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In this context, wound pH serves as an important biomarker of tissue status, highlighting the need for smart dressings capable of promoting regeneration while simultaneously monitoring the wound microenvironment. In this study, biomimetic silk fibroin films functionalized with curcuminoids extracted from Curcuma longa were developed and characterized through spectroscopic, swelling\/degradation, antioxidant, colorimetric, and biological assays, with the aim of obtaining a multifunctional dressing with regenerative properties and pH responsiveness. The results showed that curcuminoids were physically incorporated into the protein matrix without altering its chemical structure. The films exhibited a high absorption ability and antioxidant activity in the initial stages, and a clear and reversible color change in response to pH. Biological assays on 3T3 fibroblasts further confirmed the high cytocompatibility of the materials and their ability to support cell migration and wound closure in vitro. The developed films represent a promising biomimetic platform for advanced wound dressings, capable of combining support for tissue regeneration, antioxidant protection, and visual monitoring of wound status through the detection of pH changes.<\/jats:p>","DOI":"10.3390\/biomimetics11090635","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:12:25Z","timestamp":1788783145000},"page":"635","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Silk Fibroin\u2013Curcuminoid Films Combining Regenerative and Antioxidant Properties with pH Sensing for Wound Dressing Applications"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-8896","authenticated-orcid":false,"given":"Rebecca","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-859X","authenticated-orcid":false,"given":"Maria Rosa","family":"Iaquinta","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6310-4093","authenticated-orcid":false,"given":"Annalia","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-6471","authenticated-orcid":false,"given":"Mauro","family":"Pollini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-6353","authenticated-orcid":false,"given":"Federica","family":"Paladini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/jdv.20808","article-title":"Skin graft bolstered by negative pressure therapy in chronic wounds: A systematic review","volume":"40","author":"Gamel","year":"2026","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_2","first-page":"1","article-title":"Chronic Wounds and Dressings: An Overview of Management and Effectiveness","volume":"60","author":"Sengul","year":"2025","journal-title":"Nurs. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e15854","DOI":"10.1002\/adma.202515854","article-title":"Self-Adaptive Wound Dressings for Wound Healing and Repair","volume":"38","author":"Zhao","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbe.2025.12.001","article-title":"Advances in wound healing: Physiology, complications, the role of oxygen and innovative treatment strategies enhancing oxygenation","volume":"46","author":"Drabik","year":"2026","journal-title":"Biocybern. Biomed. Eng."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"585159","DOI":"10.2147\/NSA.S585159","article-title":"Nanostructured Lipid Carrier-Gels for Wound Healing: A Narrative Review of Formulation Strategies, Mechanisms, and Translational Potential","volume":"19","author":"Alquraisy","year":"2026","journal-title":"Nanotechnol. Sci. Appl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"123667","DOI":"10.1016\/j.biomaterials.2025.123667","article-title":"Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes","volume":"326","author":"Caston","year":"2026","journal-title":"Biomaterials"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13471","DOI":"10.1021\/acsami.5c24549","article-title":"A pH-Adaptive Nanocomposite: A Multi-enzymatic HOF Integrated with CaO2 for On-Demand Bacterial Disinfection, Anti-inflammation, and Accelerated Infected Wound Healing","volume":"18","author":"Lin","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"172702","DOI":"10.1016\/j.cej.2026.172702","article-title":"Platelet membrane modified nanoplatform accelerates diabetic wound healing by regulating inflammation, oxidative stress and angiogenesis through PDE4C-cAMP-PKA signaling pathway","volume":"530","author":"He","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1007\/s00210-024-03722-3","article-title":"Quercetin as a therapeutic agent for skin problems: A systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer","volume":"398","author":"Okselni","year":"2025","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2500810","DOI":"10.1002\/adhm.202500810","article-title":"pH and Glucose Dual-Responsive Hydrogels Promoted Diabetic Wound Healing by Remodeling the Wound Microenvironment","volume":"14","author":"Zhou","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e12807","DOI":"10.1002\/adfm.202512807","article-title":"A Mechanical Contraction-Driven Hydrogel Dressing for pH Visualization and Tailored Acute\/Chronic Wound Healing","volume":"36","author":"Zhong","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e71798","DOI":"10.1002\/hsr2.71798","article-title":"Rethinking Chronic Wound Treatment: Unlocking the Potential of Combination Products for an Unmet Multifactorial Need: A Review Study","volume":"9","author":"Ramos","year":"2026","journal-title":"Health Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sarpong, C., Larson, J.M., Oh, I., Devisetti, N., and Gupta, S. (2026). Advancements in Smart Wound Dressings: Leveraging Sensor Technology for Real-Time Wound Monitoring and Management. Plast. Surg.\/Chir. Plast., 22925503261440483.","DOI":"10.1177\/22925503261440483"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1080\/09205063.2025.2540362","article-title":"Next-generation smart wound dressings: AI integration, biosensors, and electrospun nanofibers for chronic wound therapy","volume":"37","author":"Palani","year":"2026","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e70141","DOI":"10.1002\/app.70141","article-title":"Smart Dressings for Skin Wound Healing: A Systematic Review of Mechanisms, Materials, and Applications","volume":"143","author":"Wang","year":"2026","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jbm.b.33085","article-title":"In vivo testing of silver treated fibers for the evaluation of skin irritation effect and hypoallergenicity","volume":"102","author":"Paladini","year":"2014","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s43246-026-01108-x","article-title":"Synthesis and application of silk fibroin nanoparticles for drug delivery","volume":"7","author":"Bao","year":"2026","journal-title":"Commun. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e70026","DOI":"10.1002\/bmm2.70026","article-title":"Silk fibroin-based biomaterials for spinal cord injury repair: Recent advances and future prospects","volume":"4","author":"Cui","year":"2026","journal-title":"BMEMat"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tomljenovic-Hanic, S., and Khalid, A. (2026). Silk Fibroin for Biomedical Applications with Emphasis on Bioimaging, Biosensing and Regenerative Systems: A Review. Molecules, 31.","DOI":"10.3390\/molecules31071142"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jbm.b.34090","article-title":"Development of regenerative and flexible fibroin-based wound dressings","volume":"107","author":"Panico","year":"2019","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1021\/acssuschemeng.5c13003","article-title":"Silk Protein-Based Smart Hydrogels Combining Sutureless Self-Adhesion, Skin Regeneration, and Sensing: A Novel Strategy for Wound Treatment","volume":"14","author":"Yang","year":"2026","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wu, Y., Chen, J., Han, L., Zhang, Y., and Wei, L. (2026). Multifunctional Silk Fibroin Hydrogel with Antibacterial and Regenerative Properties for Accelerated Wound Healing. Gels, 12.","DOI":"10.3390\/gels12050417"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1021\/acsabm.5c02246","article-title":"Bioactive Chemically Modified Silk Fibroin Accelerates Wound Healing via the Regulation of Macrophage Polarization","volume":"9","author":"Lyu","year":"2026","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Masi, A., Pellegrino, R., Paladini, F., and Pollini, M. (2026). Silver-Functionalized Silk Fibroin Films: Development and Characterization for Antibacterial Wound Dressings. Macromol, 6.","DOI":"10.3390\/macromol6020029"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"38313","DOI":"10.1021\/acsomega.6c02513","article-title":"Silk-Fibroin-Based Adhesive Hydrogels: Mechanistic Insights and Biomedical Applications\u2500A Review","volume":"11","author":"Jitpibull","year":"2026","journal-title":"ACS Omega"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pollini, M., and Paladini, F. (2020). Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin. Materials, 13.","DOI":"10.3390\/ma13153361"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nguyen, T.P., Nguyen, Q.V., Nguyen, V.-H., Le, T.-H., Huynh, V.Q., Vo, D.-V.N., Trinh, Q.T., Kim, S.Y., and Le, Q.V. (2019). Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review. Polymers, 11.","DOI":"10.3390\/polym11121933"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e70129","DOI":"10.1002\/ardp.70129","article-title":"A Review on Curcumin: Pharmacological Promises and Biomedical Activities","volume":"358","author":"Younis","year":"2025","journal-title":"Arch. Pharm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"114269","DOI":"10.1016\/j.microc.2025.114269","article-title":"Extraction of curcumin and curcuminoids: From conventional methods to innovative extraction using deep eutectic solvents","volume":"215","author":"Nisoa","year":"2025","journal-title":"Microchem. J."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Deng, X., Ratnayake, J., and Ali, A. (2025). Curcumin-Loaded Drug Delivery Systems for Acute and Chronic Wound Management: A Review. Bioengineering, 12.","DOI":"10.3390\/bioengineering12080860"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Meng, Q., Xiao, F., Jiang, D., Jiang, W., Lin, W., Gan, H., Ye, T., Jiang, J., and Lu, L. (2026). Recent Progress in Curcumin Extraction, Synthesis, and Applications: A Comprehensive Review. Foods, 15.","DOI":"10.3390\/foods15020354"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24627","DOI":"10.1039\/D6RA00713A","article-title":"Curcumin release from hydrogels incorporated with turmeric extract\u2013cyclodextrin complexes for wound dressing applications","volume":"16","author":"Morarad","year":"2026","journal-title":"RSC Adv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-026-10235-9","article-title":"From phytochemistry to biomaterials: Curcumin-based scaffolds in wound management","volume":"25","author":"Bose","year":"2026","journal-title":"Phytochem. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wang, M., Liu, H., Zhao, W., Wang, H., Zhuang, Y., Yang, J., Liu, Z., Zhu, J., Chen, S., and Cheng, J. (2025). Design and Characterization of Curcumin-Modified Polyurethane Material with Good Mechanical, Shape-Memory, pH-Responsive, and Biocompatible Properties. Biomolecules, 15.","DOI":"10.3390\/biom15081070"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1039\/D4AN01570C","article-title":"Curcumin\u2014A natural colorant-based pH indicator for molecular diagnostics","volume":"150","author":"Sivakumar","year":"2025","journal-title":"Analyst"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.carbpol.2011.11.068","article-title":"In vivo evaluation of curcumin nanoformulation loaded methoxy poly(ethylene glycol)-graft-chitosan composite film for wound healing application","volume":"88","author":"Li","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chiaoprakobkij, N., Suwanmajo, T., Sanchavanakit, N., and Phisalaphong, M. (2020). Curcumin-Loaded Bacterial Cellulose\/Alginate\/Gelatin as A Multifunctional Biopolymer Composite Film. Molecules, 25.","DOI":"10.3390\/molecules25173800"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101289","DOI":"10.1016\/j.mtchem.2022.101289","article-title":"Biodegradable silk-curcumin composite for sustained drug release and visual wound monitoring","volume":"27","author":"Shanmugarajan","year":"2023","journal-title":"Mater. Today Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/jbm.b.32753","article-title":"Fabrication and characterization of curcumin-releasing silk fibroin scaffold","volume":"100B","author":"Kasoju","year":"2012","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhang, X., Chen, Z., Bao, H., Liang, J., Xu, S., Cheng, G., and Zhu, Y. (2019). Fabrication and Characterization of Silk Fibroin\/Curcumin Sustained-Release Film. Materials, 12.","DOI":"10.3390\/ma12203340"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ardelean Rusu, M.L., Muselin, F., Doma, A.O., Florea, B., Cristina, R.T., and Dumitrescu, E. (2026). Curcuma longa L. and Curcumin in Veterinary Medicine and Animal Production: Phytochemistry, Biological Mechanisms and Practical Applications. Plants, 15.","DOI":"10.3390\/plants15111604"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Palma, P.J., Marques, J.A., Santos, J., Falacho, R.I., Sequeira, D., Diogo, P., Caramelo, F., Ramos, J.C., and Santos, J.M. (2020). Tooth Discoloration after Regenerative Endodontic Procedures with Calcium Silicate-Based Cements\u2014An Ex Vivo Study. Appl. Sci., 10.","DOI":"10.3390\/app10175793"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Pollini, M., Lanzillotti, C., De Sangro, M.A., Cazzato, M.R., Abbruzzese, L., and Paladini, F. (2025). Biomimetic Silk Fibroin Scaffolds Functionalized with Hydroxyapatite and Platelet Growth Factors for Bone Tissue Engineering. Biomimetics, 10.","DOI":"10.3390\/biomimetics10100703"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Iaquinta, M.R., Martini, F., D\u2019Agostino, A., Trevisiol, L., Bersani, M., Torreggiani, E., Tognon, M., Rotondo, J.C., and Mazzoni, E. (2022). Stem Cell Fate and Immunomodulation Promote Bone Regeneration via Composite Bio-Oss\u00ae\/AviteneTM Biomaterial. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.873814"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Pellegrino, R., Lanzillotti, C., Pollini, M., and Paladini, F. (2026). UV-Assisted Silver Functionalization of Cotton Gauze for Antimicrobial and Biocompatible Wound Healing Applications. Microorganisms, 14.","DOI":"10.3390\/microorganisms14010213"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e13281","DOI":"10.14814\/phy2.13281","article-title":"Matrix stiffness regulates migration of human lung fibroblasts","volume":"5","author":"Asano","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e31256","DOI":"10.1002\/jcp.31256","article-title":"Osteosarcoma cell death induced by innovative scaffolds doped with chemotherapeutics","volume":"239","author":"Lanzillotti","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e71120","DOI":"10.1096\/fj.202500657RR","article-title":"Resveratrol Affects Cell Activities, Induces Apoptosis and Regulates AMPK Signaling Pathway in Pleural Mesothelioma Cells","volume":"39","author":"Iaquinta","year":"2025","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105314","DOI":"10.1016\/j.jff.2022.105314","article-title":"Effects of turmeric powder on intestinal and biliary functions: The influence of curcuminoids concentration on spontaneous contractility","volume":"99","author":"Micucci","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"El-Saadony, M.T., Yang, T., Korma, S.A., Sitohy, M., Abd El-Mageed, T.A., Selim, S., Al Jaouni, S.K., Salem, H.M., Mahmmod, Y., and Soliman, S.M. (2023). Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1040259"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3923\/rjmp.2015.179.186","article-title":"Analysis of curcumin in curcuma longa and Curcuma xanthorriza using FTIR spectroscopy and chemometrics","volume":"9","author":"Rohman","year":"2015","journal-title":"Res. J. Med. Plant"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1039\/C2SM26945G","article-title":"Effect of regeneration of liquid silk fibroin on its structure and characterization","volume":"9","author":"Wang","year":"2013","journal-title":"Soft Matter"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0301-4622(00)00213-1","article-title":"Conformation transition kinetics of regenerated Bombyx mori silk fibroin membrane monitored by time-resolved FTIR spectroscopy","volume":"89","author":"Chen","year":"2001","journal-title":"Biophys. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"171596","DOI":"10.1016\/j.cej.2025.171596","article-title":"Construction of silk fibroin-based composite nanofiber films with effective antibacterial and filtration properties","volume":"527","author":"Wang","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acsbiomaterials.4c02122","article-title":"Modulation of Secondary Structure, Bioavailability, Immunomodulation, and Tissue Repair Outcomes Using Differential Processing of Silk Biomaterials","volume":"11","author":"Pallod","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"27558","DOI":"10.1039\/C5RA01018G","article-title":"Fabrication and characterization of silk fibroin\/chitosan\/Nano \u03b3-alumina composite scaffolds for tissue engineering applications","volume":"5","author":"Teimouri","year":"2015","journal-title":"RSC Adv."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Montalb\u00e1n, M.G., Coburn, J.M., Lozano-P\u00e9rez, A.A., Cenis, J.L., V\u00edllora, G., and Kaplan, D.L. (2018). Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy. Nanomaterials, 8.","DOI":"10.3390\/nano8020126"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1111\/ijfs.16671","article-title":"Curcuma particle size evolution by application of bead milling process and curcuminoids content determination","volume":"58","author":"Valenta","year":"2023","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Opustilov\u00e1, K., Lap\u010d\u00edkov\u00e1, B., Lap\u010d\u00edk, L., Gautam, S., Valenta, T., and Li, P. (2023). Physico-Chemical Study of Curcumin and Its Application in O\/W\/O Multiple Emulsion. Foods, 12.","DOI":"10.3390\/foods12071394"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chaala, M., Sebba, F.Z., Fuster, M.G., Moulefera, I., Montalb\u00e1n, M.G., Carissimi, G., and V\u00edllora, G. (2023). Accelerated Simple Preparation of Curcumin-Loaded Silk Fibroin\/Hyaluronic Acid Hydrogels for Biomedical Applications. Polymers, 15.","DOI":"10.48158\/MeCCE-15.T2-P-01"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Baliyan, S., Mukherjee, R., Priyadarshini, A., Vibhuti, A., Gupta, A., Pandey, R.P., and Chang, C.M. (2022). Determination of Antioxidants by DPPH Radical Scavenging Activity and Quantitative Phytochemical Analysis of Ficus religiosa. Molecules, 27.","DOI":"10.3390\/molecules27041326"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.actbio.2014.08.009","article-title":"Curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells","volume":"11","author":"Li","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Pollini, M., and Paladini, F. (2024). The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems. Biomimetics, 9.","DOI":"10.3390\/biomimetics9050295"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1700121","DOI":"10.1002\/adhm.201700121","article-title":"Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial","volume":"6","author":"Zhang","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"114228","DOI":"10.1016\/j.jconrel.2025.114228","article-title":"In situ forming silk fibroin hydrogel dressing accelerates acute wound healing via immunomodulation and extracellular matrix regeneration","volume":"387","author":"Chen","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"118810","DOI":"10.1016\/j.lwt.2025.118810","article-title":"Green chemistry-based sustainable extraction of curcuminoids from turmeric (Curcuma longa L.) using deep eutectic solvents for efficient extraction","volume":"237","author":"Jung","year":"2025","journal-title":"LWT"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1039\/D3TB00639E","article-title":"Recent advances in novel materials and techniques for developing transparent wound dressings","volume":"11","author":"Kuddushi","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.fmre.2021.10.001","article-title":"Transparent photothermal hydrogels for wound visualization and accelerated healing","volume":"2","author":"Xie","year":"2022","journal-title":"Fundam. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zhao, M., Qi, Z., Tao, X., Newkirk, C., Hu, X., and Lu, S. (2021). Chemical, Thermal, Time, and Enzymatic Stability of Silk Materials with Silk I Structure. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084136"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15913","DOI":"10.1039\/D0RA02634D","article-title":"Influence of alcohol treatments on properties of silk-fibroin-based films for highly optically transparent coating applications","volume":"10","author":"Kaewpirom","year":"2020","journal-title":"RSC Adv."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7603\/s40681-015-0022-9","article-title":"Wound dressings\u2014A review","volume":"5","author":"Dhivya","year":"2015","journal-title":"Biomedicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1039\/D2RA07673J","article-title":"Biomedical materials for wound dressing: Recent advances and applications","volume":"13","author":"Nguyen","year":"2023","journal-title":"RSC Adv."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Nitti, P., Narayanan, A., Pellegrino, R., Villani, S., Madaghiele, M., and Demitri, C. (2023). Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials. Bioengineering, 10.","DOI":"10.20944\/preprints202308.0491.v1"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.msec.2016.03.027","article-title":"Development of hybrid cotton\/hydrogel yarns with improved absorption properties for biomedical applications","volume":"63","author":"Pollini","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/bm101422j","article-title":"Degradation Mechanism and Control of Silk Fibroin","volume":"12","author":"Lu","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jbm.a.37331","article-title":"The post-processing temperature or humidity can importantly control the secondary structure and characteristics of silk fibroin films","volume":"110","author":"Wang","year":"2022","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1039\/C5BM00471C","article-title":"Silk fibroin gelation via non-solvent induced phase separation","volume":"4","author":"Kasoju","year":"2016","journal-title":"Biomater. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0003702817706368","article-title":"Methanol-Water-Dependent Structural Changes of Regenerated Silk Fibroin Probed Using Terahertz Spectroscopy","volume":"71","author":"Wu","year":"2017","journal-title":"Appl. Spectrosc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.progpolymsci.2007.05.013","article-title":"Silk as a Biomaterial","volume":"32","author":"Vepari","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Mora, C., Mrowiec, A., Garc\u00eda-Vizca\u00edno, E.M., Alcaraz, A., Cenis, J.L., and Nicol\u00e1s, F.J. (2012). Fibroin and sericin from Bombyx mori silk stimulate cell migration through upregulation and phosphorylation of c-Jun. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042271"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.08.016","article-title":"Curcumin as a wound healing agent","volume":"116","author":"Akbik","year":"2014","journal-title":"Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.1021\/acsomega.4c08089","article-title":"Dual Cross-Linked Chitosan-Based Films with pH-Sensitive Coloration and Drug Release Kinetics for Smart Wound Dressings","volume":"10","author":"Chalitangkoon","year":"2025","journal-title":"ACS Omega"},{"key":"ref_83","first-page":"4592","article-title":"An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing","volume":"6","author":"Hu","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wang, D., Zhou, S., Li, N., and Lin, D. (2025). Curcumin: A Magical Small Molecule with a Large Role in Active-Intelligent Degradable Food Packaging. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083917"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Cialdai, F., Risaliti, C., and Monici, M. (2022). Role of fibroblasts in wound healing and tissue remodeling on Earth and in space. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.958381"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Paladini, F., Lanzillotti, C., Panico, A., and Pollini, M. (2025). Biological Evaluation of Silver-Treated Silk Fibroin Scaffolds for Application as Antibacterial and Regenerative Wound Dressings. Nanomaterials, 15.","DOI":"10.3390\/nano15120919"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Paladini, F., Russo, F., Masi, A., Lanzillotti, C., Sannino, A., and Pollini, M. (2024). Silver-Treated Silk Fibroin Scaffolds for Prevention of Critical Wound Infections. Biomimetics, 9.","DOI":"10.3390\/biomimetics9110659"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1801092","DOI":"10.1002\/adhm.201801092","article-title":"In Situ Forming Injectable Silk Fibroin Hydrogel Promotes Skin Regeneration in Full Thickness Burn Wounds","volume":"7","author":"Chouhan","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Momotyuk, E., Ebrahim, N., Shakirova, K., and Dashinimaev, E. (2025). Role of the cytoskeleton in cellular reprogramming: Effects of biophysical and biochemical factors. Front. Mol. Biosci., 12.","DOI":"10.3389\/fmolb.2025.1538806"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jobcr.2025.04.006","article-title":"Effects of different curcumin concentrations on human periodontal ligament fibroblast adhesion and proliferation on periodontally involved root surfaces: In-vitro study","volume":"15","author":"Farag","year":"2025","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_91","first-page":"1","article-title":"Fibroblasts: The arbiters of extracellular matrix remodeling","volume":"91\u201392","author":"Barker","year":"2020","journal-title":"Matrix Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2041731414551661","DOI":"10.1177\/2041731414551661","article-title":"Electrospun silk fibroin fiber diameter influences in vitro dermal fibroblast behavior and promotes healing of ex vivo wound models","volume":"5","author":"Hodgkinson","year":"2014","journal-title":"J. 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