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In this work, a scoping review was carried out on adverse effects due to the prolonged use of upper-limb exoskeletons, which have been evidenced in the scientific literature. The causes of the effects are described in terms of their impacts on the physiological, psychological, and technological aspects that affect the user. A scoping review of articles of the last ten years on negative effects of upper-extremity exoskeletons for industrial tasks was carried out following the guidelines of the PRISMA\u00ae methodology with three phases: formulation of questions, definition of scopes and exhaustive search in SCOPUS, Web of Science, Science Direct, Taylor &amp; Francis, and PubMed. The selection was made by two review authors with a Cohen\u2019s Kappa coefficient of 0.9530, indicating high agreement. The effectiveness of upper-limb exoskeletons depends on the environment and the task, so an adaptable ergonomic design, field validations, and standards are required to ensure their functionality and acceptance. Use of exoskeletons mainly activates the posterior deltoid and latissimus dorsi and reduces the activity of muscles such as the trapezius, pectoralis major, anterior and middle deltoids, biceps brachii, brachioradialis, and flexor carpi radialis.<\/jats:p>","DOI":"10.3390\/biomimetics10050340","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:05:17Z","timestamp":1747800317000},"page":"340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adverse Effects Due to the Use of Upper Limbs Exoskeletons in the Work Environment: A Scoping Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Omar","family":"Flor-Unda","sequence":"first","affiliation":[{"name":"Ingenier\u00eda Industrial, Facultad de Ingenier\u00eda y Ciencias Aplicadas, Universidad de Las Am\u00e9ricas, Quito 170125, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8686-9668","authenticated-orcid":false,"given":"Rafael","family":"Arcos-Reina","sequence":"additional","affiliation":[{"name":"Escuela de Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Las Am\u00e9ricas, Quito 170125, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-6725","authenticated-orcid":false,"given":"Susana","family":"Nunez-Nagy","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Humanization in the Intervention of Physiotherapy for the Integral Attention to the People Group (HIPATIA) Group, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-5716","authenticated-orcid":false,"given":"Bernardo","family":"Alarcos","sequence":"additional","affiliation":[{"name":"Polytechnic School, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/ajim.23282","article-title":"Effects of an arm-support exoskeleton on perceived work intensity and musculoskeletal discomfort: An 18-month field study in automotive assembly","volume":"64","author":"Kim","year":"2021","journal-title":"Am. 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