{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:12:48Z","timestamp":1760058768392,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Background: Complex hindfoot pathologies involving critical-sized bone defects of the talus are difficult to manage. The current management involves arthrodesis and bone grafting with the defective talus, which have limitations in restoring structural integrity and functional goals. The advancement of 3D-printed scaffolds has opened new avenues to address such complex hindfoot pathologies, which may potentially improve treatment outcomes. The addition of platelet-rich fibrin further enhances healing potential. Method: This is a retrospective study involving six patients with severe talar bone loss secondary to osteomyelitis or avascular necrosis, where 3D-printed scaffolds coated with PRF were implemented in salvage surgery performed from 2023 to 2024. We intended to investigate the clinical outcomes in terms of healing time and union rate. Additionally, we evaluated the degree of deformity corrections and the patients\u2019 clinical outcomes. Results: This study reports six complex reconstructions which achieved CT-confirmed union after a mean duration of 20.2 weeks. All patients were able to ambulate with full weight bearing after an average duration of 23.3 weeks. The patients demonstrated improved radiological parameters, VAS scores from 7.5 \u00b1 1.4 points to 2.3 \u00b1 1.2, and functional scores in all domains for AOFAS, FFI and SF-36. Conclusion: This study demonstrates the benefits of PRF-coated 3D-printed scaffolds in managing complex hindfoot cases, especially in the presence of significant bony defects. This modality has the potential to achieve a good union rate, near-anatomical correction and good functional outcomes.<\/jats:p>","DOI":"10.3390\/biomimetics10050269","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T06:23:32Z","timestamp":1745821412000},"page":"269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Platelet-Rich Fibrin-Coated Three-Dimensionally (3D) Printed Scaffolds in Salvage of Complex Hindfoot Cases"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8355-1198","authenticated-orcid":false,"given":"Ken Meng","family":"Tai","sequence":"first","affiliation":[{"name":"Wythenshawe Hospital, Manchester University NHS Foundation Trust (MFT), Southmoor Rd, Wythenshawe, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-1784","authenticated-orcid":false,"given":"Justin","family":"Mooteeram","sequence":"additional","affiliation":[{"name":"Wythenshawe Hospital, Manchester University NHS Foundation Trust (MFT), Southmoor Rd, Wythenshawe, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-2669","authenticated-orcid":false,"given":"Anand","family":"Pillai","sequence":"additional","affiliation":[{"name":"Wythenshawe Hospital, Manchester University NHS Foundation Trust (MFT), Southmoor Rd, Wythenshawe, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.gaitpost.2021.10.043","article-title":"Determination of Relationship between Foot Arch, Hindfoot, and Hallux Motion Using Oxford Foot Model: Comparison between Walking and Running","volume":"92","author":"Shono","year":"2022","journal-title":"Gait Posture"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/acr.22546","article-title":"Epidemiology of Posterior Heel Pain in the General Population: Cross-Sectional Findings from the Clinical Assessment Study of the Foot","volume":"67","author":"Chatterton","year":"2015","journal-title":"Arthritis Care Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ocl.2004.02.010","article-title":"Avascular Necrosis of the Talus","volume":"35","author":"Adelaar","year":"2004","journal-title":"Orthop. 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