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Although the prior and quick diagnosis of respiratory viruses is critical in the outbreak of infectious disease, ELISA, PCR, and RT-PCR have been used to detect respiratory viruses for pandemic control that are limited for point-of-care testing. SERS provides quantitative data with high specificity and sensitivity in a real-time, label-free, and multiplex manner recognizing molecular fingerprints. Recently, the design of Raman spectroscopy system was simplified from a complicated design to a small and easily accessible form that enables point-of-care testing. We review the optical design (e.g., laser wavelength\/power and detectors) of commercialized and customized handheld Raman instruments. As respiratory viruses have prominent risk on the pandemic, we review the applications of handheld Raman devices for detecting respiratory viruses. By instrumentation and commercialization advancements, the advent of the portable SERS device creates a fast, accurate, practical, and cost-effective analytical method for virus detection, and would continue to attract more attention in point-of-care testing.<\/jats:p>","DOI":"10.3390\/bios12080590","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T21:41:37Z","timestamp":1659476497000},"page":"590","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Miniaturized Raman Instruments for SERS-Based Point-of-Care Testing on Respiratory Viruses"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-7258","authenticated-orcid":false,"given":"Ahmed","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering, Sukkur IBA University, Sukkur 65200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel Edward","family":"Nettey-Oppong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Effah","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Yeong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-7114","authenticated-orcid":false,"given":"Riaz","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-0026","authenticated-orcid":false,"given":"Toufique Ahmed","family":"Soomro","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Quid-e-Awam University of Engineering, Science and Technology, Larkana 77150, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Korea"},{"name":"Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Korea"},{"name":"Department of Integrative Medicine, Major in Digital Healthcare, Yonsei University College of Medicine, Seoul 06229, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s000160200002","article-title":"CV raman and the discovery of the raman effect","volume":"4","author":"Singh","year":"2002","journal-title":"Phys. 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