{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:46:14Z","timestamp":1784205974562,"version":"3.55.0"},"reference-count":77,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:00:00Z","timestamp":1570924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The voltage-gated sodium channel is vital for cardiomyocyte function, and consists of a protein complex containing a pore-forming \u03b1 subunit and two associated \u03b2 subunits. A fundamental, yet unsolved, question is to define the precise function of \u03b2 subunits. While their location in vivo remains unclear, large evidence shows that they regulate localization of \u03b1 and the biophysical properties of the channel. The current data support that one of these subunits, \u03b22, promotes cell surface expression of \u03b1. The main \u03b1 isoform in an adult heart is NaV1.5, and mutations in SCN5A, the gene encoding NaV1.5, often lead to hereditary arrhythmias and sudden death. The association of \u03b22 with cardiac arrhythmias has also been described, which could be due to alterations in trafficking, anchoring, and localization of NaV1.5 at the cardiomyocyte surface. Here, we will discuss research dealing with mechanisms that regulate \u03b22 trafficking, and how \u03b22 could be pivotal for the correct localization of NaV1.5, which influences cellular excitability and electrical coupling of the heart. Moreover, \u03b22 may have yet to be discovered roles on cell adhesion and signaling, implying that diverse defects leading to human disease may arise due to \u03b22 mutations.<\/jats:p>","DOI":"10.3390\/biom9100604","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T03:54:13Z","timestamp":1571025253000},"page":"604","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Trafficking and Function of the Voltage-Gated Sodium Channel \u03b22 Subunit"],"prefix":"10.3390","volume":"9","author":[{"given":"Eric","family":"Cortada","sequence":"first","affiliation":[{"name":"Cardiovascular Genetics Group, Girona Biomedical Research Institute (IDIBGI), C\/ Doctor Castany, s\/n\u2014Edifici IDIBGI, 17190 Girona, Spain"},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Brugada","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Group, Girona Biomedical Research Institute (IDIBGI), C\/ Doctor Castany, s\/n\u2014Edifici IDIBGI, 17190 Girona, Spain"},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), 28029 Madrid, Spain"},{"name":"Medical Sciences Department, University of Girona Medical School, 17003 Girona, Spain"},{"name":"Cardiology Department, Hospital Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-223X","authenticated-orcid":false,"given":"Marcel","family":"Verges","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Group, Girona Biomedical Research Institute (IDIBGI), C\/ Doctor Castany, s\/n\u2014Edifici IDIBGI, 17190 Girona, Spain"},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), 28029 Madrid, Spain"},{"name":"Medical Sciences Department, University of Girona Medical School, 17003 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1172\/JCI26381","article-title":"Mechanisms of sudden cardiac death","volume":"115","author":"Rubart","year":"2005","journal-title":"J. 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