{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:20:32Z","timestamp":1792844432161,"version":"4.5.0"},"reference-count":108,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Atenci\u00f3n Primaria, Cronicidad y Promoci\u00f3n de la Salud","doi-asserted-by":"publisher","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Atenci\u00f3n Primaria, Cronicidad y Promoci\u00f3n de la Salud","doi-asserted-by":"publisher","award":["PI19\/01577"],"award-info":[{"award-number":["PI19\/01577"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Atenci\u00f3n Primaria, Cronicidad y Promoci\u00f3n de la Salud","doi-asserted-by":"publisher","award":["PND 2019\/040"],"award-info":[{"award-number":["PND 2019\/040"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Atenci\u00f3n Primaria, Cronicidad y Promoci\u00f3n de la Salud","doi-asserted-by":"publisher","award":["RIC-0111-2019"],"award-info":[{"award-number":["RIC-0111-2019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Atenci\u00f3n Primaria, Cronicidad y Promoci\u00f3n de la Salud","doi-asserted-by":"publisher","award":["CM19\/00025"],"award-info":[{"award-number":["CM19\/00025"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Atenci\u00f3n Primaria, Cronicidad y Promoci\u00f3n de la Salud","doi-asserted-by":"publisher","award":["CM19\/00240"],"award-info":[{"award-number":["CM19\/00240"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["PI19\/01577"],"award-info":[{"award-number":["PI19\/01577"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["PND 2019\/040"],"award-info":[{"award-number":["PND 2019\/040"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["RIC-0111-2019"],"award-info":[{"award-number":["RIC-0111-2019"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["CM19\/00025"],"award-info":[{"award-number":["CM19\/00025"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["CM19\/00240"],"award-info":[{"award-number":["CM19\/00240"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Salud y Familia, Junta de Andaluc\u00eda","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}]},{"name":"Consejer\u00eda de Salud y Familia, Junta de Andaluc\u00eda","award":["PI19\/01577"],"award-info":[{"award-number":["PI19\/01577"]}]},{"name":"Consejer\u00eda de Salud y Familia, Junta de Andaluc\u00eda","award":["PND 2019\/040"],"award-info":[{"award-number":["PND 2019\/040"]}]},{"name":"Consejer\u00eda de Salud y Familia, Junta de Andaluc\u00eda","award":["RIC-0111-2019"],"award-info":[{"award-number":["RIC-0111-2019"]}]},{"name":"Consejer\u00eda de Salud y Familia, Junta de Andaluc\u00eda","award":["CM19\/00025"],"award-info":[{"award-number":["CM19\/00025"]}]},{"name":"Consejer\u00eda de Salud y Familia, Junta de Andaluc\u00eda","award":["CM19\/00240"],"award-info":[{"award-number":["CM19\/00240"]}]},{"DOI":"10.13039\/501100004587","name":"National System of Health, ISCIII, ERDF-EU","doi-asserted-by":"publisher","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"National System of Health, ISCIII, ERDF-EU","doi-asserted-by":"publisher","award":["PI19\/01577"],"award-info":[{"award-number":["PI19\/01577"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"National System of Health, ISCIII, ERDF-EU","doi-asserted-by":"publisher","award":["PND 2019\/040"],"award-info":[{"award-number":["PND 2019\/040"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"National System of Health, ISCIII, ERDF-EU","doi-asserted-by":"publisher","award":["RIC-0111-2019"],"award-info":[{"award-number":["RIC-0111-2019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"National System of Health, ISCIII, ERDF-EU","doi-asserted-by":"publisher","award":["CM19\/00025"],"award-info":[{"award-number":["CM19\/00025"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"National System of Health, ISCIII, ERDF-EU","doi-asserted-by":"publisher","award":["CM19\/00240"],"award-info":[{"award-number":["CM19\/00240"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Andalusia Government","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}]},{"name":"Andalusia Government","award":["PI19\/01577"],"award-info":[{"award-number":["PI19\/01577"]}]},{"name":"Andalusia Government","award":["PND 2019\/040"],"award-info":[{"award-number":["PND 2019\/040"]}]},{"name":"Andalusia Government","award":["RIC-0111-2019"],"award-info":[{"award-number":["RIC-0111-2019"]}]},{"name":"Andalusia Government","award":["CM19\/00025"],"award-info":[{"award-number":["CM19\/00025"]}]},{"name":"Andalusia Government","award":["CM19\/00240"],"award-info":[{"award-number":["CM19\/00240"]}]},{"name":"Universidad de M\u00e1laga\/CBUA","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}]},{"name":"Universidad de M\u00e1laga\/CBUA","award":["PI19\/01577"],"award-info":[{"award-number":["PI19\/01577"]}]},{"name":"Universidad de M\u00e1laga\/CBUA","award":["PND 2019\/040"],"award-info":[{"award-number":["PND 2019\/040"]}]},{"name":"Universidad de M\u00e1laga\/CBUA","award":["RIC-0111-2019"],"award-info":[{"award-number":["RIC-0111-2019"]}]},{"name":"Universidad de M\u00e1laga\/CBUA","award":["CM19\/00025"],"award-info":[{"award-number":["CM19\/00025"]}]},{"name":"Universidad de M\u00e1laga\/CBUA","award":["CM19\/00240"],"award-info":[{"award-number":["CM19\/00240"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedicines"],"abstract":"<jats:p>Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the relationship between inflammatory and neurotrophic factors and clinical, social and environmental factors involved in the development and the characterization of BD. Web of Science, PubMed, PsycINFO, Scopus and Science Direct were searched by two independent reviewers. The systematic review was registered in PROSPERO (CRD42020180626). A total of 51 studies with 4547 patients with a diagnosis of BD were selected for systematic review. Among them, 18 articles were included for meta-analysis. The study found some evidence of associations between BDNF and\/or inflammatory factors and different stressors and functional and cognitive impairment, but limitations prevented firm conclusions. The main finding of the meta-analysis was a negative correlation between circulating levels of BDNF and depression severity score (standardized mean difference = \u22120.22, Confidence Interval 95% = \u22120.38, \u22120.05, p = 0.01). Evidence indicates that BDNF has a role in the depressive component of BD. However, the poor consistency found for other inflammatory mediators clearly indicates that highly controlled studies are needed to identity precise biomarkers of this disorder.<\/jats:p>","DOI":"10.3390\/biomedicines10061368","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:49:14Z","timestamp":1654771754000},"page":"1368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"10","author":[{"given":"Amanda","family":"Vega-N\u00fa\u00f1ez","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Facultad de Psicolog\u00eda, Campus de Teatinos, Universidad of M\u00e1laga, Andalucia Tech, 29071 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, Plaza Hospital Civil s\/n, Planta 1, Pabell\u00f3n 4, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-9792","authenticated-orcid":false,"given":"Carlos","family":"G\u00f3mez-S\u00e1nchez-Lafuente","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Facultad de Psicolog\u00eda, Campus de Teatinos, Universidad of M\u00e1laga, Andalucia Tech, 29071 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, Plaza Hospital Civil s\/n, Planta 1, Pabell\u00f3n 4, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-9672","authenticated-orcid":false,"given":"Ferm\u00edn","family":"Mayoral-Cleries","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, Plaza Hospital Civil s\/n, Planta 1, Pabell\u00f3n 4, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bordallo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, Plaza Hospital Civil s\/n, Planta 1, Pabell\u00f3n 4, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-5795","authenticated-orcid":false,"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, Plaza Hospital Civil s\/n, Planta 1, Pabell\u00f3n 4, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-9802","authenticated-orcid":false,"given":"Juan","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Departamento de Anatom\u00eda Humana Medicina Legal e Historia de la Ciencia, Facultad de Medicina, Universidad de M\u00e1laga, Bulevar Louis Pausteur 32, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-6435","authenticated-orcid":false,"given":"Jos\u00e9","family":"Guzm\u00e1n-Parra","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Parque Tecnol\u00f3gico de Andaluc\u00eda, Severo Ochoa 35, 29590 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, Plaza Hospital Civil s\/n, Planta 1, Pabell\u00f3n 4, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/mp.2010.101","article-title":"Days out of Role Due to Common Physical and Mental Conditions: Results from the WHO World Mental Health Surveys","volume":"16","author":"Alonso","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archpsyc.64.5.543","article-title":"Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication","volume":"64","author":"Merikangas","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/hup.612","article-title":"Comorbidity in Bipolar Disorder: A Framework for Rational Treatment Selection","volume":"19","author":"McIntyre","year":"2004","journal-title":"Hum. Psychopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/bdi.12684","article-title":"Increasing Mortality Gap for Patients Diagnosed with Bipolar Disorder-A Nationwide Study with 20 Years of Follow-Up","volume":"21","author":"Licht","year":"2019","journal-title":"Bipolar Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/archpsyc.58.9.844","article-title":"Excess Mortality in Bipolar and Unipolar Disorder in Sweden","volume":"58","author":"Osby","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jad.2012.04.041","article-title":"Suicidal Behavior in Bipolar Disorder: Epidemiology, Characteristics and Major Risk Factors","volume":"143","author":"Gonda","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0140-6736(20)31544-0","article-title":"Bipolar Disorders","volume":"396","author":"McIntyre","year":"2020","journal-title":"Lancet Lond. Engl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/bdi.12087","article-title":"Epidemiology of Suicide in Bipolar Disorders: A Systematic Review of the Literature","volume":"15","author":"Pompili","year":"2013","journal-title":"Bipolar Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1399-5618.2009.00686.x","article-title":"Retrospective Age at Onset of Bipolar Disorder and Outcome during Two-Year Follow-up: Results from the STEP-BD Study","volume":"11","author":"Perlis","year":"2009","journal-title":"Bipolar Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jad.2011.04.055","article-title":"Gender Differences in a Cohort Study of 604 Bipolar Patients: The Role of Predominant Polarity","volume":"133","author":"Nivoli","year":"2011","journal-title":"J. Affect. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0140-6736(13)60989-7","article-title":"Bipolar Disorder Diagnosis: Challenges and Future Directions","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet Lond. Engl."},{"key":"ref_13","first-page":"3111","article-title":"Cognitive Dysfunction in Bipolar Disorder and Schizophrenia: A Systematic Review of Meta-Analyses","volume":"11","author":"Bortolato","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1399-5618.2007.00327.x","article-title":"Functional Outcome in Bipolar Disorder: The Role of Clinical and Cognitive Factors","volume":"9","author":"Vieta","year":"2007","journal-title":"Bipolar Disord."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.euroneuro.2015.01.007","article-title":"Cognition as a Target in Schizophrenia, Bipolar Disorder and Depression","volume":"25","author":"Vieta","year":"2015","journal-title":"Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0447.2007.01055.x","article-title":"Neuropsychological Functioning in Euthymic Bipolar Disorder: A Meta-Analysis","volume":"116","author":"Torres","year":"2007","journal-title":"Acta Psychiatr. Scand. Suppl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.4088\/JCP.08m04997yel","article-title":"Neurocognitive Functioning in Patients with Bipolar I Disorder Recently Recovered from a First Manic Episode","volume":"71","author":"Torres","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2014.06.019","article-title":"A Meta-Analysis of Neuropsychological Functioning in First-Episode Bipolar Disorders","volume":"57","author":"Lee","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psychres.2014.12.044","article-title":"Neurocognitive Functioning in the Premorbid Stage and in the First Episode of Bipolar Disorder: A Systematic Review","volume":"226","author":"Martino","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/acps.12003","article-title":"Occupational Disability in Bipolar Disorder: Analysis of Predictors of Being on Severe Disablement Benefit (PREBIS Study Data)","volume":"127","author":"Grande","year":"2013","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4088\/JCP.v64n0209","article-title":"Perceptions and Impact of Bipolar Disorder: How Far Have We Really Come? Results of the National Depressive and Manic-Depressive Association 2000 Survey of Individuals with Bipolar Disorder","volume":"64","author":"Hirschfeld","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/ijnp\/pyx032","article-title":"Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies","volume":"20","author":"Torrent","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cpr.2017.11.006","article-title":"Cognitive Deficits in Bipolar Disorders: Implications for Emotion","volume":"59","author":"Lima","year":"2018","journal-title":"Clin. Psychol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103963","DOI":"10.1016\/j.brat.2021.103963","article-title":"Frozen in (e)Motion: How Reactive Motor Inhibition Is Influenced by the Emotional Content of Stimuli in Healthy and Psychiatric Populations","volume":"146","author":"Battaglia","year":"2021","journal-title":"Behav. Res. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/bdi.12341","article-title":"A Review on the Impact of Cognitive Dysfunction on Social, Occupational, and General Functional Outcomes in Bipolar Disorder","volume":"17","author":"Baune","year":"2015","journal-title":"Bipolar Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1399-5618.2012.01011.x","article-title":"Meta-Analysis of the Association between Cognitive Abilities and Everyday Functioning in Bipolar Disorder","volume":"14","author":"Depp","year":"2012","journal-title":"Bipolar Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jad.2014.06.045","article-title":"Cognitive Performance and Quality of Life Early in the Course of Bipolar Disorder","volume":"168","author":"Mackala","year":"2014","journal-title":"J. Affect. Disord."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1017\/S0033291712001948","article-title":"Persistence of Cognitive Impairment and Its Negative Impact on Psychosocial Functioning in Lithium-Treated, Euthymic Bipolar Patients: A 6-Year Follow-up Study","volume":"43","author":"Mora","year":"2013","journal-title":"Psychol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jad.2015.07.050","article-title":"Emotion-Relevant Impulsivity Predicts Sustained Anger and Aggression after Remission in Bipolar I Disorder","volume":"189","author":"Johnson","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/sltb.12274","article-title":"Suicidality in Bipolar Disorder: The Role of Emotion-Triggered Impulsivity","volume":"47","author":"Johnson","year":"2017","journal-title":"Suicide Life. Threat. Behav."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11920-020-1130-0","article-title":"Bipolar Disorder and Suicide: A Review","volume":"22","author":"Miller","year":"2020","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1017\/S0033291720003086","article-title":"Impulsivity, Decision-Making and Risk-Taking Behaviour in Bipolar Disorder: A Systematic Review and Meta-Analysis","volume":"50","year":"2020","journal-title":"Psychol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"706933","DOI":"10.3389\/fpsyt.2021.706933","article-title":"Impulsivity as a Risk Factor for Suicide in Bipolar Disorder","volume":"12","author":"Zakowicz","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5498\/wjp.v5.i3.255","article-title":"On the Role of Impulsivity and Decision-Making in Suicidal Behavior","volume":"5","author":"Gvion","year":"2015","journal-title":"World J. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Battaglia, S., Fabius, J.H., Moravkova, K., Fracasso, A., and Borgomaneri, S. (2022). The Neurobiological Correlates of Gaze Perception in Healthy Individuals and Neurologic Patients. Biomedicines, 10.","DOI":"10.3390\/biomedicines10030627"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Tanaka, M., T\u00f3th, F., Poly\u00e1k, H., Szab\u00f3, \u00c1., M\u00e1ndi, Y., and V\u00e9csei, L. (2021). Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway. Biomedicines, 9.","DOI":"10.20944\/preprints202106.0344.v1"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Rodrigues, J.E., Martinho, A., Santos, V., Santa, C., Madeira, N., Martins, M.J., Pato, C.N., Macedo, A., and Manadas, B. (2022). Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105460"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/7854_2020_153","article-title":"The Role of Genetics in Bipolar Disorder","volume":"48","author":"Fabbri","year":"2021","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.psychres.2019.06.010","article-title":"A Population-Based Heritability Estimate of Bipolar Disorder\u2014In a Swedish Twin Sample","volume":"278","author":"Johansson","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/jmg.36.8.585","article-title":"Genetics of Bipolar Disorder","volume":"36","author":"Craddock","year":"1999","journal-title":"J. Med. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S0140-6736(13)60855-7","article-title":"Genetics of Bipolar Disorder","volume":"381","author":"Craddock","year":"2013","journal-title":"Lancet Lond. Engl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","article-title":"Bipolar Disorder","volume":"387","author":"Grande","year":"2016","journal-title":"Lancet Lond. Engl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1176\/ajp.2006.163.7.1138","article-title":"Reflections on the Relationship between Psychiatric Genetics and Psychiatric Nosology","volume":"163","author":"Kendler","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.pnpbp.2008.04.017","article-title":"Neurodevelopmental Basis of Bipolar Disorder: A Critical Appraisal","volume":"32","author":"Sanches","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.euroneuro.2014.09.007","article-title":"Developmental Trajectory of Cognitive Impairment in Bipolar Disorder: Comparison with Schizophrenia","volume":"25","author":"Bora","year":"2015","journal-title":"Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/cap.2008.064","article-title":"A Quantitative and Qualitative Review of Neurocognitive Performance in Pediatric Bipolar Disorder","volume":"18","author":"Joseph","year":"2008","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jpsychires.2012.02.004","article-title":"Neurobiological Correlates of Illness Progression in the Recurrent Affective Disorders","volume":"46","author":"Post","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1017\/S0033291707001675","article-title":"Meta-Analyses of Cognitive Functioning in Euthymic Bipolar Patients and Their First-Degree Relatives","volume":"38","author":"Arts","year":"2008","journal-title":"Psychol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.neubiorev.2008.05.019","article-title":"Neurocognitive Endophenotypes (Endophenocognitypes) from Studies of Relatives of Bipolar Disorder Subjects: A Systematic Review","volume":"32","author":"Rubio","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2008.06.009","article-title":"Cognitive Endophenotypes of Bipolar Disorder: A Meta-Analysis of Neuropsychological Deficits in Euthymic Patients and Their First-Degree Relatives","volume":"113","author":"Bora","year":"2009","journal-title":"J. Affect. Disord."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tanaka, M., and V\u00e9csei, L. (2021). Editorial of Special Issue \u201cCrosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry\u201d. Biomedicines, 9.","DOI":"10.3390\/biomedicines9050517"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4088\/JCP.08r04505","article-title":"Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder: A Systematic Review of the Literature","volume":"70","author":"Goldstein","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","article-title":"Inflamed Moods: A Review of the Interactions between Inflammation and Mood Disorders","volume":"53","author":"Rosenblat","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.psc.2015.09.006","article-title":"Bipolar Disorder and Inflammation","volume":"39","author":"Rosenblat","year":"2016","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jpsychires.2013.05.018","article-title":"Cytokines in Bipolar Disorder vs. Healthy Control Subjects: A Systematic Review and Meta-Analysis","volume":"47","author":"Munkholm","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jpsychires.2017.03.018","article-title":"A Systematic Review of Evidence for the Role of Inflammatory Biomarkers in Bipolar Patients","volume":"92","author":"Sayana","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4306\/pi.2010.7.4.243","article-title":"The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder","volume":"7","author":"Grande","year":"2010","journal-title":"Psychiatry Investig."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1192\/bjp.2018.144","article-title":"Neurotrophins, Cytokines, Oxidative Stress Mediators and Mood State in Bipolar Disorder: Systematic Review and Meta-Analyses","volume":"213","author":"Rowland","year":"2018","journal-title":"Br. J. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41380-019-0634-7","article-title":"The Genetics of Bipolar Disorder","volume":"25","author":"Gordovez","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40345-019-0152-1","article-title":"Epigenetic Markers in Inflammation-Related Genes Associated with Mood Disorder: A Cross-Sectional and Longitudinal Study in High-Risk Offspring of Bipolar Parents","volume":"7","author":"Duffy","year":"2019","journal-title":"Int. J. Bipolar Disord."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Alameda, L., Trotta, G., Quigley, H., Rodriguez, V., Gadelrab, R., Dwir, D., Dempster, E., Wong, C.C.Y., and Forti, M.D. (2022). Can Epigenetics Shine a Light on the Biological Pathways Underlying Major Mental Disorders?. Psychol. Med., 1\u201321.","DOI":"10.1017\/S0033291721005559"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jad.2015.12.055","article-title":"The Role of Environmental Exposures as Risk Factors for Bipolar Disorder: A Systematic Review of Longitudinal Studies","volume":"193","author":"Marangoni","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/HRP.0000000000000161","article-title":"Clinical and Environmental Risk Factors for Bipolar Disorder: Review of Prospective Studies","volume":"26","author":"Marangoni","year":"2018","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/pcn.12433","article-title":"Environmental Factors, Life Events, and Trauma in the Course of Bipolar Disorder","volume":"71","author":"Aldinger","year":"2017","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/bdi.12490","article-title":"Systematic Assessment of Environmental Risk Factors for Bipolar Disorder: An Umbrella Review of Systematic Reviews and Meta-Analyses","volume":"19","author":"Bortolato","year":"2017","journal-title":"Bipolar Disord."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1566524016666160126143741","article-title":"Exposure to Perinatal Infections and Bipolar Disorder: A Systematic Review","volume":"16","author":"Barichello","year":"2016","journal-title":"Curr. Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psychres.2018.11.023","article-title":"Maternal Stress, Prenatal Medical Illnesses and Obstetric Complications: Risk Factors for Schizophrenia Spectrum Disorder, Bipolar Disorder and Major Depressive Disorder","volume":"271","author":"Pugliese","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1192\/bjp.186.2.121","article-title":"Impact of Childhood Abuse on the Clinical Course of Bipolar Disorder","volume":"186","author":"Garno","year":"2005","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S2215-0366(15)00544-1","article-title":"Childhood Maltreatment and Unfavourable Clinical Outcomes in Bipolar Disorder: A Systematic Review and Meta-Analysis","volume":"3","author":"Danese","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1192\/bjp.bp.115.179655","article-title":"Relationship between Childhood Adversity and Bipolar Affective Disorder: Systematic Review and Meta-Analysis","volume":"209","author":"Berry","year":"2016","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1017\/S0033291713000147","article-title":"Chronic Stressors and Trauma: Prospective Influences on the Course of Bipolar Disorder","volume":"43","author":"Gershon","year":"2013","journal-title":"Psychol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2014.02.036","article-title":"Stressful Life Events in Bipolar I and II Disorder: Cause or Consequence of Mood Symptoms?","volume":"161","author":"Koenders","year":"2014","journal-title":"J. Affect. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jad.2014.08.043","article-title":"The Prevalence and Effect of Life Events in 222 Bipolar I and II Patients: A Prospective, Naturalistic 4 Year Follow-up Study","volume":"170","author":"Simhandl","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1111\/j.1360-0443.2011.03520.x","article-title":"Non-Medical Prescription Use Increases the Risk for the Onset and Recurrence of Psychopathology: Results from the National Epidemiological Survey on Alcohol and Related Conditions","volume":"106","author":"Schepis","year":"2011","journal-title":"Addict. Abingdon Engl."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jad.2014.10.006","article-title":"The Association between Cannabis Use and Mood Disorders: A Longitudinal Study","volume":"172","author":"Feingold","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jpsychires.2012.10.015","article-title":"Brain-Derived Neurotrophic Factor Val66met Genotype and Early Life Stress Effects upon Bipolar Course","volume":"47","author":"Miller","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 Statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jad.2017.09.042","article-title":"Translating the HAM-D into the MADRS and Vice Versa with Equipercentile Linking","volume":"226","author":"Leucht","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"IntHout, J., Ioannidis, J.P.A., and Borm, G.F. (2014). The Hartung-Knapp-Sidik-Jonkman Method for Random Effects Meta-Analysis Is Straightforward and Considerably Outperforms the Standard DerSimonian-Laird Method. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-25"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/sim.791","article-title":"On Tests of the Overall Treatment Effect in Meta-Analysis with Normally Distributed Responses","volume":"20","author":"Hartung","year":"2001","journal-title":"Stat. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for Examining and Interpreting Funnel Plot Asymmetry in Meta-Analyses of Randomised Controlled Trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A Tool for Assessing Risk of Bias in Non-Randomised Studies of Interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"626906","DOI":"10.3389\/fnbeh.2021.626906","article-title":"Blood Brain-Derived Neurotrophic Factor (BDNF) and Major Depression: Do We Have a Translational Perspective?","volume":"15","author":"Arosio","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/mp.2013.172","article-title":"Decreased Peripheral Brain-Derived Neurotrophic Factor Levels Are a Biomarker of Disease Activity in Major Psychiatric Disorders: A Comparative Meta-Analysis","volume":"19","author":"Fernandes","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.psychres.2019.02.051","article-title":"Brain-Derived Neurotrophic Factor (BDNF) and Bipolar Disorder","volume":"274","author":"Chiou","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Fernandes, B.S., Molendijk, M.L., K\u00f6hler, C.A., Soares, J.C., Leite, C.M.G.S., Machado-Vieira, R., Ribeiro, T.L., Silva, J.C., Sales, P.M.G., and Quevedo, J. (2015). Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Bipolar Disorder: A Meta-Analysis of 52 Studies. BMC Med., 13.","DOI":"10.1186\/s12916-015-0529-7"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/mp.2015.54","article-title":"Peripheral Blood Brain-Derived Neurotrophic Factor in Bipolar Disorder: A Comprehensive Systematic Review and Meta-Analysis","volume":"21","author":"Munkholm","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jpsychires.2011.03.002","article-title":"Brain-Derived Neurotrophic Factor as a State-Marker of Mood Episodes in Bipolar Disorders: A Systematic Review and Meta-Regression Analysis","volume":"45","author":"Fernandes","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/adb.12668","article-title":"Alcohol-Induced Cognitive Deficits Are Associated with Decreased Circulating Levels of the Neurotrophin BDNF in Humans and Rats","volume":"24","author":"Araos","year":"2019","journal-title":"Addict. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbi.2017.09.017","article-title":"Differences in the Association between Persistent Pathogens and Mood Disorders among Young- to Middle-Aged Women and Men in the U.S","volume":"68","author":"Simanek","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jad.2020.11.128","article-title":"Effects of Infliximab on Brain Neurochemistry of Adults with Bipolar Depression","volume":"281","author":"Mansur","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2021.07.014","article-title":"Peripheral Levels of C-Reactive Protein, Tumor Necrosis Factor-\u03b1, Interleukin-6, and Interleukin-1\u03b2 across the Mood Spectrum in Bipolar Disorder: A Meta-Analysis of Mean Differences and Variability","volume":"97","author":"Solmi","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jad.2021.10.074","article-title":"Alzheimer\u2019s Disease Related Biomarkers in Bipolar Disorder\u2014A Longitudinal One-Year Case-Control Study","volume":"297","author":"Knorr","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Maloum, Z., Taheri, M., Ghafouri-Fard, S., and Shirvani-Farsani, Z. (2022). Significant Reduction of Long Non-Coding RNAs Expression in Bipolar Disorder. BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-03899-y"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jpsychires.2021.09.012","article-title":"Glial Fibrillary Acidic Protein as Blood Biomarker for Differential Diagnosis and Severity of Major Depressive Disorder","volume":"144","author":"Steinacker","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbi.2017.05.002","article-title":"Markers of Neuroinflammation and Neuronal Injury in Bipolar Disorder: Relation to Prospective Clinical Outcomes","volume":"65","author":"Isgren","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Niu, Z., Wu, X., Zhu, Y., Yang, L., Shi, Y., Wang, Y., Qiu, H., Gu, W., Wu, Y., and Long, X. (2022). Early Diagnosis of Bipolar Disorder Coming Soon: Application of an Oxidative Stress Injury Biomarker (BIOS) Model. Neurosci. Bull.","DOI":"10.1007\/s12264-022-00871-4"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2022.05.062","article-title":"Effects of Metabolic Syndrome and Obesity on Suicidality in Individuals with Bipolar Disorder","volume":"311","author":"Stenzel","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Wei, Y., Womer, F.Y., Sun, K., Zhu, Y., Sun, D., Duan, J., Zhang, R., Wei, S., Jiang, X., and Zhang, Y. (2022). Applying Dimensional Psychopathology: Transdiagnostic Prediction of Executive Cognition Using Brain Connectivity and Inflammatory Biomarkers. Psychol. Med., 1\u201311.","DOI":"10.1017\/S0033291722000174"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cattarinussi, G., Kubera, K.M., Hirjak, D., Wolf, R.C., and Sambataro, F. (Biol. Psychiatry, 2022). Neural Correlates of the Risk for Schizophrenia and Bipolar Disorder: A Meta-Analysis of Structural and Functional Neuroimaging Studies, Biol. Psychiatry, in press.","DOI":"10.1016\/j.biopsych.2022.02.960"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/ijmr.IJMR_1386_16","article-title":"Potential Biomarkers for Bipolar Disorder: Where Do We Stand?","volume":"145","author":"Sagar","year":"2017","journal-title":"Indian J. Med. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s11920-014-0514-4","article-title":"Current State of Biomarkers in Bipolar Disorder","volume":"16","author":"Scola","year":"2014","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/pcn.12476","article-title":"Biological Hypotheses and Biomarkers of Bipolar Disorder","volume":"71","author":"Sigitova","year":"2017","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_104","first-page":"359","article-title":"Influence of Acute and Chronic High-Intensity Intermittent Aerobic Plus Strength Exercise on BDNF, Lipid and Autonomic Parameters","volume":"18","author":"Figueiredo","year":"2019","journal-title":"J. Sports Sci. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0022-3956(99)00021-7","article-title":"Plasma Levels of Cytokines and Soluble Cytokine Receptors in Psychiatric Patients upon Hospital Admission: Effects of Confounding Factors and Diagnosis","volume":"33","author":"Haack","year":"1999","journal-title":"J. Psychiatr. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12026-014-8491-6","article-title":"Effects of Serum and Plasma Matrices on Multiplex Immunoassays","volume":"58","author":"Hansmann","year":"2014","journal-title":"Immunol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cyto.2018.06.009","article-title":"Effect of Storage Duration on Cytokine Stability in Human Serum and Plasma","volume":"113","author":"Vincent","year":"2019","journal-title":"Cytokine"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1038\/s41598-019-45976-5","article-title":"Associations between Serum and Plasma Brain-Derived Neurotrophic Factor and Influence of Storage Time and Centrifugation Strategy","volume":"9","author":"Gejl","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Biomedicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9059\/10\/6\/1368\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:27:13Z","timestamp":1760138833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9059\/10\/6\/1368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":108,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["biomedicines10061368"],"URL":"https:\/\/doi.org\/10.3390\/biomedicines10061368","relation":{},"ISSN":["2227-9059"],"issn-type":[{"value":"2227-9059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,9]]}}}