{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:24:55Z","timestamp":1787131495453,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001738","name":"Israeli Ministry of Innovation, Science, and Technology","doi-asserted-by":"publisher","award":["0008243"],"award-info":[{"award-number":["0008243"]}],"id":[{"id":"10.13039\/501100001738","id-type":"DOI","asserted-by":"publisher"}]},{"award":["0008243"],"award-info":[{"award-number":["0008243"]}],"id":[{"id":"https:\/\/ror.org\/02heb2n75","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Replicating the nonlinear, pressure-dependent mechanical behavior of native arteries remains a central challenge in small-diameter vascular graft design, where compliance mismatch between synthetic grafts and host vessels is strongly linked to graft failure. Building on a silk fiber-reinforced alginate\u2013polyacrylamide interpenetrating polymer network (IPN) hydrogel platform, we investigated whether biomimetic vascular structural motifs, specifically fiber reorientation and crimp, can be used as programmable design parameters to tune the tensile and pressure-dependent mechanical response of tubular constructs toward native coronary artery behavior. Three architectures were fabricated: a cross-plied (CP) baseline, a 25\u00b0 reoriented configuration, and a crimped CP configuration. Under internal pressurization, fiber reorientation and crimp significantly increased compliance at low physiological pressures, with a consistent directional trend across the full pressure range, by extending the low-stiffness toe region preceding fiber recruitment while preserving tensile stiffness. Across the investigated pressure range, all architectures exhibited compliance within the reported range of native coronary arteries, with crimped constructs producing pressure\u2013diameter behavior that most closely resembled young coronary arteries, whereas the CP baseline more closely resembled aged coronary arteries. These findings demonstrate that biomimetic structural motifs, without altering material composition, can serve as programmable design parameters for engineering vascular mechanics, enabling a single material platform to reproduce distinct physiological mechanical phenotypes through architecture alone.<\/jats:p>","DOI":"10.3390\/biomimetics11080591","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:58:23Z","timestamp":1787126303000},"page":"591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Motifs as Programmable Design Parameters for Tuning Vascular Mechanics in Fiber-Reinforced Hydrogel Grafts"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7356-6770","authenticated-orcid":false,"given":"Dekel","family":"Maroz","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Mechatronics, Ariel University, Ariel 407000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Aharonov","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Mechatronics, Ariel University, Ariel 407000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hod","family":"Hoenig","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Mechatronics, Ariel University, Ariel 407000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-154X","authenticated-orcid":false,"given":"Mirit","family":"Sharabi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Mechatronics, Ariel University, Ariel 407000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrcardio.2013.77","article-title":"Small-Diameter Vascular Tissue Engineering","volume":"10","author":"Seifu","year":"2013","journal-title":"Nat. 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