{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:33:58Z","timestamp":1791819238610,"version":"4.3.4"},"reference-count":99,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 110-2628-E-011-003"],"award-info":[{"award-number":["MOST 110-2628-E-011-003"]}]},{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 109-2923-E-011-003-MY"],"award-info":[{"award-number":["MOST 109-2923-E-011-003-MY"]}]},{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 111-NU-E-011-001-NU"],"award-info":[{"award-number":["MOST 111-NU-E-011-001-NU"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>COVID-19 continues to spread and has been declared a global emergency. Individuals with current or past infection should be identified as soon as possible to prevent the spread of disease. Surface-enhanced Raman spectroscopy (SERS) is an analytical technique that has the potential to be used to detect viruses at the site of therapy. In this context, SERS is an exciting technique because it provides a fingerprint for any material. It has been used with many COVID-19 virus subtypes, including Deltacron and Omicron, a novel coronavirus. Moreover, flexible SERS substrates, due to their unique advantages of sensitivity and flexibility, have recently attracted growing research interest in real-world applications such as medicine. Reviewing the latest flexible SERS-substrate developments is crucial for the further development of quality detection platforms. This article discusses the ultra-responsive detection methods used by flexible SERS substrate. Multiplex assays that combine ultra-responsive detection methods with their unique biomarkers and\/or biomarkers for secondary diseases triggered by the development of infection are critical, according to this study. In addition, we discuss how flexible SERS-substrate-based ultrasensitive detection methods could transform disease diagnosis, control, and surveillance in the future. This study is believed to help researchers design and manufacture flexible SERS substrates with higher performance and lower cost, and ultimately better understand practical applications.<\/jats:p>","DOI":"10.3390\/bios12070466","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T23:59:22Z","timestamp":1656460762000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-9286","authenticated-orcid":false,"given":"Seyyed Mojtaba","family":"Mousavi","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City 106335, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Alireza","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Rahmanian","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoomeh Yari","family":"Kalashgrani","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Shiraz University of Medical Science, Shiraz 71468-64685, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-159X","authenticated-orcid":false,"given":"Ahmad","family":"Gholami","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Shiraz University of Medical Science, Shiraz 71468-64685, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Omidifar","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71468-64685, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-6696","authenticated-orcid":false,"given":"Wei-Hung","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City 106335, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"ref_1","first-page":"22","article-title":"Application of nano-antibiotics in the diagnosis and treatment of infectious diseases","volume":"3","author":"Kalashgarani","year":"2022","journal-title":"Adv. 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