{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:31:28Z","timestamp":1787232688407,"version":"build-2736575974"},"reference-count":453,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Mesenchymal stem\/stromal cells (MSCs) are promising candidates in regenerative medicine, but their effectiveness is significantly influenced by the surrounding metabolic and nutritional conditions. Increasing evidence suggests that lipids act not only as energy sources but also as regulators of MSC fate. This review explores how lipid metabolism influences the balance among stemness, immunomodulation, and differentiation into adipogenic or osteogenic lineages. It does so through mechanisms such as fatty acid uptake, \u03b2-oxidation, de novo lipogenesis, and membrane remodeling, all orchestrated by CD36, carnitine palmitoyltransferase 1A, PPAR\u03b3, AMP-activated protein kinase, and the PI3K\/AKT\/mTOR pathway. We then examine how diet reshapes the MSC lipidome: obesity and high-fat diets promote adipogenesis and senescence, while omega-3 fatty acids, caloric restriction, micronutrients, and a balanced microbiota help preserve regenerative capacity. Lastly, we discuss how combining lipidomics with multi-omics could uncover lipid-metabolic signatures and regulatory nodes that connect diet to MSC function. Overall, the diet\u2013lipid\u2013MSC axis emerges as a modifiable determinant of MSC function.<\/jats:p>","DOI":"10.3390\/biom16081216","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:57:53Z","timestamp":1787230673000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-3658","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Ba\u015far G\u00f6kcen","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Fethiye Faculty of Health Sciences, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48300 Mugla, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra","family":"Atabilen P\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Karamano\u011flu Mehmetbey University, 70200 Karaman, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-1302","authenticated-orcid":false,"given":"Men\u015fure Nur","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Ondokuz May\u0131s University, 55270 Samsun, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-0974","authenticated-orcid":false,"given":"Zeynep B\u00fc\u015fra","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, Ankara University, 06520 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-8440","authenticated-orcid":false,"given":"Bence","family":"Raposa","sequence":"additional","affiliation":[{"name":"Institute of Basics of Health Sciences, Midwifery and Health Visiting, Faculty of Health Sciences, University of P\u00e9cs, 7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-0012","authenticated-orcid":false,"given":"Duygu","family":"A\u011fag\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, 06490 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41536-020-00106-y","article-title":"Challenges and translational considerations of mesenchymal stem\/stromal cell therapy for Parkinson\u2019s disease","volume":"5","author":"Korchak","year":"2020","journal-title":"npj Regen. 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