{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:32:45Z","timestamp":1788690765997,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Organotrialkoxysilanes like 3-aminopropyltrimethoxysilane (3-APTMS)-treated noble metal cations were rapidly converted into their respective nanoparticles in the presence of 3-glycidoxypropylytrimethoxysilane (3-GPTMS). The micellar activity of 3-APTMS also allowed us to replace 3-GPTMS with other suitable organic reagents (e.g., formaldehyde); this approach has significant advantages for preparing bimetallic and trimetallic analogs of noble metal nanoparticles that display efficient activity in many practical applications. The formation of monometallic gold, silver, and palladium nanoparticles, bimetallic Ag-Pd, and Au-Pd nanoparticles at various ratios of noble metal cations, and trimetallic Ag-Au-Pd nanoparticles were studied; their biocatalytic activity in non-enzymatic sensing of glucose based on monitoring synchronous fluorescence spectroscopy (SFS) was assessed. Of these nanoparticles, Au-Pd made with an 80:20 Au:Pd ratio displayed excellent catalytic activity for glucose sensing. These nanoparticles could also be homogenized with Nafion to enhance the resonance Rayleigh scattering (RRS) signal. In this study, the structural characterization of noble metal nanoparticles as well as bi- and tri-metallic nanoparticles in addition to their use in non-enzymatic sensing of glucose are reported.<\/jats:p>","DOI":"10.3390\/bios11040122","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:11:00Z","timestamp":1618488660000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Organotrialkoxysilane-Functionalized Noble Metal Monometallic, Bimetallic, and Trimetallic Nanoparticle Mediated Non-Enzymatic Sensing of Glucose by Resonance Rayleigh Scattering"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6053-902X","authenticated-orcid":false,"given":"Prem C.","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murli Dhar","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-2245","authenticated-orcid":false,"given":"Shubhangi","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-9869","authenticated-orcid":false,"given":"Roger J","family":"Narayan","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599-7575, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1039\/C1AN15843K","article-title":"3-Glycidoxypropyltrimethoxysilane mediated in situ synthesis of noble metal nanoparticles: Application to hydrogen peroxide sensing","volume":"137","author":"Pandey","year":"2011","journal-title":"Analyst"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1166\/jnn.2014.9378","article-title":"Functionalized alkoxysilane mediated controlled synthesis of noble metal nanoparticles dispersible in aqueous and non-aqueous medium","volume":"14","author":"Pandey","year":"2014","journal-title":"J. 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