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Nonetheless, there is a remarkable amount of studies about the consequences of pathological conditions on its development and functioning. This bibliographic review aims to cover mostly findings related to changes in the physical distribution of neurons and their connections\u2014the connectome\u2014both structural and functional, as well as their modelling approaches. It does not intend to offer an extensive description of all conditions affecting the brain; rather, it presents the most common ones. Thus, here, we highlight the need for accurate brain modelling that can subsequently be used to understand brain function and be applied to diagnose, track, and simulate treatments for the most prevalent pathologies affecting the brain.<\/jats:p>","DOI":"10.3390\/biomimetics9060362","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:29:43Z","timestamp":1718605783000},"page":"362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Review of the Brain\u2019s Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM)"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-237X","authenticated-orcid":false,"given":"Luis","family":"Irastorza-Valera","sequence":"first","affiliation":[{"name":"E.T.S. de Ingenier\u00eda Aeron\u00e1utica y del Espacio, Universidad Polit\u00e9cnica de Madrid, Pza. Cardenal Cisneros 3, 28040 Madrid, Spain"},{"name":"PIMM Laboratory, ENSAM\u2013Arts et M\u00e9tiers ParisTech, 151 Bd de l\u2019H\u00f4pital, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-5915","authenticated-orcid":false,"given":"Edgar","family":"Soria-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Ach\u00facarro Basque Center for Neuroscience, Barrio Sarriena, s\/n, 48940 Leioa, Spain"},{"name":"Ikerbasque, Basque Foundation for Science, Plaza Euskadi, 5, 48009 Bilbao, Spain"},{"name":"Department of Neurosciences, University of the Basque Country UPV\/EHU, Barrio Sarriena, s\/n, 48940 Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-0713","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Benitez","sequence":"additional","affiliation":[{"name":"E.T.S. de Ingenier\u00eda Aeron\u00e1utica y del Espacio, Universidad Polit\u00e9cnica de Madrid, Pza. 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Cardenal Cisneros 3, 28040 Madrid, Spain"},{"name":"Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PJ, UK"},{"name":"Department of Nuclear Science and Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Ave, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Padamsey, Z., and Rochefort, N.L. (2023). Paying the brain\u2019s energy bill. Curr. Opin. Neurobiol., 78.","DOI":"10.1016\/j.conb.2022.102668"},{"key":"ref_2","unstructured":"Ritchie, H., Spooner, F., and Roser, M. (2023, October 19). Causes of Death. Our World in Data. 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