{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:55:19Z","timestamp":1789646119946,"version":"4.0.0"},"reference-count":45,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFF1202704"],"award-info":[{"award-number":["2022YFF1202704"]}]},{"name":"National Key Research and Development Program of China","award":["82001922"],"award-info":[{"award-number":["82001922"]}]},{"name":"National Key Research and Development Program of China","award":["XJ2021034"],"award-info":[{"award-number":["XJ2021034"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022YFF1202704"],"award-info":[{"award-number":["2022YFF1202704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001922"],"award-info":[{"award-number":["82001922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["XJ2021034"],"award-info":[{"award-number":["XJ2021034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Scholars Program","award":["2022YFF1202704"],"award-info":[{"award-number":["2022YFF1202704"]}]},{"name":"Hong Kong Scholars Program","award":["82001922"],"award-info":[{"award-number":["82001922"]}]},{"name":"Hong Kong Scholars Program","award":["XJ2021034"],"award-info":[{"award-number":["XJ2021034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>8-Hydroxydeoxyguanosine (8-OHdG) is the most widely used oxidative stress biomarker of the free radical-induced oxidative damage product of DNA, which may allow a premature assessment of various diseases. This paper designs a label-free, portable biosensor device to directly detect 8-OHdG by plasma-coupled electrochemistry on a transparent and conductive indium tin oxide (ITO) electrode. We reported a flexible printed ITO electrode made from particle-free silver and carbon inks. After inkjet printing, the working electrode was sequentially assembled by gold nanotriangles (AuNTAs) and platinum nanoparticles (PtNPs). This nanomaterial-modified portable biosensor showed excellent electrochemical performance for 8-OHdG detection from 10 \u03bcg\/mL to 100 \u03bcg\/mL by our self-developed constant voltage source integrated circuit system. This work demonstrated a portable biosensor for simultaneously integrating nanostructure, electroconductivity, and biocompatibility to construct advanced biosensors for oxidative damage biomarkers. The proposed nanomaterial-modified ITO-based electrochemical portable device was a potential biosensor to approach 8-OHdG point-of-care testing (POCT) in various biological fluid samples, such as saliva and urine samples.<\/jats:p>","DOI":"10.3390\/bios13060643","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T02:56:34Z","timestamp":1686624994000},"page":"643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO\/AuNTAs\/PtNPs Electrode"],"prefix":"10.3390","volume":"13","author":[{"given":"Yongchang","family":"Bai","sequence":"first","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-5087","authenticated-orcid":false,"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102364","DOI":"10.1016\/j.canep.2023.102364","article-title":"Gender-specific trends in cigarette smoking and lung cancer incidence: A two-stage age-stratified Bayesian joinpoint model","volume":"84","author":"Kafle","year":"2023","journal-title":"Cancer Epidemiol."},{"key":"ref_2","first-page":"27","article-title":"Global Trends of Prostate Cancer by Age, and Their Associations with Gross Domestic Product (GDP), Human Development Index (HDI), Smoking, and Alcohol Drinking","volume":"8","author":"Huang","year":"2023","journal-title":"Clin. 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