{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:26:41Z","timestamp":1787898401885,"version":"build-2784847793"},"reference-count":57,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iran National Science Foundation (INSF)","award":["99021685"],"award-info":[{"award-number":["99021685"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Imatinib mesylate, an anticancer drug, is prescribed to treat gastrointestinal stromal tumors and chronic myelogenous leukemia. A hybrid nanocomposite of N,S-doped carbon dots\/carbon nanotube-poly(amidoamine) dendrimer (N,S-CDs\/CNTD) was successfully synthesized and used as a significant modifier to design a new and highly selective electrochemical sensor for the determination of imatinib mesylate. A rigorous study with electrochemical techniques, such as cyclic voltammetry and differential pulse voltammetry, was performed to elucidate the electrocatalytic properties of the as-prepared nanocomposite and the preparation procedure of the modified glassy carbon electrode (GCE). A higher oxidation peak current was generated for the imatinib mesylate on a N,S-CDs\/CNTD\/GCE surface compared to the GCE and CNTD\/GCE. The N,S-CDs\/CNTD\/GCE showed a linear relationship between the concentration and oxidation peak current of the imatinib mesylate in 0.01\u2013100 \u03bcM, with a detection limit of 3 nM. Finally, the imatinib mesylate\u2019s quantification in blood-serum samples was successfully performed. The N,S-CDs\/CNTD\/GCE\u2019s reproducibility and stability were indeed excellent.<\/jats:p>","DOI":"10.3390\/bios13050547","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T08:33:01Z","timestamp":1684139581000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Modified Electrochemical Sensor Based on N,S-Doped Carbon Dots\/Carbon Nanotube-Poly(Amidoamine) Dendrimer Hybrids for Imatinib Mesylate Determination"],"prefix":"10.3390","volume":"13","author":[{"given":"Maryam","family":"Saleh Mohammadnia","sequence":"first","affiliation":[{"name":"Faculty of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz 533184-1133, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-7679","authenticated-orcid":false,"given":"Hossein","family":"Roghani-Mamaqani","sequence":"additional","affiliation":[{"name":"Faculty of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz 533184-1133, Iran"},{"name":"Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz 533184-1133, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-1805","authenticated-orcid":false,"given":"Masoumeh","family":"Ghalkhani","sequence":"additional","affiliation":[{"name":"Electrochemical Sensors Research Laboratory, Department of Chemistry, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, P.O. Box 16785-163, Tehran 167881-5811, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salar","family":"Hemmati","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 516661-6471, Iran"},{"name":"Biotechnology Research Center, Tabriz University of Medical Science, Tabriz 516661-6471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111658","DOI":"10.1016\/j.micromeso.2021.111658","article-title":"Synthesis of the decorated carbon nano onions with aminated MCM-41\/Fe3O4 NPs: Morphology and electrochemical sensing performance for methotrexate analysis","volume":"331","author":"Ghalkhani","year":"2021","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1056\/NEJMoa1613125","article-title":"KIT inhibition by imatinib in patients with severe refractory asthma","volume":"376","author":"Cahill","year":"2017","journal-title":"N. 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