{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:38:36Z","timestamp":1773769116762,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"publisher","award":["NV 19-09-00088"],"award-info":[{"award-number":["NV 19-09-00088"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedicines"],"abstract":"<jats:p>Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-intent, proven pathological diagnosis of PDAC, preoperative EUS-FNA and post-resection follow-up of at least 60 months. The systematic literature search of published data was used for the GSM growth evaluation using Pearson correlation and the linear regression analyses. Results: The inclusion criteria met 59\/134 cases, 16 (27%) had retained needle tract (15 following distal pancreatectomy, 1 following pylorus-sparing head resection). In total, 3\/16 cases (19%) developed identical solitary GSM (10\u201326th month following primary surgery) and were radically resected. A total of 30 published cases of PDAC GSM following EUS-FNA were identified. Lesion was resected in 20 distal pancreatectomy cases with complete information in 14 cases. A correlation between the metastasis size and time (r = 0.612) was proven. The regression coefficient b = 0.72 expresses the growth of 0.72 mm per month. Conclusions: The GSM represent a preventable and curable condition. A remarkably high number of GSM following EUS-FNA was identified, leading to follow-up recommendation of EUS-FNA sampled patients. Multimodal management (gastric resection, adjuvant chemotherapy) may prolong survival.<\/jats:p>","DOI":"10.3390\/biomedicines10061392","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T09:26:48Z","timestamp":1655026008000},"page":"1392","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection\u2014Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-9643","authenticated-orcid":false,"given":"Martin","family":"Love\u010dek","sequence":"first","affiliation":[{"name":"Department of Surgery I, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Skalick\u00fd","sequence":"additional","affiliation":[{"name":"Department of Surgery I, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-7912","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Gastroentrology and Geriatrics, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Tesa\u0159\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Surgery I, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kliment","sequence":"additional","affiliation":[{"name":"Helios Kliniken Schwerin, Klinik f\u00fcr Gastroenterologie und Infektiologie, Wismarsche Strasse 393-397, 19055 Schwerin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f3bert","family":"Ps\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hn\u011bvot\u00ednsk\u00e1 976\/3, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"\u0160v\u00e9bi\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Urban","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Hn\u011bvot\u00ednsk\u00e1 1333\/5, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Moheln\u00edkov\u00e1-Ducho\u0148ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Hn\u011bvot\u00ednsk\u00e1 1333\/5, 77900 Olomouc, Czech Republic"},{"name":"Department of Oncology, Faculty of Medicine and Dentistry, Palack\u00fd University, Hn\u011bvot\u00ednsk\u00e1 976\/3, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-4418","authenticated-orcid":false,"given":"Du\u0161an","family":"Klos","sequence":"additional","affiliation":[{"name":"Department of Surgery I, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sta\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Surgery I, University Hospital Olomouc, I.P. Pavlova 185\/6, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1055\/s-0043-109021","article-title":"Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European society of gastrointestinal endoscopy (ESGE) clinical guideline","volume":"49","author":"Dumonceau","year":"2017","journal-title":"Endoscopy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.gie.2018.06.024","article-title":"Preoperative EUS-guided FNA: Effects on peritoneal recurrence and survival in patients with pancreatic cancer","volume":"88","author":"Kim","year":"2018","journal-title":"Gastrointest. 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