{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:35:40Z","timestamp":1783661740663,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","award":["MHIQ Collaborative Interdisciplinary Grants 2021"],"award-info":[{"award-number":["MHIQ Collaborative Interdisciplinary Grants 2021"]}],"id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP180100055;DE210100692; FT180100361"],"award-info":[{"award-number":["DP180100055;DE210100692; FT180100361"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Plasma extraction from blood is essential for diagnosis of many diseases. The critical process of plasma extraction requires removal of blood cells from whole blood. Fluid viscoelasticity promotes cell migration towards the central axis of flow due to differences in normal stress and physical properties of cells. We investigated the effects of altering fluid viscoelasticity on blood plasma extraction in a serpentine microchannel. Poly (ethylene oxide) (PEO) was dissolved into blood to increase its viscoelasticity. The influences of PEO concentration, blood dilution, and flow rate on the performance of cell focusing were examined. We found that focusing performance can be significantly enhanced by adding PEO into blood. The optimal PEO concentration ranged from 100 to 200 ppm with respect to effective blood cell focusing. An optimal flow rate from 1 to 15 \u00b5L\/min was determined, at least for our experimental setup. Given less than 1% haemolysis was detected at the outlets in all experimental combinations, the proposed microfluidic methodology appears suitable for applications sensitive to haemocompatibility.<\/jats:p>","DOI":"10.3390\/bios12020120","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T20:26:42Z","timestamp":1644870402000},"page":"120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enhanced Blood Plasma Extraction Utilising Viscoelastic Effects in a Serpentine Microchannel"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-4040","authenticated-orcid":false,"given":"Yuchen","family":"Dai","sequence":"first","affiliation":[{"name":"Queensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Cha","sequence":"additional","affiliation":[{"name":"Queensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Biorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-4782","authenticated-orcid":false,"given":"Hedieh","family":"Fallahi","sequence":"additional","affiliation":[{"name":"Queensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"An","sequence":"additional","affiliation":[{"name":"Queensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-0472","authenticated-orcid":false,"given":"Hang T.","family":"Ta","sequence":"additional","affiliation":[{"name":"School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-5361","authenticated-orcid":false,"given":"Nam-Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Queensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1113-6264","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Queensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony P.","family":"McNamee","sequence":"additional","affiliation":[{"name":"Biorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10408363.2011.600228","article-title":"Hemolyzed specimens: A major challenge for emergency departments and clinical laboratories","volume":"48","author":"Lippi","year":"2011","journal-title":"Crit. 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