{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:30:38Z","timestamp":1791232238831,"version":"4.1.0"},"reference-count":176,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs in the human body. Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ethanol alters expression of a wide variety of microRNAs that can regulate alcohol-induced complications or dysfunctions. In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal epithelial barrier dysfunction, and brain damage including altered hippocampus structure and function, and neuronal loss, alcoholic cardiomyopathy, and muscle damage. Further, we have reviewed the role of altered microRNAs in the circulation, teratogenic effects of alcohol, and during maternal or paternal alcohol consumption.<\/jats:p>","DOI":"10.3390\/biom5043309","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T01:57:02Z","timestamp":1448330222000},"page":"3309-3338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Role of microRNAs in Alcohol-Induced Multi-Organ Injury"],"prefix":"10.3390","volume":"5","author":[{"given":"Sathish","family":"Natarajan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Pachunka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Mott","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature05983","article-title":"Intronic microRNA precursors that bypass drosha processing","volume":"448","author":"Ruby","year":"2007","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1261\/rna.5167604","article-title":"Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs","volume":"10","author":"Bohnsack","year":"2004","journal-title":"RNA"},{"key":"ref_4","unstructured":"Natarajan, S.K., Rasineni, K., Ganesan, M., Feng, D., McVicker, B.L., McNiven, M.A., Osna, N.A., Mott, J.L., Casey, C.A., and Kharbanda, K.K. (2015). Structure, function and metabolism of hepatic and adipose tissue lipid droplets: Implications in alcoholic liver disease. Curr. Mol. Pharmacol., in press."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1530-0277.2009.01126.x","article-title":"Micrornas: Master regulators of ethanol abuse and toxicity?","volume":"34","author":"Miranda","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-94-007-5881-0_6","article-title":"Cyp2e1-catalyzed alcohol metabolism: Role of oxidant generation in interferon signaling, antigen presentation and autophagy","volume":"67","author":"Osna","year":"2013","journal-title":"Subcell. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"G65","DOI":"10.1152\/ajpgi.00419.2001","article-title":"Alcoholic pancreatitis in rats: Injury from nonoxidative metabolites of ethanol","volume":"283","author":"Werner","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.pan.2015.02.009","article-title":"The role of fat and alcohol in acute pancreatitis: A dangerous liaison","volume":"15","author":"Criddle","year":"2015","journal-title":"Pancreatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1136\/gutjnl-2012-304058","article-title":"Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis","volume":"63","author":"Huang","year":"2014","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/clinchem\/43.8.1527","article-title":"Fatty acid ethyl esters: Short-term and long-term serum markers of ethanol intake","volume":"43","author":"Laposata","year":"1997","journal-title":"Clin. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/alcalc\/agh005","article-title":"Concentration of fatty acid ethyl esters in hair of alcoholics: Comparison to other biological state markers and self reported-ethanol intake","volume":"39","author":"Wurst","year":"2004","journal-title":"Alcohol. Alcohol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e58561","DOI":"10.1371\/journal.pone.0058561","article-title":"Fatty acid ethyl esters induce intestinal epithelial barrier dysfunction via a reactive oxygen species-dependent mechanism in a three-dimensional cell culture model","volume":"8","author":"Elamin","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_13","first-page":"52","article-title":"Inhibition of pancreatic stellate cell activation by lisinopril for prevention fibrogenesis in experimental chronic alcoholic pancreatitis","volume":"7","author":"Nichitailo","year":"2012","journal-title":"Klin. khirurhiia"},{"key":"ref_14","first-page":"376","article-title":"Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas","volume":"13","author":"Cyriac","year":"2012","journal-title":"JOP"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00006676-200311000-00008","article-title":"Stellate cell activation in alcoholic pancreatitis","volume":"27","author":"Apte","year":"2003","journal-title":"Pancreas"},{"key":"ref_16","first-page":"48","article-title":"Role of alcohol metabolism in chronic pancreatitis","volume":"30","author":"Vonlaufen","year":"2007","journal-title":"Alcohol. Res. Health"},{"key":"ref_17","first-page":"2060","article-title":"Pancreatic fibrosis in patients with chronic alcohol abuse: Correlation with alcoholic pancreatitis","volume":"89","author":"Suda","year":"1994","journal-title":"Am. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12079-014-0220-3","article-title":"Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes","volume":"8","author":"Charrier","year":"2014","journal-title":"J. Cell Commun. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/labinvest.2010.82","article-title":"Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis","volume":"90","author":"Charrier","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/hep.26768","article-title":"Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells","volume":"59","author":"Chen","year":"2014","journal-title":"Hepatology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1093\/nar\/gkq601","article-title":"Export of microRNAs and microRNA-protective protein by mammalian cells","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1093\/nar\/gkr254","article-title":"Characterization of extracellular circulating microrna","volume":"39","author":"Turchinovich","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4161\/rna.21083","article-title":"Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma","volume":"9","author":"Turchinovich","year":"2012","journal-title":"RNA Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-62703-453-1_8","article-title":"Isolation of circulating microRNA associated with RNA-binding protein","volume":"1024","author":"Turchinovich","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/hep.25873","article-title":"Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases","volume":"56","author":"Bala","year":"2012","journal-title":"Hepatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/gutjnl-2014-306996","article-title":"Circulating microRNA signature in non-alcoholic fatty liver disease: From serum non-coding rnas to liver histology and disease pathogenesis","volume":"64","author":"Pirola","year":"2015","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/liv.12196","article-title":"Circulating microRNAs as potential biomarkers for alcoholic steatohepatitis","volume":"33","author":"Chen","year":"2013","journal-title":"Liver Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1158\/1940-6207.CAPR-11-0370","article-title":"Blood cell origin of circulating microRNAs: A cautionary note for cancer biomarker studies","volume":"5","author":"Pritchard","year":"2012","journal-title":"Cancer Prev. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000356447","article-title":"MicroRNA function in human diseases","volume":"1","author":"Natarajan","year":"2013","journal-title":"Med. Epigenetics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCRESAHA.111.300539","article-title":"Circulating microRNAs as novel biomarkers for platelet activation","volume":"112","author":"Willeit","year":"2013","journal-title":"Circ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1161\/CIRCRESAHA.113.300859","article-title":"Platelet microRNAs: Novy Mir* or mired in human complexity?","volume":"112","author":"Curtis","year":"2013","journal-title":"Circ. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1097\/01.alc.0000183011.86768.61","article-title":"Alcohol consumption and platelet activation and aggregation among women and men: The framingham offspring study","volume":"29","author":"Mukamal","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"38333","DOI":"10.1074\/jbc.M304566200","article-title":"Chronic ethanol exposure increases the binding of hur to the tnfalpha 3'-untranslated region in macrophages","volume":"278","author":"McMullen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1365-2249.2012.04609.x","article-title":"Hepatic expression of CCL2 in alcoholic liver disease is associated with disease severity and neutrophil infiltrates","volume":"169","author":"Degre","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","article-title":"The interleukin-17 pathway is involved in human alcoholic liver disease","volume":"49","author":"Lemmers","year":"2009","journal-title":"Hepatology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-0034-1397347","article-title":"MicroRNAs in alcoholic liver disease","volume":"35","author":"Szabo","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Momen-Heravi, F., Bala, S., Kodys, K., and Szabo, G. (2015). Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Sci. Rep.","DOI":"10.1038\/srep09991"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/jn\/119.3.416","article-title":"Vitamin B-12 and folate function in chronic alcoholic men with peripheral neuropathy and encephalopathy","volume":"119","author":"Gimsing","year":"1989","journal-title":"J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/alcalc\/agq098","article-title":"Vitamin D and nutritional status are related to bone fractures in alcoholics","volume":"46","year":"2011","journal-title":"Alcohol. Alcohol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4321\/S1130-01082013001000006","article-title":"Alcoholic liver disease and changes in bone mineral density","volume":"105","author":"Lucendo","year":"2013","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1530-0277.2008.00847.x","article-title":"Low bone mineral density and impaired bone metabolism in young alcoholic patients without liver cirrhosis: A cross-sectional study","volume":"33","author":"Malik","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1530-0277.1999.tb04126.x","article-title":"Ethanol and acetaldehyde inhibit the formation of early osteoblast progenitors in murine and human bone marrow cultures","volume":"23","author":"Giuliani","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/acer.12366","article-title":"Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cortical bone microarchitecture in adult male rats","volume":"38","author":"Johnson","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1111\/j.1572-0241.2008.01993.x","article-title":"Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis","volume":"103","author":"Pai","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1089\/scd.2011.0074","article-title":"Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis","volume":"20","author":"Saito","year":"2011","journal-title":"Stem Cells Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e53719","DOI":"10.1371\/journal.pone.0053719","article-title":"Autologous bone marrow mononuclear cell transplantation in patients with decompensated alcoholic liver disease: A randomized controlled trial","volume":"8","author":"Spahr","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4254\/wjh.v7.i9.1258","article-title":"Bone changes in alcoholic liver disease","volume":"7","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1080\/15476286.2014.996462","article-title":"The role of microRNAs in osteoclasts and osteoporosis","volume":"11","author":"Tang","year":"2014","journal-title":"RNA Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2015.05.027","article-title":"Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation","volume":"79","author":"Weilner","year":"2015","journal-title":"Bone"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/jcmm.12223","article-title":"The functional role of microRNAs in alcoholic liver injury","volume":"18","author":"McDaniel","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.jhep.2014.07.017","article-title":"Circulating microRNAs as markers of liver inflammation, fibrosis and cancer","volume":"61","author":"Roderburg","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Marabita, F., de Candia, P., Torri, A., Tegner, J., Abrignani, S., and Rossi, R.L. (2015). Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR. Brief. Bioinform.","DOI":"10.1093\/bib\/bbv056"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Benz, F., Roderburg, C., Vargas Cardenas, D., Vucur, M., Gautheron, J., Koch, A., Zimmermann, H., Janssen, J., Nieuwenhuijsen, L., and Luedde, M. (2013). U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis. Exp. Mol. Med.","DOI":"10.1038\/emm.2013.81"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1373\/clinchem.2010.157198","article-title":"Analysis of circulating microRNA: Preanalytical and analytical challenges","volume":"57","author":"McDonald","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.molcel.2012.05.036","article-title":"Short structured rnas with low GC content are selectively lost during extraction from a small number of cells","volume":"46","author":"Kim","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e1002363","DOI":"10.1371\/journal.pgen.1002363","article-title":"Capture of microRNA-bound mrnas identifies the tumor suppressor miR-34a as a regulator of growth factor signaling","volume":"7","author":"Lal","year":"2011","journal-title":"PLoS Genet."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Bala, S., and Szabo, G. (2012). MicroRNA signature in alcoholic liver disease. Int. J. Hepatol., 2012.","DOI":"10.1155\/2012\/498232"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/j.1530-0277.2009.01007.x","article-title":"MicroRNA expression profile in lieber-decarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice","volume":"33","author":"Dolganiuc","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ajpath.2012.06.010","article-title":"Epigenetic regulation of miR-34a expression in alcoholic liver injury","volume":"181","author":"Meng","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.4049\/jimmunol.0901084","article-title":"Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microRNA-199","volume":"183","author":"Yeligar","year":"2009","journal-title":"J. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jhep.2011.07.024","article-title":"HIF-1alpha induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice","volume":"56","author":"Nishiyama","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.25497","article-title":"Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases","volume":"55","author":"Nath","year":"2012","journal-title":"Hepatology"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Paredes-Turrubiarte, G., Gonzalez-Chavez, A., Perez-Tamayo, R., Salazar-Vazquez, B.Y., Hernandez, V.S., Garibay-Nieto, N., Fragoso, J.M., and Escobedo, G. (2015). Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients. Clin. Exp. Med.","DOI":"10.1007\/s10238-015-0347-4"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/hep.27640","article-title":"Tumor necrosis factor alpha-induced receptor 1 signaling in alcoholic liver disease: A gut reaction?","volume":"61","author":"Barve","year":"2015","journal-title":"Hepatology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"248S","DOI":"10.1111\/j.1530-0277.1998.tb04011.x","article-title":"Tumor necrosis factor and alcoholic liver disease","volume":"22","author":"McClain","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.4049\/jimmunol.179.8.5082","article-title":"Modulation of miR-155 and miR-125b levels following lipopolysaccharide\/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock","volume":"179","author":"Tili","year":"2007","journal-title":"J. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1074\/jbc.M110.145870","article-title":"Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor \u03b1 (TNF\u03b1) production via increased mRNA half-life in alcoholic liver disease","volume":"286","author":"Bala","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1210\/me.2009-0117","article-title":"MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1","volume":"23","author":"Strum","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.ajpath.2014.12.020","article-title":"Deletion of miR155 prevents fas-induced liver injury through up-regulation of MCL-1","volume":"185","author":"Chen","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1111\/acer.12483","article-title":"Micro-Rna-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice","volume":"38","author":"Lippai","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1074\/jbc.M111.333534","article-title":"microRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating sirt1","volume":"287","author":"Yin","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_75","first-page":"88","article-title":"Sirtuin 1 signaling and alcoholic fatty liver disease","volume":"4","author":"You","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.ajpath.2015.01.030","article-title":"miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1 signaling","volume":"185","author":"Yin","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hep.24708","article-title":"Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase\/sterol regulatory element-binding protein 1 signaling in mice","volume":"55","author":"Hu","year":"2012","journal-title":"Hepatology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nri1980","article-title":"Snareing immunity: The role of snares in the immune system","volume":"6","author":"Stow","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCRESAHA.115.303100","article-title":"Control of very low-density lipoprotein secretion by N-ethylmaleimide-sensitive factor and miR-33","volume":"115","author":"Allen","year":"2014","journal-title":"Circ. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11010-009-0044-2","article-title":"Betaine administration corrects ethanol-induced defective VLDL secretion","volume":"327","author":"Kharbanda","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/ars.2010.3780","article-title":"Role of sirt1-foxo1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice","volume":"15","author":"Liang","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1096\/fj.09-151308","article-title":"SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress","volume":"24","author":"Caito","year":"2010","journal-title":"FASEB J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/hep.23547","article-title":"MicroRNAs control hepatocyte proliferation during liver regeneration","volume":"51","author":"Song","year":"2010","journal-title":"Hepatology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"G733","DOI":"10.1152\/ajpgi.00019.2012","article-title":"Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats","volume":"303","author":"Dippold","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27526","DOI":"10.1074\/jbc.M114.602383","article-title":"Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury","volume":"289","author":"Francis","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ygyno.2014.01.034","article-title":"The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer","volume":"132","author":"Chan","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature09284","article-title":"Oncomir addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma","volume":"467","author":"Medina","year":"2010","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1006\/bbrc.1993.2522","article-title":"Alcohol administration attenuates LPS-induced expression of inducible nitric oxide synthase in kupffer and hepatic endothelial cells","volume":"197","author":"Spolarics","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1194\/jlr.M800156-JLR200","article-title":"Chylomicrons promote intestinal absorption of lipopolysaccharides","volume":"50","author":"Ghoshal","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000063791","article-title":"Fatty acid and triacylglycerol utilisation by perfused rat spleen: Differential metabolic fate and the effect of endotoxin","volume":"12","author":"Hauton","year":"2002","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/978-1-4757-5140-6_44","article-title":"Metabolic fate of endotoxin in rat","volume":"256","author":"Freudenberg","year":"1990","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e96864","DOI":"10.1371\/journal.pone.0096864","article-title":"Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals","volume":"9","author":"Bala","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e53028","DOI":"10.1371\/journal.pone.0053028","article-title":"Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of lactobacillus rhamnosus GG treatment","volume":"8","author":"Feng","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.gastro.2014.09.014","article-title":"Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice","volume":"148","author":"Chen","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1021\/pr400362z","article-title":"Chronic ethanol consumption alters mammalian gastrointestinal content metabolites","volume":"12","author":"Xie","year":"2013","journal-title":"J. Proteome Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/003655299750024878","article-title":"Butyrate hastens restoration of barrier function after thermal and detergent injury to rat distal colon in vitro","volume":"34","author":"Venkatraman","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","article-title":"Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice","volume":"145","author":"Kim","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/IAI.06165-11","article-title":"Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice","volume":"80","author":"Loonen","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbadis.2009.02.013","article-title":"miR-155 gene: A typical multifunctional microRNA","volume":"1792","author":"Faraoni","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Pathak, S., Grillo, A.R., Scarpa, M., Brun, P., D\u2019Inca, R., Nai, L., Banerjee, A., Cavallo, D., Barzon, L., and Palu, G. (2015). miR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis. Exp. Mol. Med.","DOI":"10.1038\/emm.2015.21"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"54.15","DOI":"10.4049\/jimmunol.188.Supp.54.15","article-title":"MicroRNA-155 regulates inflammation in alcoholic liver disease via targeting SOCS1 and SHIP1","volume":"188","author":"Bala","year":"2012","journal-title":"J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e70945","DOI":"10.1371\/journal.pone.0070945","article-title":"Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice","volume":"8","author":"Lippai","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1530-0277.2007.00584.x","article-title":"Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease","volume":"32","author":"Tang","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2011.07.005","article-title":"MicroRNA regulation of intestinal epithelial tight junction permeability","volume":"141","author":"Ye","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.toxlet.2015.03.002","article-title":"Inhibition of miR122a by lactobacillus rhamnosus GG culture supernatant increases intestinal occludin expression and protects mice from alcoholic liver disease","volume":"234","author":"Zhao","year":"2015","journal-title":"Toxicol. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/hep.21097","article-title":"Intestinal mucosal alterations in rats with carbon tetrachloride-induced cirrhosis: Changes in glycosylation and luminal bacteria","volume":"43","author":"Natarajan","year":"2006","journal-title":"Hepatology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1440-1746.2001.02444.x","article-title":"Intestinal dysfunction in liver cirrhosis: Its role in spontaneous bacterial peritonitis","volume":"16","author":"Ramachandran","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1053\/jhep.2002.31656","article-title":"Intestinal mucosal alterations in experimental cirrhosis in the rat: Role of oxygen free radicals","volume":"35","author":"Ramachandran","year":"2002","journal-title":"Hepatology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1242\/bio.20147765","article-title":"MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells","volume":"3","author":"Tsai","year":"2014","journal-title":"Biol. Open"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1523\/JNEUROSCI.1269-07.2007","article-title":"Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: Evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium","volume":"27","author":"Sathyan","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Miranda, R.C. (2012). MicroRNAs and fetal brain development: Implications for ethanol teratology during the second trimester period of neurogenesis. Front. Genet.","DOI":"10.3389\/fgene.2012.00077"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1074\/jbc.M113.535195","article-title":"MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1\/RAX\/PKR cascade","volume":"289","author":"Qi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1073\/pnas.0900735106","article-title":"The double-stranded Rna-binding protein, pact, is required for postnatal anterior pituitary proliferation","volume":"106","author":"Peters","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neuron.2008.05.032","article-title":"Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol","volume":"59","author":"Pietrzykowski","year":"2008","journal-title":"Neuron"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"17543","DOI":"10.1073\/pnas.0801068105","article-title":"Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol","volume":"105","author":"Martin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","first-page":"S1","article-title":"Youth risk behavior surveillance\u2014United States, 2013","volume":"63","author":"Kann","year":"2014","journal-title":"MMWR Surveill. Summ."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/j.1530-0277.2000.tb02091.x","article-title":"Binge pattern ethanol exposure in adolescent and adult rats: Differential impact on subsequent responsiveness to ethanol","volume":"24","author":"White","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e83166","DOI":"10.1371\/journal.pone.0083166","article-title":"Long-term effects of peripubertal binge etoh exposure on hippocampal microRNA expression in the rat","volume":"9","author":"Prins","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e18350","DOI":"10.1371\/journal.pone.0018350","article-title":"Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity","volume":"6","author":"Mott","year":"2011","journal-title":"PLoS ONE"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/acer.12139","article-title":"Suppression and epigenetic regulation of miR-9 contributes to ethanol teratology: Evidence from zebrafish and murine fetal neural stem cell models","volume":"37","author":"Balaraman","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_122","first-page":"701","article-title":"Effects of ethanol on physiological retinoic acid levels","volume":"63","author":"Napoli","year":"2011","journal-title":"IUBMB Life"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.4049\/jimmunol.1202584","article-title":"Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets","volume":"190","author":"Nimmagadda","year":"2013","journal-title":"J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e21759","DOI":"10.1371\/journal.pone.0021759","article-title":"Overexpression of Sirt1 in mouse forebrain impairs lipid\/glucose metabolism and motor function","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS ONE"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/jcbfm.2014.185","article-title":"Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection","volume":"35","author":"Neumann","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/oxfordjournals.alcalc.a044994","article-title":"Neuropathology of alcoholism","volume":"25","author":"Harper","year":"1990","journal-title":"Alcohol. Alcohol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF01991778","article-title":"The contribution of alcohol, thiamine deficiency and cirrhosis of the liver to cerebral cortical damage in alcoholics","volume":"10","author":"Kril","year":"1995","journal-title":"Metab. Brain Dis."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1111\/j.1530-0277.2011.01544.x","article-title":"Up-regulation of microRNAs in brain of human alcoholics","volume":"35","author":"Lewohl","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"37347","DOI":"10.1074\/jbc.M111.235531","article-title":"MiR-497 and miR-302B regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2","volume":"286","author":"Yadav","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Nunez, Y.O., and Mayfield, R.D. (2012). Understanding alcoholism through microRNA signatures in brains of human alcoholics. Front. Genet., 3.","DOI":"10.3389\/fgene.2012.00043"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.molcel.2010.08.011","article-title":"The nuclear-retained noncoding RNA malat1 regulates alternative splicing by modulating sr splicing factor phosphorylation","volume":"39","author":"Tripathi","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"D174","DOI":"10.1093\/nar\/gku1060","article-title":"An update on lncipedia: A database for annotated human lncRNA sequences","volume":"43","author":"Volders","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Clark, B.S., and Blackshaw, S. (2014). Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Front. Genet.","DOI":"10.3389\/fgene.2014.00164"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.alcohol.2012.04.002","article-title":"Malat-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics","volume":"46","author":"Kryger","year":"2012","journal-title":"Alcohol"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.lfs.2010.02.001","article-title":"Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line","volume":"86","author":"Koshimizu","year":"2010","journal-title":"Life Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0278-5846(97)00080-8","article-title":"Abnormal plasma oxytocin and beta-endorphin levels in alcoholics after short and long term abstinence","volume":"21","author":"Marchesi","year":"1997","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-12-801105-8.00011-4","article-title":"RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain","volume":"116","author":"Farris","year":"2014","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3945\/an.113.004846","article-title":"Nutrition implications for fetal alcohol spectrum disorder","volume":"5","author":"Young","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/humrep\/den439","article-title":"Ethanol exposure induces differential microrna and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation","volume":"24","author":"Wang","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1053\/j.gastro.2009.08.065","article-title":"Retinoic acid receptor antagonists inhibit miR-10A expression and block metastatic behavior of pancreatic cancer","volume":"137","author":"Weiss","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/ng1421","article-title":"Microrna-responsive \u201csensor\u201d transgenes uncover hox-like and other developmentally regulated patterns of vertebrate microrna expression","volume":"36","author":"Mansfield","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s00246-014-0901-y","article-title":"MiR-10a and miR-10b target the 3'-untranslated region of TBX5 to repress its expression","volume":"35","author":"Wang","year":"2014","journal-title":"Pediatr. Cardiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"75.e7","DOI":"10.1016\/j.ajog.2010.03.017","article-title":"Fetal alcohol syndrome: Cardiac birth defects in mice and prevention with folate","volume":"203","author":"Serrano","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1530-0277.1993.tb00805.x","article-title":"Maternal ethanol ingestion effects on fetal rat brain vitamin a as a model for fetal alcohol syndrome","volume":"17","author":"Grummer","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Chokroborty-Hoque, A., Alberry, B., and Singh, S.M. (2014). Exploring the complexity of intellectual disability in fetal alcohol spectrum disorders. Front. Pediatr.","DOI":"10.3389\/fped.2014.00090"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbr.2011.05.005","article-title":"Maternal voluntary drinking in c57bl\/6j mice: Advancing a model for fetal alcohol spectrum disorders","volume":"223","author":"Kleiber","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000357496","article-title":"Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: From immediate effects to long-term adaptation","volume":"36","author":"Mantha","year":"2014","journal-title":"Dev. Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/dev.21311","article-title":"Hippocampal neuron populations are reduced in vervet monkeys with fetal alcohol exposure","volume":"57","author":"Burke","year":"2015","journal-title":"Dev. Psychobiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1186\/1868-7083-5-14","article-title":"Reduced expression of brain cannabinoid receptor 1 (CNR1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders","volume":"5","author":"Stringer","year":"2013","journal-title":"Clin. Epigenetics"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Blazquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., Garcia-Rincon, D., Sendtner, M., Timmusk, T., Lutz, B., and Galve-Roperh, I. (2015). The cb cannabinoid receptor signals striatal neuroprotection via a PI3K\/AKT\/MTORC1\/BDNF pathway. Cell Death Differ.","DOI":"10.1038\/cdd.2015.11"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1523\/JNEUROSCI.0849-13.2014","article-title":"Changes in cerebral CB1 receptor availability after acute and chronic alcohol abuse and monitored abstinence","volume":"34","author":"Ceccarini","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuropharm.2014.01.025","article-title":"Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation","volume":"81","author":"Liang","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.yhbeh.2010.06.018","article-title":"Epigenetics and the origins of paternal effects","volume":"59","author":"Curley","year":"2011","journal-title":"Horm. Behav."},{"key":"ref_154","first-page":"e57","article-title":"Investigating the fetal and postnatal effects of paternal alcohol exposure in mouse offspring: A review","volume":"22","author":"Baber","year":"2015","journal-title":"J. Popul. Ther. Clin. Pharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.alcohol.2015.02.008","article-title":"Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations","volume":"49","author":"Finegersh","year":"2015","journal-title":"Alcohol"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1530-0277.2002.tb02544.x","article-title":"Paternal alcohol exposure affects sperm cytosine methyltransferase messenger RNA levels","volume":"26","author":"Bielawski","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1073\/pnas.1110368109","article-title":"Sperm-borne microRNA-34c is required for the first cleavage division in mouse","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.oraloncology.2013.10.018","article-title":"P27 and BCL2 expression predicts response to chemotherapy in head and neck squamous cell carcinomas","volume":"50","author":"Hermsen","year":"2014","journal-title":"Oral Oncol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1523\/JNEUROSCI.0914-13.2013","article-title":"Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation","volume":"33","author":"Rodgers","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000365026","article-title":"Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring","volume":"64","author":"McPherson","year":"2014","journal-title":"Ann. Nutr. Metab."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"E805","DOI":"10.1152\/ajpendo.00013.2015","article-title":"Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring","volume":"308","author":"McPherson","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11883-008-0017-z","article-title":"Alcohol consumption and heart failure: A systematic review","volume":"10","author":"Djousse","year":"2008","journal-title":"Curr. Atheroscler Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jchf.2014.07.014","article-title":"Natural history and prognostic factors in alcoholic cardiomyopathy","volume":"3","author":"Segovia","year":"2015","journal-title":"JACC Heart Fail."},{"key":"ref_164","first-page":"E176","article-title":"A case of heart failure due to alcoholic cardiomyopathy combined with acute pulmonary embolism","volume":"6","author":"Xiao","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4330\/wjc.v6.i8.771","article-title":"Alcoholic cardiomyopathy","volume":"6","year":"2014","journal-title":"World J. Cardiol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12012-014-9252-4","article-title":"Alcoholic cardiomyopathy: Pathophysiologic insights","volume":"14","author":"Piano","year":"2014","journal-title":"Cardiovasc Toxicol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Lai, Y.J., Hung, C.L., Hong, R.C., Tseng, Y.M., Lin, C.I., Ko, Y.S., Tsai, C.H., and Yeh, H.I. (2011). Slow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion. J. Biomed. Sci.","DOI":"10.1186\/1423-0127-18-72"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1111\/j.1530-0277.2009.01006.x","article-title":"Alcohol-induced electrical remodeling: Effects of sustained short-term ethanol infusion on ion currents in rabbit atrium","volume":"33","author":"Laszlo","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11919","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nature"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4161\/auto.18997","article-title":"Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts","volume":"8","author":"Guo","year":"2012","journal-title":"Autophagy"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000370028","article-title":"Investigation of microRNA expression profiles associated with human alcoholic cardiomyopathy","volume":"130","author":"Jing","year":"2015","journal-title":"Cardiology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/jn\/133.4.1154","article-title":"Alcohol affects the skeletal muscle proteins, titin and nebulin in male and female rats","volume":"133","author":"Hunter","year":"2003","journal-title":"J. Nutr."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1001\/jama.1995.03530020067034","article-title":"The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men","volume":"274","author":"Estruch","year":"1995","journal-title":"JAMA"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/hep.510270503","article-title":"Decreased muscle strength in patients with alcoholic liver cirrhosis in relation to nutritional status, alcohol abstinence, liver function, and neuropathy","volume":"27","author":"Andersen","year":"1998","journal-title":"Hepatology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1080\/00365520510012361","article-title":"Magnesium supplementation and muscle function in patients with alcoholic liver disease: A randomized, placebo-controlled trial","volume":"40","author":"Aagaard","year":"2005","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Ignacio, C., Hicks, S.D., Burke, P., Lewis, L., Szombathyne-Meszaros, Z., and Middleton, F.A. (2015). Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain. 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