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Motor neuron diseases (MNDs), including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are characterized by the progressive degeneration of this network, resulting in motor dysfunction. Emerging evidence underscores the significant roles of long non-coding RNAs (lncRNAs) in motor neuron development and disease. However, only a few have been experimentally confirmed as true ceRNA regulators, highlighting the need to differentiate validated mechanisms from mere associations or predictions. This review summarizes the regulatory roles of lncRNA-associated ceRNA networks in motor neuron development, evaluates the evidence for their involvement in MNDs, and explores their potential impact on disease progression. It also addresses current challenges, knowledge gaps, and future research directions for understanding ceRNA-mediated mechanisms and developing therapeutic strategies for MNDs.<\/jats:p>","DOI":"10.3390\/biom16081208","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:58:23Z","timestamp":1787126303000},"page":"1208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Prospective Regulatory Functions of lncRNAs and Their ceRNA Networks in the Development of Motor Neurons and Associated Diseases"],"prefix":"10.3390","volume":"16","author":[{"given":"Zhenzhen","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University Xiamen Campus, No. 668 Jimei Street, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Fu","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University Xiamen Campus, No. 668 Jimei Street, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5999-6239","authenticated-orcid":false,"given":"Siqi","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University Xiamen Campus, No. 668 Jimei Street, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University Xiamen Campus, No. 668 Jimei Street, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-2226","authenticated-orcid":false,"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University Xiamen Campus, No. 668 Jimei Street, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-985X","authenticated-orcid":false,"given":"Nan","family":"Miao","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University Xiamen Campus, No. 668 Jimei Street, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","first-page":"463","article-title":"Motor Neurons","volume":"16","author":"Hounsgaard","year":"2017","journal-title":"Compr. 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