{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:18:16Z","timestamp":1787890696203,"version":"build-2784847793"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Science University of Zagreb, Croatia","award":["20286659"],"award-info":[{"award-number":["20286659"]}]},{"award":["20286659"],"award-info":[{"award-number":["20286659"]}],"id":[{"id":"https:\/\/ror.org\/00mv6sv71","id-type":"ROR","asserted-by":"publisher"}]},{"name":"EU support NextGenerationEU, Faculty of Science, University of Zagreb","award":["106-F26-00044"],"award-info":[{"award-number":["106-F26-00044"]}]},{"award":["106-F26-00044"],"award-info":[{"award-number":["106-F26-00044"]}],"id":[{"id":"https:\/\/ror.org\/00mv6sv71","id-type":"ROR","asserted-by":"publisher"}]},{"name":"CERRM EU Grant Agreement, Rudjer Bo\u0161kovi\u0107 Institute, Zagreb","award":["KK01.1.1.01.0008"],"award-info":[{"award-number":["KK01.1.1.01.0008"]}]},{"award":["KK01.1.1.01.0008"],"award-info":[{"award-number":["KK01.1.1.01.0008"]}],"id":[{"id":"https:\/\/ror.org\/02mw21745","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Terry Fox Zagreb run with Croatian League Against Cancer"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The urokinase plasminogen activator or urokinase is a highly specific extracellular protease involved in numerous physiological and pathological processes. Its activity is a consequence of its interplay with its inhibitor, PAI1, and receptor, uPAR, and is finely regulated at several levels. The aim of the work was to investigate whether endoplasmic reticulum stress can modulate urokinase activity. Two tumor cell lines grown in cell culture were treated with Thapsigargin and sodium salicylate, inducers of ER stress response. Urokinase activity was determined in the conditioned media, and expression of uPA system molecules and molecules involved in response to ER stress in cell lysates was measured. ER stress influenced urokinase activity: while in the glioblastoma line its activity was increased, in breast cancer cells it was decreased. Differences in activity were a consequence of urokinase and PAI1 expression at the protein and RNA level. However, ER stress decreased cell migration, invasion, and proliferation regardless of the changes in urokinase activity. Gene expression analysis indicated that cell specific activation of some transcription factors and pathways could be responsible for different urokinase activity regulation.<\/jats:p>","DOI":"10.3390\/biom16091235","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:32Z","timestamp":1787756672000},"page":"1235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Endoplasmic Reticulum Stress on Urokinase Plasminogen Activation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-6303","authenticated-orcid":false,"given":"Diana","family":"Culej Bo\u0161njak","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Janji\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-2114","authenticated-orcid":false,"given":"Petra","family":"Kora\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-1078","authenticated-orcid":false,"given":"Mariastefania","family":"Antica","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10 000 Zagreb, Croatia"},{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute, Bijeni\u010dka 54, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3498-5616","authenticated-orcid":false,"given":"Maja","family":"Matuli\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-230X(08)60028-7","article-title":"Plasminogen activators, tissue degradation, and cancer","volume":"44","author":"Andreasen","year":"1985","journal-title":"Adv. Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/PL00000615","article-title":"The plasminogen activator system: Biology and regulation","volume":"56","author":"Irigoyen","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1006\/bbrc.1999.1202","article-title":"Cytoskeletal reorganization leads to induction of the urokinase-type plasminogen activator gene by activating FAK and Src and subsequently the Ras\/Erk signaling pathway","volume":"262","author":"Irigoyen","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1006\/bbrc.2001.5803","article-title":"Signal transduction-mediated regulation of urokinase gene expression in human prostate cancer","volume":"288","author":"Eandi","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/ijc.25455","article-title":"\u03b2-Catenin and NF-\u03baB cooperate to regulate the uPA\/uPAR system in cancer cells","volume":"128","author":"Moreau","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1055\/s-0037-1616763","article-title":"Differential mechanisms of plasminogen activator inhibitor-1 gene activation by transforming growth factor-\u03b2 and tumor necrosis factor-\u03b1 in endothelial cells","volume":"86","author":"Chen","year":"2001","journal-title":"J. Thromb. Haemost."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11010-005-3453-x","article-title":"Protein synthesis and urokinase mRNA metabolism","volume":"271","author":"Shetty","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-5793(96)00223-2","article-title":"Expression of urokinase-type plasminogen activator, its receptor and type-1 plasminogen activator inhibitor is differently regulated by inhibitors of protein synthesis in human cancer cell lines","volume":"383","author":"Lund","year":"1996","journal-title":"FEBS Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0215(19980504)76:3<362::AID-IJC13>3.0.CO;2-D","article-title":"Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine kinase pathway in mammary tumor cells","volume":"76","author":"Alonso","year":"1998","journal-title":"Int. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41420-024-02110-3","article-title":"Endoplasmic reticulum stress\u2014A key guardian in cancer","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: Molecular mechanism and therapeutic targets","volume":"15","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Koryga","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17067","DOI":"10.1016\/S0021-9258(19)47340-7","article-title":"Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps","volume":"266","author":"Lytton","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_14","first-page":"5","article-title":"Induction of urokinase-type plasminogen activator by sodium salicylate in a glioblastoma cell strain","volume":"39","author":"Brdar","year":"2001","journal-title":"Food Technol. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","article-title":"In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors","volume":"51","author":"Giard","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_16","unstructured":"Doyle, A., Griffiths, J.B., and Newell, D.G. (1995). Cell and Tissue Culture: Laboratory Procedures, John Wiley and Sons. Available online: https:\/\/archive.org\/stream\/Cell_And_Tissue_Culture_Laboratory_Procedures_In_Biotechnology\/Cell_And_Tissue_Culture_Laboratory_Procedures_In_Biotechnology_djvu.txt."},{"key":"ref_17","unstructured":"Sambrook, J.F., and Russell, D.W. (2001). Molecular Cloning: A Laboratory Manual, ColdSpring Harbor Laboratory Press. [3rd ed.]."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Horvat, L., Maduni\u0107, J., Grubar, M., Antica, M., and Matuli\u0107, M. (2019). Induction of Urokinase Activity by Retinoic Acid in Two Cell Lines of Neuronal Origin. Biomedicines, 7.","DOI":"10.3390\/biomedicines7030070"},{"key":"ref_19","first-page":"51046","article-title":"In vitro cell migration and invasion assays","volume":"88","author":"Justus","year":"2014","journal-title":"J. Vis. Exp."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lu, P., Struijs, M.C., Mei, J., Witte-Bouma, J., Korteland-van Male, A.M., de Bruijn, A.C., van Goudoever, J.B., and Renes, I.B. (2013). Endoplasmic reticulum stress, unfolded protein response and altered T cell differentiation in necrotizing enterocolitis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078491"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1074\/jbc.M609996200","article-title":"Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner","volume":"282","author":"Silva","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.clbc.2017.03.015","article-title":"Sodium salicylate inhibits urokinase activity in MDA MB-231 breast cancer cells","volume":"17","author":"Horvat","year":"2017","journal-title":"Clin. Breast Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3892\/ijo.2021.5257","article-title":"Sequestosome 1\/p62: A multitasker in the regulation of malignant tumor aggression (Review)","volume":"59","author":"Tang","year":"2021","journal-title":"Int. J. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/2211-5463.13484","article-title":"A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress","volume":"12","author":"Kapuy","year":"2022","journal-title":"FEBS Open Bio"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wischhusen, J., Melero, I., and Fridman, W.H. (2020). Growth\/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00951"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41419-017-0164-7","article-title":"Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells","volume":"9","author":"Gil","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Culej Bo\u0161njak, D., Balent, T., Kora\u0107, P., Antica, M., and Matuli\u0107, M. (2025). Urokinase Plasminogen Activation System Modulation in Transformed Cell Lines. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020675"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1158\/1541-7786.MCR-18-0224","article-title":"PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance","volume":"16","author":"Dadey","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/jphp.12002","article-title":"Implication of eIF2\u03b1 kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate","volume":"65","author":"Gentz","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1074\/jbc.RA118.002121","article-title":"ER stress signaling has an activating transcription factor 6\u03b1 (ATF6)-dependent \u201coff-switch\u201d","volume":"293","author":"Walter","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00774-007-0825-1","article-title":"Microarray analysis of thapsigargin-induced stress to the endoplasmic reticulum of mouse osteoblasts","volume":"26","author":"Hamamura","year":"2008","journal-title":"J. Bone Miner. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1038\/s41467-020-16747-y","article-title":"A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites","volume":"11","author":"Reich","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cellsig.2012.09.023","article-title":"Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells","volume":"25","author":"Han","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.3390\/ijms15058959","article-title":"Genes and gene networks involved in sodium fluoride-elicited cell death accompanying endoplasmic reticulum stress in oral epithelial cells","volume":"15","author":"Tabuchi","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tem.2017.07.003","article-title":"Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells","volume":"28","author":"Wortel","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14161","DOI":"10.1038\/s41598-021-93663-1","article-title":"Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide","volume":"11","author":"Lorenz","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Epple, L.M., Dodd, R.D., Merz, A.L., Dechkovskaia, A.M., Herring, M., Winston, B.A., Lencioni, A.M., Russell, R.L., Madsen, H., and Nega, M. (2013). Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073267"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Heinrich, R., Aronheim, A., Cheng, Y.C., and Perlman, I. (2024). Editorial: ATF3: A crucial stress-responsive gene of glia and neurons in CNS. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1484487"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Katz, H.R., Arcese, A.A., Bloom, O., and Morgan, J.R. (2022). Activating Transcription Factor 3 (ATF3) is a Highly Conserved Pro-regenerative Transcription Factor in the Vertebrate Nervous System. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.824036"},{"key":"ref_40","unstructured":"Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., and Walter, P. (2015). Molecular Biology of the Cell, Garland Science, Taylor & Francis Group. [6th ed.]."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17449","DOI":"10.1074\/jbc.M413141200","article-title":"Dynamic Assembly of the Urokinase-Type Plasminogen Activator Signaling Receptor Complex Determines the Mitogenic Activity of Urokinase-Type Plasminogen Activator","volume":"280","author":"Jo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/mc.22267","article-title":"Urokinase Is a Negative Modulator of EGF-Dependent Proliferation and Motility in the Two Breast Cancer Cell Lines MCF-7 and MDA-MB-231","volume":"55","author":"Kozlova","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_43","first-page":"1463","article-title":"Urokinase-Type Plasminogen Activator Induces Proliferation in Breast Cancer Cells","volume":"28","author":"Gandhari","year":"2006","journal-title":"Int. J. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0950-3536(05)80273-2","article-title":"The Urokinase\/Urokinase-Receptor System and Cancer Invasion","volume":"8","author":"Conese","year":"1995","journal-title":"Bailli\u00e8re\u2019s Clin. Haematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1096\/fj.04-1644com","article-title":"Urokinase Signal Transduction and Its Role in Cell Migration","volume":"19","author":"Carlin","year":"2005","journal-title":"FASEB J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/bbrc.1995.1465","article-title":"Suppression of in Vitro Invasion of Human Fibrosarcoma Cells by a Leupeptin Analogue Inhibiting the Urokinase-Plasmin System","volume":"209","author":"Kawada","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Echavidre, W., Picco, V., Faraggi, M., and Montemagno, C. (2022). Integrin-\u03b1v\u03b23 as a Therapeutic Target in Glioblastoma: Back to the Future?. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14051053"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jamison, S., Lin, Y., and Lin, W. (2015). Pancreatic Endoplasmic Reticulum Kinase Activation Promotes Medulloblastoma Cell Migration and Invasion through Induction of Vascular Endothelial Growth Factor A. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120252"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"26480","DOI":"10.18632\/oncotarget.8419","article-title":"FOXM1 Promotes Invasion and Migration of Colorectal Cancer Cells Partially Dependent on HSPA5 Transactivation","volume":"7","author":"Luo","year":"2016","journal-title":"Oncotarget"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41420-024-02200-2","article-title":"Deciphering the nexus between long non-coding RNAs and endoplasmic reticulum stress in hepatocellular carcinoma: Biomarker discovery and therapeutic horizons","volume":"10","author":"Goyal","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_51","first-page":"1","article-title":"Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain","volume":"40","author":"Brdar","year":"2002","journal-title":"Food Technol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1158\/1078-0432.CCR-12-2675","article-title":"ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1","volume":"19","author":"Siles","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10616-014-9829-6","article-title":"Modulation of Urokinase Plasminogen Activator System by Poly(ADP-Ribose) Polymerase-1 Inhibition","volume":"68","author":"Antica","year":"2016","journal-title":"Cytotechnology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/stmcls\/sxae057","article-title":"Metformin acts on miR-181a-5p\/PAI-1 axis in stem cells providing new strategies for improving age-related osteogenic differentiation decline","volume":"42","author":"Hong","year":"2024","journal-title":"Stem Cells"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00412-025-00830-8","article-title":"Regulatory effects of lncRNA PVT1 on transcriptome in human breast cancer MDA-MB-231 cell line determined by in silico analyses","volume":"134","author":"Jahanafrooz","year":"2025","journal-title":"Chromosoma"},{"key":"ref_56","first-page":"e44722","article-title":"Stress granules counteract senescence by sequestration of PAI-1","volume":"9","author":"Omer","year":"2018","journal-title":"EMBO Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1096\/fba.2020-00056","article-title":"Endoplasmic reticulum stress induces hepatic plasminogen activator inhibitor 1 in murine nonalcoholic steatohepatitis","volume":"2","author":"Olivares","year":"2020","journal-title":"FASEB BioAdv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/cvr\/cvs352","article-title":"SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence","volume":"97","author":"Cardus","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1016\/j.molcel.2024.10.003","article-title":"Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype","volume":"84","author":"Payea","year":"2024","journal-title":"Mol. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.18632\/aging.100971","article-title":"Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses","volume":"8","author":"Alessio","year":"2016","journal-title":"Aging"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9809","DOI":"10.1158\/0008-5472.CAN-07-0625","article-title":"The Unfolded Protein Response Regulator GRP78\/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas","volume":"67","author":"Pyrko","year":"2007","journal-title":"Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2003.12.031","article-title":"Regulation of Urokinase Plasminogen Activator by Epigallocatechin-3-Gallate in Human Fibrosarcoma Cells","volume":"487","author":"Kim","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"22176","DOI":"10.1074\/jbc.274.32.22176","article-title":"Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation","volume":"274","author":"Alpert","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/(SICI)1097-4652(199904)179:1<109::AID-JCP13>3.0.CO;2-W","article-title":"Cell-type-specific activation of c-Jun N-terminal kinase by salicylates","volume":"179","author":"Schwenger","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/MCB.18.1.78","article-title":"Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation","volume":"18","author":"Schwenger","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1074\/jbc.271.14.8089","article-title":"Inhibition of Tumor Necrosis Factor-Induced p42\/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate","volume":"271","author":"Schwenger","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/BJ20150122","article-title":"Salicylate Activates AMPK and Synergizes with Metformin to Reduce the Survival of Prostate and Lung Cancer Cells ex Vivo through Inhibition of de Novo Lipogenesis","volume":"469","author":"Villani","year":"2015","journal-title":"Biochem. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"11011","DOI":"10.1093\/nar\/gku814","article-title":"Transcriptional Complexity and Roles of Fra-1\/AP-1 at the uPA\/Plau Locus in Aggressive Breast Cancer","volume":"42","author":"Tolza","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1160\/TH04-12-0814","article-title":"Transcriptional and Posttranscriptional Regulation of the Plasminogen Activator System","volume":"93","author":"Nagamine","year":"2005","journal-title":"Thromb. Haemost."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/MCB.00982-14","article-title":"Extracellular signal-regulated kinase signaling regulates the opposing roles of JUN family transcription factors at ETS\/AP-1 sites and in cell migration","volume":"35","author":"Selvaraj","year":"2015","journal-title":"Mol. Cell. 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