{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:58Z","timestamp":1791438598838,"version":"4.3.3"},"reference-count":120,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Nanomedicine has provided cutting-edge technologies and innovative methods for modern biomedical research, offering unprecedented opportunities to tackle crucial biomedical issues. Nanomaterials with unique structures and properties can integrate multiple functions to achieve more precise diagnosis and treatment, making up for the shortcomings of traditional treatment methods. Among them, metal\u2013polyphenol coordination polymers (MPCPs), composed of metal ions and phenolic ligands, are considered as ideal nanoplatforms for disease diagnosis and treatment. Recently, MPCPs have been extensively investigated in the field of biomedicine due to their facile synthesis, adjustable structures, and excellent biocompatibility, as well as pH-responsiveness. In this review, the classification of various MPCPs and their fabrication strategies are firstly summarized. Then, their significant achievements in the biomedical field such as biosensing, drug delivery, bioimaging, tumor therapy, and antibacterial applications are highlighted. Finally, the main limitations and outlooks regarding MPCPs are discussed.<\/jats:p>","DOI":"10.3390\/bios13080776","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:08:14Z","timestamp":1690798094000},"page":"776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Recent Advances of Metal\u2013Polyphenol Coordination Polymers for Biomedical Applications"],"prefix":"10.3390","volume":"13","author":[{"given":"Jing","family":"Qin","sequence":"first","affiliation":[{"name":"College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100022","DOI":"10.1016\/j.giant.2020.100022","article-title":"Natural polyphenols in drug delivery systems: Current status and future challenges","volume":"3","author":"Wang","year":"2020","journal-title":"Giant"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2016.06.003","article-title":"Nanoparticles in Practice for molecular-imaging applications: An overview","volume":"41","author":"Padmanabhan","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2202684","DOI":"10.1002\/advs.202202684","article-title":"Recent advances in the development and antimicrobial applications of metal-phenolic networks","volume":"9","author":"Li","year":"2022","journal-title":"Adv. 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