{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T15:31:00Z","timestamp":1762788660378,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Green nanotechnology offers a sustainable and eco-friendly approach for nanoframework synthesis. The present study intended to synthesize a novel eco-friendly encapsulated Zeolitic Imidazolate Framework-8 (ZIF-8) in a one-pot method using metabolites from the mangrove plant Conocarpus erectus (CE). Gas Chromatography\u2013Mass Spectrometry (GC-MS) analysis of the extract revealed the presence of important bioactive metabolites. The synthesized material was evaluated by UV-Vis spectroscopy, X-ray diffraction (XRD), particle size analysis (PSA), zeta potential measurement, high-resolution transmission electron microscopy (HR-TEM), and Fourier transform infrared (FT-IR) spectroscopy studies. The environment-friendly mangrove metabolites aided by Zeolitic Imidazolate Framework-8 was found to be crystalline, rhombic dodecahedron structured, and size dispersed without agglomeration. The nanomaterial possessed a broad antimicrobial effect on drug-resistant microorganisms, including Candida krusei, Escherichia coli, Streptococcus Sp., Staphylococcus aureus, Enterococcus Sp., Pseudomonas aeruginosa, Klebsiella pneumoniae, C. propicalis, and C. albicans. Further, its cytotoxicity against MDA-MB-231 cells was found to be efficient. The morphological alterations exhibited by the antiproliferative impact on the breast cancer cell line were detected using DAPI and AO\/EB staining. Therefore, ZIF-8 encapsulated mangrove metabolites could serve as an effective biomaterial with biomedical properties in the future.<\/jats:p>","DOI":"10.3390\/biomimetics10110755","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T15:07:31Z","timestamp":1762787251000},"page":"755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytofabrication of ZIF-8 Using Mangrove Metabolites for Dual Action Against Drug-Resistant Microbes and Breast Cancer Cells"],"prefix":"10.3390","volume":"10","author":[{"given":"Srinath","family":"Rajeswaran","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithuna Shaji","family":"Kumarikrishna","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesh","family":"Giriprasath","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandi","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murugan","family":"Anbazhagan","sequence":"additional","affiliation":[{"name":"Department of Science and Humanities, Karpagam College of Engineering, Coimbatore 641032, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva","family":"Vadivel","sequence":"additional","affiliation":[{"name":"Centre for Energy and Environment, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India"},{"name":"Department of Physics, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-5487","authenticated-orcid":false,"given":"Maharshi","family":"Bhaswant","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, SRM\u2014Institute of Science and Technology, Tiruchirappalli Campus, Tiruchirappalli 621105, Tamil Nadu, India"},{"name":"New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"ref_1","first-page":"100866","article-title":"Mangrove synthesized bio-nanomaterial and its applications: A Review","volume":"20","author":"Vaish","year":"2023","journal-title":"Environ. 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