{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:03:03Z","timestamp":1789534983890,"version":"build-2803163510"},"reference-count":122,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["YCJJ20252414"],"award-info":[{"award-number":["YCJJ20252414"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Periodontitis-associated alveolar bone loss reflects not only persistent inflammation but also profound metabolic remodeling within the periodontal microenvironment. This review synthesizes current evidence on how lipid metabolic reprogramming regulates periodontal bone remodeling and its therapeutic significance. Under physiological conditions, fatty acid uptake and \u03b2-oxidation, lipid droplet turnover, and lipid-derived signaling support osteoblast bioenergetics, stem-cell osteogenesis, and balanced bone remodeling. In contrast, dyslipidemia and chronic inflammatory stress promote the accumulation of free fatty acids, oxidized lipoproteins, cholesterol derivatives, and sphingolipid metabolites, thereby enhancing reactive oxygen species production, lipid peroxidation, inflammasome activation, and pro-inflammatory immune polarization. These changes suppress osteogenic differentiation, stimulate osteoclastogenesis, and impair periodontal regeneration. We further integrate major regulatory networks, including PPAR\u03b3\u2013Wnt\/\u03b2-catenin, AMPK\u2013mTOR, NF-\u03baB\/NLRP3, and GSK3\u03b2\u2013NRF2\/ferroptosis signaling. Therapeutic strategies targeting these lipid\u2013redox\u2013immune circuits include specialized pro-resolving lipid mediators, n-3 polyunsaturated fatty acids, statins, metabolic modulators, and local biomaterial- or nanocarrier-based delivery systems. Accordingly, lipid metabolic reprogramming may provide a framework for developing metabolism-oriented adjunctive and regenerative strategies for periodontitis.<\/jats:p>","DOI":"10.3390\/biom16091334","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:10:23Z","timestamp":1789373423000},"page":"1334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid Metabolic Reprogramming in Periodontitis-Associated Alveolar Bone Remodeling: Mechanisms, Signaling Pathways, and Therapeutic Implications"],"prefix":"10.3390","volume":"16","author":[{"given":"Jinping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, 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Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, 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2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11914-023-00774-x","article-title":"Osteoimmunology in Periodontitis and Orthodontic Tooth Movement","volume":"21","author":"Alghamdi","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1042\/CS20201394","article-title":"Cholesterol metabolism: A new molecular switch to control inflammation","volume":"135","author":"Cardoso","year":"2021","journal-title":"Clin. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101122","DOI":"10.1016\/j.gendis.2023.101122","article-title":"The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism","volume":"11","author":"Zhang","year":"2024","journal-title":"Genes Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/jre.13242","article-title":"Lipotoxicity: The missing link between diabetes and periodontitis?","volume":"59","author":"Sun","year":"2024","journal-title":"J. Periodontal Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lee, C.-T., Li, R., Zhu, L., Tribble, G.D., Zheng, W.J., Ferguson, B., Maddipati, K.R., Angelov, N., and Van Dyke, T.E. (2021). Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.691216"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ma, W., Zou, Z., Yang, L., Lin, D., Guo, J., Shan, Z., Hu, Q., Wang, Z., Li, B., and Fang, J. (2024). Exploring the bi-directional relationship between periodontitis and dyslipidemia: A comprehensive systematic review and meta-analysis. BMC Oral Health, 24.","DOI":"10.1186\/s12903-023-03668-7"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1038\/s12276-023-01122-w","article-title":"Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss","volume":"55","author":"Tran","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/jcpe.14112","article-title":"LRP5 Down-Regulation Exacerbates Inflammation and Alveolar Bone Loss in Periodontitis by Inhibiting PI3K\/c-FOS Signalling","volume":"52","author":"Jiang","year":"2025","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"114434","DOI":"10.1016\/j.intimp.2025.114434","article-title":"The role of cellular lipid metabolism and lipid-lowering drugs in periodontitis","volume":"152","author":"Kiarashi","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e72141","DOI":"10.1096\/fj.202600558RRR","article-title":"Metabolic Reprogramming of Macrophages Plays a Dual Role in Periodontitis: From Pathogenesis to Therapy","volume":"40","author":"Chen","year":"2026","journal-title":"FASEB J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.2174\/0109298673323591240923051742","article-title":"Lipidomics in Periodontal Disease Research: A Systematic Review","volume":"32","author":"Silva","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41556-024-01364-4","article-title":"Lipid droplets and cellular lipid flux","volume":"26","author":"Mathiowetz","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41413-023-00297-2","article-title":"Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status","volume":"11","author":"Nandy","year":"2023","journal-title":"Bone Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/MCB.01343-14","article-title":"Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast","volume":"35","author":"Frey","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e92704","DOI":"10.1172\/jci.insight.92704","article-title":"Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner","volume":"2","author":"Kim","year":"2017","journal-title":"JCI Insight"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101113","DOI":"10.1016\/j.plipres.2021.101113","article-title":"Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism","volume":"83","author":"Abshirini","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1039\/D0FO00884B","article-title":"The opposite effects of Antarctic krill oil and arachidonic acid-rich oil on bone resorption in ovariectomized mice","volume":"11","author":"Zhan","year":"2020","journal-title":"Food Funct."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kishikawa, A., Kitaura, H., Kimura, K., Ogawa, S., Qi, J., Shen, W.R., Ohori, F., Noguchi, T., Marahleh, A., and Nara, Y. (2019). Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-\u03b1 Production in Macrophages and Directly Inhibiting Osteoclast Formation. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00157"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.33160\/yam.2018.03.002","article-title":"Resolvin E1 Inhibits Osteoclastogenesis and Bone Resorption by Suppressing IL-17-induced RANKL Expression in Osteoblasts and RANKL-induced Osteoclast Differentiation","volume":"61","author":"Funaki","year":"2018","journal-title":"Yonago Acta Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102326","DOI":"10.1016\/j.redox.2022.102326","article-title":"Fatty acids derived from apoptotic chondrocytes fuel macrophages FAO through MSR1 for facilitating BMSCs osteogenic differentiation","volume":"53","author":"Zheng","year":"2022","journal-title":"Redox Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"108337","DOI":"10.1016\/j.jnutbio.2019.108337","article-title":"Atherogenic diet-induced bone loss is primarily due to increased osteoclastogenesis in mice","volume":"79","author":"Sul","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-biochem-052521-040313","article-title":"The Inseparable Relationship Between Cholesterol and Hedgehog Signaling","volume":"92","author":"Siebold","year":"2023","journal-title":"Annu. Rev. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00018-023-04821-9","article-title":"Hedgehog signaling regulates bone homeostasis through orchestrating osteoclast differentiation and osteoclast-osteoblast coupling","volume":"80","author":"Lu","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Muruganandan, S., Ionescu, A.M., and Sinal, C.J. (2020). At the Crossroads of the Adipocyte and Osteoclast Differentiation Programs: Future Therapeutic Perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072277"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101322","DOI":"10.1016\/j.molmet.2021.101322","article-title":"Loss of chemerin triggers bone remodeling in vivo and in vitro","volume":"53","author":"Han","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Deepika, F., Bathina, S., and Armamento-Villareal, R. (2023). Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020644"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Franco-Trepat, E., Guill\u00e1n-Fresco, M., Alonso-P\u00e9rez, A., Jorge-Mora, A., Francisco, V., Gualillo, O., and G\u00f3mez, R. (2019). Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081178"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tariq, S., Tariq, S., Abualhamael, S.A., and Shahzad, M. (2022). Effect of Ibandronate Therapy on Serum Chemerin, Vaspin, Omentin-1 and Osteoprotegerin (OPG) in Postmenopausal Osteoporotic Females. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.822671"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3892\/mmr.2022.12648","article-title":"Omentin-1 induces osteoblast viability and differentiation via the TGF-\u03b2\/Smad signaling pathway in osteoporosis","volume":"25","author":"Tang","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Qi, T., Li, L., and Weidong, T. (2021). The Role of Sphingolipid Metabolism in Bone Remodeling. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.752540"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108453","DOI":"10.1016\/j.pharmthera.2023.108453","article-title":"Resolution of inflammation in oral diseases","volume":"247","author":"Eltay","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/jre.70148","article-title":"Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling","volume":"61","author":"Tetradis","year":"2026","journal-title":"J. Periodontal Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Schuldt, L., Reimann, M., von Brandenstein, K., Steinmetz, J., D\u00f6ding, A., Schulze-Sp\u00e4te, U., Jacobs, C., and Symmank, J. (2022). Palmitate-Triggered COX2\/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation. Cells, 11.","DOI":"10.20944\/preprints202201.0321.v1"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12944-018-0787-4","article-title":"Toll-like receptor 2 activation primes and upregulates osteoclastogenesis via lox-1","volume":"17","author":"Ohgi","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jre.13319","article-title":"Effects of oxidized LDL versus IL-1\u00df\/TNF-\u0251\/INF\u0263 on human gingival mesenchymal stem cells properties","volume":"60","author":"Mahlandt","year":"2025","journal-title":"J. Periodontal Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, C.T., and Tribble, G.D. (2023). Roles of specialized pro-resolving mediators and omega-3 polyunsaturated fatty acids in periodontal inflammation and impact on oral microbiota. Front. Oral Health, 4.","DOI":"10.3389\/froh.2023.1217088"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1002\/jcp.25029","article-title":"Possible Involvement of Palmitate in Pathogenesis of Periodontitis","volume":"230","author":"Shikama","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Varela-L\u00f3pez, A., Bull\u00f3n, P., Ram\u00edrez-Tortosa, C.L., Navarro-Hortal, M.D., Robles-Almaz\u00e1n, M., Bull\u00f3n, B., Cordero, M.D., Battino, M., and Quiles, J.L. (2020). A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease. Nutrients, 12.","DOI":"10.3390\/nu12051405"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41598-020-80748-6","article-title":"Fucoxanthin from microalgae Phaeodactylum tricornutum inhibits pro-inflammatory cytokines by regulating both NF-\u03baB and NLRP3 inflammasome activation","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e75157","DOI":"10.1002\/advs.75157","article-title":"Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3beta Dependent Ubiquitin-Mediated NRF2 Degradation","volume":"13","author":"Zhang","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/odi.14105","article-title":"High-fat diet-induced metabolic syndrome increases ligature-induced alveolar bone loss in mice","volume":"29","author":"Lu","year":"2023","journal-title":"Oral Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"104681","DOI":"10.1016\/j.archoralbio.2020.104681","article-title":"Palmitate induces apoptosis and inhibits osteogenic differentiation of human periodontal ligament stem cells","volume":"112","author":"Takeuchi","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e13411","DOI":"10.1111\/cpr.13411","article-title":"Long non-coding RNA AC018926.2 regulates palmitic acid exposure-compromised osteogenic potential of periodontal ligament stem cells via the ITGA2\/FAK\/AKT pathway","volume":"56","author":"Qu","year":"2023","journal-title":"Cell Prolif."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Hou, J., Xu, J., Liu, Y., Zhang, H., Wang, S., Jiao, Y., Guo, L., and Li, S. (2022). Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02255-6"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13287-017-0725-9","article-title":"Evaluating the oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol in periodontal regeneration using periodontal ligament stem cells and alveolar bone healing models","volume":"8","author":"Lee","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_48","first-page":"672","article-title":"Systematically transplanted human gingiva-derived mesenchymal stem cells regulate lipid metabolism and inflammation in hyperlipidemic mice with periodontitis","volume":"19","author":"Liu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103231","DOI":"10.1016\/j.mtbio.2026.103231","article-title":"Met@MPDA rejuvenates BMSC energy metabolism to promote bone regeneration in semaglutide-treated obese periodontitis","volume":"38","author":"Jiang","year":"2026","journal-title":"Mater. Today Bio"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/JPER.22-0306","article-title":"Characteristics of mesenchymal stem cells from supracrestal gingival connective tissue","volume":"94","author":"Srithanyarat","year":"2023","journal-title":"J. Periodontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6631905","DOI":"10.1155\/2021\/6631905","article-title":"Comparison of Osteogenic Differentiation Potential of Human Dental-Derived Stem Cells Isolated from Dental Pulp, Periodontal Ligament, Dental Follicle, and Alveolar Bone","volume":"2021","author":"Qu","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3674931","DOI":"10.1155\/2022\/3674931","article-title":"Energy Metabolism and Lipidome Are Highly Regulated during Osteogenic Differentiation of Dental Follicle Cells","volume":"2022","author":"Pieles","year":"2022","journal-title":"Stem Cells Int."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Santilli, F., Fabrizi, J., Martellucci, S., Santacroce, C., Iorio, E., Pisanu, M.E., Chirico, M., Lancia, L., Pulcini, F., and Manganelli, V. (2023). Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs). Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1274462"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Yuan, H., Suzuki, S., Hirata-Tsuchiya, S., Sato, A., Nemoto, E., Saito, M., Shiba, H., and Yamada, S. (2021). PPAR\u03b3-Induced Global H3K27 Acetylation Maintains Osteo\/Cementogenic Abilities of Periodontal Ligament Fibroblasts. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168646"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105162","DOI":"10.1016\/j.archoralbio.2021.105162","article-title":"The platelet derived growth factor BB promotes osteogenic differentiation of periodontal ligament stem cells via the Wnt\/\u03b2-catenin signaling pathway","volume":"129","author":"Deng","year":"2021","journal-title":"Arch. Oral Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jcpe.12891","article-title":"Peroxisome proliferator-activated receptor \u03b3 plays dual roles on experimental periodontitis in rats","volume":"45","author":"Qiao","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wu, Y., Wang, X., Zhang, Y., Wen, Z., Li, Y., Zhang, K., Gosar, N., Li, Q., Mao, J., and Gong, S. (2024). Proanthocyanidins Ameliorate LPS-Inhibited Osteogenesis of PDLSCs by Restoring Lysine Lactylation. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052947"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/00220345241286490","article-title":"Wnt\/\u03b2-catenin Promotes Cementum Apposition in Periodontal Regeneration","volume":"104","author":"Ono","year":"2025","journal-title":"J. Dent. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.identj.2025.02.012","article-title":"Serum Starvation Regulates Autophagy of Human Periodontal Ligament Cells Through Reactive Oxygen Species Mediated Adenosine Monophosphate-Activated Protein Kinase\/Mechanistic Target of RAPAMYCIN Axis","volume":"75","author":"Wei","year":"2025","journal-title":"Int. Dent. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"116444","DOI":"10.1016\/j.bone.2022.116444","article-title":"Lactate inhibits osteogenic differentiation of human periodontal ligament stem cells via autophagy through the MCT1-mTOR signaling pathway","volume":"162","author":"Luo","year":"2022","journal-title":"Bone"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.gendis.2021.06.003","article-title":"Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis","volume":"10","author":"Sun","year":"2023","journal-title":"Genes Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"13329","DOI":"10.1038\/s41598-020-70277-7","article-title":"NOTCH2 participates in Jagged1-induced osteogenic differentiation in human periodontal ligament cells","volume":"10","author":"Manokawinchoke","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/jre.12357","article-title":"Jagged1 inhibits osteoprotegerin expression by human periodontal ligament cells","volume":"51","author":"Manokawinchoke","year":"2016","journal-title":"J. Periodontal Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/stem.3245","article-title":"Canonical Notch signaling is required for bone morphogenetic protein-mediated human osteoblast differentiation","volume":"38","author":"Wagley","year":"2020","journal-title":"Stem Cells"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/JPER.20-0517","article-title":"NELL1 augments osteogenesis and inhibits inflammation of human periodontal ligament stem cells induced by BMP9","volume":"93","author":"Wang","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.7150\/ijms.56151","article-title":"Leptin regulates OPG and RANKL expression in Gingival Fibroblasts and Tissues of Chronic Periodontitis Patients","volume":"18","author":"Guo","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/jbmr\/zjae036","article-title":"Leptin receptor (+) stromal cells respond to periodontitis and attenuate alveolar bone repair via CCRL2-mediated Wnt inhibition","volume":"39","author":"Chen","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"116259","DOI":"10.1016\/j.intimp.2026.116259","article-title":"High-cholesterol-load-triggered pyroptosis of gingival fibroblasts promotes periodontitis","volume":"174","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/jcpe.13710","article-title":"Lipidomic analysis reveals altered lipid profiles of gingival tissues with periodontitis","volume":"49","author":"Zhou","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6014706","DOI":"10.1155\/2023\/6014706","article-title":"Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis","volume":"2023","author":"Mohideen","year":"2023","journal-title":"Int. J. Dent."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7407","DOI":"10.1007\/s00784-023-05330-6","article-title":"Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis","volume":"27","author":"Cekici","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/bph.16009","article-title":"Soluble epoxide hydrolase inhibition enhances production of specialized pro-resolving lipid mediator and promotes macrophage plasticity","volume":"180","author":"Abdalla","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4049\/jimmunol.2300650","article-title":"Modulating the sEH\/EETs Axis Restrains Specialized Proresolving Mediator Impairment and Regulates T Cell Imbalance in Experimental Periodontitis","volume":"212","author":"Abdalla","year":"2024","journal-title":"J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1111\/jcpe.13555","article-title":"Associations between metabolic biomarkers and localized stage II\/III periodontitis in young adults: The CHIEF Oral Health study","volume":"48","author":"Tsai","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s40200-022-01071-7","article-title":"Association of periodontitis with lipid profile: An updated systematic review and meta-analysis","volume":"21","author":"Mirzaei","year":"2022","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"101584","DOI":"10.1016\/j.diabet.2024.101584","article-title":"Periodontitis adversely affects lipoprotein subfractions-results from the cohort study SHIP-TREND: Periodontitis adversely affects lipoprotein subfractions","volume":"50","author":"Basdorf","year":"2024","journal-title":"Diabetes Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/jcpe.13554","article-title":"Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review","volume":"49","author":"Orlandi","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Chen, Z., Song, J., and Tang, L. (2023). Investigation on the association between serum lipid levels and periodontitis: A bidirectional Mendelian randomization analysis. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03575-x"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Kim, C.M., Lee, S., Hwang, W., Son, E., Kim, T.W., Kim, K., and Kim, Y.H. (2022). Obesity and periodontitis: A systematic review and updated meta-analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.999455"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/jcpe.13881","article-title":"Periodontitis and the incidence of metabolic syndrome: An 8-year longitudinal study of an adult Japanese cohort","volume":"51","author":"Saito","year":"2024","journal-title":"J. Clin. Periodontol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/jcpe.13807","article-title":"Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe)","volume":"50","author":"Herrera","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1177\/00220345211008811","article-title":"Periodontal Pathogens Promote Foam Cell Formation by Blocking Lipid Efflux","volume":"100","author":"Rho","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jare.2023.04.007","article-title":"The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT\/MAPK\/NF-kappaB pathways","volume":"57","author":"Shen","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/jre.12951","article-title":"Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss","volume":"57","author":"Li","year":"2022","journal-title":"J. Periodontal Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/JLB.1HI0620-230R","article-title":"Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection","volume":"108","author":"Zhao","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/omi.12447","article-title":"Activation of liver X receptors suppresses the abundance and osteoclastogenic potential of osteoclast precursors and periodontal bone loss","volume":"39","author":"Zhao","year":"2024","journal-title":"Mol. Oral Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14239","DOI":"10.1038\/s41598-022-18412-4","article-title":"Effects of extracellular vesicles derived from oral bacteria on osteoclast differentiation and activation","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2499284","DOI":"10.1080\/20002297.2025.2499284","article-title":"Patients with periodontitis exhibit persistent dysbiosis of the gut microbiota and distinct serum metabolome","volume":"17","author":"Miyauchi","year":"2025","journal-title":"J. Oral Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"18398","DOI":"10.1038\/s41598-021-97868-2","article-title":"Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model","volume":"11","author":"Kashiwagi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1177\/00220345211009449","article-title":"Gut Microbiota May Mediate the Influence of Periodontitis on Prediabetes","volume":"100","author":"Li","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/jcpe.13708","article-title":"Periodontitis may impair the homeostasis of systemic bone through regulation of gut microbiota in ApoE\u2212\/\u2212 mice","volume":"49","author":"Li","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41368-022-00212-1","article-title":"Systemic antibiotics increase microbiota pathogenicity and oral bone loss","volume":"15","author":"Yuan","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Hatanaka, K., Shirahase, Y., Yoshida, T., Kono, M., Toya, N., Sakasegawa, S.I., Konishi, K., Yamamoto, T., Ochiai, K., and Takashiba, S. (2022). Enzymatic measurement of short-chain fatty acids and application in periodontal disease diagnosis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0268671"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jds.2022.08.034","article-title":"Butyrate-treatment induces gingival epithelial cell death in a three-dimensional gingival-connective tissue hybrid co-culture system","volume":"18","author":"Kurosawa","year":"2023","journal-title":"J. Dent. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1038\/s41598-025-91105-w","article-title":"Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression","volume":"15","author":"Ishihara","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.42765","article-title":"Mitigation of Osteoclast-Mediated Arthritic Bone Remodeling By Short Chain Fatty Acids","volume":"76","author":"Yang","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1080\/09637486.2022.2078285","article-title":"Short-chain fatty acids, acetate and propionate, directly upregulate osteoblastic differentiation","volume":"73","author":"Kondo","year":"2022","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e71428","DOI":"10.1096\/fj.202504201R","article-title":"Butyrate Alleviates Diabetic Periodontitis by Suppressing Macrophage M1 Polarization and PANoptosis-Like Cell Death","volume":"40","author":"Yang","year":"2026","journal-title":"FASEB J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/JPER.21-0708","article-title":"Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: A randomized clinical trial","volume":"93","author":"Killeen","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2162159","DOI":"10.1080\/10717544.2022.2162159","article-title":"Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: Statistical optimization and clinical assessment","volume":"30","author":"Elgendy","year":"2023","journal-title":"Drug Deliv."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1600-051X.2010.01619.x","article-title":"Effect of atorvastatin on chronic periodontitis: A randomized pilot study","volume":"37","author":"Fajardo","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.36740\/WLek202407104","article-title":"Index assessment of periodontal status in patients on the background of administering a drug with circadian activity","volume":"77","author":"Vasko","year":"2024","journal-title":"Wiad. Lek."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e29393","DOI":"10.1097\/MD.0000000000029393","article-title":"Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis","volume":"101","author":"Zhang","year":"2022","journal-title":"Medicine"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Nikniaz, S., Vaziri, F., and Mansouri, R. (2023). Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: A randomized clinical trail. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-02877-4"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jcpe.13576","article-title":"Effect of the Mediterranean diet on gingivitis: A randomized controlled trial","volume":"49","author":"Bartha","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Maybodi, F.R., Fakhari, M., and Tavakoli, F. (2022). Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in periodontitis patients: A randomized clinical trial. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02569-5"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/jre.12984","article-title":"Does the use of omega-3 fatty acids as an adjunct to non-surgical periodontal therapy provide additional benefits in the treatment of periodontitis? A systematic review and meta-analysis","volume":"57","author":"Furukawa","year":"2022","journal-title":"J. Periodontal Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s00784-023-04870-1","article-title":"Bifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: A randomized controlled clinical trial","volume":"27","author":"Kuru","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Thierbach, R., Eigenmann, A., Naim, J., Hannig, M., Rupf, S., and Gund, M.P. (2024). L. reuteri in Supportive Periodontal Therapy-Are There Already Clinical Effects after 3 Months with One Lozenge a Day? A Double-Blind Randomized Placebo-Controlled Study. Microorganisms, 12.","DOI":"10.3390\/microorganisms12040648"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhou, L.N., Zhang, Z., and Wang, Z.T. (2026). Therapeutic potential of low-dose rosiglitazone in periodontitis: Attenuation of inflammation and bone loss through macrophage reprogramming. BMC Oral Health, 26.","DOI":"10.1186\/s12903-026-08251-4"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"167333","DOI":"10.1016\/j.bbadis.2024.167333","article-title":"FoxO1-modulated macrophage polarization regulates osteogenesis via PPAR-\u03b3 signaling","volume":"1870","author":"Wang","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Mohammad, C.A., Ali, K.M., Al-Rawi, R.A., and Gul, S.S. (2022). Effects of Curcumin and Tetracycline Gel on Experimental Induced Periodontitis as an Anti-Inflammatory, Osteogenesis Promoter and Enhanced Bone Density through Altered Iron Levels: Histopathological Study. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040521"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jcpe.13751","article-title":"Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a Porphyromonas gingivalis inoculation model","volume":"50","author":"Nachtsheim","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.actbio.2025.05.034","article-title":"A Chitosan-based Hydrogel to Modulate Immune Cells and Promote Periodontitis Healing in the High-Fat Diet-induced Periodontitis Rat Model","volume":"200","author":"Zhu","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1021\/acs.molpharmaceut.0c01196","article-title":"Thermoresponsive Hydrogel-Based Local Delivery of Simvastatin for the Treatment of Periodontitis","volume":"18","author":"Chen","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1021\/acs.molpharmaceut.3c00508","article-title":"The Development of Thermoresponsive Polymeric Simvastatin Prodrug for the Treatment of Experimental Periodontitis in Rats","volume":"20","author":"Xu","year":"2023","journal-title":"Mol. Pharm."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"24182","DOI":"10.1021\/acsnano.4c05558","article-title":"Hierarchical Chitin Nanocrystal-Based 3D Printed Dual-Layer Membranes Hydrogels: A Dual Drug Delivery Nano-Platform for Periodontal Tissue Regeneration","volume":"18","author":"Moon","year":"2024","journal-title":"ACS Nano"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ijbiomac.2020.04.183","article-title":"Core-Shell poly-(D,l-Lactide-co-Glycolide)-chitosan Nanospheres with simvastatin-doxycycline for periodontal and osseous repair","volume":"158","author":"Chang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Sun, L., Du, X., Kuang, H., Sun, H., Luo, W., and Yang, C. (2023). Stem cell-based therapy in periodontal regeneration: A systematic review and meta-analysis of clinical studies. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03186-6"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1177\/00220345221090879","article-title":"Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3","volume":"101","author":"Rakian","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"580","DOI":"10.21037\/atm-22-2207","article-title":"Peroxisome proliferator-activated receptor gamma preserves intracellular homeostasis of insulin-resistant periodontal ligament stem cells","volume":"10","author":"Qian","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/s41467-022-29633-6","article-title":"CHD7 regulates bone-fat balance by suppressing PPAR-\u03b3 signaling","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/9\/1334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:20:09Z","timestamp":1789532409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/9\/1334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":122,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["biom16091334"],"URL":"https:\/\/doi.org\/10.3390\/biom16091334","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}