{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:08:25Z","timestamp":1789016905758,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32473082"],"award-info":[{"award-number":["32473082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["32473082"],"award-info":[{"award-number":["32473082"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"The National Key Research and Development Program of China","award":["2023YFD1800805"],"award-info":[{"award-number":["2023YFD1800805"]}]},{"name":"China Agriculture Research System","award":["CARS-36"],"award-info":[{"award-number":["CARS-36"]}]},{"award":["CARS-36"],"award-info":[{"award-number":["CARS-36"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the Innovation Project of Traditional Chinese Veterinary Medicine and Clinical Science","award":["CAAS-ASTIP-2015-LIHPS"],"award-info":[{"award-number":["CAAS-ASTIP-2015-LIHPS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Acute lung injury (ALI) is a common clinical acute respiratory disorder driven primarily by a diffuse pulmonary inflammatory response. Cordycepin (COR) is a bioactive metabolite extracted from the fungus Cordyceps militaris, which possesses antioxidant and anti-inflammatory properties. However, its underlying molecular mechanism remains to be elucidated. This study evaluated the therapeutic effect of COR on ALI and the underlying molecular mechanisms. MH-S cells were primed with lipopolysaccharide (LPS) at 1 \u00b5g\/mL for 24 h and then treated with varying doses of COR for an additional 24 h. WB and RT-qPCR analyses showed that COR inhibited the phosphorylation of TGF-\u03b2-activated kinase 1 (TAK1) as well as the key kinases in the MAPK and NF-\u03baB pathways in LPS-induced MH-S cells, as evidenced by decreased TAK1, p38, JNK, I\u03baB-\u03b1 and P65 expression levels, as well as decreased TNF-\u03b1, IL-6, IL-1\u03b2, MAP3K7, MAPK8 and MAPK14 relative expression. Six-week-old BALB\/c mice were intranasally instilled with LPS at 3 mg\/kg, followed 24 h later by oral gavage administration of various concentrations of COR. The results showed that COR can effectively suppress the progression of pulmonary tissue injury; similarly, the expression levels of key proteins and inflammatory factors in the TAK1-MAPK and NF-\u03baB signaling pathways were downregulated. In summary, COR exerts a therapeutic effect on ALI by directly targeting TAK1 to inhibit the activation of the MAPK and NF-\u03baB signaling pathways and concurrently suppressing key inflammatory cytokines.<\/jats:p>","DOI":"10.3390\/biom16091279","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:21:21Z","timestamp":1788452481000},"page":"1279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cordycepin Alleviates Acute Lung Injury by Targeting TAK1 to Inhibit MAPK and NF-\u03baB Signaling Pathways"],"prefix":"10.3390","volume":"16","author":[{"given":"Junyan","family":"Wang","sequence":"first","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"},{"name":"College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiting","family":"Guo","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Xu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Feng","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"},{"name":"College of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"},{"name":"College of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Traditional Chinese Veterinary Technology Innovation Center of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, 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Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s10753-021-01435-w","article-title":"Trelagliptin alleviates lipopolysaccharide (LPS)-induced inflammation and oxidative stress in acute lung injury mice","volume":"44","author":"Zhou","year":"2021","journal-title":"Inflammation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/pupt.2000.0231","article-title":"Lipopolysaccharide-induced lung injury in mice. I. Concomitant evaluation of inflammatory cells and haemorrhagic lung damage","volume":"13","author":"Asti","year":"2000","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","article-title":"Acute lung injury: A clinical and molecular review","volume":"140","author":"Butt","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"152809","DOI":"10.1016\/j.imbio.2024.152809","article-title":"The involvement of oxidative stress and the TLR4\/NF-\u03baB\/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia","volume":"229","author":"Cao","year":"2024","journal-title":"Immunobiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.5414\/CP204438","article-title":"Research on acute lung injury inflammatory network","volume":"61","author":"Li","year":"2023","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Park, M.Y., Ha, S.E., and Kim, H.H. (2022). Scutellarein inhibits LPS-Induced inflammation through NF-\u03baB\/MAPKs signaling pathway in RAW264.7 cells. Molecules, 27.","DOI":"10.3390\/molecules27123782"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.18632\/oncotarget.2739","article-title":"Targeting of TGF-beta-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer","volume":"6","author":"Huang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10753-018-0890-8","article-title":"Review: The role and mechanisms of macrophage autophagy in sepsis","volume":"42","author":"Qiu","year":"2019","journal-title":"Inflammation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tips.2012.06.007","article-title":"Targeting of TAK1 in inflammatory disorders and cancer","volume":"33","author":"Sakurai","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100532","DOI":"10.1016\/j.jhepr.2022.100532","article-title":"Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death","volume":"4","author":"Zhan","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.ijbiomac.2022.10.024","article-title":"Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway","volume":"222","author":"Meng","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shi, Y., Liu, T., Nieman, D.C., Cui, Y., Li, F., Yang, L., Shi, H., and Chen, P. (2020). Aerobic exercise attenuates acute lung injury through NET inhibition. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00409"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10753-022-01726-w","article-title":"The role of macrophages and alveolar epithelial cells in the development of ARDS","volume":"46","author":"Tao","year":"2023","journal-title":"Inflammation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s11658-025-00750-6","article-title":"Targeting alveolar macrophages: A promising intervention for pulmonary infection and acute lung injury","volume":"30","author":"Hou","year":"2025","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/mmr.2024.13381","article-title":"Macrophage driven pathogenesis in acute lung injury\/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions","volume":"31","author":"Li","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1186\/s12967-025-06994-2","article-title":"Acute lung injury: Pathogenesis and treatment","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1007\/s00134-011-2380-4","article-title":"The ALIEN study: Incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation","volume":"37","author":"Villar","year":"2011","journal-title":"Intensive Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wang, J., Yan, Z., Zhang, X., Wang, S., Jiao, L., Zhu, B., Tan, B., and Yang, A. (2025). Exploring the pathogenesis of acute lung injury and its treatment through Traditional Chinese Medicine: A state-of-the-art review. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1592458"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"155562","DOI":"10.1016\/j.phymed.2024.155562","article-title":"Pharmacological mechanisms of traditional Chinese medicine against acute lung injury: From active ingredients to herbal formulae","volume":"135","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13020-024-00918-w","article-title":"Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis","volume":"19","author":"Chen","year":"2024","journal-title":"Chin. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12958-024-01318-3","article-title":"Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro","volume":"22","author":"Shan","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.chembiol.2020.01.004","article-title":"Mechanism of Activation of AMPK by Cordycepin","volume":"27","author":"Hawley","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e23824","DOI":"10.1002\/jbt.23824","article-title":"Cordycepin ameliorates kidney injury by inhibiting gasdermin D-mediated pyroptosis of renal macrophages through nuclear factor NF-\u03baB","volume":"38","author":"Tang","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejphar.2011.04.052","article-title":"Cordycepin protects against cerebral ischemia\/reperfusion injury in vivo and in vitro","volume":"664","author":"Cheng","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155073","DOI":"10.1016\/j.phymed.2023.155073","article-title":"Network pharmacology analysis and animal experiment validation of neuroinflammation inhibition by total ginsenoside in treating CSM","volume":"126","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1039\/D1FO04386B","article-title":"Network pharmacology combined with metabolomics and lipidomics to reveal the hypolipidemic mechanism of Alismatis rhizoma in hyperlipidemic mice","volume":"13","author":"Yan","year":"2022","journal-title":"Food Funct."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"115876","DOI":"10.1016\/j.jep.2022.115876","article-title":"Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation","volume":"302","author":"Shang","year":"2023","journal-title":"J. Ethnoparmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e31055","DOI":"10.1097\/MD.0000000000031055","article-title":"Network pharmacology and molecular docking reveal the mechanism of angelica daturic against osteosarcoma","volume":"44","author":"Zhang","year":"2022","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41419-022-05046-7","article-title":"FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NF\u03baB pathway","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_31","first-page":"156","article-title":"Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis","volume":"227","author":"He","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biopha.2016.09.020","article-title":"Resveratrol ameliorates LPS-induced acute lung injury via NLRP3 inflammasome modulation","volume":"84","author":"Jiang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhang, K., Zhang, J., Xu, G., Guo, Z., Lu, X., Liang, C., Gu, X., Huang, L., and Liu, S. (2025). Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1528222"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American thoracic society workshop report: Features and measurements of experimental acute lung injury in animals","volume":"44","author":"Downey","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"31570","DOI":"10.1038\/s41598-025-16560-x","article-title":"Tenofovir attenuates cytokine storm and bronchiolar damage in a mouse model of bleomycin-induced acute lung injury","volume":"15","author":"Romero","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.intimp.2010.09.011","article-title":"Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1487287","DOI":"10.1155\/2021\/1487287","article-title":"The role of inflammasome activation in early HIV infection","volume":"2021","author":"Ekabe","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101364","DOI":"10.1016\/j.redox.2019.101364","article-title":"The nuclear transcription factor fox G1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways","volume":"28","author":"He","year":"2020","journal-title":"Redox Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jare.2023.08.006","article-title":"Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-\u03b3\/RXR-\u03b1 complex","volume":"60","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-pathol-011110-130158","article-title":"The acute respiratory distress syndrome: Pathogenesis and treatment","volume":"6","author":"Matthay","year":"2011","journal-title":"Annu. Rev. Pathol.-Mech. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-013-0121-9","article-title":"Pharmacological and therapeutic potential of cordyceps with special reference to cordycepin","volume":"4","author":"Tuli","year":"2014","journal-title":"3 Biotech"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41467-019-10386-8","article-title":"Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"120300","DOI":"10.1016\/j.jep.2025.120300","article-title":"Metabolomics-guided analysis combined with network pharmacology and molecular simulations reveals the mechanism of JHT in treating septic intestinal dysfunction","volume":"353","author":"Deng","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, X., Peng, Z., Wang, L., Zhang, J., Zhang, K., Guo, Z., Xu, G., and Li, J. (2023). Cordyceps militaris solid medium extract alleviates lipoteichoic acid-induced MH-S inflammation by inhibiting TLR2\/NF-\u03baB\/NLRP3 pathways. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115519"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9569","DOI":"10.1038\/s41598-023-36687-z","article-title":"Use of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma","volume":"13","author":"Hu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115211","DOI":"10.1016\/j.jep.2022.115211","article-title":"Preventive effect of atractylodis rhizoma extract on DSS-induced acute ulcerative colitis through the regulation of the MAPK\/NF-\u03baB signals in vivo and in vitro","volume":"292","author":"Lin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"112105","DOI":"10.1016\/j.jep.2019.112105","article-title":"A review of pharmacological and clinical studies on the application of Shenling Baizhu San in treatment of ulcerative colitis","volume":"244","author":"Ma","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6138723","DOI":"10.1155\/2019\/6138723","article-title":"Andrographolide derivative AL-1 ameliorates dextran sodium sulfate-induced murine colitis by inhibiting NF-\u03baB and MAPK signaling pathways","volume":"2019","author":"Jing","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.biomaterials.2015.04.025","article-title":"Inhibition of MAP kinase\/NF-\u03baB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles","volume":"59","author":"Selvaraj","year":"2015","journal-title":"Biomaterials"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14470","DOI":"10.1038\/srep14470","article-title":"Activating transcription factor 3 represses inflammatory responses by binding to the p65 subunit of NF-\u03baB","volume":"5","author":"Kwon","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10142-024-01506-9","article-title":"Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p\/PTGS2\/MAPK axis","volume":"25","author":"Ming","year":"2024","journal-title":"Funct. Integr. Genom."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"154538","DOI":"10.1016\/j.phymed.2022.154538","article-title":"Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology","volume":"108","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10456-021-09787-5","article-title":"TAK1 signaling is a potential therapeutic target for pathological angiogenesis","volume":"24","author":"Zhu","year":"2021","journal-title":"Angiogenesis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1146\/annurev.biochem.78.070907.102750","article-title":"The role of ubiquitin in NF-\u03baB regulatory pathways","volume":"78","author":"Skaug","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ncb1780","article-title":"The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner","volume":"10","author":"Sorrentino","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"109148","DOI":"10.1016\/j.intimp.2022.109148","article-title":"Eupalinolide B attenuates lipopolysaccharide-induced acute lung injury through inhibition of NF-\u03baB and MAPKs signaling by targeting TAK1 protein","volume":"111","author":"Yang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41419-020-03278-z","article-title":"TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-\u03baB pathways","volume":"12","author":"Zhou","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhang, J., Yang, Z., Zhao, Z., and Zhang, N. (2024). Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2024.1367820"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cui, L., Zhao, L., Shen, G., Yu, D., Yuan, T., Zhang, Y., and Yang, B. (2024). Antitumor mechanism and therapeutic potential of cordycepin derivatives. Molecules, 29.","DOI":"10.3390\/molecules29020483"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/9\/1279\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:25:11Z","timestamp":1789014311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/9\/1279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":59,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["biom16091279"],"URL":"https:\/\/doi.org\/10.3390\/biom16091279","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]}}}