{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:33:09Z","timestamp":1791437589909,"version":"4.3.3"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>The recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and\/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-established therapeutic approach in medicine and periodontal and oral surgery. Recently, the concept of biomimetic regeneration has been further expanded to treat the loss of hard dental tissues. Self-assembling peptides have emerged as a promising biomaterial for biomimetic regeneration due to their ability to construct a protein scaffold in the body of early carious lesions and provide a matrix that promotes remineralization. This review article accompanies the development of self-assembling peptide P11-4 for the treatment of initial carious lesions. In vitro and in vivo studies on the safety, clinical applicability, and efficacy of P11-4 are discussed. Furthermore, different treatment options and potential areas of application are presented.<\/jats:p>","DOI":"10.3390\/biomimetics8030290","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:37:28Z","timestamp":1688517448000},"page":"290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9817-3206","authenticated-orcid":false,"given":"Mohammad","family":"Alkilzy","sequence":"first","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-5747","authenticated-orcid":false,"given":"Ghalib","family":"Qadri","sequence":"additional","affiliation":[{"name":"Department of Orthodontic and Pediatric Dentistry, Arab American University, Jenin P.O. Box 240, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H.","family":"Splieth","sequence":"additional","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-6351","authenticated-orcid":false,"given":"Ruth M.","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000077752","article-title":"Changes in dental caries 1953\u20132003","volume":"38","author":"Marthaler","year":"2004","journal-title":"Caries Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17030","DOI":"10.1038\/nrdp.2017.30","article-title":"Dental caries","volume":"3","author":"Pitts","year":"2017","journal-title":"Nat. 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