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The currently available algorithms and models enable a sequence-based design strategy to predict regions prone to transform into liquid\u2013liquid phase-separated (LLPS) condensed or solidified aggregated states; for the latter, one can distinguish amyloid and prion-like aggregates. In this study, we performed a comprehensive in silico experiment; more than 40 models were used to test amino acid sequences of various proteins known to aggregate in neurodegenerative diseases, certain progressive myoclonic epilepsies and mental illnesses. Altogether, 20 proteins were analyzed and their proneness to aggregate or condensate was discussed in view of their possible normal and\/or toxic function. The reported large set of computational models enables highly accurate predictions of proteins that are prone to aggregation and\/or condensation. Furthermore, such aggregation profiling can be performed for any protein sequence of interest.<\/jats:p>","DOI":"10.3390\/biom16091286","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:07:06Z","timestamp":1788768426000},"page":"1286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Aggregation- and Condensation-Prone Regions of Proteins Involved in Neurodegenerative, Neurological and Mental-State Diseases"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-234X","authenticated-orcid":false,"given":"Katja","family":"Venko","sequence":"first","affiliation":[{"name":"Theory Department, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-8200","authenticated-orcid":false,"given":"Eva","family":"\u017derovnik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular and Structural Biology, Jo\u017eef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia"},{"name":"Jo\u017eef Stefan International Postgraduate School, Jamova 39, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moda, F., Ciullini, A., Dellarole, I.L., Lombardo, A., Campanella, N., Bufano, G., Cazzaniga, F.A., and Giaccone, G. 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