{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:11:18Z","timestamp":1793225478723,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"framework of the project \u201cDesarrollo y validaci\u00f3n de un nuevo concepto de caracterizaci\u00f3n biomec\u00e1nica-morfofuncional de la c\u00f3rnea\u201d","doi-asserted-by":"publisher","award":["DTS21\/00103"],"award-info":[{"award-number":["DTS21\/00103"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["DTS21\/00103"],"award-info":[{"award-number":["DTS21\/00103"]}]},{"name":"European Union","award":["DTS21\/00103"],"award-info":[{"award-number":["DTS21\/00103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Implementing in silico corneal biomechanical models for surgery applications can be boosted by developing patient-specific finite element models adapted to clinical requirements and optimized to reduce computational times. This research proposes a novel corneal multizone-based finite element model with octants and circumferential zones of clinical interest for material definition. The proposed model was applied to four patient-specific physiological geometries of keratoconus-affected corneas. Free-stress geometries were calculated by two iterative methods, the displacements and prestress methods, and the influence of two boundary conditions: embedded and pivoting. The results showed that the displacements, stress and strain fields differed for the stress-free geometry but were similar and strongly depended on the boundary conditions for the estimated physiological geometry when considering both iterative methods. The comparison between the embedded and pivoting boundary conditions showed bigger differences in the posterior limbus zone, which remained closer in the central zone. The computational calculation times for the stress-free geometries were evaluated. The results revealed that the computational time was prolonged with disease severity, and the displacements method was faster in all the analyzed cases. Computational times can be reduced with multicore parallel calculation, which offers the possibility of applying patient-specific finite element models in clinical applications.<\/jats:p>","DOI":"10.3390\/biomimetics9020073","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:32:38Z","timestamp":1706178758000},"page":"73","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Study of the Influence of Boundary Conditions on Corneal Deformation Based on the Finite Element Method of a Corneal Biomechanics Model"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-9165","authenticated-orcid":false,"given":"Carmelo","family":"G\u00f3mez","sequence":"first","affiliation":[{"name":"International School of Doctorate, Technical University of Cartagena, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-4807","authenticated-orcid":false,"given":"David P.","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5177-4490","authenticated-orcid":false,"given":"Manuel","family":"Paredes","sequence":"additional","affiliation":[{"name":"ICA, Universit\u00e9 de Toulouse, UPS, INSA, ISAE-SUPAERO, MINES-ALBI, CNRS, 3 rue Caroline Aigle, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Ali\u00f3","sequence":"additional","affiliation":[{"name":"Cornea, Cataract and Refractive Surgery Department, VISSUM, 03016 Alicante, Spain"},{"name":"Division of Ophthalmology, Department of Pathology and Surgery, Faculty of Medicine, Miguel Hern\u00e1ndez University, 03202 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-0688","authenticated-orcid":false,"given":"Francisco","family":"Cavas","sequence":"additional","affiliation":[{"name":"Department of Structures, Construction and Graphic Expression, Technical University of Cartagena, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/cxo.12230","article-title":"Corneal biomechanics: A review","volume":"98","year":"2015","journal-title":"Clin. 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