{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:08:29Z","timestamp":1789549709476,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["962344"],"award-info":[{"award-number":["962344"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"award":["962344"],"award-info":[{"award-number":["962344"]}],"id":[{"id":"https:\/\/ror.org\/01frxsf98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting with altered iron homeostasis and dysregulated lipid metabolism. Insulin resistance and obesity are common in DMD, but their impact on disease progression, particularly during glucocorticoid (GC) treatment, remains unclear. The role of ferroptosis, iron-dependent cell death, in DMD muscle pathology remains uncertain. We hypothesized that ferroptotic signaling would increase in mdx skeletal muscle, be further exacerbated by a high-fat, high-sucrose diet (HFHSD), and be attenuated by GC treatment. Male C57 and mdx mice were fed a control diet or HFHSD, with or without prednisolone, for 19 weeks before diaphragm western blot analysis. Dystrophic diaphragms had an increased abundance of transferrin (131%, p = 0.0006), transferrin receptor (72%, p = 0.0041), ferritin heavy chain (281%, p &lt; 0.0001), acyl-CoA synthetase long-chain family member 4 (36%, p = 0.0080), and 5-lipoxygenase (101%, p = 0.0016) compared with C57. Despite these pro-ferroptotic changes, malondialdehyde and 4-hydroxynonenal were unchanged. Glutathione peroxidase 4 was robustly increased (800%, p &lt; 0.0001), suggesting maintenance of redox balance and suppression of ferroptotic death. The HFHSD did not exacerbate ferroptotic signaling, whereas GC treatment partially offset disease-related changes in iron-handling and antioxidant proteins. These findings indicate that dystrophic diaphragms experience ferroptotic stress that is actively constrained, likely by compensatory GPX4 changes.<\/jats:p>","DOI":"10.3390\/biom16091347","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:58:59Z","timestamp":1789545539000},"page":"1347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dystrophin Deficiency Creates a Pro-Ferroptotic Environment in Diaphragm of mdx Mice That Is Modified by Diet and Glucocorticoid Treatment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0242-7687","authenticated-orcid":false,"given":"Morgan E.","family":"Vorwald","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University, 806 Stange Rd., Kildee Hall, Ames, IA 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-9130","authenticated-orcid":false,"given":"Melissa","family":"Roths","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, 806 Stange Rd., Kildee Hall, Ames, IA 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-6615","authenticated-orcid":false,"given":"Rudy J.","family":"Valentine","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Kinesiology, University of Massachusetts Lowell, 114 Wilder Street, Suite 300, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-7539","authenticated-orcid":false,"given":"Joshua T.","family":"Selsby","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, 806 Stange Rd., Kildee Hall, Ames, IA 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-021-00248-3","article-title":"Duchenne muscular dystrophy","volume":"7","author":"Duan","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Angulski, A., Hosny, N., Cohen, H., Martin, A., Hahn, D., Bauer, J., and Metzger, J. (2023). Duchenne muscular dystrophy: Disease mechanism and therapeutic strategies. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1183101"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mareedu, S., Million, E.D., Duan, D., and Babu, G.J. (2021). Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.647010"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/jcsm.12950","article-title":"Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy","volume":"13","author":"Alves","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/cvr\/cvad182","article-title":"Dysregulated iron homeostasis in dystrophin-deficient cardiomyocytes: Correction by gene editing and pharmacological treatment","volume":"120","author":"Andrysiak","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2353\/ajpath.2006.050673","article-title":"Lipid Peroxidation Inhibition Blunts Nuclear Factor-\u03baB Activation, Reduces Skeletal Muscle Degeneration, and Enhances Muscle Function in mdx Mice","volume":"168","author":"Messina","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mosca, N., Petrillo, S., Bortolani, S., Monforte, M., Ricci, E., Piemonte, F., and Tasca, G. (2021). Redox Homeostasis in Muscular Dystrophies. Cells, 10.","DOI":"10.3390\/cells10061364"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of Ferroptotic Cancer Cell Death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lee, J.-Y., Kim, W.K., Bae, K.-H., Lee, S.C., and Lee, E.-W. (2021). Lipid Metabolism and Ferroptosis. Biology, 10.","DOI":"10.3390\/biology10030184"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12\/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"ref_16","first-page":"1","article-title":"Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and\/or pathological conditions","volume":"157","year":"2009","journal-title":"Chem. Phys. Lipids"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1249\/JES.0000000000000328","article-title":"The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance","volume":"52","author":"Krishna","year":"2024","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"R692","DOI":"10.1152\/ajpregu.00246.2022","article-title":"A fat- and sucrose-enriched diet causes metabolic alterations in mdx mice","volume":"325","author":"Krishna","year":"2023","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_20","first-page":"867273","article-title":"Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy","volume":"2015","author":"Sanchez","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wernio, E., Wasilewska, E., Czaja-Stolc, S., \u015aledzi\u0144ska, K., Wierzba, J., Szlagatys-Sidorkiewicz, A., and Ma\u0142gorzewicz, S. (2024). Nutritional Issues among Children with Duchenne Muscular Dystrophy\u2014Incidence of Deficiency and Excess Body Mass. Nutrients, 16.","DOI":"10.3390\/nu16132143"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Billich, N., Adams, J., Carroll, K., Truby, H., Evans, M., Ryan, M.M., and Davidson, Z.E. (2022). The Relationship between Obesity and Clinical Outcomes in Young People with Duchenne Muscular Dystrophy. Nutrients, 14.","DOI":"10.3390\/nu14163304"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13023-021-01758-9","article-title":"Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: Can we do better?","volume":"16","author":"Kourakis","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1172\/JCI91445","article-title":"Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy","volume":"127","author":"Quattrocelli","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pakiet, A., Jakubiak, A., Mierzejewska, P., Zwara, A., Liakh, I., Sledzinski, T., and Mika, A. (2020). The Effect of a High-Fat Diet on the Fatty Acid Composition in the Hearts of Mice. Nutrients, 12.","DOI":"10.3390\/nu12030824"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jiang, J.-J., Zhang, G.-F., Zheng, J.-Y., Sun, J.-H., and Ding, S.-B. (2022). Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.876550"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.nut.2017.07.007","article-title":"Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues","volume":"45","author":"Valenzuela","year":"2018","journal-title":"Nutrition"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1210\/me.2008-0464","article-title":"Direct Effect of Glucocorticoids on Lipolysis in Adipocytes","volume":"23","author":"Xu","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.metabol.2011.06.012","article-title":"The effects of glucocorticoids on adipose tissue lipid metabolism","volume":"60","author":"Peckett","year":"2011","journal-title":"Metabolism"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/EC9.0000000000000148","article-title":"Glucocorticoid triggers endothelial cell ferroptosis via NOX4-mediated reactive oxygen species and lipid peroxidation","volume":"5","author":"Fang","year":"2025","journal-title":"Emerg. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Jeong, J.-Y., Son, Y., Kim, Y., Lee, N., Kim, Y., Heo, Y.J., Choi, S.-E., Choi, J., Han, S.J., and Jeon, J. (2025). Deferoxamine prevents dexamethasone-induced muscle atrophy by reducing MuRF1 and atrogin-1. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1582216"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1001\/jama.2022.4315","article-title":"Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Duchenne Muscular Dystrophy","volume":"327","author":"Guglieri","year":"2022","journal-title":"JAMA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"P451","DOI":"10.1016\/S0140-6736(17)32160-8","article-title":"Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: A prospective cohort study","volume":"391","author":"McDonald","year":"2018","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fefelova, N., Pamarthi, S.H., Mareedu, S., Ivessa, A., Fraidenraich, D., Babu, G.J., Gwathmey, J.K., and Xie, L.-H. (2026). Potential Involvement of Ferroptosis in Duchenne Muscular Dystrophy-Associated Cardiomyopathy. Biomedicines, 14.","DOI":"10.3390\/biomedicines14020472"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1113\/JP289832","article-title":"A high-fat, high-sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin-deficient mice","volume":"604","author":"Vorwald","year":"2026","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.3168\/jds.2022-22678","article-title":"Effects of heat stress on markers of skeletal muscle proteolysis in dairy cattle","volume":"106","author":"Roths","year":"2023","journal-title":"J. Dairy Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/bj2880591","article-title":"Evidence of H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin","volume":"288","author":"Levi","year":"1992","journal-title":"Biochem. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0968-0004(83)90217-7","article-title":"Iron uptake and utilization by mammalian cells. I: Cellular uptake of transferrin and iron","volume":"8","author":"Octave","year":"1983","journal-title":"Trends Biochem. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1007\/s00394-022-02940-w","article-title":"Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells","volume":"61","author":"Shan","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101947","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer\u2019s diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Endale, H.T., Tesfaye, W., and Mengstie, T.A. (2023). ROS induced lipid peroxidation and their role in ferroptosis. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1226044"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.nmd.2018.03.008","article-title":"High urinary ferritin reflects myoglobin iron evacuation in DMD patients","volume":"28","author":"Rouillon","year":"2018","journal-title":"Neuromuscul. Disord."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s11064-011-0683-z","article-title":"Oxidative Damage in Muscular Dystrophy Correlates with the Severity of the Pathology: Role of Glutathione Metabolism","volume":"37","author":"Renjini","year":"2012","journal-title":"Neurochem. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12011-015-0290-y","article-title":"Reduction of Oxidative Damage and Inflammatory Response in the Diaphragm Muscle of mdx Mice Using Iron Chelator Deferoxamine","volume":"167","author":"Moraes","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_47","first-page":"e70180","article-title":"Gene editing restores full-length dystrophin and affects iron homeostasis in hiPSC-derived cardiomyocytes from Becker Muscular Dystrophy patients","volume":"17","author":"Kwiatkowska","year":"2026","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Gozzelino, R., and Arosio, P. (2016). Iron Homeostasis in Health and Disease. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010130"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1039\/C4MT00164H","article-title":"Iron regulatory proteins and their role in controlling iron metabolism","volume":"7","year":"2015","journal-title":"Metallomics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1186\/s12967-026-08407-4","article-title":"Bacteroides-derived endocannabinoid-like commendamide attenuates skeletal muscle ferroptosis in vitro: Implications for Duchenne muscular dystrophy","volume":"24","author":"Panza","year":"2026","journal-title":"J. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jcsm.12405","article-title":"Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2O2 emission during impaired oxidative phosphorylation","volume":"10","author":"Hughes","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1113\/expphysiol.2010.054379","article-title":"Increased catalase expression improves muscle function in mdx mice","volume":"96","author":"Selsby","year":"2011","journal-title":"Exp. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e02523","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine\u2013glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1800311","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0024-3205(97)00193-8","article-title":"Induction of antioxidant enzymes by dexamethasone in the adult rat lung","volume":"60","author":"Berenice","year":"1997","journal-title":"Life Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/mus.20036","article-title":"Oxidative stress\u2013associated mitochondrial dysfunction in corticosteroid-treated muscle cells","volume":"30","author":"Oshima","year":"2004","journal-title":"Muscle Nerve"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41594-024-01329-z","article-title":"PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis","volume":"31","author":"Fujita","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.redox.2017.08.008","article-title":"Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes","volume":"14","author":"Fisher","year":"2018","journal-title":"Redox Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1016\/j.molcel.2025.11.023","article-title":"Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression","volume":"85","author":"Hu","year":"2025","journal-title":"Mol. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1158\/0008-5472.CAN-24-4207","article-title":"Lipid Composition Alters Ferroptosis Sensitivity","volume":"85","author":"Park","year":"2025","journal-title":"Cancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kratschmar, D.V., Calabrese, D., Walsh, J., Lister, A., Birk, J., Appenzeller-Herzog, C., Moulin, P., Goldring, C.E., and Odermatt, A. (2012). Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11\u03b2-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036774"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"108873","DOI":"10.1016\/j.abb.2021.108873","article-title":"Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes","volume":"704","author":"Ulla","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/352536a0","article-title":"The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy","volume":"352","author":"Stedman","year":"1991","journal-title":"Nature"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/9\/1347\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:44:25Z","timestamp":1789548265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/9\/1347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":66,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["biom16091347"],"URL":"https:\/\/doi.org\/10.3390\/biom16091347","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}