00166-09","article-title":"Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1749-6632.2009.05377.x","article-title":"Role of mitochondrial reactive oxygen species in osteoclast differentiation","volume":"1192","author":"Srinivasan","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/HP.S95960","article-title":"Hypoxic regulation of osteoclast differentiation and bone resorption activity","volume":"3","author":"Knowles","year":"2015","journal-title":"Hypoxia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"103023","DOI":"10.1016\/j.redox.2023.103023","article-title":"PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment","volume":"69","author":"Jang","year":"2024","journal-title":"Redox Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/embor.2008.246","article-title":"DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy","volume":"10","author":"Zalckvar","year":"2009","journal-title":"EMBO Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e146728","DOI":"10.1172\/jci.insight.146728","article-title":"Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency","volume":"6","author":"Ling","year":"2021","journal-title":"JCI Insight"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"115827","DOI":"10.1016\/j.bone.2020.115827","article-title":"Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice","volume":"144","author":"Li","year":"2021","journal-title":"Bone"},{"key":"ref_106","first-page":"18","article-title":"A Molecular Approach to Mitophagy and Mitochondrial Dynamics","volume":"41","author":"Yoo","year":"2018","journal-title":"Mol. Cells"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev-physiol-060721-095517","article-title":"AMPK and the Adaptation to Exercise","volume":"84","author":"Spaulding","year":"2022","journal-title":"Annu. Rev. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Spiegelman, B. (2017). The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals. Hormones, Metabolism and the Benefits of Exercise, Springer.","DOI":"10.1007\/978-3-319-72790-5"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41467-017-00520-9","article-title":"Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy","volume":"8","author":"Laker","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1139\/apnm-2020-0005","article-title":"PGC-1alpha-mediated regulation of mitochondrial function and physiological implications","volume":"45","author":"Halling","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"Tabara","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.addr.2009.06.006","article-title":"Mitochondrial biogenesis in exercise and in ageing","volume":"61","author":"Vina","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"111238","DOI":"10.1016\/j.cbi.2024.111238","article-title":"Telomerase reverse transcriptase protects against diabetic kidney disease by promoting AMPK\/PGC-1a-regulated mitochondrial energy homeostasis","volume":"403","author":"Ma","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","article-title":"Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"308","DOI":"10.7150\/ijbs.124043","article-title":"Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK\/SIRT1-mediated PGC-1alpha deacetylation to ameliorate bone loss in disuse osteoporosis","volume":"22","author":"Chen","year":"2026","journal-title":"Int. J. Biol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2018.08.001","article-title":"Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling pathway","volume":"126","author":"Chen","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zheng, Y.L., Wang, R., Wang, X.Q., and Zhang, H. (2022). Exercise for osteoporosis: A literature review of pathology and mechanism. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1005665"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00421-022-04909-3","article-title":"Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle","volume":"122","author":"Nava","year":"2022","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e12462","DOI":"10.14814\/phy2.12462","article-title":"Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle","volume":"3","author":"Combes","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Mallet, R.T., Burtscher, J., Pialoux, V., Pasha, Q., Ahmad, Y., Millet, G.P., and Burtscher, M. (2023). Molecular Mechanisms of High-Altitude Acclimatization. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021698"},{"key":"ref_121","first-page":"318","article-title":"Effects of long-term aerobic exercise on vitamin D receptor expression in bone tissue of aged rats","volume":"38","author":"Bing","year":"2018","journal-title":"J. Jiangxi Agric. Univ."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jare.2016.07.001","article-title":"Effect of exercise on serum vitamin D and tissue vitamin D receptors in experimentally induced type 2 Diabetes Mellitus","volume":"7","author":"Aly","year":"2016","journal-title":"J. Adv. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"112260","DOI":"10.1016\/j.cellsig.2025.112260","article-title":"Exercise attenuates hepatic lipid accumulation via VDR\/AMPK-mediated autophagy activation in vitamin D-deficient mice","volume":"138","author":"Liu","year":"2026","journal-title":"Cell. Signal."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"105500","DOI":"10.1016\/j.jsbmb.2019.105500","article-title":"Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression","volume":"196","author":"Meyer","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11154-015-9318-z","article-title":"The PTH-Vitamin D-FGF23 axis","volume":"16","author":"Blau","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_126","first-page":"367","article-title":"Parathyroid hormone and physical exercise: A brief review","volume":"5","author":"Bouassida","year":"2006","journal-title":"J. Sports Sci. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"557","DOI":"10.7754\/Clin.Lab.2012.120505","article-title":"The effects of acute and regular exercise on calcium, phosphorus and trace elements in young amateur boxers","volume":"59","author":"Karakukcu","year":"2013","journal-title":"Clin. Lab."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e1321","DOI":"10.52225\/narra.v4i3.1321","article-title":"Effect of walking and bone joint exercise on enhancing bone remodeling in menopausal women: A randomized controlled trial","volume":"4","author":"Pasa","year":"2024","journal-title":"Narra J."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Zhang, W., Li, X., He, Q., and Wang, X. (2025). Effects of exercise on bone metabolism in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1597046"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"332","DOI":"10.7150\/ijms.90195","article-title":"Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in Chronic Kidney Disease: A systematic review with meta-analysis","volume":"21","author":"Castillo","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Prud\u2019homme, G.J., Kurt, M., and Wang, Q. (2022). Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations. Front. Aging, 3.","DOI":"10.3389\/fragi.2022.931331"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00421-010-1426-6","article-title":"Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment","volume":"109","author":"Hao","year":"2010","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lin, Y.Y., Chen, J.S., Wu, X.B., Shyu, W.C., Chaunchaiyakul, R., Zhao, X.L., Kuo, C.H., Cheng, Y.J., Yang, A.L., and Lee, S.D. (2018). Combined effects of 17beta-estradiol and exercise training on cardiac apoptosis in ovariectomized rats. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0208633"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"103510","DOI":"10.1016\/j.resp.2020.103510","article-title":"The effect of moderate-intensity aerobic training on pulmonary function and estrogen receptor-alpha gene in postmenopausal women with vitamin D deficiency: A randomized control trial","volume":"281","author":"Malandish","year":"2020","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_135","first-page":"100026","article-title":"The effect of moderate intensity aerobic exercise on cardiovascular function, cardiorespiratory fitness and estrogen receptor alpha gene in overweight\/obese postmenopausal women: A randomized controlled trial","volume":"2","author":"Malandish","year":"2022","journal-title":"J. Mol. Cell. Cardiol. Plus"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"14300","DOI":"10.1038\/s41598-023-41415-8","article-title":"Effect of exercise on the hypothalamic-pituitary-gonadal axis in a rat model of Alzheimer\u2019s disease","volume":"13","author":"Khairy","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.anireprosci.2017.06.018","article-title":"Irisin stimulates gonadotropins gene expression in tilapia (Oreochromis niloticus) pituitary cells","volume":"185","author":"Jiang","year":"2017","journal-title":"Anim. Reprod. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s12020-022-02981-5","article-title":"Irisin: Circulating levels in serum and its relation to gonadal axis","volume":"75","author":"Luo","year":"2022","journal-title":"Endocrine"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"103735","DOI":"10.1016\/j.redox.2025.103735","article-title":"Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic E2 synthesis-independent mechanism","volume":"85","author":"Tian","year":"2025","journal-title":"Redox Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e14203","DOI":"10.1111\/apha.14203","article-title":"A single bout of resistance exercise triggers mitophagy, potentially involving the ejection of mitochondria in human skeletal muscle","volume":"240","author":"Rivera","year":"2024","journal-title":"Acta Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1987149","DOI":"10.1155\/2016\/1987149","article-title":"Acute Exercise-Induced Mitochondrial Stress Triggers an Inflammatory Response in the Myocardium via NLRP3 Inflammasome Activation with Mitophagy","volume":"2016","author":"Li","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.5213\/inj.1938038.019","article-title":"Effects of Acute Exercise on Mitochondrial Function, Dynamics, and Mitophagy in Rat Cardiac and Skeletal Muscles","volume":"23","author":"Yoo","year":"2019","journal-title":"Int. Neurourol. J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15384101.2018.1559556","article-title":"Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria","volume":"18","author":"Drake","year":"2019","journal-title":"Cell Cycle"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"101674","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Braganza","year":"2020","journal-title":"Redox Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10522-012-9408-1","article-title":"PGC-1alpha transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males","volume":"13","author":"Cobley","year":"2012","journal-title":"Biogerontology"},{"key":"ref_146","first-page":"670","article-title":"Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly","volume":"46","author":"Iversen","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"R734","DOI":"10.1152\/ajpregu.00005.2014","article-title":"Effects of age and unaccustomed resistance exercise on mitochondrial transcript and protein abundance in skeletal muscle of men","volume":"308","author":"Ogborn","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12035-022-03035-7","article-title":"Treadmill Exercise Improves PINK1\/Parkin-Mediated Mitophagy Activity Against Alzheimer\u2019s Disease Pathologies by Upregulated SIRT1-FOXO1\/3 Axis in APP\/PS1 Mice","volume":"60","author":"Zhao","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4149\/gpb_2018020","article-title":"Exercise training and dietary restriction affect PINK1\/Parkin and Bnip3\/Nix-mediated cardiac mitophagy in mice","volume":"37","author":"Zhao","year":"2018","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e14397","DOI":"10.1111\/jfbc.14397","article-title":"Twelve weeks of treadmill exercise training with green tea extract reduces myocardial oxidative stress and alleviates cardiomyocyte apoptosis in aging rat: The emerging role of BNIP3 and HIF-1alpha\/IGFBP3 pathway","volume":"46","author":"Arabzadeh","year":"2022","journal-title":"J. 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