{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:06:40Z","timestamp":1789499200833,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Telomeres (chromosome-end nucleoprotein complexes) are prone to replication fork stalling because of their G-rich repetitive sequences, G-quadruplexes, t-loops, oxidative lesions, and telomeric R-loops generated when telomeric repeat-containing RNA (TERRA) hybridizes with telomeric DNA. In this review, we will summarize how telomeres are replicated and maintained and the mechanisms by which replication stress occurs at telomeres. Subsequently, we will review the role of POT1 mutations in cancer development and pathology and discuss therapeutic strategies targeting telomere biology in cancer.<\/jats:p>","DOI":"10.3390\/biom16091344","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:23:53Z","timestamp":1789496633000},"page":"1344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond End Protection: Shelterin, POT1 Dysfunction, and Telomere Replication Stress in Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Tadahiko","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Hematology, Graduate School of Medicine, Kyoto University, Kyoto 606-8303, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-4284","authenticated-orcid":false,"given":"Akifumi","family":"Takaori-Kondo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Graduate School of Medicine, Kyoto University, Kyoto 606-8303, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/350569a0","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn","year":"1991","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-genet-032918-021921","article-title":"Shelterin-Mediated Telomere Protection","volume":"52","year":"2018","journal-title":"Annu. 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