{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:52:33Z","timestamp":1787917953360,"version":"build-2784847793"},"reference-count":245,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001342","name":"Department of Science and Technology, Science and Engineering Research Board","doi-asserted-by":"publisher","award":["DST-SERB\/RJF\/2021\/000113"],"award-info":[{"award-number":["DST-SERB\/RJF\/2021\/000113"]}],"id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Indian Institute of Technology Palakkad","award":["DST-SERB\/RJF\/2021\/000113"],"award-info":[{"award-number":["DST-SERB\/RJF\/2021\/000113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Cancer is one of the major public health issues in the world. It has become the second leading cause of death, with approximately 75% of cancer deaths transpiring in low- or middle-income countries. It causes a heavy global economic cost estimated at more than a trillion dollars per year. The most common cancers are breast, colon, rectum, prostate, and lung cancers. Many of these cancers can be treated effectively and cured if detected at the primary stage. Nowadays, around 50% of cancers are detected at late stages, leading to serious health complications and death. Early diagnosis of cancer diseases substantially increases the efficient treatment and high chances of survival. Biosensors are one of the potential screening methodologies useful in the early screening of cancer biomarkers. This review summarizes the recent findings about novel cancer biomarkers and their advantages over traditional biomarkers, and novel biosensing and diagnostic methods for them; thus, this review may be helpful in the early recognition and monitoring of treatment response of various human cancers.<\/jats:p>","DOI":"10.3390\/bios13030398","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:05:23Z","timestamp":1679285123000},"page":"398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1909-9624","authenticated-orcid":false,"given":"Jagadeeswara","family":"Rao Bommi","sequence":"first","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekher","family":"Kummari","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad 678 557, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Lakavath","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad 678 557, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshmi A.","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad 678 557, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi R.","family":"Panicker","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad 678 557, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-9887","authenticated-orcid":false,"given":"Jean Louis","family":"Marty","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Perpignan Via Domitia, 52 Avenue Paul Alduy, 66860 Perpignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-0489","authenticated-orcid":false,"given":"Kotagiri","family":"Yugender Goud","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad 678 557, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer Statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA A Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/jnci\/djab122","article-title":"Association of the COVID-19 Pandemic with Patterns of Statewide Cancer Services","volume":"114","author":"Yabroff","year":"2022","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1001\/jamaoncol.2020.2592","article-title":"Benign vs Malignant Tumors","volume":"6","author":"Patel","year":"2020","journal-title":"JAMA Oncol."},{"key":"ref_5","unstructured":"(2022, November 11). WHO Cancer and Carcinogens. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer)."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/j.seminoncol.2010.05.006","article-title":"Principles of Cancer Screening: Lessons from History and Study Design Issues","volume":"37","author":"Croswell","year":"2010","journal-title":"Semin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrclinonc.2016.109","article-title":"Improving early diagnosis of symptomatic cancer","volume":"13","author":"Hamilton","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_8","first-page":"00072","article-title":"Biosensors and Biomarkers: Promising Tools for Cancer Diagnosis","volume":"3","author":"Patel","year":"2017","journal-title":"Int. J. Biosens. Bioelectron."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1038\/bjc.2015.48","article-title":"Is Increased Time to Diagnosis and Treatment in Symptomatic Cancer Associated with Poorer Outcomes? Systematic Review","volume":"112","author":"Neal","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Summerfield, C., Smith, L., Todd, O., Renzi, C., Lyratzopoulos, G., Neal, R.D., and Jones, D. (2022). The Effect of Older Age and Frailty on the Time to Diagnosis of Cancer: A Connected Bradford Electronic Health Records Study. Cancers, 14.","DOI":"10.3390\/cancers14225666"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/bjc.2012.408","article-title":"Routes to Diagnosis for Cancer\u2014Determining the Patient Journey Using Multiple Routine Data Sets","volume":"107","author":"McPhail","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1470-2045(19)30658-8","article-title":"Earlier Diagnosis: The Importance of Cancer Symptoms","volume":"21","author":"Whitaker","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1136\/thoraxjnl-2018-211842","article-title":"Lung Cancer Stage-Shift Following a Symptom Awareness Campaign","volume":"73","author":"Kennedy","year":"2018","journal-title":"Thorax"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1038\/bjc.2015.32","article-title":"Change in Public Awareness of Symptoms and Perceived Barriers to Seeing a Doctor Following Be Clear on Cancer Campaigns in England","volume":"112","author":"Power","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.soncn.2017.02.002","article-title":"Cancer Screening and Early Detection in the 21 St Century","volume":"33","author":"Loud","year":"2017","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1158\/1055-9965.EPI-20-0110","article-title":"The Evolution of Our Understanding of the Biology of Cancer Is the Key to Avoiding Overdiagnosis and Overtreatment","volume":"29","author":"Hewitt","year":"2020","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41698-018-0075-9","article-title":"Cancer Prevention and Screening: The next Step in the Era of Precision Medicine","volume":"3","author":"Umar","year":"2019","journal-title":"Npj Precis. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"djw290","DOI":"10.1093\/jnci\/djw290","article-title":"Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial","volume":"109","author":"Shieh","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41523-017-0035-5","article-title":"The WISDOM Study: Breaking the Deadlock in the Breast Cancer Screening Debate","volume":"3","author":"Esserman","year":"2017","journal-title":"Npj Breast Cancer"},{"key":"ref_20","first-page":"1","article-title":"Surveillance of Screening-Detected Cancers","volume":"59","author":"Henley","year":"2010","journal-title":"MMWR Surveill. Summ."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1002\/cncr.31549","article-title":"Annual Report to the Nation on the Status of Cancer, Part II: Recent Changes in Prostate Cancer Trends and Disease Characteristics","volume":"124","author":"Negoita","year":"2018","journal-title":"Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3322\/caac.21652","article-title":"Blueprint for Cancer Research: Critical Gaps and Opportunities","volume":"71","author":"Elmore","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14694\/EdBook_AM.2015.35.57","article-title":"Early Detection of Cancer: Past, Present, and Future","volume":"35","author":"Schiffman","year":"2015","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2214\/ajr.147.2.357","article-title":"Dynamic Spin-Echo MRI of Liver Cancer Using Gadolinium-DTPA: Animal Investigation","volume":"147","author":"Saini","year":"1986","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_25","first-page":"855","article-title":"Modeling and Integration of N-Glycan Biomarkers in a Comprehensive Biomarker Data Model","volume":"32","author":"Lyman","year":"2022","journal-title":"Glycobiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/cge.13514","article-title":"Liquid Biopsy in Breast Cancer: A Comprehensive Review","volume":"95","author":"Alimirzaie","year":"2019","journal-title":"Clin. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-022-01351-y","article-title":"Liquid Biopsy: Current Technology and Clinical Applications","volume":"15","author":"Nikanjam","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1038\/s41467-020-17316-z","article-title":"Non-Invasive Early Detection of Cancer Four Years before Conventional Diagnosis Using a Blood Test","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"170465","DOI":"10.5888\/pcd15.170465","article-title":"Patterns and Trends in Cancer Screening in the United States","volume":"15","author":"Hall","year":"2018","journal-title":"Prev. Chronic Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e1764","DOI":"10.1002\/cnr2.1764","article-title":"Technological advancements in cancer diagnostics: Improvements and limitations","volume":"6","author":"Pulumati","year":"2023","journal-title":"Cancer Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s43856-021-00013-3","article-title":"Determining Breast Cancer Biomarker Status and Associated Morphological Features Using Deep Learning","volume":"1","author":"Gamble","year":"2021","journal-title":"Commun. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zygulska, A.L., and Pierzchalski, P. (2022). Novel Diagnostic Biomarkers in Colorectal Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020852"},{"key":"ref_33","first-page":"300","article-title":"Modern Biomarkers in Prostate Cancer Diagnosis","volume":"73","author":"Porzycki","year":"2020","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Atallah, G.A., Aziz, N.H.A., Teik, C.K., Shafiee, M.N., and Kampan, N.C. (2021). New Predictive Biomarkers for Ovarian Cancer. Diagnostics, 11.","DOI":"10.3390\/diagnostics11030465"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/14737159.2020.1835472","article-title":"Cervical Cancer Risk Profiling: Molecular Biomarkers Predicting the Outcome of HrHPV Infection","volume":"20","author":"Molina","year":"2020","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.addr.2013.09.007","article-title":"Molecular Imaging for Cancer Diagnosis and Surgery","volume":"66","author":"Hussain","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1470-2045(19)30687-4","article-title":"Adjuvant Denosumab in Early Breast Cancer (D-CARE): An International, Multicentre, Randomised, Controlled, Phase 3 Trial","volume":"21","author":"Coleman","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jmri.25196","article-title":"Diffusion-Weighted Imaging Outside the Brain: Consensus Statement From an ISMRM-Sponsored Workshop","volume":"44","author":"Taouli","year":"2016","journal-title":"J. Magn. Reason. Imaging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1593\/neo.81328","article-title":"Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations","volume":"1","author":"Padhani","year":"2009","journal-title":"Neoplasia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.snb.2013.07.078","article-title":"Biomarkers and Biosensors for the Early Diagnosis of Lung Cancer","volume":"188","author":"Altintas","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.copbio.2010.07.010","article-title":"Diseases as Network Perturbations","volume":"21","author":"Balling","year":"2010","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sarhadi, V.K., and Armengol, G. (2022). Molecular Biomarkers in Cancer. Biomolecules, 12.","DOI":"10.3390\/biom12081021"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bios.2016.12.014","article-title":"Recent Advances in Biosensor Development for the Detection of Cancer Biomarkers","volume":"91","author":"Jayanthi","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2009.01.015","article-title":"Biosensors for Cancer Markers Diagnosis","volume":"20","author":"Tothill","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/PPO.0b013e31827654ea","article-title":"Biomarkers in Pancreatic Cancer: Diagnostic, Prognostic, and Predictive","volume":"18","author":"Fong","year":"2012","journal-title":"Cancer J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1158\/0008-5472.CAN-05-3433","article-title":"Common Cancer Biomarkers","volume":"66","author":"Basil","year":"2006","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10142-022-00951-8","article-title":"Exosomal miRNAs\u2014a diagnostic biomarker acting as a guiding light in the diagnosis of prostate cancer","volume":"23","author":"Chowdhury","year":"2023","journal-title":"Funct. Integr. Genom."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molonc.2012.01.010","article-title":"Cancer Biomarkers","volume":"6","author":"Henry","year":"2012","journal-title":"Mol. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1200\/JCO.1996.14.10.2843","article-title":"Clinical Practice Guidelines for the Use of Tumor Markers in Breast and Colorectal Cancer. Adopted on May 17, 1996 by the American Society of Clinical Oncology","volume":"14","author":"Somerfield","year":"1996","journal-title":"J. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ijc.1626","article-title":"Comprehensive Analysis of 989 Patients with Breast or Ovarian Cancer Provides BRCA1 and BRCA2 Mutation Profiles and Frequencies for the German Population","volume":"97","author":"Meindl","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_51","first-page":"265","article-title":"Breast and Ovarian Cancer Incidence in BRCA1-Mutation Carriers. Breast Cancer Linkage Consortium","volume":"56","author":"Easton","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2018.3710","article-title":"Screening for Prostate Cancer USPreventive Services task force recommendation Statement","volume":"319","author":"Grossman","year":"2018","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"192","DOI":"10.7326\/0003-4819-149-3-200808050-00009","article-title":"Benefits and Harms of Prostate-Specific Antigen Screening for Prostate Cancer: An Evidence Update for the U.S. Preventive Services Task Force","volume":"149","author":"Lin","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.7326\/0003-4819-149-3-200808050-00008","article-title":"Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement","volume":"149","author":"Calonge","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1200\/JCO.2005.12.005","article-title":"Gene Expression Profiling of Breast Cancer: A New Tumor Marker","volume":"23","author":"Paik","year":"2005","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1056\/NEJMoa041588","article-title":"A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer","volume":"351","author":"Paik","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.aar3247","article-title":"Detection and Localization of Surgically Resectable Cancers with a Multi-Analyte Blood Test","volume":"359","author":"Cohen","year":"2018","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJMoa040766","article-title":"Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer","volume":"351","author":"Cristofanilli","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1024783","DOI":"10.3389\/fonc.2022.1024783","article-title":"Prognostic Value of Epithelial-Mesenchymal Transition Circulating Tumor Cells in Female Breast Cancer: A Meta-Analysis","volume":"12","author":"Zhao","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-022-09615-z","article-title":"Clinical Impact of Primary Tumor Sidedness and Sex on Unresectable Post-Recurrence Survival in Resected Pathological Stage II-III Colorectal Cancers: A Nationwide Multicenter Retrospective Study","volume":"22","author":"Abe","year":"2022","journal-title":"BMC Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1200\/JCO.2009.21.9170","article-title":"American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients with Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy","volume":"27","author":"Allegra","year":"2009","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S1470-2045(17)30111-0","article-title":"Trastuzumab Emtansine versus Taxane Use for Previously Treated HER2-Positive Locally Advanced or Metastatic Gastric or Gastro-Oesophageal Junction Adenocarcinoma (GATSBY): An International Randomised, Open-Label, Adaptive, Phase 2\/3 Study","volume":"18","author":"Shah","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(10)61121-X","article-title":"Trastuzumab in Combination with Chemotherapy versus Chemotherapy Alone for Treatment of HER2-Positive Advanced Gastric or Gastro-Oesophageal Junction Cancer (ToGA): A Phase 3, Open-Label, Randomised Controlled Trial","volume":"376","author":"Bang","year":"2010","journal-title":"Lancet"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.breast.2022.10.017","article-title":"Adjuvant Trastuzumab without Chemotherapy for Treating Early HER2-Positive Breast Cancer in Older Patients: A Propensity Score-Adjusted Analysis of a Prospective Cohort Study","volume":"66","author":"Sawaki","year":"2022","journal-title":"Breast"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1056\/NEJMoa052306","article-title":"Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer","volume":"353","author":"Procter","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/jamaoncol.2015.3239","article-title":"Association of Stromal Tumor-Infiltrating Lymphocytes with Recurrence-Free Survival in the N9831 Adjuvant Trial in Patients with Early-Stage HER2-Positive Breast Cancer","volume":"2","author":"Perez","year":"2016","journal-title":"JAMA Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1056\/NEJMoa052122","article-title":"Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer","volume":"353","author":"Romond","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5469163","DOI":"10.1155\/2022\/5469163","article-title":"Clinical Features and Prognosis Analysis of Hormone Receptor-Positive, HER2-Negative Breast Cancer with Differential Expression Levels of Estrogen and Progesterone Receptors: A 10-Year Retrospective Study","volume":"2022","author":"Liu","year":"2022","journal-title":"Breast J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0140-6736(11)60993-8","article-title":"Relevance of Breast Cancer Hormone Receptors and Other Factors to the Efficacy of Adjuvant Tamoxifen: Patient-Level Meta-Analysis of Randomised Trials","volume":"378","author":"Abe","year":"2011","journal-title":"Lancet"},{"key":"ref_70","first-page":"3","article-title":"The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: Methods of the EGAPP Working Group","volume":"11","author":"Teutsch","year":"2009","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nature06916","article-title":"Mining the Plasma Proteome for Cancer Biomarkers","volume":"452","author":"Hanash","year":"2008","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"893832","DOI":"10.3389\/fgene.2022.893832","article-title":"From the Patient to the Population: Use of Genomics for Population Screening","volume":"13","author":"Mighton","year":"2022","journal-title":"Front. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41698-022-00324-1","article-title":"Identification of Novel Prognostic and Predictive Biomarkers in Salivary Duct Carcinoma via Comprehensive Molecular Profiling","volume":"6","author":"Kohsaka","year":"2022","journal-title":"Npj Precis. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"12431","DOI":"10.1080\/21655979.2021.2005747","article-title":"Identification of Novel Biomarkers in Breast Cancer via Integrated Bioinformatics Analysis and Experimental Validation","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1533033821992081","DOI":"10.1177\/1533033821992081","article-title":"Identification of Novel Biomarkers Associated with the Prognosis and Potential Pathogenesis of Breast Cancer via Integrated Bioinformatics Analysis","volume":"20","author":"Wu","year":"2021","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Li, C.-J., Lin, L.-T., Chu, P.-Y., Chiang, A.-J., Tsai, H.-W., Chiu, Y.-H., Huang, M.-S., Wen, Z.-H., Tsui, K.-H., and Li, C.-J. (2021). Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer. J. Pers. Med., 11.","DOI":"10.3390\/jpm11040316"},{"key":"ref_77","unstructured":"Islam, S.U., Ahmed, M.B., Ahsan, H., and Lee, Y.S. (2022). Cancer Biomarkers in Diagnosis and Therapeutics, Springer."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Janjua, K.A., Shahzad, R., and Shehzad, A. (2022). Cancer Biomarkers in Diagnosis and Therapeutics, Springer.","DOI":"10.1007\/978-981-16-5759-7"},{"key":"ref_79","first-page":"1","article-title":"Biosensors: The New Wave in Cancer Diagnosis","volume":"4","author":"Bohunicky","year":"2011","journal-title":"Nanotechnol. Sci. Appl."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.biopha.2018.07.145","article-title":"Current Trends and Emerging Diagnostic Techniques for Lung Cancer","volume":"106","author":"Prabhakar","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1038\/s41598-021-83244-7","article-title":"A Novel Biosensor for the Ultrasensitive Detection of the LncRNA Biomarker MALAT1 in Non-Small Cell Lung Cancer","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1902980","DOI":"10.1002\/advs.201902980","article-title":"Recent Trends in Electrochemical Sensors for Vital Biomedical Markers Using Hybrid Nanostructured Materials","volume":"7","author":"Reddy","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ferraro, S., Bussetti, M., Bassani, N., Rossi, R.S., Incarbone, G.P., Bianchi, F., Maggioni, M., Runza, L., Ceriotti, F., and Panteghini, M. (2021). Definition of Outcome-Based Prostate-Specific Antigen (PSA) Thresholds for Advanced Prostate Cancer Risk Prediction. Cancers, 13.","DOI":"10.3390\/cancers13143381"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1503\/cmaj.060955","article-title":"Prostate-Specific Antigen in the Early Detection of Prostate Cancer","volume":"176","author":"Thompson","year":"2007","journal-title":"CMAJ Can. Med. Assoc. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1177\/0300060518789304","article-title":"Analysis of Serum Alpha-Fetoprotein (AFP) and AFP-L3 Levels by Protein Microarray","volume":"46","author":"Wu","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"50015","DOI":"10.18632\/oncotarget.18388","article-title":"The Effect of CA125 on Metastasis of Ovarian Cancer: Old Marker New Function","volume":"8","author":"Yuan","year":"2017","journal-title":"Oncotarget"},{"key":"ref_87","first-page":"1535","article-title":"Role of Tumour Markers in Monitoring Epithelial Ovarian Cancer","volume":"82","author":"Meyer","year":"2000","journal-title":"Br. J. Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"936654","DOI":"10.3389\/fcvm.2022.936654","article-title":"Bidirectional Relationship Between Cancer and Heart Failure: Insights on Circulating Biomarkers","volume":"9","author":"Chianca","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0305-7372(95)90002-0","article-title":"Tumor Markers in the Management of Patients with Ovarian Cancer","volume":"21","author":"Tuxen","year":"1995","journal-title":"Cancer Treat. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/(SICI)1097-0142(19971101)80:9<1852::AID-CNCR25>3.0.CO;2-3","article-title":"The Early Detection of Prostate Carcinoma with Prostate Specific Antigen: The Washington University Experience","volume":"80","author":"Smith","year":"1997","journal-title":"Cancer"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJMoa043739","article-title":"Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer","volume":"352","author":"Holmberg","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1016\/S1470-2045(17)30698-8","article-title":"Future Cancer Research Priorities in the USA: A Lancet Oncology Commission","volume":"18","author":"Jaffee","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_93","unstructured":"National Cancer Institute (2022). Prostate-Specific Antigen (PSA) Test\u2014NCI, National Cancer Institute."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13534-021-00204-w","article-title":"Technological Advances in Electrochemical Biosensors for the Detection of Disease Biomarkers","volume":"11","author":"Kim","year":"2021","journal-title":"Biomed. Eng. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Dutsch-Wicherek, M., Tomaszewska, R., Lazar, A., Wicherek, L., and Skladzien, J. (2009). The Association between RCAS1 Expression in Laryngeal and Pharyngeal Cancer and Its Healthy Stroma with Cancer Relapse. BMC Cancer, 9.","DOI":"10.1186\/1471-2407-9-35"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00441-015-2157-0","article-title":"Analysis of the Intensity of Immune Cell Infiltration and Immunoreactivity of RCAS1 in Diffuse Large B-Cell Lymphoma of the Palatine Tonsil and Its Microenvironment","volume":"361","author":"Kazmierczak","year":"2015","journal-title":"Cell Tissue Res."},{"key":"ref_97","first-page":"695","article-title":"Aberrant Intracellular Localization of RCAS1 Is Associated with Tumor Progression of Gastric Cancer","volume":"19","author":"Kubokawa","year":"2001","journal-title":"Int. J. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00795-010-0511-6","article-title":"Accuracy of Differential Diagnosis for Pancreatic Cancer Is Improved in the Combination of RCAS1 and CEA Measurements and Cytology in Pancreatic Juice","volume":"44","author":"Naito","year":"2011","journal-title":"Med. Mol. Morphol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1373\/clinchem.2005.059832","article-title":"Serum Tumor Markers in Breast Cancer: Are They of Clinical Value?","volume":"52","author":"Duffy","year":"2006","journal-title":"Clin. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.33393\/jcb.2022.2446","article-title":"Diagnostic Impact of CEA and CA 15-3 on Chemotherapy Monitoring of Breast Cancer Patients","volume":"11","author":"Hasan","year":"2022","journal-title":"J. Circ. Biomark."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/bjc.1997.124","article-title":"Relationship between CA 15-3 Serum Levels and Disease Extent in Predicting Overall Survival of Breast Cancer Patients with Newly Diagnosed Metastatic Disease","volume":"75","author":"Tampellini","year":"1997","journal-title":"Br. J. Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e22875","DOI":"10.1002\/jcla.22875","article-title":"The Association of Five Preoperative Serum Tumor Markers and Pathological Features in Patients with Breast Cancer","volume":"33","author":"Lian","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1200\/JCO.2001.19.6.1865","article-title":"2000 Update of Recommendations for the Use of Tumor Markers in Breast and Colorectal Cancer: Clinical Practice Guidelines of the American Society of Clinical Oncology","volume":"19","author":"Bast","year":"2001","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s43018-022-00418-6","article-title":"Cancer Vaccines: The next Immunotherapy Frontier","volume":"3","author":"Lin","year":"2022","journal-title":"Nat. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Chow, S., Berek, J.S., and Dorigo, O. (2020). Development of Therapeutic Vaccines for Ovarian Cancer. Vaccines, 8.","DOI":"10.3390\/vaccines8040657"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.187.2.265","article-title":"Simultaneous Humoral and Cellular Immune Response against Cancer-Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2-Binding Peptide Epitopes","volume":"187","author":"Chen","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s00262-008-0478-5","article-title":"Induction of Immune Response against NY-ESO-1 by CHP-NY-ESO-1 Vaccination and Immune Regulation in a Melanoma Patient","volume":"57","author":"Tsuji","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/(SICI)1097-0215(19991022)84:5<506::AID-IJC10>3.0.CO;2-6","article-title":"Humoral Immune Responses of Cancer Patients against \u201cCancer-Testis\u201d Antigen NY-ESO-1: Correlation with Clinical Events","volume":"84","author":"Stockert","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1158\/1078-0432.CCR-10-1811","article-title":"Efficient in Vivo Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naive Prostate Cancer Patients","volume":"17","author":"Karbach","year":"2011","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1084\/jem.187.8.1349","article-title":"A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens","volume":"187","author":"Stockert","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_111","first-page":"2125","article-title":"[Targeting Cancer Antigen (MAGE-A4, NY-ESO -1) for Immunotherapy]","volume":"70","author":"Imai","year":"2012","journal-title":"Nihon Rinsho. Jpn. J. Clin. Med."},{"key":"ref_112","first-page":"1","article-title":"Unleashing the Immune Response to NY-ESO-1 Cancer Testis Antigen as a Potential Target for Cancer Immunotherapy","volume":"18","author":"Raza","year":"2020","journal-title":"J. Transl. Med. J. Transl. Med."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Babaier, A., Mal, H., Alselwi, W., and Ghatage, P. (2022). Low-Grade Serous Carcinoma of the Ovary: The Current Status. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020458"},{"key":"ref_114","first-page":"126","article-title":"Ovarian Cancer Screening","volume":"36","author":"Neesham","year":"2007","journal-title":"Aust. Fam. Physician"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1470-2045(09)70026-9","article-title":"Sensitivity and Specificity of Multimodal and Ultrasound Screening for Ovarian Cancer, and Stage Distribution of Detected Cancers: Results of the Prevalence Screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)","volume":"10","author":"Menon","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"28619","DOI":"10.1074\/jbc.M302741200","article-title":"Characterization of the Oligosaccharides Associated with the Human Ovarian Tumor Marker CA125","volume":"278","author":"Wong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/prot.26303","article-title":"Crystal Structure of a Human MUC16 SEA Domain Reveals Insight into the Nature of the CA125 Tumor Marker","volume":"90","author":"White","year":"2022","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"788","DOI":"10.21037\/atm-20-8053","article-title":"CA125-Tn ELISA Assay Improves Specificity of Pre-Operative Diagnosis of Ovarian Cancer among Patients with Elevated Serum CA125 Levels","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1242\/jcs.00312","article-title":"The Cancer Antigen CA125 Represents a Novel Counter Receptor for Galectin-1","volume":"116","author":"Seelenmeyer","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"594763","DOI":"10.3389\/fonc.2021.594763","article-title":"Prognostic Value of CEA, CA19-9, CA125, CA724, and CA242 in Serum and Ascites in Pseudomyxoma Peritonei","volume":"11","author":"Liang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"115180","DOI":"10.1016\/j.bios.2023.115180","article-title":"An ultrasensitive split-type electrochemical immunosensor based on controlled-release strategy for detection of CA19-9","volume":"227","author":"Li","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/SLA.0b013e31825ffbfb","article-title":"Screening for Pancreatic Cancer: Why, How, and Who?","volume":"257","author":"Poruk","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.3390\/curroncol29110686","article-title":"Pancreatic Tumorigenesis: Precursors, Genetic Risk Factors and Screening","volume":"29","author":"Badheeb","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000049366","article-title":"Prognostic Value of Serum Tumor Markers in Patients with Lung Cancer","volume":"69","author":"Hatzakis","year":"2002","journal-title":"Respiration"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0169-5002(03)00232-0","article-title":"Neuron-Specific Enolase Is an Effective Tumour Marker in Non-Small Cell Lung Cancer (NSCLC)","volume":"41","author":"Ferrigno","year":"2003","journal-title":"Lung Cancer"},{"key":"ref_126","first-page":"2924","article-title":"Characterization of Variant Subclasses of Cell Lines Derived from Small Cell Lung Cancer Having Distinctive Biochemical, Morphological, and Growth Properties","volume":"45","author":"Gazdar","year":"1985","journal-title":"Cancer Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-94-017-7215-0_9","article-title":"Neuron-Specifi c Enolase as a Biomarker: Biochemical and Clinical Aspects","volume":"867","author":"Bottoni","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12957-020-01894-9","article-title":"Prognostic Value of Neuron-Specific Enolase for Small Cell Lung Cancer: A Systematic Review and Meta-Analysis","volume":"18","author":"Tian","year":"2020","journal-title":"World J. Surg. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/172460088700200105","article-title":"Terminal Deoxynucleotidyl Transferase, Tdt, as a Marker for Leukemia and Lymphoma Cells","volume":"2","author":"Campagnari","year":"1987","journal-title":"Int. J. Biol. Markers"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"133400","DOI":"10.1016\/j.snb.2023.133400","article-title":"Self-activation of symbiotic multi-DNA machines transducing exponentially amplified fluorescence for ultrasensitively signaling of terminal deoxynucleotidyl transferase activity","volume":"380","author":"Peng","year":"2023","journal-title":"Sens. Actuators B. Chem"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/modpathol.3800936","article-title":"TdT Expression in Merkel Cell Carcinoma: Potential Diagnostic Pitfall with Blastic Hematological Malignancies and Expanded Immunohistochemical Analysis","volume":"20","author":"Sur","year":"2007","journal-title":"Mod. Pathol."},{"key":"ref_132","first-page":"835","article-title":"Detection of Terminal Deoxynucleotidyl Transferase (TdT) in Nonhematopoietic Small Round Cell Tumors of Children","volume":"17","author":"Mathewson","year":"1997","journal-title":"Pediatr. Pathol. Lab. Med. J. Soc. Pediatr. Pathol. Affil. Int. Paediatr. Pathol. Assoc."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0973-6883(11)60110-2","article-title":"Circulating CYFRA 21-1 Is a Specific Diagnostic and Prognostic Biomarker in Biliary Tract Cancer","volume":"1","author":"Chapman","year":"2011","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Zhang, L., Liu, D., Li, L., Pu, D., Zhou, P., Jing, Y., Yu, H., Wang, Y., Zhu, Y., and He, Y. (2017). The Important Role of Circulating CYFRA21-1 in Metastasis Diagnosis and Prognostic Value Compared with Carcinoembryonic Antigen and Neuron-Specific Enolase in Lung Cancer Patients. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3070-6"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12967-019-1828-0","article-title":"The Role of CEA, CYFRA21-1 and NSE in Monitoring Tumor Response to Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients","volume":"17","author":"Filiberti","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1183\/09031936.95.08030407","article-title":"CYFRA 21-1 as a Tumour Marker for Bronchogenic Carcinoma","volume":"8","author":"Rapellino","year":"1995","journal-title":"Eur. Respir. J."},{"key":"ref_137","first-page":"1758835920952994","article-title":"CEA and CYFRA 21-1 as Prognostic Biomarker and as a Tool for Treatment Monitoring in Advanced NSCLC Treated with Immune Checkpoint Inhibitors","volume":"12","author":"Abbati","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/IJGC:25:1:23","article-title":"A Prospective Multicenter Trial Evaluating Diagnostic Validity of Multivariate Analysis and Individual Serum Marker in Differential Diagnosis of Pancreatic Cancer from Benign Pancreatic Diseases","volume":"25","author":"Hayakawa","year":"1999","journal-title":"Int. J. Pancreatol. Off. J. Int. Assoc. Pancreatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1080\/21655979.2021.1960775","article-title":"Identification of Candidate Biomarkers Correlated with Poor Prognosis of Breast Cancer Based on Bioinformatics Analysis","volume":"12","author":"Chen","year":"2021","journal-title":"Bioengineered"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/13547500600775011","article-title":"Biomarkers in Cancer Screening, Research and Detection: Present and Future: A Review","volume":"11","author":"Kumar","year":"2008","journal-title":"Biomarkers"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1517\/14796694.1.1.37","article-title":"Cancer Biomarkers: Knowing the Present and Predicting the Future","volume":"1","author":"Chatterjee","year":"2005","journal-title":"Future Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.molonc.2014.10.004","article-title":"Biomarker Validation and Testing","volume":"9","author":"Hayes","year":"2015","journal-title":"Mol. Oncol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/jnci\/88.20.1456","article-title":"Tumor Marker Utility Grading System: A Framework to Evaluate Clinical Utility of Tumor Markers","volume":"88","author":"Hayes","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1200\/JCO.2015.62.3397","article-title":"Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients with Platinum-Resistant Ovarian Cancer","volume":"33","author":"Hamanishi","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/jnci\/64.6.1329","article-title":"Serum Alpha-Fetoprotein Estimations and Doubling Time in Hepatocellular Carcinoma: Influence of Therapy and Possible Value in Early Detection","volume":"64","author":"Johnson","year":"1980","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"834992","DOI":"10.3389\/fonc.2022.834992","article-title":"Prognostic Value of Postoperative Circulating Tumor DNA in Patients with Early- and Intermediate-Stage Hepatocellular Carcinoma","volume":"12","author":"Ye","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1245\/s10434-010-1038-8","article-title":"Enhanced Detection of Early Hepatocellular Carcinoma by Serum SELDI-TOF Proteomic Signature Combined with Alpha-Fetoprotein Marker","volume":"17","author":"Chen","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bjmsu.2011.08.006","article-title":"PSA Velocity and Doubling Time in Diagnosis and Prognosis of Prostate Cancer","volume":"5","author":"Vickers","year":"2012","journal-title":"Br. J. Med. Surg. Urol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.eururo.2013.06.052","article-title":"Next-Generation Prostate-Specific Antigen Test: Ready to Use?","volume":"64","author":"Bjartell","year":"2013","journal-title":"Eur. Urol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.soncn.2017.02.003","article-title":"Prostate Cancer Screening","volume":"33","author":"Dunn","year":"2017","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000089260","article-title":"Tumor Markers in Breast Cancer- European Group on Tumor Markers Recommendations","volume":"26","author":"Molina","year":"2005","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"101731","DOI":"10.1016\/j.bpg.2021.101731","article-title":"Early Detection of Gastric Cancer beyond Endoscopy\u2014New Methods","volume":"50\u201351","author":"Leja","year":"2021","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/172460089100600101","article-title":"Possible Utility of Serum Determinations of CA 125 and CA 27.29 in Breast Cancer Management","volume":"6","author":"Jensen","year":"1991","journal-title":"Int. J. Biol. Markers"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrc1739","article-title":"Biomarkers in Cancer Staging, Prognosis and Treatment Selection","volume":"5","author":"Ludwig","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/172460088600100102","article-title":"The Clinical Value of the Tumor Markers CA 19\/9 and Carcinoembryonic Antigen (CEA) in Colorectal Carcinomas: A Critical Comparison","volume":"1","year":"1986","journal-title":"Int. J. Biol. Markers"},{"key":"ref_156","first-page":"523","article-title":"[Clinical evaluation of four tumor markers (CEA, TPA, CA50 and CA72-4) in colorectal cancer]","volume":"40","author":"Koizumi","year":"1992","journal-title":"Rinsho Byori. Jpn. J. Clin. Pathol."},{"key":"ref_157","first-page":"117","article-title":"Calcitonin as Biomarker for the Medullary Thyroid Carcinoma","volume":"204","author":"Bae","year":"2015","journal-title":"Recent Results Cancer Res. Fortschr. Der Krebsforschung. Prog. Dans Les Rech. Sur Le Cancer"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1200\/JCO.2005.04.7985","article-title":"Gene Expression and Benefit of Chemotherapy in Women with Node-Negative, Estrogen Receptor-Positive Breast Cancer","volume":"24","author":"Paik","year":"2006","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Porras, L., Gorse, F., Thiombane, N.K., Gaboury, L., and Mader, S. (2022). CAXII Is a Surrogate Marker for Luminal Breast Tumors Regulated by ER and GATA3. Cancers, 14.","DOI":"10.3390\/cancers14215453"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1002\/1097-0142(197706)39:6<2934::AID-CNCR2820390680>3.0.CO;2-P","article-title":"Current Status of Estrogen and Progesterone Receptors in Breast Cancer","volume":"39","author":"McGuire","year":"1977","journal-title":"Cancer"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ijc.29808","article-title":"Brief-Exposure to Preoperative Bevacizumab Reveals a TGF-\u03b2 Signature Predictive of Response in HER2-Negative Breast Cancers","volume":"138","author":"Varadan","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of Mutational Processes in Human Cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"ref_163","first-page":"129","article-title":"Cancer Biomarkers\u2014Current Perspectives","volume":"132","author":"Bhatt","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000101740","article-title":"Dialogue between Blastocyst HCG and Endometrial LH\/HCG Receptor: Which Role in Implantation?","volume":"64","author":"Berndt","year":"2007","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1055\/s-2001-13912","article-title":"A Proposed Role for HCG in Clinical Obstetrics","volume":"19","author":"Kurtzman","year":"2001","journal-title":"Semin. Reprod. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02934929","article-title":"Neuron-Specific Enolase (NSE) as a Tumour Marker and Comparative Evaluation with Carcinoembryonic Antigen (CEA) in Small-Cell Lung Cancer","volume":"4","author":"Adewole","year":"1987","journal-title":"Med. Oncol. Tumor Pharmacother."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0042-1750396","article-title":"Preradioactive Iodine Thyroglobulin Levels as Predictors of Metastasis in Well-Differentiated Thyroid Carcinoma Patients","volume":"21","author":"Darmawan","year":"2022","journal-title":"World J. Nucl. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1210\/jc.2002-021702","article-title":"A Consensus Report of the Role of Serum Thyroglobulin as a Monitoring Method for Low-Risk Patients with Papillary Thyroid Carcinoma","volume":"88","author":"Mazzaferri","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/pros.20564","article-title":"Molecular PCA3 Diagnostics on Prostatic Fluid","volume":"67","author":"Cornel","year":"2007","journal-title":"Prostate"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3389\/fimmu.2018.00947","article-title":"NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives","volume":"9","author":"Thomas","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/jclinpath-2012-201194","article-title":"EGFR Mutation Testing in Lung Cancer: A Review of Available Methods and Their Use for Analysis of Tumour Tissue and Cytology Samples","volume":"66","author":"Ellison","year":"2013","journal-title":"J. Clin. Pathol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-pathol-011110-130206","article-title":"EGFR Mutations and Lung Cancer","volume":"6","author":"Shepherd","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"23874","DOI":"10.18632\/oncotarget.8074","article-title":"Clinicopathologic Characteristics of EGFR, KRAS, and ALK Alterations in 6595 Lung Cancers","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1183\/09031936.00018013","article-title":"EGFR, KRAS, BRAF and ALK Gene Alterations in Lung Adenocarcinomas: Patient Outcome, Interplay with Morphology and Immunophenotype","volume":"43","author":"Warth","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/17474086.2017.1270202","article-title":"Diagnostic, Prognostic and Therapeutic Role of CD30 in Lymphoma","volume":"10","author":"Pierce","year":"2017","journal-title":"Expert Rev. Hematol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e603","DOI":"10.1038\/bcj.2017.85","article-title":"Understanding CD30 Biology and Therapeutic Targeting: A Historical Perspective Providing Insight into Future Directions","volume":"7","author":"Pileri","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jjco\/hyi244","article-title":"Comparison of NMP22 BladderChek Test and Urine Cytology for the Detection of Recurrent Bladder Cancer","volume":"36","author":"Kumar","year":"2006","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_178","first-page":"31","article-title":"Prognostic Value of Cytology, Nuclear Matrix Protein 22 (NMP22) Test, and Urinary Bladder Cancer II (UBC II) Test in Early Recurrent Transitional Cell Carcinoma of the Bladder","volume":"36","author":"Kibar","year":"2006","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/1724600819847999","article-title":"Predictive Significance of CYFRA21-1, Squamous Cell Carcinoma Antigen and Carcinoembryonic Antigen for Lymph Node Metastasis in Patients with Esophageal Squamous Cancer","volume":"34","author":"Mei","year":"2019","journal-title":"Int. J. Biol. Markers"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/dote\/11.1.35","article-title":"CYFRA 21\u20131 as a Tumor Marker for Squamous Cell Carcinoma of the Esophagus","volume":"11","author":"Nakamura","year":"1998","journal-title":"Dis. Esophagus"},{"key":"ref_181","first-page":"4249","article-title":"CYFRA 21-1 Serum Analysis in Patients with Esophageal Cancer","volume":"6","author":"Brockmann","year":"2000","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2119\/2008.00061.McCarthy","article-title":"Surface Expression of Bcl-2 in Chronic Lymphocytic Leukemia and Other B-Cell and Lymphomas without a Breakpoint t(14;18)","volume":"14","author":"McCarthy","year":"2008","journal-title":"Mol. Med."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/sj.bjc.6605736","article-title":"BCL2 in Breast Cancer: A Favourable Prognostic Marker across Molecular Subtypes and Independent of Adjuvant Therapy Received","volume":"103","author":"Dawson","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2147\/CMAR.S154608","article-title":"Bax, Bcl-2, and Bax\/Bcl-2 as Prognostic Markers in Acute Myeloid Leukemia: Are We Ready for Bcl-2-Directed Therapy?","volume":"10","author":"Kulsoom","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3889\/oamjms.2015.040","article-title":"Detection of BCR\/ABL Translocation in Bone Marrow Derived Mesenchymal Stem Cells in Egyptian CML Patients","volume":"3","author":"Gaafar","year":"2015","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_186","first-page":"858","article-title":"Extensive Amplification of Bcr\/Abl Fusion Genes Clustered on Three Marker Chromosomes in Human Leukemic Cell Line K-562","volume":"9","author":"Wu","year":"1995","journal-title":"Leukemia"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/PAI.0b013e31825d550a","article-title":"Selective Immunophenotyping for Diagnosis of B-Cell Neoplasms: Immunohistochemistry and Flow Cytometry Strategies and Results","volume":"21","author":"Boyd","year":"2013","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1182\/blood-2008-01-131987","article-title":"Soluble CD22 as a Tumor Marker for Hairy Cell Leukemia","volume":"112","author":"Matsushita","year":"2008","journal-title":"Blood"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Li, J., Ran, Q., Xu, B., Luo, X., Song, S., Xu, D., and Zhang, X. (2020). Role of CD25 Expression on Prognosis of Acute Myeloid Leukemia: A Literature Review and Meta-Analysis. PLOS ONE, 15.","DOI":"10.1371\/journal.pone.0236124"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1758835919890285","DOI":"10.1177\/1758835919890285","article-title":"Targeted Therapies for Advanced Bladder Cancer: New Strategies with FGFR Inhibitors","volume":"11","author":"Casadei","year":"2019","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00345-007-0213-4","article-title":"Role of FGFR3 in Urothelial Cell Carcinoma: Biomarker and Potential Therapeutic Target","volume":"25","author":"Knowles","year":"2007","journal-title":"World J. Urol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000052455","article-title":"Assessment of Fibrin-Fibrinogen Degradation Products (Accu-Dx) Test in Bladder Cancer Patients","volume":"39","author":"Topsakal","year":"2001","journal-title":"Eur. Urol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1097\/01.ju.0000067461.30468.6d","article-title":"Tumor Markers in the Diagnosis of Primary Bladder Cancer. A Systematic Review","volume":"169","author":"Glas","year":"2003","journal-title":"J. Urol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.lungcan.2005.03.020","article-title":"Soluble Mesothelin-Related Protein\u2014A Blood Test for Mesothelioma","volume":"49","author":"Robinson","year":"2005","journal-title":"Lung Cancer"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1182\/bloodadvances.2021004424","article-title":"Mesothelin Is a Novel Cell Surface Disease Marker and Potential Therapeutic Target in Acute Myeloid Leukemia","volume":"5","author":"Kaeding","year":"2021","journal-title":"Blood Adv."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00428-016-2000-3","article-title":"Testing for ROS1 in Non-Small Cell Lung Cancer: A Review with Recommendations","volume":"469","author":"Bubendorf","year":"2016","journal-title":"Virchows Arch. Int. J. Pathol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40291-013-0027-6","article-title":"Biomarker Testing for Ovarian Cancer: Clinical Utility of Multiplex Assays","volume":"17","author":"Nolen","year":"2013","journal-title":"Mol. Diagn. Ther."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Jelski, W., and Mroczko, B. (2021). Molecular and Circulating Biomarkers of Brain Tumors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137039"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"129352","DOI":"10.1016\/j.snb.2020.129352","article-title":"Functionalized SERS Substrate Based on Silicon Nanowires for Rapid Detection of Prostate Specific Antigen","volume":"330","author":"Ouhibi","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1021\/acsabm.0c01002","article-title":"Tailored Biofunctionalized Biosensor for the Label-Free Sensing of Prostate-Specific Antigen","volume":"3","author":"Mishra","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1021\/acs.analchem.0c05367","article-title":"Electrochemistry-Assisted Surface Plasmon Resonance Biosensor for Detection of CA 15\u20133","volume":"93","author":"Ribeiro","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"113250","DOI":"10.1016\/j.bios.2021.113250","article-title":"Engineering Paper-Based Visible Light-Responsive Sn-Self Doped Domed SnO2 Nanotubes for Ultrasensitive Photoelectrochemical Sensor","volume":"185","author":"Yu","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"111697","DOI":"10.1016\/j.bios.2019.111697","article-title":"A 2D Transition Metal Carbide MXene-Based SPR Biosensor for Ultrasensitive Carcinoembryonic Antigen Detection","volume":"144","author":"Wu","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bios.2018.11.013","article-title":"A Novel ECL Sensor Based on a Boronate Affinity Molecular Imprinting Technique and Functionalized SiO2@CQDs\/AuNPs\/MPBA Nanocomposites for Sensitive Determination of Alpha-Fetoprotein","volume":"126","author":"Mo","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.aca.2020.10.030","article-title":"Fluorescence Sensing Strategy Based on Aptamer Recognition and Mismatched Catalytic Hairpin Assembly for Highly Sensitive Detection of Alpha-Fetoprotein","volume":"1141","author":"Li","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"113024","DOI":"10.1016\/j.bios.2021.113024","article-title":"Spatially-Resolved Dual-Potential Sandwich Electrochemiluminescence Immunosensor for the Simultaneous Determination of Carbohydrate Antigen 19\u20139 and Carbohydrate Antigen 24-2","volume":"178","author":"Mo","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s13738-020-01924-z","article-title":"An Eco-Friendly MIP-Solid Surface Fluorescence Immunosensor for Detection of CA 19-9 Tumor Marker Using Ni Nanocluster as an Emitter Labels","volume":"17","author":"Bahari","year":"2020","journal-title":"J. Iran. Chem. Soc."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.aca.2017.11.008","article-title":"Ultrasensitive Flexible FET-Type Aptasensor for CA 125 Cancer Marker Detection Based on Carboxylated Multiwalled Carbon Nanotubes Immobilized onto Reduced Graphene Oxide Film","volume":"1000","author":"Salimi","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"120187","DOI":"10.1016\/j.talanta.2019.120187","article-title":"A Biosensor for Determination of the Circulating Biomarker CA125\/MUC16 by Surface Plasmon Resonance Imaging","volume":"206","author":"Lukaszewski","year":"2020","journal-title":"Talanta"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"121451","DOI":"10.1016\/j.talanta.2020.121451","article-title":"A Novel Aptasensor Based on HCR and G-Quadruplex DNAzyme for Fluorescence Detection of Carcinoembryonic Antigen","volume":"221","author":"Bai","year":"2021","journal-title":"Talanta"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Y\u0131lmaz, M., Bakhshpour, M., G\u00f6kt\u00fcrk, I., Pi\u015fkin, A.K., and Denizli, A. (2021). Quartz Crystal Microbalance (QCM) Based Biosensor Functionalized by HER2\/Neu Antibody for Breast Cancer Cell Detection. Chemosensors, 9.","DOI":"10.3390\/chemosensors9040080"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"23718","DOI":"10.1021\/acsomega.0c02578","article-title":"Red-Fluorescent Pt Nanoclusters for Detecting and Imaging HER2 in Breast Cancer Cells","volume":"5","author":"Tanaka","year":"2020","journal-title":"ACS Omega"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"124071","DOI":"10.1016\/j.talanta.2022.124071","article-title":"A Sensitive \u201cTurn-on\u201d Fluorescent Biosensor for the Detection of Biomarkers Based on Three-Dimensional DNA Walker","volume":"253","author":"Xie","year":"2023","journal-title":"Talanta"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"128816","DOI":"10.1016\/j.snb.2020.128816","article-title":"Double Stopband Bilayer Photonic Crystal Based Upconversion Fluorescence PSA Sensor","volume":"326","author":"Hu","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"129249","DOI":"10.1016\/j.snb.2020.129249","article-title":"A Fluorescent Biosensor Based on Prismatic Hollow Metal-Polydopamine Frameworks and 6-Carboxyfluorescein (FAM)-Labeled Protein Aptamer for CA15-3 Detection","volume":"329","author":"Wu","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"28865","DOI":"10.1039\/D0RA06191C","article-title":"A Highly Sensitive Fluorescent Immunosensor for Sensitive Detection of Nuclear Matrix Protein 22 as Biomarker for Early Stage Diagnosis of Bladder Cancer","volume":"10","author":"Othman","year":"2020","journal-title":"RSC Adv."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"104966","DOI":"10.1016\/j.microc.2020.104966","article-title":"Fluorescence Immunoassay Based on Nitrogen Doped Carbon Dots for the Detection of Human Nuclear Matrix Protein NMP22 as Biomarker for Early Stage Diagnosis of Bladder Cancer","volume":"157","author":"Othman","year":"2020","journal-title":"Microchem. J."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12678-017-0357-y","article-title":"Conducting Polymer-Layered Carbon Nanotube as Sensor Interface for Electrochemical Detection of Dacarbazine In-Vitro","volume":"8","author":"Satyanarayana","year":"2017","journal-title":"Electrocatalysis"},{"key":"ref_219","unstructured":"Goud, K.Y., Satyanarayana, M., Hayat, A., Gobi, K.V., and Marty, J.L. (2019). Nanoparticles in Pharmacotherapy, Elsevier."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1002\/elan.202060157","article-title":"Facile Electrochemically Reduced Graphene Oxide-Multi-walled Carbon Nanotube Nanocomposite as Sensitive Probe for In-vitro Determination of Nitrofurantoin in Biological Fluids","volume":"32","author":"Kummari","year":"2020","journal-title":"Electroanalysis"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"121399","DOI":"10.1016\/j.ica.2023.121399","article-title":"Gold Nanoparticle Assimilated Polymer Layer on Carbon Nanotube Matrices for Sensitive Detection of Serotonin in Presence of Dopamine In-Vitro","volume":"549","author":"Shekher","year":"2023","journal-title":"Inorg. Chim. Acta"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"114216","DOI":"10.1016\/j.bios.2022.114216","article-title":"Magnetic Antifouling Material Based Ratiometric Electrochemical Biosensor for the Accurate Detection of CEA in Clinical Serum","volume":"208","author":"Yang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.snb.2017.10.027","article-title":"Molecularly Imprinted Electrochemical Sensor for the Point-of-Care Detection of a Breast Cancer Biomarker (CA 15-3)","volume":"256","author":"Pacheco","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bios.2018.08.067","article-title":"Graphene Nanocomposites Modified Electrochemical Aptamer Sensor for Rapid and Highly Sensitive Detection of Prostate Specific Antigen","volume":"121","author":"Wei","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.msec.2018.12.108","article-title":"hasan Employing AgNPs Doped Amidoxime-Modified Polyacrylonitrile (PAN-Oxime) Nanofibers for Target Induced Strand Displacement-Based Electrochemical Aptasensing of CA125 in Ovarian Cancer Patients","volume":"97","author":"Farzin","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"129515","DOI":"10.1016\/j.snb.2021.129515","article-title":"Dual Assaying of Breast Cancer Biomarkers by Using a Sandwich\u2013Type Electrochemical Aptasensor Based on a Gold Nanoparticles\u20133D Graphene Hydrogel Nanocomposite and Redox Probes Labeled Aptamers","volume":"332","author":"Shekari","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"113741","DOI":"10.1016\/j.bios.2021.113741","article-title":"An Ultrasensitive Carcinoembryonic Antigen Electrochemical Aptasensor Based on 3D DNA Nanoprobe and Exo III","volume":"196","author":"Ji","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"123146","DOI":"10.1016\/j.talanta.2021.123146","article-title":"Dual-Template Rectangular Nanotube Molecularly Imprinted Polypyrrole for Label-Free Impedimetric Sensing of AFP and CEA as Lung Cancer Biomarkers","volume":"239","author":"Taheri","year":"2022","journal-title":"Talanta"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"13969","DOI":"10.1038\/s41598-021-93399-y","article-title":"A Simple Label-Free Electrochemical Sensor for Sensitive Detection of Alpha-Fetoprotein Based on Specific Aptamer Immobilized Platinum Nanoparticles\/Carboxylated-Graphene Oxide","volume":"11","author":"Upan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Casta\u00f1o-Guerrero, Y., Romaguera-Barcelay, Y., Moreira, F.T.C., Brito, W.R., Fortunato, E., and Sales, M.G.F. (2022). Poly(Thionine)-Modified Screen-Printed Electrodes for CA 19-9 Detection and Its Properties in Raman Spectroscopy. Chemosensors, 10.","DOI":"10.3390\/chemosensors10030092"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"106643","DOI":"10.1016\/j.microc.2021.106643","article-title":"Carbohydrate Antigen 19-9 Electrochemical Immunosensor Based on 1D-MoS2 Nanorods\/LiNb3O8 and Polyoxometalate-Incorporated Gold Nanoparticles","volume":"170","author":"Yola","year":"2021","journal-title":"Microchem. J."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.aca.2019.07.050","article-title":"Molecularly Imprinted Polymer SPE Sensor for Analysis of CA-125 on Serum","volume":"1082","author":"Rebelo","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"111536","DOI":"10.1016\/j.bios.2019.111536","article-title":"Construction of Tb-MOF-on-Fe-MOF Conjugate as a Novel Platform for Ultrasensitive Detection of Carbohydrate Antigen 125 and Living Cancer Cells","volume":"142","author":"Wang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/elan.201800537","article-title":"Electrochemical Sensing Platforms for HER2-ECD Breast Cancer Biomarker Detection","volume":"31","author":"Freitas","year":"2019","journal-title":"Electroanalysis"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1021\/acs.analchem.8b00023","article-title":"Polycytosine DNA Electric-Current-Generated Immunosensor for Electrochemical Detection of Human Epidermal Growth Factor Receptor 2 (HER2)","volume":"90","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1021\/acs.analchem.1c01350","article-title":"Antifouling Peptide Hydrogel Based Electrochemical Biosensors for Highly Sensitive Detection of Cancer Biomarker HER2 in Human Serum","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.snb.2018.06.113","article-title":"Breast Cancer Biomarker (HER2-ECD) Detection Using a Molecularly Imprinted Electrochemical Sensor","volume":"273","author":"Pacheco","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"112872","DOI":"10.1016\/j.bios.2020.112872","article-title":"Impedimetric Aptamer-Based Glycan PSA Score for Discrimination of Prostate Cancer from Other Prostate Diseases","volume":"175","author":"Estrela","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ijbiomac.2018.03.183","article-title":"An Innovative Immunosensor for Ultrasensitive Detection of Breast Cancer Specific Carbohydrate (CA 15-3) in Unprocessed Human Plasma and MCF-7 Breast Cancer Cell Lysates Using Gold Nanospear Electrochemically Assembled onto Thiolated Graphene Quantum Dots","volume":"114","author":"Hasanzadeh","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"106410","DOI":"10.1016\/j.microc.2021.106410","article-title":"2D\/3D Material Amplification Strategy for Disposable Label-Free Electrochemical Immunosensor Based on RGO-TEPA@Cu-MOFs@SiO2@AgNPs Composites for NMP22 Detection","volume":"168","author":"Rong","year":"2021","journal-title":"Microchem. J."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jelechem.2018.12.044","article-title":"A Highly Sensitive Label-Free Electrochemical Immunosensor Based on AuNPs-PtNPs-MOFs for Nuclear Matrix Protein 22 Analysis in Urine Sample","volume":"834","author":"Zhao","year":"2019","journal-title":"J. Electroanal. Chem."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1039\/C8AN01590B","article-title":"A Label-Free Immunosensor for the Detection of Nuclear Matrix Protein-22 Based on a Chrysanthemum-like Co-MOFs\/CuAu NWs Nanocomposite","volume":"144","author":"Li","year":"2019","journal-title":"Analyst"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"113112","DOI":"10.1016\/j.bios.2021.113112","article-title":"Electrochemical Diagnostics of Infectious Viral Diseases: Trends and Challenges","volume":"180","author":"Goud","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"14050","DOI":"10.1021\/jacs.8b08894","article-title":"Delayed Sensor Activation Based on Transient Coatings: Biofouling Protection in Complex Biofluids","volume":"140","author":"Sempionatto","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.3390\/s150203236","article-title":"Wireless Integrated Biosensors for Point-of-Care Diagnostic Applications","volume":"15","year":"2015","journal-title":"Sensors"}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/13\/3\/398\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:58:16Z","timestamp":1760122696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/13\/3\/398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,18]]},"references-count":245,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["bios13030398"],"URL":"https:\/\/doi.org\/10.3390\/bios13030398","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,18]]}}}