{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:46:59Z","timestamp":1761745619191,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China under Grant","award":["2021YFB3200600, 2021YFB3200601, 2020YFC2004501"],"award-info":[{"award-number":["2021YFB3200600, 2021YFB3200601, 2020YFC2004501"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["62073307, 61774157, and 81771388"],"award-info":[{"award-number":["62073307, 61774157, and 81771388"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>This paper proposes a compact bioelectronics sensing platform, including a multi-channel electrode, intracranial electroencephalogram (iEEG) recorder, adjustable galvanometer, and shunt-current conduction circuit pathway. The developed implantable electrode made of polyurethane-insulated stainless-steel materials is capable of recording iEEG signals and shunt-current conduction. The electrochemical impedance of the conduction, ground\/reference, and working electrode were characterized in phosphate buffer saline solution, revealing in vitro results of 517.2 \u03a9@1 kHz (length of 0.1 mm, diameter of 0.8 mm), 1.374 k\u03a9@1 kHz (length of 0.3 mm, diameter of 0.1 mm), and 3.188 k\u03a9@1 kHz (length of 0.1 mm, diameter of 0.1 mm), respectively. On-bench measurement of the system revealed that the input noise of the system is less than 2 \u03bcVrms, the signal frequency bandwidth range is 1 Hz~10 kHz, and the shunt-current detection range is 0.1~3000 \u03bcA with an accuracy of above 99.985%. The electrode was implanted in the CA1 region of the right hippocampus of rats for the in vivo experiments. Kainic acid (KA)-induced seizures were detected through iEEG monitoring, and the induced shunt-current was successfully measured and conducted out of the brain through the designed circuit-body path, which verifies the potential of current conduction for the treatment of epilepsy.<\/jats:p>","DOI":"10.3390\/bios12040247","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T07:42:41Z","timestamp":1650094961000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-2303","authenticated-orcid":false,"given":"Changhua","family":"You","sequence":"first","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, China"},{"name":"School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Shanghai University, Shanghai 200444, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, China"},{"name":"School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"SPF Biotechnology Co., Ltd., Beijing 102100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ding","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery Department, Beijing Children\u2019s Hospital, Capital Medical University, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuli","family":"Liang","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery Department, Beijing Children\u2019s Hospital, Capital Medical University, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3718-9364","authenticated-orcid":false,"given":"Chunxiu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, China"},{"name":"School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Personalized Management of Chronic Respiratory Disease, Chinese Academy of Medical Sciences, Beijing 100190, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, China"},{"name":"School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Personalized Management of Chronic Respiratory Disease, Chinese Academy of Medical Sciences, Beijing 100190, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1528-1167.2006.00595.x","article-title":"Epilepsy Care in the World: Results of an ILAE\/IBE\/WHO Global Campaign Against Epilepsy Survey","volume":"47","author":"Dua","year":"2006","journal-title":"Epilepsia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3329\/taj.v14i2.8398","article-title":"Epilepsy: A Review","volume":"14","author":"Kabir","year":"2001","journal-title":"Taj J. 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