{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:00:02Z","timestamp":1792803602946,"version":"4.5.0"},"reference-count":110,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"WISE Program: Doctoral Program for World-Leading Innovative &amp; Smart Education of TUAT, granted by the Ministry of Education, Culture, Sports, Science, and Technology","id":[{"id":"https:\/\/ror.org\/048rj2z13","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Inducing tissue regeneration in many skin defects, such as large traumatic wounds, burns, other physicochemical wounds, bedsores, and chronic diabetic ulcers, has become an important clinical issue in recent years. Cultured cell sheets and scaffolds containing growth factors are already in use but have yet to restore normal skin tissue structure and function. Many tissue engineering materials that focus on the regeneration process of living tissues have been developed for the more versatile and rapid initiation of treatment. Since the discovery that cells recognize the chemical\u2013physical properties of their surrounding environment, there has been a great deal of work on mimicking the composition of the extracellular matrix (ECM) and its three-dimensional network structure. Approaches have used ECM constituent proteins as well as morphological processing methods, such as fiber sheets, sponges, and meshes. This review summarizes material design strategies in tissue engineering fields, ranging from the morphology of existing dressings and ECM structures to cellular-level microstructure mimicry, and explores directions for future approaches to precision skin tissue regeneration.<\/jats:p>","DOI":"10.3390\/biomimetics8010130","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T06:35:28Z","timestamp":1679466928000},"page":"130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration"],"prefix":"10.3390","volume":"8","author":[{"given":"Rikako","family":"Hama","sequence":"first","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"},{"name":"Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-Cho, Koganei 184-8588, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-8421","authenticated-orcid":false,"given":"James W.","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-0634","authenticated-orcid":false,"given":"Anudari","family":"Ulziibayar","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kelly","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-9249","authenticated-orcid":false,"given":"Toshiharu","family":"Shinoka","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"},{"name":"Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children\u2019s Hospital, 700 Children\u2019s Drive, Columbus, OH 43205, USA"},{"name":"Department of Surgery, Cardiovascular Tissue Engineering Program, Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human Wounds and Its Burden: An Updated Compendium of Estimates","volume":"8","author":"Sen","year":"2019","journal-title":"Adv. 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