{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:26:44Z","timestamp":1786685204051,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Mediterranean Lamiaceae species are important sources of bioactive compounds with potential applications in food, pharmaceutical, and cosmetic industries. In the present study, controlled salinity was evaluated as a biotechnological elicitation strategy to enhance the accumulation of bioactive metabolites in two species, Lavandula viridis and Thymus lotocephalus, cultured in vitro. Morphological, biochemical and metabolic responses of shoots grown for seven weeks in culture medium containing four NaCl concentrations (0, 25, 50, or 75 mM) were assessed. Mild salinity (25 mM NaCl) stimulated shoot growth in both species, whereas higher salt concentrations progressively reduced growth. Salinity induced oxidative stress, as indicated by elevated malondialdehyde (MDA) levels at 25 mM NaCl in both species, while hydrogen peroxide (H2O2) exhibited contrasting patterns, decreasing with increasing salinity in L. viridis but peaking at 50 mM NaCl in T. lotocephalus. Salt stress caused reductions in photosynthetic pigments, phenolic compounds, antioxidant capacity (DPPH, FRAP, ABTS, and ORAC), and overall metabolic performance in L. viridis, indicating limited tolerance to salinity. Conversely, T. lotocephalus displayed greater metabolic plasticity, characterized by increased levels of phenolic compounds, particularly rosmarinic acid and its derivatives, and higher antioxidant activity of the extracts, as well as the accumulation of proline and soluble sugars. These findings demonstrate marked species-specific differences in salinity responses and identify controlled salinity as an effective elicitation strategy to sustainably produce high-value bioactive compounds in T. lotocephalus.<\/jats:p>","DOI":"10.3390\/biom16081178","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:02:11Z","timestamp":1786532531000},"page":"1178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salinity-Induced Modulation of Phenolic Compounds and Antioxidant Activity in Lavandula viridis and Thymus lotocephalus"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9632-8876","authenticated-orcid":false,"given":"In\u00eas","family":"Mansinhos","sequence":"first","affiliation":[{"name":"MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-4434","authenticated-orcid":false,"given":"Sandra","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-7387","authenticated-orcid":false,"given":"Raquel","family":"Rodr\u00edguez-Solana","sequence":"additional","affiliation":[{"name":"MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"},{"name":"Department of Agroindustry and Food Quality, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA), Rancho de la Merced Center, Carretera Ca\u00f1ada de la Loba (CA-3102) Km 3.1., SN, 11471 Jerez de la Frontera, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3162-0432","authenticated-orcid":false,"given":"Gema","family":"Pereira-Caro","sequence":"additional","affiliation":[{"name":"Department of Agroindustry and Food Quality, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA), Alameda del Obispo Center, Avenida Menendez-Pidal, SN, 14004 C\u00f3rdoba, C\u00f3rdoba, Spain"},{"name":"Foods for Health Group, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Avenida Menendez-Pidal, SN, 14004 C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-7428","authenticated-orcid":false,"given":"Anabela","family":"Romano","sequence":"additional","affiliation":[{"name":"MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Szekely-Varga, Z., Gonz\u00e1lez-Orenga, S., Cantor, M., Jucan, D., Boscaiu, M., and Vicente, O. (2020). Effects of Drought and Salinity on Two Commercial Varieties of Lavandula angustifolia Mill. Plants, 9.","DOI":"10.3390\/plants9050637"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100319","DOI":"10.1016\/j.stress.2023.100319","article-title":"Soil Salinity and Drought Tolerance: An Evaluation of Plant Growth, Productivity, Microbial Diversity, and Amelioration Strategies","volume":"11","author":"Muhammad","year":"2024","journal-title":"Plant Stress"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jing, Z., Liu, N., Zhang, Z., and Hou, X. (2024). Research Progress on Plant Responses to Stress Combinations in the Context of Climate Change. Plants, 13.","DOI":"10.3390\/plants13040469"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kougioumoutzis, K., Papanikolaou, A., Kokkoris, I.P., Strid, A., Dimopoulos, P., and Panitsa, M. (2022). Climate Change Impacts and Extinction Risk Assessment of Nepeta Representatives (Lamiaceae) in Greece. Sustainability, 14.","DOI":"10.3390\/su14074269"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"106010","DOI":"10.1016\/j.envexpbot.2024.106010","article-title":"Insights into the Multifaceted Roles of Soil Microbes in Mitigating Abiotic Stress in Crop Plants: A Review","volume":"228","author":"Singh","year":"2024","journal-title":"Environ. Exp. Bot."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mansinhos, I., Gon\u00e7alves, S., and Romano, A. (2024). How Climate Change-Related Abiotic Factors Affect the Production of Industrial Valuable Compounds in Lamiaceae Plant Species: A Review. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1370810"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.2134\/agronj2016.06.0368","article-title":"Soil Salinity: A Threat to Global Food Security","volume":"108","author":"Butcher","year":"2016","journal-title":"Agron. J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ondrasek, G., Rathod, S., Manohara, K.K., Gireesh, C., Anantha, M.S., Sakhare, A.S., Parmar, B., Yadav, B.K., Bandumula, N., and Raihan, F. (2022). Salt Stress in Plants and Mitigation Approaches. Plants, 11.","DOI":"10.3390\/plants11060717"},{"key":"ref_9","first-page":"100255","article-title":"Understanding the Consequence of Environmental Stress for Accumulation of Secondary Metabolites in Medicinal and Aromatic Plants","volume":"18","author":"Mahajan","year":"2020","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Acosta-Motos, J.R., Ortu\u00f1o, M.F., Bernal-Vicente, A., Diaz-Vivancos, P., Sanchez-Blanco, M.J., and Hernandez, J.A. (2017). Plant Responses to Salt Stress: Adaptive Mechanisms. Agronomy, 7.","DOI":"10.20944\/preprints201702.0083.v2"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tokarz, B., W\u00f3jtowicz, T., Makowski, W., J\u0119drzejczyk, R.J., and Tokarz, K.M. (2020). What Is the Difference between the Response of Grass Pea (Lathyrus sativus L.) to Salinity and Drought Stress?\u2014A Physiological Study. Agronomy, 10.","DOI":"10.3390\/agronomy10060833"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mansinhos, I., Gon\u00e7alves, S., Rodr\u00edguez-Solana, R., Pereira-Caro, G., Moreno-Rojas, J.M., and Romano, A. (2024). Nutrient Deficiency-Induced Stress Improves Skincare Effects and Phytochemical Content of Green Extracts from Lamiaceae In Vitro Cultures. Horticulturae, 10.","DOI":"10.3390\/horticulturae10090947"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11240-025-03180-6","article-title":"Harnessing Metabolites from Plant Cell Tissue and Organ Culture for Sustainable Biotechnology","volume":"162","author":"Pathirana","year":"2025","journal-title":"Plant Cell Tissue Organ Cult."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131767","DOI":"10.1016\/j.foodchem.2021.131767","article-title":"Sustainable Diets & Medicinal Aromatic Plants in Greece: Perspectives towards Climate Change","volume":"374","author":"Tomou","year":"2022","journal-title":"Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mansinhos, I., Gon\u00e7alves, S., Rodr\u00edguez-Solana, R., Ord\u00f3\u00f1ez-D\u00edaz, J.L., Moreno-Rojas, J.M., and Romano, A. (2022). Impact of Temperature on Phenolic and Osmolyte Contents in in Vitro Cultures and Micropropagated Plants of Two Mediterranean Plant Species, Lavandula viridis and Thymus lotocephalus. Plants, 11.","DOI":"10.3390\/plants11243516"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1023\/A:1012963021126","article-title":"Rapid Clonal Multiplication of Lavandula viridis L\u2019H\u00e9r through in Vitro Axillary Shoot Proliferation","volume":"68","author":"Dias","year":"2002","journal-title":"Plant Cell Tissue Organ Cult."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10725-011-9630-x","article-title":"Establishment of an in Vitro Propagation Protocol for Thymus lotocephalus, a Rare Aromatic Species of the Algarve (Portugal)","volume":"66","author":"Coelho","year":"2012","journal-title":"Plant Growth Regul."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1399-3054.1962.tb08052.x","article-title":"A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue Cultures","volume":"15","author":"Murashige","year":"1962","journal-title":"Physiol. Plant."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Paraskevopoulou, A.T., Karantzi, A.K., Liakopoulos, G., Londra, P.A., and Bertsouklis, K. (2020). The Effect of Salinity on the Growth of Lavender Species. Water, 12.","DOI":"10.3390\/w12030618"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.indcrop.2019.04.055","article-title":"Effect of Salinity Stress on the Physiological Characteristics, Phenolic Compounds and Antioxidant Activity of Thymus vulgaris L. and Thymus daenensis Celak","volume":"135","author":"Bistgani","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Chrysargyris, A., Michailidi, E., and Tzortzakis, N. (2018). Physiological and Biochemical Responses of Lavandula angustifolia to Salinity Under Mineral Foliar Application. Front. Plant Sci., 9.","DOI":"10.3389\/fpls.2018.00489"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.2478\/s11756-020-00562-3","article-title":"Salinity Stress Alters Ion Homeostasis, Antioxidant Activities and the Production of Rosmarinic Acid, Luteolin and Apigenin in Dracocephalum kotschyi Boiss","volume":"75","author":"Vafadar","year":"2020","journal-title":"Biologia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0076-6879(87)48036-1","article-title":"Chlorophylls and Carotenoids: Pigments of Photosynthetic Biomembranes","volume":"Volume 148","author":"Lichtenthaler","year":"1987","journal-title":"Methods in Enzymology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1002\/jsfa.70652","article-title":"Chitosan-Induced Modulation of Secondary Metabolism and Stress Tolerance in Salvia rosmarinus under Combined Drought and Heat Stress","volume":"106","author":"Mansinhos","year":"2026","journal-title":"J. Sci. Food Agric."},{"key":"ref_25","first-page":"797","article-title":"Variation in Antioxidant Metabolism of Faba Bean (Vicia faba) under Drought Stress Induced by Polyethylene Glycol Reveals Biochemical Markers Associated with Antioxidant Defense","volume":"155","author":"Abid","year":"2021","journal-title":"Plant Biosyst. Int. J. Deal. All Asp. Plant Biol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mansinhos, I., Gon\u00e7alves, S., Rodr\u00edguez-Solana, R., Ord\u00f3\u00f1ez-D\u00edaz, J.L., Moreno-Rojas, J.M., and Romano, A. (2021). Ultrasonic-Assisted Extraction and Natural Deep Eutectic Solvents Combination: A Green Strategy to Improve the Recovery of Phenolic Compounds from Lavandula pedunculata Subsp. Lusitanica (Chaytor) Franco. Antioxidants, 10.","DOI":"10.3390\/antiox10040582"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed Minimum Reporting Standards for Chemical Analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Miri, A., Rezayian, M., and Niknam, V. (2025). Exogenous Curcumin Alleviates Salt Stress in Lavender Plants: A Physiological and Biochemical Investigation. BMC Plant Biol., 25.","DOI":"10.1186\/s12870-025-07705-1"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Grzeszczuk, M., Salachna, P., and Meller, E. (2018). Changes in Photosynthetic Pigments, Total Phenolic Content, and Antioxidant Activity of Salvia coccinea Buc\u2019hoz Ex Etl. Induced by Exogenous Salicylic Acid and Soil Salinity. Molecules, 23.","DOI":"10.3390\/molecules23061296"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jpln.201600062","article-title":"Lavandula multifida Response to Salinity: Growth, Nutrient Uptake, and Physiological Changes","volume":"180","author":"Llanderal","year":"2017","journal-title":"J. Plant Nutr. Soil Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mansinhos, I., Gon\u00e7alves, S., Rodr\u00edguez-Solana, R., Duarte, H., Ord\u00f3\u00f1ez-D\u00edaz, J.L., Moreno-Rojas, J.M., and Romano, A. (2022). Response of Thymus lotocephalus In Vitro Cultures to Drought Stress and Role of Green Extracts in Cosmetics. Antioxidants, 11.","DOI":"10.3390\/antiox11081475"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"114445","DOI":"10.1016\/j.scienta.2025.114445","article-title":"Impact of Salinity and Harvest Date on the Yield, Phenolic and Volatile Contents of Thyme (Thymus vulgaris L.), Coriander (Coriandrum sativum L.) and Dill (Anethum graveolens L.)","volume":"352","author":"Zamljen","year":"2025","journal-title":"Sci. Hortic."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"112165","DOI":"10.1016\/j.indcrop.2020.112165","article-title":"Seed Priming with Melatonin Effects on Growth, Essential Oil Compounds and Antioxidant Activity of Basil (Ocimum basilicum L.) under Salinity Stress","volume":"146","author":"Bahcesular","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100557","DOI":"10.1016\/j.stress.2024.100557","article-title":"Unravelling the Impact of Drought and Salt Stresses on Thymus pannonicus: Morpho-Physiological and Biochemical Insights","volume":"13","author":"Etri","year":"2024","journal-title":"Plant Stress"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"109376","DOI":"10.1016\/j.plaphy.2024.109376","article-title":"Investigation into the Mechanisms of Photosynthetic Regulation and Adaptation under Salt Stress in Lavender","volume":"219","author":"Li","year":"2025","journal-title":"Plant Physiol. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10661-024-12377-9","article-title":"Investigation of The Alleviating Effect of Liquid Seaweed Fertilizer on Lavandula officinalis under Salt Stress","volume":"196","author":"Korkmaz","year":"2024","journal-title":"Environ. Monit. Assess."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1007\/s42729-025-02431-x","article-title":"Harnessing Sheep Wool Fertilizer to Enhance Lavandula officinalis Mill. Resilience to Salt Stress","volume":"25","year":"2025","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"El-Esawi, M.A., Elansary, H.O., El-Shanhorey, N.A., Abdel-Hamid, A.M.E., Ali, H.M., and Elshikh, M.S. (2017). Salicylic Acid-Regulated Antioxidant Mechanisms and Gene Expression Enhance Rosemary Performance under Saline Conditions. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00716"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/15324982.2018.1551817","article-title":"The Impact of Foliar Fertilizers on Growth and Biochemical Responses of Thymus vulgaris to Salinity Stress","volume":"33","author":"Zrig","year":"2019","journal-title":"Arid. Land Res. Manag."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cappellari, L.d.R., Chiappero, J., Palermo, T.B., Giordano, W., and Banchio, E. (2020). Volatile Organic Compounds from Rhizobacteria Increase the Biosynthesis of Secondary Metabolites and Improve the Antioxidant Status in Mentha piperita L. Grown under Salt Stress. Agronomy, 10.","DOI":"10.3390\/agronomy10081094"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110202","DOI":"10.1016\/j.scienta.2021.110202","article-title":"Using Halloysite Nanotubes as Carrier for Proline to Alleviate Salt Stress Effects in Sweet Basil (Ocimum basilicum L.)","volume":"285","author":"Masoudniaragh","year":"2021","journal-title":"Sci. Hortic."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/aob\/mcn125","article-title":"Photosynthesis under Drought and Salt Stress: Regulation Mechanisms from Whole Plant to Cell","volume":"103","author":"Chaves","year":"2009","journal-title":"Ann. Bot."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/tpj.12386","article-title":"Carotenoid Oxidation Products as Stress Signals in Plants","volume":"79","author":"Havaux","year":"2014","journal-title":"Plant J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"16272","DOI":"10.1038\/s41598-025-00768-y","article-title":"Time Course of Physiological and Biochemical Responses of Thymus vulgaris to Short-Term Salinity Stress in Hydroponics","volume":"15","author":"Akhoundi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Debbagh-Nour, H., El Mouttaqi, A., Lazaar, K., Mnaouer, I., Malki, S., Ducousso, M., Boukcim, H., and Hirich, A. (2026). Water Deficit and Salinity Stresses Modulate Growth, Physiology, and Phytochemical Composition of Lavandula coronopifolia Poir. Grown in Pots under Controlled Conditions. Front. Plant Sci., 16.","DOI":"10.3389\/fpls.2025.1719460"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s40995-016-0022-y","article-title":"Salinity Effects on Phenolic Content and Antioxidant Activity of Salvia macrosiphon","volume":"41","author":"Valifard","year":"2017","journal-title":"Iran. J. Sci. Technol. Trans. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ko\u017ami\u0144ska, A., Hanus-Fajerska, E., Halecki, W., and Ciarkowska, K. (2021). Beet Molasses Enhance Salinity Tolerance in Thymus serpyllum\u2014A Study under Greenhouse Condition. Plants, 10.","DOI":"10.3390\/plants10091819"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.indcrop.2018.10.048","article-title":"Salinity from NaCl Changes the Nutrient and Polyphenolic Composition of Basil Leaves","volume":"127","author":"Scagel","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sharma, A., Shahzad, B., Rehman, A., Bhardwaj, R., Landi, M., and Zheng, B. (2019). Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress. Molecules, 24.","DOI":"10.3390\/molecules24132452"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kowalczyk, A., Tuberoso, C.I.G., and Jerkovi\u0107, I. (2024). The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity. Antioxidants, 13.","DOI":"10.3390\/antiox13111313"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/07388551.2011.596804","article-title":"Rosmarinic Acid and Its Derivatives: Biotechnology and Applications","volume":"32","author":"Bulgakov","year":"2012","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.plantsci.2012.07.014","article-title":"Flavonoids as Antioxidants in Plants: Location and Functional Significance","volume":"196","author":"Agati","year":"2012","journal-title":"Plant Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100162","DOI":"10.1016\/j.cpb.2020.100162","article-title":"New Insights into Rosmarinic Acid Biosynthesis Based on Molecular Studies","volume":"23","year":"2020","journal-title":"Curr. Plant Biol."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/8\/1178\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:27:18Z","timestamp":1786681638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/8\/1178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":53,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["biom16081178"],"URL":"https:\/\/doi.org\/10.3390\/biom16081178","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}