{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:59:52Z","timestamp":1787320792711,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Background: Clear aligner therapy (CAT) represents a biomimetic orthodontic approach that uses flexible thermoplastic materials to reproduce the physiological tooth movement and mechanical load distribution of natural tissues. While these materials promote oral hygiene and aesthetic comfort, their long-term biological impact on the caries process remains uncertain. This retrospective study aimed to evaluate changes in the number of decayed teeth (\u0394D) before and after clear aligner treatment and to identify duration-dependent risk factors. Methods: This retrospective study included 362 patients (279 females, 83 males) treated with Invisalign\u00ae aligners between 2020 and 2024. Baseline and post-treatment panoramic radiographs were analyzed to determine decayed tooth counts. Age, sex, and total aligner count were recorded. Non-parametric tests, multivariable regression, and ROC analysis were used to assess predictors of \u0394D. Results: The mean number of decayed teeth increased slightly from 3.54 \u00b1 2.76 to 3.83 \u00b1 2.93 (p &lt; 0.001). Longer treatment duration was independently associated with caries progression (\u03b2 = +0.0088 per tray, p = 0.0037), and each 10-tray increment increased the odds of new decay by 55% (OR = 1.55, 95% CI: 1.26\u20131.90). ROC analysis identified \u226542 trays as a clinically relevant threshold (AUC = 0.67). Conclusions: Clear aligner therapy demonstrated a statistically significant yet clinically small increase in caries incidence, primarily related to treatment duration. As a biomimetic orthodontic approach that integrates mechanical and biological dynamics, extended clear aligner use may alter biofilm\u2013surface interactions and salivary conditions over time. Therefore, preventive strategies\u2013such as professional fluoride applications, strict cleaning protocols, and shorter recall intervals\u2013should be emphasized for long-duration treatments to preserve the biological benefits of this biomimetic system.<\/jats:p>","DOI":"10.3390\/biomimetics10110786","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:17:27Z","timestamp":1763551047000},"page":"786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Duration-Dependent Caries Risk During Clear Aligner Therapy: A Retrospective Analysis"],"prefix":"10.3390","volume":"10","author":[{"given":"Abdurrahman","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry, Batman University, 72000 Batman, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursezen","family":"Kavaso\u011flu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Batman University, 72000 Batman, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2174\/1874210601610010236","article-title":"Orthodontic Treatment of Malocclusion and its Impact on Oral Health-Related Quality of Life","volume":"10","author":"Jamilian","year":"2016","journal-title":"Open Dent. 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