{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:43:34Z","timestamp":1788857014859,"version":"build-2803163510"},"reference-count":70,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Graduate Studies and Scientific Research, Jazan University, Saudi Arabia","award":["GSSRD-24"],"award-info":[{"award-number":["GSSRD-24"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>The color masking ability of resin infiltration (RI) and curodont repair fluoride plus\u2013self-assembling peptide (CRFP-SAP) was investigated under various simulated oral challenging conditions. Sixty-four extracted caries-free human canines were randomly divided into two groups: Group 1 (RI) and Group 2 (CRFP-SAP). The baseline color values of samples were recorded using a spectrophotometer (VITA Easyshade\u00ae Advance 4.0 VITA Zahnfabrik, Bad Sackingen, Germany). The samples were stored in a demineralization solution for 4 days to induce artificial enamel lesions (AELs). The AELs of Groups I and II were treated with RI (Icon, DMG, Hamburg, Germany) and CRFP-SAP (vVARDIS, Zug, Switzerland), respectively, followed by color measurements. Each group was subjected to challenges such as remineralization, pH cycling, staining, and thermocycling, followed by color measurements. The difference between the mean \u2206E (color difference value) of sound enamel and both treatment groups was less than 3.7 1-week post treatment. Meanwhile, the difference between the mean \u2206E of RI-treated samples and all kinds of challenges was more than 3.7, while for the CRFP-SAP-treated samples, it was less than 3.7 for all kinds of challenges, except for the thermocycling, for which the mean \u2206E difference was 4.3. RI and CRFP-SAP treatments were effective in masking the discoloration caused by AELs. However, the color was not stable for RI-treated samples, whereas it was stable for CRFP-SAP-treated samples under all challenges, except for thermocycling.<\/jats:p>","DOI":"10.3390\/biomimetics9120764","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:46:02Z","timestamp":1734407162000},"page":"764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Color Masking Ability of Guided Enamel Regeneration with a Novel Self-Assembling Peptide and Resin Infiltration on Artificial Enamel Lesions Under Various Challenges: An In Vitro Spectrophotometric Analysis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-4712","authenticated-orcid":false,"given":"Nassreen","family":"Albar","sequence":"first","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-2425","authenticated-orcid":false,"given":"Syed Nahid","family":"Basheer","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M. Al","family":"Moaleem","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Ageel","sequence":"additional","affiliation":[{"name":"Interns Affairs Unit, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Abbas","sequence":"additional","affiliation":[{"name":"Interns Affairs Unit, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaa","family":"Hakami","sequence":"additional","affiliation":[{"name":"Interns Affairs Unit, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-1818","authenticated-orcid":false,"given":"Arwa","family":"Daghrery","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sawady","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-9664","authenticated-orcid":false,"given":"Syed Wali","family":"Peeran","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-3872","authenticated-orcid":false,"given":"Thilla Sekar","family":"Vinothkumar","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-3914","authenticated-orcid":false,"given":"Bassam","family":"Zidane","sequence":"additional","affiliation":[{"name":"Restorative Dentistry Department Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e06164","DOI":"10.1016\/j.heliyon.2021.e06164","article-title":"Tooth Shade Variation in Indian Population: An Objective Guide to Age Estimation","volume":"7","author":"Srikant","year":"2021","journal-title":"Heliyon"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.1365-2842.2004.01353.x","article-title":"Calculation of Colour Resulting from Composite\/Compomer Layering Techniques","volume":"31","author":"Lee","year":"2004","journal-title":"J. Oral Rehabil."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hardan, L., Bourgi, R., Cuevas-Su\u00e1rez, C.E., Lukomska-Szymanska, M., Monjar\u00e1s-\u00c1vila, A.J., Zarow, M., Jakubowicz, N., Jorquera, G., Ashi, T., and Mancino, D. (2022). Novel Trends in Dental Color Match Using Different Shade Selection Methods: A Systematic Review and Meta-Analysis. Materials, 15.","DOI":"10.3390\/ma15020468"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.5037\/jomr.2014.5104","article-title":"Factors Affecting the Formation, Severity and Location of White Spot Lesions during Orthodontic Treatment with Fixed Appliances","volume":"5","author":"Khalaf","year":"2014","journal-title":"J. Oral Maxillofac. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.15517\/ijds.2021.46061","article-title":"Oral Health Status after Orthodontic Treatment: A Retrospective Study","volume":"29","author":"Telatar","year":"2021","journal-title":"Odovtos-Int. J. Dent. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-263X.2011.01126.x","article-title":"The Evaluation of Resin Infiltration for Masking Labial Enamel White Spot Lesions","volume":"21","author":"Kim","year":"2011","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_7","first-page":"180","article-title":"In Vitro Assessments of Experimental NaF Dentifrices Containing a Prospective Calcium Phosphate Technology","volume":"22","author":"Karlinsey","year":"2009","journal-title":"Am. J. Dent."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Puleio, F., Di Spirito, F., Lo Giudice, G., Pantaleo, G., Rizzo, D., and Lo Giudice, R. (2023). Long-Term Chromatic Durability of White Spot Lesions through Employment of Infiltration Resin Treatment. Medicina, 59.","DOI":"10.3390\/medicina59040749"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/denthyp.denthyp_129_21","article-title":"Spectrophotometric Evaluation of the Color Change of Artificial White Spot Lesions Treated with Three Different Commercially Available Remineralizing Agents","volume":"13","author":"Malekipoor","year":"2022","journal-title":"Dent. Hypotheses"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chistyakov, E.M., Kolpinskaya, N., Posokhova, V., and Chuev, V. (2020). Dental Composition Modified with Aryloxyphosphazene Containing Carboxyl Groups. Polymers, 12.","DOI":"10.3390\/polym12051176"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12903-023-02808-3","article-title":"Biomimetic Approaches and Materials in Restorative and Regenerative Dentistry: Review Article","volume":"23","author":"Singer","year":"2023","journal-title":"BMC Oral Health"},{"key":"ref_12","first-page":"111","article-title":"Hardness and Compressive Strength Evaluation of Dental Composites Containing Biosilica-Encapsulated Healing Liquid","volume":"1069","author":"Wang","year":"2022","journal-title":"Mater. Sci. For."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.dental.2018.04.010","article-title":"In-Vitro Subsurface Remineralisation of Artificial Enamel White Spot Lesions Pre-Treated with Chitosan","volume":"34","author":"Zhang","year":"2018","journal-title":"Dent. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mu\u015fat, V., Anghel, E.M., Zaharia, A., Atkinson, I., Mocioiu, O.C., Bu\u015fil\u0103, M., and Alexandru, P. (2021). A Chitosan-Agarose Polysaccharide-Based Hydrogel for Biomimetic Remineralization of Dental Enamel. Biomolecules, 11.","DOI":"10.3390\/biom11081137"},{"key":"ref_15","first-page":"e5686","article-title":"Effectiveness of Theobromine on Enamel Remineralization: A Comparative in-Vitro Study","volume":"11","author":"Premnath","year":"2019","journal-title":"Cureus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.5005\/jp-journals-10005-2619","article-title":"Effect of Liquorice Candies on Remineralization of Initial Enamel Carious Lesion","volume":"16","author":"Pooja","year":"2023","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10266-021-00675-4","article-title":"The Use of Hydroxyapatite Toothpaste to Prevent Dental Caries","volume":"110","author":"Enax","year":"2022","journal-title":"Odontology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S1566","DOI":"10.4103\/jpbs.jpbs_973_23","article-title":"The Effect of Non-Invasive Treatment Techniques on the Color Masking Ability and Surface Roughness of Induced Enamel Lesions (an in Vitro Study)","volume":"16","author":"Obead","year":"2024","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000342416","article-title":"Estimation of the Enamel and Dentin Mineral Content from the Refractive Index","volume":"47","author":"Hariri","year":"2013","journal-title":"Caries Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.37506\/ijocd.v11i1.18813","article-title":"Systematic Review on the Efficacy of Icon Resin Infiltration on White Spot Lesions","volume":"11","author":"Gousalya","year":"2023","journal-title":"Indian J. Contemp. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.biomaterials.2010.10.048","article-title":"A Bioactive Self-Assembled Membrane to Promote Angiogenesis","volume":"32","author":"Chow","year":"2011","journal-title":"Biomaterials"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1073\/pnas.0906501107","article-title":"Supramolecular Design of Self-Assembling Nanofibers for Cartilage Regeneration","volume":"107","author":"Shah","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1039\/C1CC15551B","article-title":"Self-Assembling Peptide Scaffolds for Regenerative Medicine","volume":"48","author":"Matson","year":"2012","journal-title":"Chem. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/jemt.23254","article-title":"Analysis of Efficacy of the Self-Assembling Peptide-Based Remineralization Agent on Artificial Enamel Lesions","volume":"82","year":"2019","journal-title":"Microsc. Res. Tech."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.37358\/RC.19.8.7490","article-title":"Study Regarding the Capacity of Self-Assembling Peptides to Remineralize the Acute and Chronic Incipient Caries Lesions","volume":"70","author":"Stoleriu","year":"2019","journal-title":"Rev. Chim."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kharbot, B., Askar, H., Gruber, D., and Paris, S. (2024). Biomimetic Remineralization of Artificial Caries Lesions with a Calcium Coacervate, Its Components and Self-Assembling Peptide P11-4 in Vitro. Bioengineering, 11.","DOI":"10.3390\/bioengineering11050465"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.adaj.2023.03.014","article-title":"Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P11-4 on Arrest, Cavitation, and Progression of Initial Caries Lesions","volume":"154","author":"Keeper","year":"2023","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s40368-023-00821-2","article-title":"Self-Assembling Peptides for Managing White Spot Lesions: A Systematic Review and Meta-Analysis","volume":"24","author":"Rathore","year":"2023","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/00016357.2020.1825799","article-title":"Self-Assembling Peptide P11-4 in Remineralization of Enamel Caries\u2014A Systematic Review of in-Vitro Studies","volume":"79","author":"Mohamed","year":"2021","journal-title":"Acta Odontol. Scand."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jobcr.2022.03.012","article-title":"Remineralization of Early Enamel Caries Lesions Using Self-Assembling Peptides P11-4: Systematic Review and Meta-Analysis","volume":"12","author":"R","year":"2022","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Alkilzy, M., Qadri, G., Splieth, C.H., and Santamar\u00eda, R.M. (2023). Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4. Biomimetics, 8.","DOI":"10.3390\/biomimetics8030290"},{"key":"ref_32","first-page":"168","article-title":"Performance Assessment of Vita Easy Shade Spectrophotometer on Colour Measurement of Aesthetic Dental Materials","volume":"19","author":"AlGhazali","year":"2011","journal-title":"Eur. J. Prosthodont. Restor. Dent."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e14135","DOI":"10.7717\/peerj.14135","article-title":"Time-Dependent Effect of Intense Capsule-Coffee and Bleaching on the Color of Resin-Infiltrated Enamel White Spot Lesions: An in Vitro Study","volume":"10","author":"Yeslam","year":"2022","journal-title":"PeerJ"},{"key":"ref_34","first-page":"1","article-title":"Guidelines for Infection Control in Dental Health-Care Settings--2003","volume":"52","author":"Kohn","year":"2003","journal-title":"MMWR Recomm. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4103\/0970-9290.127610","article-title":"Comparative Evaluation of Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Phosphate and Casein Phosphopeptide-Amorphous Calcium Phosphate Fluoride on Artificial Enamel White Spot Lesion: An in Vitro Light Fluorescence Study","volume":"24","author":"Mehta","year":"2013","journal-title":"Indian J. Dent. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Alahdal, K., Almohareb, T., Aldeeb, L., Maawadh, A., Alshamrani, A.S., and Alrahlah, A. (2023). Use of Reparative Agents Topical Fluoride Activated by CO2 Laser and CurodontTM Repair and NR-5TM on Vickers Hardness and Micro-Shear Bond Strength of Eroded Enamel to Composite Restoration. Appl. Sci., 13.","DOI":"10.3390\/app132312717"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.21608\/adjg.2017.5226","article-title":"Remineralization of Early Carious Lesions Using Biomimetic Selfassembling Peptides Versus Fluoride Agent. (In Vitro and In Vivo Study)","volume":"4","author":"Metwally","year":"2017","journal-title":"Al-Azhar Dent. J. Girls"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s10856-006-0545-4","article-title":"Precipitation of Octacalcium Phosphates on Artificial Enamel in Artificial Saliva","volume":"17","author":"Sato","year":"2006","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.prosdent.2022.02.003","article-title":"Durability of Infiltrated Resin Application on White Spot Lesions after Diffeliuliurent Challenges: An Ex Vivo Study","volume":"131","author":"Liu","year":"2024","journal-title":"J. Prosthet. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0300-5712(98)00037-2","article-title":"Thermal Cycling Procedures for Laboratory Testing of Dental Restorations","volume":"27","author":"Gale","year":"1999","journal-title":"J. Dent."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/00220345890680051301","article-title":"Assessment of Appearance Match by Visual Observation and Clinical Colorimetry","volume":"68","author":"Johnston","year":"1989","journal-title":"J. Dent. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21608\/acdj.2024.250755.1012","article-title":"Evaluation of the Effect of Intra-Coronal Bleaching after Using C-Phycocyanin as a Photosensitizing Agent- in Vitro Study","volume":"3","author":"Aidaros","year":"2024","journal-title":"Ahram Can. Dent. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2298\/VSP110513019T","article-title":"Reliability of Conventional Shade Guides in Teeth Color Determination","volume":"70","year":"2013","journal-title":"Vojnosanit. Pregl."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e615","DOI":"10.4317\/jced.59759","article-title":"Color Difference between the Vita Classical Shade Guide and Composite Veneers Using the Dual-Layer Technique","volume":"14","author":"Floriani","year":"2022","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"467","DOI":"10.21608\/edj.2018.78049","article-title":"The Effect of Low Temperature Degradation on Color Stability of Two Types of Monolithic Translucent Zirconia Crowns","volume":"64","author":"Hamid","year":"2018","journal-title":"Egypt. Dent. J."},{"key":"ref_46","first-page":"e511","article-title":"Comparison of Laser and Power Bleaching Techniques in Tooth Color Change","volume":"9","author":"Fekrazad","year":"2017","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/1305-7456.156848","article-title":"Effect of Storage Solutions on Microhardness of Crown Enamel and Dentin","volume":"9","author":"Pamir","year":"2015","journal-title":"Eur. J. Dent."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2147\/CCIDE.S334633","article-title":"Effect of Ageing Process and Brushing on Color Stability and Surface Roughness of Treated White Spot Lesions: An in Vitro Analysis","volume":"13","author":"Almulhim","year":"2021","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1590\/S1678-77572007000500004","article-title":"In Vitro Induction of Enamel Subsurface Demineralization for Evaluation of Diagnostic Imaging Methods","volume":"15","author":"Ferreira","year":"2007","journal-title":"J. Appl. Oral Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1875-595X.1999.tb00537.x","article-title":"Morphology of Initial Lesions of Enamel Treated with Different Commercial Dentifrices Using a PH Cycling Model: Scanning Electron Microscopy Observations","volume":"49","author":"Itthagarun","year":"1999","journal-title":"Int. Dent. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1271523","DOI":"10.1155\/2019\/1271523","article-title":"Effects of Fluoride and Calcium Phosphate Materials on Remineralization of Mild and Severe White Spot Lesions","volume":"2019","author":"Dai","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"031118","DOI":"10.1117\/1.1915488","article-title":"Ex Vivo Detection and Characterization of Early Dental Caries by Optical Coherence Tomography and Raman Spectroscopy","volume":"10","author":"Ko","year":"2005","journal-title":"J. Biomed. Opt."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"63","DOI":"10.17096\/jiufd.38691","article-title":"Icdas II Criteria (International Caries Detection and Assessment System)","volume":"49","author":"Dikmen","year":"2015","journal-title":"J. Istanb. Univ. Fac. Dent."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"103243","DOI":"10.1016\/j.jdent.2019.103243","article-title":"Evaluation of the Value of Re-Wetting Prior to Resin Infiltration of Post-Orthodontic Caries Lesions","volume":"91","author":"Kobbe","year":"2019","journal-title":"J. Dent."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.4317\/jced.56295","article-title":"Complementary Remineralizing Effect of Self-Assembling Peptide (P11-4) with CPP-ACPF or Fluoride: An in Vitro Study","volume":"12","author":"Kamal","year":"2020","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e2834","DOI":"10.1002\/cre2.834","article-title":"Evaluating Color Stability and Enamel Surface Roughness Following Resin Infiltration Treatment","volume":"10","author":"Sabti","year":"2024","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"110","DOI":"10.21608\/adjc.2023.179112.1214","article-title":"Remineralization Potential of Curodont Repair Flouride plus versus Cpp-Acp in White Spot Lesions","volume":"5","author":"Amin","year":"2023","journal-title":"Adv. Dent. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000477215","article-title":"Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in Vitro","volume":"51","author":"Wierichs","year":"2017","journal-title":"Caries Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1186\/s12903-024-04523-z","article-title":"Effect of the Use of Remineralization Agents before Resin Infiltration on the Treatment of Initial Enamel Lesions: An in-Vitro Study","volume":"24","author":"Alkan","year":"2024","journal-title":"BMC Oral Health"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1177\/0022034517698419","article-title":"Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide","volume":"96","author":"Kind","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.archoralbio.2018.07.011","article-title":"In Vitro Effect of a Resin Infiltrant on Different Artificial Caries-like Enamel Lesions","volume":"95","author":"Nunes","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4012\/dmj.2019-108","article-title":"Hydrolytic Degradation of Different Infiltrant Compositions within Different Histological Zones of Enamel Caries Like-Lesions","volume":"39","author":"Alonso","year":"2020","journal-title":"Dent. Mater. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e18283","DOI":"10.1016\/j.heliyon.2023.e18283","article-title":"Surface Roughness and Microhardness of Enamel White Spot Lesions Treated with Different Treatment Methods","volume":"9","author":"Chabuk","year":"2023","journal-title":"Heliyon"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/154405910708600507","article-title":"Self-Assembling Peptide Scaffolds Promote Enamel Remineralization","volume":"86","author":"Kirkham","year":"2007","journal-title":"J. Dent. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4012\/dmj.25.371","article-title":"Color Stability of Resin Composites after Immersion in Different Drinks","volume":"25","year":"2006","journal-title":"Dent. Mater. J."},{"key":"ref_66","first-page":"ZC26","article-title":"Effect of Ageing, Staining and Polishing on the Colour Stability of a Single, a Group Shade and Nano Fill Dental Composite: An in-Vitro Study","volume":"16","author":"Hasanain","year":"2022","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Magalh\u00e3es, G.d.A.P., Fraga, M.A.A., de Souza Ara\u00fajo, I.J., Pacheco, R.R., Correr, A.B., and Puppin-Rontani, R.M. (2022). Effect of a Self-Assembly Peptide on Surface Roughness and Hardness of Bleached Enamel. J. Funct. Biomater., 13.","DOI":"10.3390\/jfb13020079"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jds.2014.03.003","article-title":"Effect of Thermal Aging on Microleakage of Current Flowable Composite Resins","volume":"10","year":"2015","journal-title":"J. Dent. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.21608\/ajdsm.2020.46840.1123","article-title":"Evaluation of the State and Shade of White Spot Lesions after Treatment with Different Remineralizing Agents (An in-Vivo Comparative Study)","volume":"24","author":"Elsayed","year":"2021","journal-title":"Al-Azhar J. Dent. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/ccd.ccd_631_21","article-title":"Comparative Evaluation of Antimicrobial Efficacy of Fluoride-Based and Self-Assembling Peptide P11-4-Based Tooth Remineralization Agents on Streptococcus Mutans: A Microbiological Study","volume":"14","author":"Gayas","year":"2023","journal-title":"Contemp. Clin. 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