{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:44:23Z","timestamp":1774424663495,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["301728\/2019-4"],"award-info":[{"award-number":["301728\/2019-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["13\/2022"],"award-info":[{"award-number":["13\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["301728\/2019-4"],"award-info":[{"award-number":["301728\/2019-4"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["13\/2022"],"award-info":[{"award-number":["13\/2022"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pr\u00f3-reitoria de Pesquisa\u2014UNESP","award":["301728\/2019-4"],"award-info":[{"award-number":["301728\/2019-4"]}]},{"name":"Pr\u00f3-reitoria de Pesquisa\u2014UNESP","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Pr\u00f3-reitoria de Pesquisa\u2014UNESP","award":["13\/2022"],"award-info":[{"award-number":["13\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>This work reports the development and application of a highly selective core@shell-based quantum dot\u2013molecularly imprinted polymer (QD@MIP) sensor for the detection of sulfadiazine (SDZ)\u2014an antibiotic which belongs to the sulfonamide family. The synthesis of the smart material or MIP (molecularly imprinted polymer) was carried out by a precipitation method directly on the quantum dot surface, which played the role of a fluorescent probe in the optical sensor. The synthesized polymer was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Fluorescence experiments were performed in order to evaluate the effects of pH, interaction time of the QD@MIP with the analyte and SDZ concentration in different matrices. Under optimized conditions, a linear concentration range of 10.0\u201360.0 ppm and a limit of detection of 3.33 ppm were obtained. The repeatability and reproducibility of the proposed QD@MIP were evaluated in terms of the RSD, where RSD values of less than 5% were obtained in both tests. Selectivity studies were carried out in the presence of four possible interfering substances with quenching properties, and the signals obtained for these interferents confirmed the excellent selectivity of the proposed sensor; the imprinting factor value obtained for SDZ was 1.64. Finally, the proposed sensor was applied in real animal-based food samples using a spiked concentration of SDZ, where the recovery values obtained were above 90% (experiments were performed in triplicate).<\/jats:p>","DOI":"10.3390\/bios13090877","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:01:30Z","timestamp":1694160090000},"page":"877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Molecularly Imprinted Polymer-Coated CdTe Quantum Dots for Fluorometric Detection of Sulfonamide Antibiotics in Food Samples"],"prefix":"10.3390","volume":"13","author":[{"given":"Bianca","family":"Mortari","sequence":"first","affiliation":[{"name":"Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara 14801-900, SP, Brazil"},{"name":"National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Araraquara 14800-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4557-238X","authenticated-orcid":false,"given":"Sabir","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara 14801-900, SP, Brazil"},{"name":"National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Araraquara 14800-900, SP, Brazil"},{"name":"Department of Natural Sciences, Mathematics, and Statistics, Federal Rural University of the Semi-Arid, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademar","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara 14801-900, SP, Brazil"},{"name":"National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Araraquara 14800-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-7888","authenticated-orcid":false,"given":"Maria","family":"Del Pilar Taboada Sotomayor","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara 14801-900, SP, Brazil"},{"name":"National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Araraquara 14800-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0003-2670(03)00080-1","article-title":"Rapid high-performance liquid chromatographic determining technique of sulfamonomethoxine, sulfadimethoxine, and sulfaquinoxaline in eggs without use of organic solvents","volume":"481","author":"Furusawa","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1068-607X(97)00121-2","article-title":"Sulfonamide antibiotics","volume":"5","author":"Connor","year":"1998","journal-title":"Prim. Care Updat. Ob\/Gyns"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Struller, T. (1968). Progress in Sulfonamide Research, In Progress in Drug Research\/Fortschritte der Arzneimittelforschung\/Progr\u00e8s des Recherches Pharmaceutiques, Birkh\u00e4user.","DOI":"10.1007\/978-3-0348-7065-8_7"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1897\/03-582R.1","article-title":"Investigations on the fate of sulfadiazine in manured soil: Laboratory experiments and test plot studies","volume":"24","author":"Kreuzig","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exppara.2019.05.001","article-title":"Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil","volume":"202","author":"Silva","year":"2019","journal-title":"Exp. Parasitol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jconhyd.2006.08.002","article-title":"Transport of sulfadiazine in soil columns\u2014Experiments and modelling approaches","volume":"89","author":"Wehrhan","year":"2007","journal-title":"J. Contam. Hydrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.chemosphere.2008.06.066","article-title":"Sorption and desorption of sulfadiazine in soil and soil-manure systems","volume":"73","author":"Sukul","year":"2008","journal-title":"Chemosphere"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/sscp.202000051","article-title":"Rapid determination of sulfonamide residues in honey samples using non-targeted liquid chromatography-high resolution mass spectrometry","volume":"3","author":"Tahir","year":"2020","journal-title":"Sep. Sci. Plus"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/jaoac\/85.4.853","article-title":"Quantitative LC\/MS-MS Determination of Sulfonamides and Some Other Antibiotics in Honey","volume":"85","author":"Kaufmann","year":"2002","journal-title":"J. AOAC Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/jssc.201600233","article-title":"Determination of sulfadiazine in eggs using molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography","volume":"39","author":"He","year":"2016","journal-title":"J. Sep. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.3390\/ijms12095908","article-title":"Molecularly imprinted polymers: Present and future prospective","volume":"12","author":"Vasapollo","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jchromb.2004.02.013","article-title":"Molecularly imprinted polymers: Synthesis and characterisation","volume":"804","author":"Cormack","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1590\/S0100-40422005000600024","article-title":"Pol\u00edmeros biomim\u00e9ticos em qu\u00edmica anal\u00edtica. Parte 1: Preparo e aplica\u00e7\u00f5es de MIP (\u201cMolecularly Imprinted Polymers\u201d) em t\u00e9cnicas de extra\u00e7\u00e3o e separa\u00e7\u00e3o","volume":"28","author":"Tarley","year":"2005","journal-title":"Quim. Nova"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jbbm.2006.07.005","article-title":"Application of molecularly imprinted polymers to solid-phase extraction of analytes from real samples","volume":"70","author":"He","year":"2007","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bios.2014.02.041","article-title":"Selective optosensing of clenbuterol and melamine using molecularly imprinted polymer-capped CdTe quantum dots","volume":"57","author":"Seo","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1515\/nanoph-2012-0031","article-title":"Color science of nanocrystal quantum dots for lighting and displays","volume":"2","author":"Erdem","year":"2013","journal-title":"Nanophotonics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1021\/acs.accounts.0c00691","article-title":"Coupled Colloidal Quantum Dot Molecules","volume":"54","author":"Koley","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0009-2614(00)01042-3","article-title":"Photon antibunching in single CdSe\/ZnS quantum dot fluorescence","volume":"329","author":"Lounis","year":"2000","journal-title":"Chem. Phys. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1556-276X-7-480","article-title":"Quantum dots: Synthesis, bioapplications, and toxicity","volume":"7","author":"Valizadeh","year":"2012","journal-title":"Nanoscale Res. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"520A","DOI":"10.1021\/ac022124v","article-title":"Peer Reviewed: Optical Sensing with Quantum Dots","volume":"74","author":"Murphy","year":"2002","journal-title":"Anal. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.biomaterials.2005.11.018","article-title":"Advances in fluorescence imaging with quantum dot bio-probes","volume":"27","author":"Pinaud","year":"2006","journal-title":"Biomaterials"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/cphc.200400557","article-title":"Single-Molecule Quantum-Dot Fluorescence Resonance Energy Transfer","volume":"6","author":"Hohng","year":"2005","journal-title":"ChemPhysChem"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.1021\/acs.analchem.2c01031","article-title":"Inner Filter Effect Correction for Fluorescence Measurements in Microplates Using Variable Vertical Axis Focus","volume":"94","author":"Weitner","year":"2022","journal-title":"Anal. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"47099","DOI":"10.1021\/acsami.0c15482","article-title":"Smartphones and Test Paper-Assisted Ratiometric Fluorescent Sensors for Semi-Quantitative and Visual Assay of Tetracycline Based on the Target-Induced Synergistic Effect of Antenna Effect and Inner Filter Effect","volume":"12","author":"Han","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bios.2013.11.004","article-title":"Epitope imprinted polymer coating CdTe quantum dots for specific recognition and direct fluorescent quantification of the target protein bovine serum albumin","volume":"54","author":"Yang","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"122777","DOI":"10.1016\/j.matchemphys.2020.122777","article-title":"Evaluation of the performance of selective M-MIP to tetracycline using electrochemical and HPLC-UV method","volume":"245","author":"Wong","year":"2020","journal-title":"Mater. Chem. Phys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.talanta.2014.08.028","article-title":"A direct competitive assay-based aptasensor for sensitive determination of tetracycline residue in Honey","volume":"131","author":"Wang","year":"2015","journal-title":"Talanta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1872-2059(06)60020-5","article-title":"Monitoring Sulfadiazine and Sulfamethazine Residues in Eggs Using Polymer Monolith Microextraction Coupled with High Performance Liquid Chromatography","volume":"24","author":"Wen","year":"2006","journal-title":"Chin. J. Chromatogr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"365705","DOI":"10.1088\/0957-4484\/24\/36\/365705","article-title":"Synthesis, tailoring and characterization of silica nanoparticles containing a highly stable ruthenium complex","volume":"24","author":"Wencel","year":"2013","journal-title":"Nanotechnology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1590\/S0100-40422004000500017","article-title":"Valida\u00e7\u00e3o em m\u00e9todos cromatogr\u00e1ficos e eletrofor\u00e9ticos","volume":"27","author":"Ribani","year":"2004","journal-title":"Quim. Nova"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.microc.2017.07.007","article-title":"Determination of amino acids in sugarcane vinasse by ion chromatographic using nickel nanoparticles on reduced graphene oxide modified electrode","volume":"134","author":"Beluomini","year":"2017","journal-title":"Microchem. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.saa.2011.01.037","article-title":"Determination of glyphosate in foodstuff by one novel chemiluminescence-molecular imprinting sensor, Spectrochim","volume":"78","author":"Zhao","year":"2011","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.marpolbul.2019.07.010","article-title":"Application of molecular imprinting polymer anchored on CdTe quantum dots for the detection of sulfadiazine in seawater","volume":"146","author":"Shi","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"106169","DOI":"10.1016\/j.jece.2021.106169","article-title":"Metal-organic frameworks derived ZnO-Co3O4 pn heterojunction photocatalyst for the photoelectrochemical detection of sulfadiazine","volume":"9","author":"Velmurugan","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_35","first-page":"025005","article-title":"An eco-friendly fluorometric polymer nanoparticle for selectively monitoring sulfadiazine in tap water","volume":"8","author":"Gao","year":"2020","journal-title":"Methods Appl. Fluoresc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1002\/jssc.201800866","article-title":"Ratiometric fluorescence nanosensors based on core-shell structured carbon\/CdTe quantum dots and surface molecularly imprinted polymers for the detection of sulfadiazine","volume":"41","author":"Chen","year":"2018","journal-title":"J. Sep. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00604-019-3721-1","article-title":"Fluorometric determination of sulfadiazine by using molecularly imprinted poly(methyl methacrylate) nanobeads doped with manganese(II)-doped ZnS quantum dots","volume":"186","author":"Gao","year":"2019","journal-title":"Microchim. Acta"}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/13\/9\/877\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:47:24Z","timestamp":1760129244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/13\/9\/877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["bios13090877"],"URL":"https:\/\/doi.org\/10.3390\/bios13090877","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]}}}