{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:14:41Z","timestamp":1768745681233,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO2 porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. Ag2S quantum dots were deposited on SnO2\/BiOI composites by in situ growth method. The SnO2\/BiOI\/Ag2S composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO2, BiOI and Ag2S and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO2\/BiOI\/Ag2S was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg\u00b7mL\u22121~100 ng\u00b7mL\u22121, and the detection limit was 0.14 pg\u00b7mL\u22121. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy.<\/jats:p>","DOI":"10.3390\/bios11110421","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:50:28Z","timestamp":1635465028000},"page":"421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO2\/BiOI\/Ag2S Composites for Detection of Procalcitonin"],"prefix":"10.3390","volume":"11","author":[{"given":"Nuo","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, China"},{"name":"Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-331X","authenticated-orcid":false,"given":"Yaoguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daopeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bios.2018.10.048","article-title":"An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy","volume":"126","author":"Liu","year":"2019","journal-title":"Biosens. 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