{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:28:02Z","timestamp":1792175282683,"version":"4.4.0"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science and Engineering Research Council of Canada (NSERC)","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Natural Science and Engineering Research Council of Canada (NSERC)","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Natural Science and Engineering Research Council of Canada (NSERC)","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"Natural Science and Engineering Research Council of Canada (NSERC)","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Concordia University Research Chair (CURC)","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Concordia University Research Chair (CURC)","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Concordia University Research Chair (CURC)","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"Concordia University Research Chair (CURC)","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Concordia Seed","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Concordia Seed","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Concordia Seed","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"Concordia Seed","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"FRDP","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"FRDP","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"FRDP","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"FRDP","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>The colorimetric detection of glucose in urine through enzymatic reactions offers a low-cost and non-invasive method to aid in diabetes management. Nonetheless, the vulnerability of enzymes to environmental conditions, particularly elevated temperatures, and their activity loss pose significant challenges for transportation and storage. In this work, we developed a stable and portable tablet sensor as a user-friendly platform for glucose monitoring. This innovative device encapsulates glucose oxidase and horseradish peroxidase enzymes with dextran, transforming them into solid tablets and ensuring enhanced stability and practicality. The enzymatic tablet-based sensor detected glucose in urine samples within 5 min, using 3,3\u2032,5,5\u2032-tetramethylbenzidine (TMB) as the indicator. The tablet sensor exhibited responsive performance within the clinically relevant range of 0\u20136 mM glucose, with a limit of detection of 0.013 mM. Furthermore, the tablets detected glucose in spiked real human urine samples, without pre-processing, with high precision. Additionally, with regard to thermal stability, the enzyme tablets better maintained their activity at an elevated temperature as high as 60 \u00b0C compared to the solution-phase enzymes, demonstrating the enhanced stability of the enzymes under harsh conditions. The availability of these stable and portable tablet sensors will greatly ease the transportation and application of glucose sensors, enhancing the accessibility of glucose monitoring, particularly in resource-limited settings.<\/jats:p>","DOI":"10.3390\/bios13090893","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T01:32:50Z","timestamp":1695173570000},"page":"893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tablet-Based Sensor: A Stable and User-Friendly Tool for Point-of-Care Detection of Glucose in Urine"],"prefix":"10.3390","volume":"13","author":[{"given":"Hasti","family":"Hajimiri","sequence":"first","affiliation":[{"name":"Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montreal, QC H3G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hamid","family":"Safiabadi Tali","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montreal, QC H3G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna","family":"Al-Kassawneh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montreal, QC H3G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-489X","authenticated-orcid":false,"given":"Zubi","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montreal, QC H3G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Jahanshahi-Anbuhi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montreal, QC H3G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (2023, April 06). 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