{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:26:52Z","timestamp":1786685212022,"version":"build-2736575974"},"reference-count":127,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360790"],"award-info":[{"award-number":["82360790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82360790"],"award-info":[{"award-number":["82360790"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009620","name":"Gansu Provincial Science and Technology Department","doi-asserted-by":"crossref","award":["23JRRA1203"],"award-info":[{"award-number":["23JRRA1203"]}],"id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009620","name":"Gansu Provincial Science and Technology Department","doi-asserted-by":"crossref","award":["23JR6KA028"],"award-info":[{"award-number":["23JR6KA028"]}],"id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009620","name":"Gansu Provincial Science and Technology Department","doi-asserted-by":"crossref","award":["21JR1RA256"],"award-info":[{"award-number":["21JR1RA256"]}],"id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"crossref"}]},{"award":["23JRRA1203"],"award-info":[{"award-number":["23JRRA1203"]}],"id":[{"id":"https:\/\/ror.org\/03xz2hx98","id-type":"ROR","asserted-by":"publisher"}]},{"award":["23JR6KA028"],"award-info":[{"award-number":["23JR6KA028"]}],"id":[{"id":"https:\/\/ror.org\/03xz2hx98","id-type":"ROR","asserted-by":"publisher"}]},{"award":["21JR1RA256"],"award-info":[{"award-number":["21JR1RA256"]}],"id":[{"id":"https:\/\/ror.org\/03xz2hx98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Doxorubicin (DOX) is a widely used anthracycline chemotherapeutic agent; however, its clinical application is limited by dose-dependent cardiotoxicity, which can result in progressive cardiac dysfunction and heart failure. Increasing evidence indicates that DOX-induced cardiotoxicity is closely associated with premature cardiac senescence, a pathological process distinct from physiological cardiac aging. DOX induces senescence-associated alterations in multiple cardiac cell populations, disrupting cardiac homeostasis and contributing to pathological remodeling. In this review, we summarize current advances in DOX-induced cardiac senescence, focusing on the contributions of different cardiac cell types, the underlying molecular mechanisms, and emerging therapeutic strategies. We further discuss the challenges and future perspectives for developing effective interventions that alleviate cardiac senescence while preserving the anticancer efficacy of DOX. Understanding the mechanisms driving DOX-induced cardiac senescence may provide new opportunities to develop effective cardioprotective strategies and improve long-term cardiac outcomes after chemotherapy.<\/jats:p>","DOI":"10.3390\/biom16081180","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:17:52Z","timestamp":1786551472000},"page":"1180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of Doxorubicin-Induced Cardiac Senescence and Potential Therapeutic Strategies"],"prefix":"10.3390","volume":"16","author":[{"given":"Yanli","family":"Bai","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Technology, Tianshui Normal University, Tianshui 741000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China"},{"name":"Gansu Pharmaceutical Industry Innovation Research Institute, Gansu University of Chinese Medicine, Lanzhou 730000, China"},{"name":"Northwest Collaborative Innovation Center for Traditional Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12012-022-09721-1","article-title":"Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches","volume":"22","author":"Sheibani","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"178513","DOI":"10.1155\/2015\/178513","article-title":"High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage","volume":"2015","author":"Gergely","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: Many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"116677","DOI":"10.1016\/j.lfs.2019.116677","article-title":"Doxorubicin and liposomal doxorubicin induce senescence by enhancing nuclear factor kappa B and mitochondrial membrane potential","volume":"232","author":"Fallah","year":"2019","journal-title":"Life Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"H2169","DOI":"10.1152\/ajpheart.00068.2009","article-title":"Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2","volume":"297","author":"Spallarossa","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chen, L., Holder, R., Porter, C., and Shah, Z. (2021). Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKalpha\/Sirt1\/Foxo3a signaling pathway. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0252816"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00395-013-0334-4","article-title":"Doxorubicin induces senescence and impairs function of human cardiac progenitor cells","volume":"108","author":"Piegari","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Herrmann, J., Xia, M., Gummi, M.R., Greco, A., Schacke, A., van der Giet, M., Tolle, M., and Schuchardt, M. (2021). Stressor-Induced \u201cInflammaging\u201d of Vascular Smooth Muscle Cells via Nlrp3-Mediated Pro-inflammatory Auto-Loop. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.752305"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"C380","DOI":"10.1152\/ajpcell.00073.2019","article-title":"Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity","volume":"318","author":"Mitry","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"25256","DOI":"10.18632\/aging.203743","article-title":"MicroRNA therapy confers anti-senescent effects on doxorubicin-related cardiotoxicity by intracellular and paracrine signaling","volume":"13","author":"Xia","year":"2021","journal-title":"Aging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102818","DOI":"10.1016\/j.arr.2025.102818","article-title":"Targeting autophagy in doxorubicin-induced cardiotoxicity: A comprehensive review of scientific landscapes and therapeutic innovations","volume":"110","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1158\/0008-5472.CAN-07-1649","article-title":"Topoisomerase IIbeta mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane","volume":"67","author":"Lyu","year":"2007","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Vavrova, A., Jansova, H., Mackova, E., Machacek, M., Haskova, P., Tichotova, L., Sterba, M., and Simunek, T. (2013). Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076676"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nm.2919","article-title":"Identification of the molecular basis of doxorubicin-induced cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/CIRCULATIONAHA.114.013777","article-title":"Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy","volume":"131","author":"Cardinale","year":"2015","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1111\/febs.15583","article-title":"New insights into the activities and toxicities of the old anticancer drug doxorubicin","volume":"288","author":"Qiao","year":"2021","journal-title":"FEBS J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41514-024-00135-7","article-title":"A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging","volume":"10","author":"Linders","year":"2024","journal-title":"npj Aging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1474-9726.2007.00358.x","article-title":"Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage","volume":"7","author":"Maejima","year":"2008","journal-title":"Aging Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/CIRCRESAHA.116.307505","article-title":"Mitochondrial Metabolism in Aging Heart","volume":"118","author":"Lesnefsky","year":"2016","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1134\/S0006297915050132","article-title":"Morphometric Examination of Mitochondrial Ultrastructure in Aging Cardiomyocytes","volume":"80","author":"Vays","year":"2015","journal-title":"Biochem. Biokhimiia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e24662","DOI":"10.7554\/eLife.24662","article-title":"Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila","volume":"6","author":"Brandt","year":"2017","journal-title":"eLife"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"34082","DOI":"10.18632\/oncotarget.16133","article-title":"Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice","volume":"8","author":"Pillai","year":"2017","journal-title":"Oncotarget"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10565-006-0140-y","article-title":"Adriamycin-induced oxidative mitochondrial cardiotoxicity","volume":"23","author":"Berthiaume","year":"2007","journal-title":"Cell Biol. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arr.2008.07.002","article-title":"Molecular inflammation: Underpinnings of aging and age-related diseases","volume":"8","author":"Chung","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101755","DOI":"10.1016\/j.molmet.2023.101755","article-title":"Chronic inflammation and the hallmarks of aging","volume":"74","author":"Baechle","year":"2023","journal-title":"Mol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e030200","DOI":"10.1161\/JAHA.123.030200","article-title":"Zymosan A Improved Doxorubicin-Induced Ventricular Remodeling by Evoking Heightened Cardiac Inflammatory Responses and Healing in Mice","volume":"12","author":"Xu","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/2159-8290.CD-16-0241","article-title":"Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse","volume":"7","author":"Demaria","year":"2017","journal-title":"Cancer Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/cvr\/cvaa017","article-title":"MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling","volume":"117","author":"Chan","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.18632\/aging.100467","article-title":"Replicatively senescent cells are arrested in G1 and G2 phases","volume":"4","author":"Mao","year":"2012","journal-title":"Aging"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.devcel.2020.09.029","article-title":"Cellular Mechanisms and Regulation of Quiescence","volume":"55","author":"Marescal","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e002383","DOI":"10.1161\/JAHA.115.002383","article-title":"Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes","volume":"5","author":"Altieri","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Shi, Y., Li, F., Shen, M., Sun, C., Hao, W., Wu, C., Xie, Y., Zhang, S., Gao, H., and Yang, J. (2021). Luteolin Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.750186"},{"key":"ref_35","first-page":"2695","article-title":"Long intergenic non-coding RNA-p21 mediates cardiac senescence via the Wnt\/beta-catenin signaling pathway in doxorubicin-induced cardiotoxicity","volume":"17","author":"Xie","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3892\/etm.2021.10548","article-title":"Role of C5a and C5aR in doxorubicin-induced cardiomyocyte senescence","volume":"22","author":"Wen","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_37","first-page":"186","article-title":"Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation","volume":"45","author":"Huang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1161\/CIRCULATIONAHA.107.748053","article-title":"Differential behaviors of atrial versus ventricular fibroblasts: A potential role for platelet-derived growth factor in atrial-ventricular remodeling differences","volume":"117","author":"Burstein","year":"2008","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41569-019-0155-8","article-title":"Mechanical regulation of gene expression in cardiac myocytes and fibroblasts","volume":"16","author":"Saucerman","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Narikawa, M., Umemura, M., Tanaka, R., Hikichi, M., Nagasako, A., Fujita, T., Yokoyama, U., Ishigami, T., Kimura, K., and Tamura, K. (2019). Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221940"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mancilla, T.R., Davis, L.R., and Aune, G.J. (2020). Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238856"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1292\/jvms.23-0279","article-title":"Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles","volume":"85","author":"Fujioka","year":"2023","journal-title":"J. Vet. Med. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10015","DOI":"10.1038\/s41598-026-40206-1","article-title":"The matricellular protein CCN5 (WISP2) inhibits cellular senescence in cardiac myoblasts and fibroblasts","volume":"16","author":"Jo","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"H1154","DOI":"10.1152\/ajpheart.00568.2025","article-title":"MitoQ reduces senescence burden in doxorubicin-treated endothelial cells by reducing mitochondrial ROS and DNA damage","volume":"329","author":"Abdeahad","year":"2025","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Abdelgawad, I.Y., Agostinucci, K., Ismail, S.G., Grant, M.K.O., and Zordoky, B.N. (2022). EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263. Cells, 11.","DOI":"10.3390\/cells11131992"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115078","DOI":"10.1016\/j.bcp.2022.115078","article-title":"Resolvin E1 attenuates doxorubicin-induced endothelial senescence by modulating NLRP3 inflammasome activation","volume":"201","author":"Shamoon","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Abdelgawad, I.Y., Agostinucci, K., Sadaf, B., Grant, M.K.O., and Zordoky, B.N. (2023). Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells. Front. Aging, 4.","DOI":"10.3389\/fragi.2023.1170434"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"H1672","DOI":"10.1152\/ajpheart.00712.2025","article-title":"Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: Translational evidence of prevention with senolytic treatment","volume":"329","author":"Venkatasubramanian","year":"2025","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10522-013-9477-9","article-title":"A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta","volume":"15","author":"Wnuk","year":"2014","journal-title":"Biogerontology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000343000","article-title":"Urokinase receptor mediates doxorubicin-induced vascular smooth muscle cell senescence via proteasomal degradation of TRF2","volume":"50","author":"Hodjat","year":"2013","journal-title":"J. Vasc. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"66429","DOI":"10.18632\/oncotarget.12079","article-title":"NOX4 downregulation leads to senescence of human vascular smooth muscle cells","volume":"7","author":"Przybylska","year":"2016","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1634\/stemcells.2008-0428","article-title":"Concise review: Mesenchymal stromal cells: Potential for cardiovascular repair","volume":"26","author":"Psaltis","year":"2008","journal-title":"Stem Cells"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s12185-017-2346-6","article-title":"Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue","volume":"107","author":"Kozhukharova","year":"2018","journal-title":"Int. J. Hematol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1002\/jcp.29140","article-title":"Doxorubicin-induced senescence through NF-kappaB affected by the age of mouse mesenchymal stem cells","volume":"235","author":"Pourfathollah","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12185-012-1196-5","article-title":"Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells","volume":"96","author":"Prendergast","year":"2012","journal-title":"Int. J. Hematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e12931","DOI":"10.1111\/acel.12931","article-title":"Aged-senescent cells contribute to impaired heart regeneration","volume":"18","author":"Ruchaya","year":"2019","journal-title":"Aging Cell"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Smith, A.J. (2021). Effects of Cardiotoxins on Cardiac Stem and Progenitor Cell Populations. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.624028"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"110140","DOI":"10.1016\/j.abb.2024.110140","article-title":"Mechanisms of doxorubicin-induced cardiac inflammation and fibrosis; therapeutic targets and approaches","volume":"761","author":"Song","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Vitale, R., Marzocco, S., and Popolo, A. (2024). Role of Oxidative Stress and Inflammation in Doxorubicin-Induced Cardiotoxicity: A Brief Account. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202405.1681.v1"},{"key":"ref_60","first-page":"154922","article-title":"Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING\/NLRP3 signalling pathway","volume":"117","author":"Fang","year":"2023","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12964-023-01077-5","article-title":"Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy","volume":"21","author":"Shi","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"111800","DOI":"10.1016\/j.exger.2022.111800","article-title":"Characterization of cellular senescence in doxorubicin-induced aging mice","volume":"163","author":"Sun","year":"2022","journal-title":"Exp. Gerontol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1089\/ars.2012.4795","article-title":"Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection","volume":"18","author":"Sterba","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1521020","DOI":"10.1155\/2017\/1521020","article-title":"Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity","volume":"2017","author":"Cappetta","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrcardio.2013.30","article-title":"The roles of senescence and telomere shortening in cardiovascular disease","volume":"10","author":"Fyhrquist","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"12334","DOI":"10.18632\/aging.203027","article-title":"The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy","volume":"13","author":"Pillai","year":"2021","journal-title":"Aging"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1242\/jcs.061481","article-title":"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1","volume":"123","author":"Park","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cmet.2017.09.023","article-title":"Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence","volume":"26","author":"Song","year":"2017","journal-title":"Cell Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1111\/jcmm.15305","article-title":"Effects of doxorubicin-induced cardiotoxicity on cardiac mitochondrial dynamics and mitochondrial function: Insights for future interventions","volume":"24","author":"Osataphan","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"102132","DOI":"10.1016\/j.redox.2021.102132","article-title":"Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation","volume":"47","author":"Kotla","year":"2021","journal-title":"Redox Biol."},{"key":"ref_71","first-page":"4029","article-title":"Depletion of SASP senescent cardiomyocytes with senolytic drugs confers therapeutic effects in doxorubicin-related cardiotoxicity","volume":"291","author":"Xia","year":"2024","journal-title":"FEBS J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41401-020-0471-x","article-title":"Noncoding RNAs in doxorubicin-induced cardiotoxicity and their potential as biomarkers and therapeutic targets","volume":"42","author":"Fa","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_73","first-page":"1402","article-title":"Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses","volume":"38","author":"Du","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12265-018-9847-4","article-title":"Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression","volume":"12","author":"Liu","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12951-020-00716-0","article-title":"Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p","volume":"18","author":"Zhuang","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/CIRCRESAHA.116.307474","article-title":"Aging and Autophagy in the Heart","volume":"118","author":"Shirakabe","year":"2016","journal-title":"Circ. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"22488","DOI":"10.1038\/srep22488","article-title":"Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"777","DOI":"10.24976\/Discov.Med.202335178.72","article-title":"Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway","volume":"35","author":"Chen","year":"2023","journal-title":"Discov. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"119411","DOI":"10.1016\/j.bbamcr.2022.119411","article-title":"Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K\/AKT\/mTOR pathway in A549 cells","volume":"1870","author":"Fan","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"165997","DOI":"10.1016\/j.bbadis.2020.165997","article-title":"Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy","volume":"1867","author":"Gao","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/CIRCULATIONAHA.109.895771","article-title":"Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function","volume":"121","author":"Piegari","year":"2010","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jaccao.2023.03.012","article-title":"Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues","volume":"5","author":"Linders","year":"2023","journal-title":"JACC Cardio Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00280-013-2154-5","article-title":"Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding","volume":"71","author":"Hydock","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.taap.2008.05.006","article-title":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity","volume":"231","author":"Mitra","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/FJC.0000000000000350","article-title":"Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-kappaB\/iNOS\/NO Signaling Pathway Activation in H9C2 Cardiac Cells","volume":"67","author":"Wang","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_86","first-page":"157482","article-title":"Rosmarinic acid alleviates doxorubicin-induced cellular senescence and cardiotoxicity by targeting the 14-3-3\/Foxo1 signaling axis","volume":"148","author":"Fan","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"117607","DOI":"10.1016\/j.biopha.2024.117607","article-title":"The cardioprotective effects of Fruitflow(R) against Doxorubicin-induced toxicity in rat cardiomyoblast cells H9c2 (2-1) and high-fat diet-induced dyslipidemia and pathological alteration in cardiac tissue of Wistar Albino rats","volume":"180","author":"Das","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gaytan, S.L., Lawan, A., Chang, J., Nurunnabi, M., Bajpeyi, S., Boyle, J.B., Han, S.M., and Min, K. (2023). The beneficial role of exercise in preventing doxorubicin-induced cardiotoxicity. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1133423"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"885","DOI":"10.36660\/abc.20190260","article-title":"Aerobic Exercise and Cardiac Function of Murines Exposed to Doxorubicin: A Meta-Analysis","volume":"115","author":"Matos","year":"2020","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e1573403X1328856","DOI":"10.2174\/011573403X328856241219114652","article-title":"Effects of Physical Exercise and the use of Doxorubicin on Cardiac Function in Rodents: A Systematic Review and Meta-Analysis","volume":"21","author":"Linhares","year":"2025","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ymthe.2021.07.004","article-title":"ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity","volume":"30","author":"Wu","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"E922","DOI":"10.1152\/ajpendo.00140.2018","article-title":"Multitissue analysis of exercise and metformin on doxorubicin-induced iron dysregulation","volume":"316","author":"Mackay","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Montalvo, R.N., Boeno, F.P., Dowllah, I.M., Moritz, C.E.J., Nguyen, B.L., Doerr, V., Bomkamp, M.P., and Smuder, A.J. (2023). Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097689"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCRESAHA.123.323346","article-title":"Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells","volume":"134","author":"Wang","year":"2024","journal-title":"Circ. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"113097","DOI":"10.1016\/j.biopha.2022.113097","article-title":"Berberine exerts protective effects on cardiac senescence by regulating the Klotho\/SIRT1 signaling pathway","volume":"151","author":"Li","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/DDDT.S269029","article-title":"Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug Des. Devel Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.18632\/aging.205664","article-title":"CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN","volume":"16","author":"Zhou","year":"2024","journal-title":"Aging"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"103129","DOI":"10.1016\/j.redox.2024.103129","article-title":"Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction","volume":"72","author":"Li","year":"2024","journal-title":"Redox Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/cvr\/cvae025","article-title":"Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity","volume":"120","author":"Peclat","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"103753","DOI":"10.1016\/j.redox.2025.103753","article-title":"5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth","volume":"85","author":"Guo","year":"2025","journal-title":"Redox Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/cvr\/cvaf033","article-title":"Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination","volume":"121","author":"Yang","year":"2025","journal-title":"Cardiovasc. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1096\/fba.2019-00041","article-title":"Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence","volume":"1","author":"Feng","year":"2019","journal-title":"FASEB bioAdvances"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/s43587-024-00663-7","article-title":"Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice","volume":"4","author":"Zumerle","year":"2024","journal-title":"Nat. Aging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13788","DOI":"10.18632\/aging.202972","article-title":"Redd1 knockdown prevents doxorubicin-induced cardiac senescence","volume":"13","author":"Huang","year":"2021","journal-title":"Aging"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.20517\/jca.2024.06","article-title":"Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart","volume":"4","author":"Zhai","year":"2024","journal-title":"J. Cardiovasc. Aging"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"106356","DOI":"10.1016\/j.phrs.2022.106356","article-title":"Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice","volume":"183","author":"Alfonso","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"112007","DOI":"10.1016\/j.mad.2024.112007","article-title":"Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids","volume":"223","author":"Scalise","year":"2025","journal-title":"Mech. Ageing Dev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e13117","DOI":"10.1111\/acel.13117","article-title":"Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity","volume":"19","author":"He","year":"2020","journal-title":"Aging Cell"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41514-025-00197-1","article-title":"Calcium (Ca(2+)) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS)","volume":"11","author":"Huerta","year":"2025","journal-title":"npj Aging"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2024.08.001","article-title":"Suppression of autophagy induces senescence in the heart","volume":"195","author":"Zhai","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_111","first-page":"674","article-title":"Mesenchymal stem cells attenuate doxorubicin-induced cellular senescence through the VEGF\/Notch\/TGF-beta signaling pathway in H9c2 cardiomyocytes","volume":"42","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_112","first-page":"10037","article-title":"Mesenchymal stem cells confer resistance to doxorubicin-induced cardiac senescence by inhibiting microRNA-34a","volume":"15","author":"Xia","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Villa, F., Bruno, S., Costa, A., Li, M., Russo, M., Cimino, J., Altieri, P., Ruggeri, C., Gorgun, C., and De Biasio, P. (2021). The Human Fetal and Adult Stem Cell Secretome Can Exert Cardioprotective Paracrine Effects against Cardiotoxicity and Oxidative Stress from Cancer Treatment. Cancers, 13.","DOI":"10.3390\/cancers13153729"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Li, L., Li, J., Wang, Q., Zhao, X., Yang, D., Niu, L., Yang, Y., Zheng, X., Hu, L., and Li, Y. (2020). Shenmai Injection Protects Against Doxorubicin-Induced Cardiotoxicity via Maintaining Mitochondrial Homeostasis. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00815"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"117134","DOI":"10.1016\/j.jep.2023.117134","article-title":"Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3","volume":"319","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_116","first-page":"156529","article-title":"Linggui Zhugan decoction ameliorating mitochondrial damage of doxorubicin-induced cardiotoxicity by modulating the AMPK-FOXO3a pathway targeting BTG2","volume":"139","author":"Kong","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_117","first-page":"3229","article-title":"Effect of fermented Cordyceps sinensis on doxorubicin-induced cardiotoxicity in rats","volume":"18","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Yao, M., Zhang, S., Wu, Y., Huang, Y., Song, Y., Wang, L., Li, S., Jia, L., Yao, B., and Li, B. (2026). Gastrodin alleviates cardiomyocyte senescence by regulating autophagy through the AMPK\/mTOR\/4EBP1 pathway. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1851573"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Xu, H., Liu, Z., Zhuang, S., Chen, J., Geng, M., Han, X., Liu, Y., Guo, Y., Zheng, F., and Dai, Y. (2026). Protective effects of polysaccharides derived from Panax ginseng and Codonopsis pilosula against doxorubicin-induced myocardial senescence. Int. J. Biol. Macromol., 153801.","DOI":"10.1016\/j.ijbiomac.2026.153801"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"149910","DOI":"10.1016\/j.bbrc.2024.149910","article-title":"Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis","volume":"710","author":"Zhai","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"10133","DOI":"10.18632\/aging.205062","article-title":"Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1","volume":"15","author":"Meng","year":"2023","journal-title":"Aging"},{"key":"ref_122","first-page":"157037","article-title":"Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro","volume":"145","author":"Zhang","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e2300465","DOI":"10.1002\/jssc.202300465","article-title":"Qualitative and quantitative studies on chemical constituents of Ling-gui-zhu-gan decoction: In vitro and in vivo","volume":"46","author":"Li","year":"2023","journal-title":"J. Sep. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/jssc.201900980","article-title":"Pseudotargeted screening and determination of constituents in Qishen granule based on compound biosynthetic correlation using UHPLC coupled with high-resolution MS","volume":"43","author":"Li","year":"2020","journal-title":"J. Sep. Sci."},{"key":"ref_125","first-page":"555","article-title":"[Analysis of chemical constituents in Shenmai Injection by LC-Q-TOF-MS and LC-IT-MS]","volume":"45","author":"Wang","year":"2020","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"121777","DOI":"10.1016\/j.jchromb.2019.121777","article-title":"Pharmacokinetics, tissue distribution and excretion of saponins after intravenous administration of ShenMai Injection in rats","volume":"1128","author":"Li","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e9620","DOI":"10.1002\/rcm.9620","article-title":"Pharmacokinetic evaluation of 24 representative components of Ling-Gui-Zhu-Gan decoction in acute myocardial infarction model rats via a validated ultrahigh-performance liquid chromatography-tandem mass spectrometry method","volume":"37","author":"Li","year":"2023","journal-title":"Rapid Commun. Mass. Spectrom."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/8\/1180\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:29:32Z","timestamp":1786681772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/8\/1180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":127,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["biom16081180"],"URL":"https:\/\/doi.org\/10.3390\/biom16081180","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}