{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:41:47Z","timestamp":1782286907999,"version":"3.54.5"},"reference-count":107,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)","award":["2022R1F1A1064357"],"award-info":[{"award-number":["2022R1F1A1064357"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)","award":["GCU-2020-02710001"],"award-info":[{"award-number":["GCU-2020-02710001"]}]},{"name":"Gachon University research fund","award":["2022R1F1A1064357"],"award-info":[{"award-number":["2022R1F1A1064357"]}]},{"name":"Gachon University research fund","award":["GCU-2020-02710001"],"award-info":[{"award-number":["GCU-2020-02710001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Alzheimer\u2019s disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labor force, and therefore a solution is urgently needed. Recently, diverse techniques for the detection of Alzheimer\u2019s biomarkers have been researched and developed to support early diagnosis and treatment. Among them, electrochemical biosensors and electrode modification proved their effectiveness in the detection of the A\u03b2 biomarker at appropriately low concentrations for practice and point-of-care application. This review discusses the production and detection ability of amyloid beta, an Alzheimer\u2019s biomarker, by electrochemical biosensors with SAM support for antibody conjugation. In addition, future perspectives on SAM for the improvement of electrochemical biosensors are also proposed and discussed.<\/jats:p>","DOI":"10.3390\/bios13080809","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T12:10:30Z","timestamp":1691755830000},"page":"809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["SAM-Support-Based Electrochemical Sensor for A\u03b2 Biomarker Detection of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Phan Gia","family":"Le","sequence":"first","affiliation":[{"name":"Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien T. Ngoc","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dental Hygiene, Gachon University, Incheon 21936, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3839-6410","authenticated-orcid":false,"given":"Sungbo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea"},{"name":"Department of Health Sciences and Technology (GAIHST), Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S1872-2040(18)61107-7","article-title":"Advances in Detection Methods of \u03b2-Amyloid Protein","volume":"46","author":"Jiang","year":"2018","journal-title":"Chin. 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