{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:16:16Z","timestamp":1780445776504,"version":"3.54.1"},"reference-count":100,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202378"],"award-info":[{"award-number":["81202378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81311140268"],"award-info":[{"award-number":["81311140268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Hunan Science and Technology","award":["2020JJ9011"],"award-info":[{"award-number":["2020JJ9011"]}]},{"name":"Project of Hunan Science and Technology","award":["2020JJ9020"],"award-info":[{"award-number":["2020JJ9020"]}]},{"name":"Project of Hunan Science and Technology","award":["2021JJ80078"],"award-info":[{"award-number":["2021JJ80078"]}]},{"name":"Independent Exploration and Innovation 830 Program for Graduate Students of Central South University","award":["2022zzts898"],"award-info":[{"award-number":["2022zzts898"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Spread of coronavirus disease 2019 (COVID-19) has significantly impacted the public health and economic sectors. It is urgently necessary to develop rapid, convenient, and cost-effective point-of-care testing (POCT) technologies for the early diagnosis and control of the plague\u2019s transmission. Developing POCT methods and related devices is critical for achieving point-of-care diagnosis. With the advantages of miniaturization, high throughput, small sample requirements, and low actual consumption, microfluidics is an essential technology for the development of POCT devices. In this review, according to the different driving forces of the fluid, we introduce the common POCT devices based on microfluidic technology on the market, including paper-based microfluidic, centrifugal microfluidic, optical fluid, and digital microfluidic platforms. Furthermore, various microfluidic-based assays for diagnosing COVID-19 are summarized, including immunoassays, such as ELISA, and molecular assays, such as PCR. Finally, the challenges of and future perspectives on microfluidic device design and development are presented. The ultimate goals of this paper are to provide new insights and directions for the development of microfluidic diagnostics while expecting to contribute to the control of COVID-19.<\/jats:p>","DOI":"10.3390\/bios13020163","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T06:52:41Z","timestamp":1674197561000},"page":"163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Microfluidics for COVID-19: From Current Work to Future Perspective"],"prefix":"10.3390","volume":"13","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanpin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/JCMA.0000000000000270","article-title":"The outbreak of COVID-19: An overview","volume":"83","author":"Wu","year":"2020","journal-title":"J. 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