{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:06:44Z","timestamp":1779890804593,"version":"3.53.1"},"reference-count":58,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, and its early diagnosis remains a major challenge due to reliance on subjective clinical assessments. This study proposes a bio-inspired computational framework for automatic PD detection that draws explicit architectural inspiration from two biological systems: the hierarchical tonotopic organization of the human auditory cortex, which motivates the design of a 1D Convolutional Neural Network (CNN) for vocal biomarker analysis, and the basal ganglia\u2013cerebellar motor control circuit, which motivates the selection and design of features extracted from Archimedean spiral drawing tasks. Unlike previous studies that apply standard machine learning techniques without grounding architectural choices in biological mechanisms, the proposed framework establishes a direct mapping between neural processing pathways and model design decisions. A Support Vector Machine (SVM) classifier evaluated on the Kaggle vocal dataset achieved 87% test accuracy with no overfitting, outperforming AdaBoost, Random Forest, KNN, XGBoost, and Decision Trees in terms of generalization. The 1D CNN applied to UCI spiral drawing data achieved 85% test accuracy, with overfitting behavior addressed through architectural regularization strategies including early stopping. A conceptual multimodal fusion architecture integrating both modalities is proposed as a direction for future experimental validation; it was not implemented or experimentally validated within the present study. The primary novelty of the framework resides in this explicit biomimetic grounding, which distinguishes it from existing performance-driven approaches. Results confirm that biologically grounded computational models constitute promising objective decision-support tools for early PD diagnosis.<\/jats:p>","DOI":"10.3390\/biomimetics11060369","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:31:56Z","timestamp":1779885116000},"page":"369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bio-Inspired Deep Learning for Parkinson\u2019s Disease Detection: A Comparative Study Based on Vocal Biomarkers and Archimedean Spiral Analysis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-9633","authenticated-orcid":false,"given":"Ovidiu-Petru","family":"Stan","sequence":"first","affiliation":[{"name":"Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Misaros","sequence":"additional","affiliation":[{"name":"Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-7898","authenticated-orcid":false,"given":"Liviu-Cristian","family":"Miclea","sequence":"additional","affiliation":[{"name":"Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"469679","DOI":"10.1155\/2011\/469679","article-title":"Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer\u2032s Disease and Parkinson\u2032s Disease)","volume":"2011","author":"Spuch","year":"2011","journal-title":"J. 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