{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:55:37Z","timestamp":1777971337360,"version":"3.51.4"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Understanding phenotypes and their genetic determinants for metabolic syndrome (MetS) has been quite challenging. With the advent of systems genomic approaches, there is a need to decipher methods for identification and evaluating the functional role of phenotypic traits associated with complex diseases, such as MetS. The monogenic syndromes of lipodystrophy are well understood, but the molecular pathophysiology of insulin resistance (IR) underpinning the obesity, diabetes mellitus, and dyslipidemia is not well deciphered. In this commentary, we argue the role of pathophysiology of MetS, and its effects into possible understanding of genetic determinants associated with lipodystrophy-mediated diabetes mellitus.<\/jats:p>","DOI":"10.3390\/biom8030047","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T10:55:44Z","timestamp":1530874544000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome?"],"prefix":"10.3390","volume":"8","author":[{"given":"Sandeep Kumar","family":"Mathur","sequence":"first","affiliation":[{"name":"Sawai Man Singh Medical College and Hospital, JLN Marg, Jaipur 302004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-1170","authenticated-orcid":false,"given":"Sonal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-1336","authenticated-orcid":false,"given":"Nidhi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, IIS University, Mansarovar, Jaipur 302020, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surendra","family":"Nimesh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Central University of Rajasthan, Bandarsindri, N.H. 8, Kishangarh 305801, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-7721","authenticated-orcid":false,"given":"Krishna Mohan","family":"Medicherla","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-278X","authenticated-orcid":false,"given":"Prashanth","family":"Suravajhala","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrendo.2015.123","article-title":"Congenital generalized lipodystrophies-new insights into metabolic dysfunction","volume":"11","author":"Patni","year":"2015","journal-title":"Nat. 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