{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:25:20Z","timestamp":1778790320084,"version":"3.51.4"},"reference-count":65,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of South Australia","award":["FT200100154"],"award-info":[{"award-number":["FT200100154"]}]},{"name":"Australian Research Council (ARC) Future Fellowship","award":["FT200100154"],"award-info":[{"award-number":["FT200100154"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Dysregulated production of hydrogen sulphide in the human body has been associated with various diseases including cancer, underlining the importance of accurate detection of this molecule. Here, we report the detection of hydrogen sulphide using fluorescence-emission enhancement of two 1,8-naphthalimide fluorescent probes with an azide moiety in position 4. One probe, serving as a control, featured a methoxyethyl moiety through the imide to evaluate its effectiveness for hydrogen sulphide detection, while the other probe was modified with (3-aminopropyl)triethoxysilane (APTES) to enable direct covalent attachment to an optical fibre tip. We coated the optical fibre tip relatively homogeneously with the APTES-azide fluorophore, as confirmed via x-ray photoelectron spectroscopy (XPS). The absorption and fluorescence responses of the control fluorophore free in PBS were analysed using UV-Vis and fluorescence spectrophotometry, while the fluorescence emission of the APTES-azide fluorophore-coated optical fibres was examined using a simple, low-cost optical fibre-based setup. Both fluorescent probes exhibited a significant increase (more than double the initial value) in fluorescence emission upon the addition of HS\u2212 when excited with 405 nm. However, the fluorescence enhancement of the coated optical fibres demonstrated a much faster response time of 2 min (time for the fluorescence intensity to reach 90% of its maximum value) compared to the control fluorophore in solution (30 min). Additionally, the temporal evolution of fluorescence intensity of the fluorophore coated on the optical fibre was studied at two pH values (7.4 and 6.4), demonstrating a reasonable overlap and confirming the compound pH insensitivity within this range. The promising results from this study indicate the potential for developing an optical fibre-based sensing system for HS\u2212 detection using the synthesised fluorophore, which could have significant applications in health monitoring and disease detection.<\/jats:p>","DOI":"10.3390\/bios13110949","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:39:04Z","timestamp":1698147544000},"page":"949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Surface Functionalised Optical Fibre for Detection of Hydrogen Sulphide"],"prefix":"10.3390","volume":"13","author":[{"given":"Shaghayegh","family":"Baghapour","sequence":"first","affiliation":[{"name":"Laser Physics and Photonic Devices Laboratory, UniSA STEM, University of South Australia, Adelaide, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-2980","authenticated-orcid":false,"given":"Jasmine","family":"Nehema","sequence":"additional","affiliation":[{"name":"Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laser Physics and Photonic Devices Laboratory, UniSA STEM, University of South Australia, Adelaide, SA 5095, Australia"},{"name":"Future Industries Institute, University of South Australia, Adelaide, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-6344","authenticated-orcid":false,"given":"Stephen C.","family":"Warren-Smith","sequence":"additional","affiliation":[{"name":"Laser Physics and Photonic Devices Laboratory, UniSA STEM, University of South Australia, Adelaide, SA 5095, Australia"},{"name":"Future Industries Institute, University of South Australia, Adelaide, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-531X","authenticated-orcid":false,"given":"Shane M.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-9154","authenticated-orcid":false,"given":"Sally E.","family":"Plush","sequence":"additional","affiliation":[{"name":"Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahraam","family":"Afshar Vahid","sequence":"additional","affiliation":[{"name":"Laser Physics and Photonic Devices Laboratory, UniSA STEM, University of South Australia, Adelaide, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.snb.2015.04.108","article-title":"Fibre optic hydrogen sulfide gas sensors utilizing ZnO thin film\/ZnO nanoparticles: A comparison of surface plasmon resonance and lossy mode resonance","volume":"218","author":"Usha","year":"2015","journal-title":"Sens. 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